Ultrasonic System for Diagnosis of Functional Gastrointestinal Disorders: Development, Verification and Clinical Trials

The number of people who are suffering from Functional gastrointestinal disorders is increasing. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes [1, 2]. Recently our research group identified that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders is more rigid than healthy people. we noticed it with palpating the abdominal regions overlaying the gastrointestinal tract. Therefore we developed a system to detect the rigid organs with ultrasonic technique, which can quantify the characteristic above related to the rigidity of the gastrointestinal tract well.

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The difference of disrupted rhythms of life, work and entertainment between patients with FGIDs and healthy people and their associations with psychological disorders under COVID-19 pandemic

International Journal of Social Psychiatry ◽

10.1177/0020764021992835 ◽

2021 ◽

pp. 002076402199283

Author(s):

Jing Wang ◽

Ping He ◽

Tianwei Deng ◽

Xiaoming Xu ◽

Duowu Zou ◽

...

Keyword(s):

Mood Disorders ◽

Functional Gastrointestinal Disorders ◽

Depression Scale ◽

Healthy People ◽

Gastrointestinal Disorders ◽

Related Factors ◽

Healthy Group ◽

Self Rating ◽

The Difference ◽

Life Work

Aims: To investigate the differences in disrupted rhythms between healthy people and patients with functional gastrointestinal disorders (FGIDs) and their associations with mood disorders during the coronavirus disease 2019 (COVID-19) pandemic. Methods: The rhythm scales were composed of subscales 1 and 2 for the assessment of life-work and entertainment rhythms, respectively; Zung’s Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to assess mood disorders. Results: A total of 671 patients with FGIDs and 4373 healthy people successfully participated. The scores of subscales 1 and 2 for patients with FGIDs were significantly higher than those for healthy people ( p < .005). The SAS and SDS scores, their prevalence rates were significantly higher than those for the healthy group (all p < .001). Health status, current occupation, life-work rhythm, SDS, and SAS were independent related factors of FGIDs. The score of life-work-entertainment rhythm was significantly positively correlated with SDS and SAS (both p < .001). Conclusion: Disrupted rhythms in patients with FGIDs under the COVID-19 pandemic were more frequently and significantly positively associated with mood disorders.

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Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children

Beneficial Microbes ◽

10.3920/bm2014.0067 ◽

2015 ◽

Vol 6 (2) ◽

pp. 209-217 ◽

Cited By ~ 16

Author(s):

S. Guandalini ◽

E. Cernat ◽

D. Moscoso

Keyword(s):

Inflammatory Bowel Disease ◽

Clinical Trials ◽

Irritable Bowel Syndrome ◽

Abdominal Pain ◽

Intestinal Microbiota ◽

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Controlled Trials ◽

Inflammatory Bowel ◽

Irritable Bowel

Underlying pathophysiological mechanisms of irritable bowel syndrome (IBS), a common disorder characterized by abdominal pain associated to a change in stool consistency or frequency, include low-grade inflammation and intestinal microbiota changes. Few and disappointing data are available for prebiotics. A few controlled trials (RCTs) of probiotics are instead available with favourable effects, although most are limited by suboptimal design and small sample size. A recent report from the Rome foundation group included 32 RCTs of probiotics, most of which showed an overall modest improvement in symptoms, with the patients most benefitting from probiotics being those with predominant diarrhoea and those having a post-infectious IBS. A review focusing only on children with functional gastrointestinal disorders concluded that probiotics are more effective than placebo in the treatment of patients with abdominal pain-related functional gastrointestinal disorders, although no effect on constipation was evident. The role for probiotics in inflammatory bowel disease (IBD) appears logical: the endogenous intestinal microbiota plays a central role in their development, and various probiotics have been found effective in animal models of IBD. However, research in humans has been overall quite limited, and it would seem that after a phase of intense research in the first decade of this century, the pace has slowed down, with fewer clinical trials been published in the past 2-3 years. To summarize current evidence: no probiotic has proven successful in Crohn's disease. In ulcerative colitis, on the other hand, data are more promising, and a very recent meta-analysis, that included 23 randomized controlled trials, concluded that there is evidence of efficacy for the probiotic mixture VSL#3 in helping inducing and maintaining remission, as well as in maintaining remission in patients with pouchitis. It is fair to state that for both IBD and IBS, more well-designed, rigorous, randomized clinical trials must be performed.

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Persistent delusions of modern gastroenterology

Herald of Pancreatic Club ◽

10.33149/vkp.2017.01.09 ◽

2017 ◽

Vol 35 (1) ◽

pp. 46-54

Author(s):

Y. S. Tsimmerman

Keyword(s):

Gastric Cancer ◽

Clinical Trials ◽

Helicobacter Pylori ◽

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Ethical Aspects ◽

Ulcer Disease ◽

Common Concept ◽

The Common

The author shares his thoughts about exaggerating the role of infection with Helicobacter pylori in etiology and pathogenesis of chronic gastritis, peptic ulcer disease, gastric cancer. Arguments against the common concept of functional gastrointestinal disorders, formulation of syndromic rather than nosological diagnosis are represented. Particular attention is paid to the moral and ethical aspects of the use of placebo in clinical trials. The shortcomings and errors of the terms that are used in modern gastroenterology are analyzed in detail.

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microecological and associative structure of intestinal biocenosis in children with functional gastrointestinal disorders

Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук ◽

10.12737/23344 ◽

2016 ◽

Vol 1 (5) ◽

pp. 22-25

Author(s):

Немченко ◽

Ulyana Nemchenko ◽

Савелькаева ◽

Marina Savelkaeva ◽

Колесникова ◽

...

Keyword(s):

Large Intestine ◽

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Healthy Children ◽

Functional Disorders ◽

Associative Structure ◽

Intestinal Microbial Community ◽

One Year ◽

Micro Organisms ◽

And Staphylococcus Aureus

The article is devoted to one of actual problems of gastroenterology – study of microbiocenosis of gastrointestinal tract in functional disorders. Functional gastrointestinal disorders (FGID) or minimal dysfunctions of digestion are frequent in the first months of child’s life and provoke anxiety both in parents and in pediatricians. Aim: to explore the microbial landscape and the associative structure of the microbiota of the large intestine in children with functional disorders of the gastrointestinal tract.Subjects and methods: Intestinal microbiota composition of 225 children with functional gastrointestinal disorders and 100 healthy children was studied using bacteriological method.Results. The 88.4 % frequency of detection of intestinal eubiosis disorders is discussed. Information is provided on the species composition of the major opportunistic organisms that inhabit this biotope. According to the results, decrease of bifidobacteria amount in structure of large intestine microbiota increases rate of detection of opportunistic micro-organisms – predominantly, Klebsiella genus bacteria and Staphylococcus aureus. The intestinal microbial community is dominated by multicomponent transient association. The frequency of detection of pathogenic Staphylococcus in children under one year is discussed in detail.Conclusions. A distinctive feature of the intestinal biocenosis microecological status is significantly greater spread of enterococci than in healthy children, which can be a risk for the emergence of strains with the presence of a number of pathogenecity factors that cause infectious processes.

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Global Dietary Patterns and Functional Gastrointestinal Disorders

Children ◽

10.3390/children7100152 ◽

2020 ◽

Vol 7 (10) ◽

pp. 152

Author(s):

Cara Hannah Axelrod ◽

Miguel Saps

Keyword(s):

Clinical Trials ◽

Treatment Options ◽

Functional Gastrointestinal Disorders ◽

The United States ◽

Gastrointestinal Disorders ◽

Dietary Interventions ◽

Nonpharmacological Treatment ◽

Abdominal Symptoms ◽

The World ◽

Consensus View

Functional Gastrointestinal Disorders (FGIDs) are common. In the United States alone, approximately 25 million Americans are estimated to have at least one FGID. Nonpharmacological treatment options include psychological/behavioral approaches, and dietary interventions that can vary across countries. The aim of this review is to evaluate the available evidence for dietary interventions for the treatment of childhood FGIDs amongst various cultures and regions of the world. This review includes clinical trials of dietary therapies for the treatment of FGIDs in children posted on or before 13 July 2020 in PubMed. Overall, the consensus view suggests that the westernization of diets is linked to the development of FGIDs, and diets low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAPs) may reduce abdominal symptoms. However, more work is needed to confirm these findings.

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