scholarly journals Peripheral blood lymphocyte subtypes in dogs with different stages of myxomatous mitral valve disease

2021 ◽  
Author(s):  
Natalia Druzhaeva ◽  
Alenka Nemec Svete ◽  
Alojz Ihan ◽  
Katka Pohar ◽  
Aleksandra Domanjko Petrič
Keyword(s):  
Mitral Valve ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Mitral Valve Disease ◽  
Blood Lymphocyte ◽  
Valve Disease

scholarly journals Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

2014 ◽  
Vol 58 (1) ◽  
pp. 135-140
Author(s):  
Magdalena Garncarz ◽  
Magdalena Hulanicka ◽  
Marta Parzeniecka-Jaworska ◽  
Jacek Garncarz ◽  
Michał Jank
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Mitral Valve ◽  
Peripheral Blood ◽  
Mitral Valve Disease ◽  
Clinical Signs ◽  
Valve Disease ◽  
Non Invasive ◽  
The Status ◽  
Healthy Dogs

Abstract The aim of the study was to demonstrate differences in the gene expression of signalling pathways between healthy dogs and dogs with chronic mitral valve disease in different heart failure groups. Blood samples were collected from 49 dogs of various breeds between 1.4 and 15.2 years of age. Isolated RNA samples were analysed for quality and integrity and the gene expression profile was determined. The study demonstrated that nucleated cells from peripheral blood can be used to assess the status of heart failure in dogs. Furthermore, significant differences in the expression of the genes were noticed between healthy dogs and dogs with clinical signs of chronic mitral valve disease. This is a preliminary non-invasive study showing the feasibility of genetic testing from peripheral blood nucleated cells, which at the same time has made it possible to set the future directions of genetic studies in clinical cases of canine chronic mitral valve disease.

scholarly journals Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

2016 ◽  
Vol 19 (4) ◽  
pp. 849-857 ◽  
Author(s):  
M. Garncarz ◽  
M. Hulanicka ◽  
H. Maciejewski ◽  
M. Parzeniecka-Jaworska ◽  
M. Jank
Keyword(s):  
Gene Expression ◽  
Heart Disease ◽  
Mitral Valve ◽  
Peripheral Blood ◽  
Mitral Valve Disease ◽  
Expression Profiles ◽  
Valve Disease ◽  
Microarray Data Analysis ◽  
Future Research ◽  
Tissue Samples

Abstract Studies identifying specific pathologically expressed genes have been performed on diseased myocardial tissue samples, however less invasive studies on gene expression of peripheral blood mononucleated cells give promising results. This study assessed transcriptomic data that may be used to evaluate Dachshunds with chronic mitral valve disease. Dachshunds with different stages of heart disease were compared to a control, healthy group. Microarray data analysis revealed clusters of patients with similar expression profiles. The clusters were compared to the clinical classification scheme. Unsupervised classification of the studied groups showed three clusters. Clinical and laboratory parameters of patients from the cluster 1 were in accordance with those found in patients without heart disease. Data obtained from patients from the cluster 3 were typical of advanced heart failure patients. Comparison of the cluster 1 and 3 groups revealed 1133 differentially expressed probes, 7 significantly regulated process pathways and 2 significantly regulated Ariadne Metabolic Pathways. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease.

Early and long-term outcomes of surgery for acute decompensated mitral valve disease

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
S Leontyev ◽  
P Davierwala ◽  
M Schneevoigt ◽  
S Lehmann ◽  
J Seeburger ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Valve Disease ◽  
Long Term Outcomes
Sign in / Sign up

Export Citation Format

Share Document