A Numerical Investigation of the Fluid Flow in a Chandler Loop for Thrombus Studies

2013 ◽  
Author(s):  
Hisham Touma ◽  
Iskender Sahin ◽  
Tidimogo Gaamangwe ◽  
Maud B. Gorbet ◽  
Sean D. Peterson
Keyword(s):  
Laminar Flow ◽  
Stress Field ◽  
Strain Rate ◽  
Rotation Rate ◽  
Fluid Dynamic ◽  
Working Fluid ◽  
Straight Tube ◽  
Dean Number ◽  
Chandler Loop

The Chandler loop is an artificial circulatory platform for in vitro hemodynamic experiments. In most experiments, the working fluid is subjected to a stress field via rotation of the Chandler loop, which, in turn, induces biochemical responses of the suspended cells. For very low rotation rates, the stress field can be approximated using laminar flow in a straight tube as a model. However, as the rotation rate increases, while still maintaining laminar flow, the effect of the tube curvature causes the stress field to deviate considerably from the straight tube approximation. In this manuscript, we investigate the flow and associated strain rate field of an incompressible Newtonian fluid in a Chandler loop as a function of the governing non-dimensional fluid dynamic parameters. We find that the Dean number, which is proportional to the rotation rate, is the dominant parameter in determining the fluid strain rate. We propose an empirical formula for predicting the average fluid strain rate magnitude in the working fluid that is valid over a wide parameter space to be used in lieu of the common, yet restrictive, straight tube-based prediction.

Numerical Investigation of Fluid Flow in a Chandler Loop

2014 ◽  
Vol 136 (7) ◽  
Author(s):  
Hisham Touma ◽  
Iskender Sahin ◽  
Tidimogo Gaamangwe ◽  
Maud B. Gorbet ◽  
Sean D. Peterson
Keyword(s):  
Strain Rate ◽  
Rotation Rate ◽  
Tangential Velocity ◽  
Working Fluid ◽  
Radius Of Curvature ◽  
Straight Tube ◽  
Dean Number ◽  
Fill Ratio ◽  
Chandler Loop ◽  
Strain Rate Field

The Chandler loop is an artificial circulatory platform for in vitro hemodynamic experiments. In most experiments, the working fluid is subjected to a strain rate field via rotation of the Chandler loop, which, in turn, induces biochemical responses of the suspended cells. For low rotation rates, the strain rate field can be approximated using laminar flow in a straight tube. However, as the rotation rate increases, the effect of the tube curvature causes significant deviation from the laminar straight tube approximation. In this manuscript, we investigate the flow and associated strain rate field of an incompressible Newtonian fluid in a Chandler loop as a function of the governing nondimensional parameters. Analytical estimates of the strain rate from a perturbation solution for pressure driven steady flow in a curved tube suggest that the strain rate should increase with Dean number, which is proportional to the tangential velocity of the rotating tube, and the radius to radius of curvature ratio of the loop. Parametrically varying the rotation rate, tube geometry, and fill ratio of the loop show that strain rate can actually decrease with Dean number. We show that this is due to the nonlinear relationship between the tube rotation rate and height difference between the two menisci in the rotating tube, which provides the driving pressure gradient. An alternative Dean number is presented to naturally incorporate the fill ratio and collapse the numerical data. Using this modified Dean number, we propose an empirical formula for predicting the average fluid strain rate magnitude that is valid over a much wider parameter range than the more restrictive straight tube-based prediction.

Fluid Dynamic Investigation of the ATS 3F Enable Sutureless Heart Valve

2011 ◽  
Vol 6 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Sebastian Stühle ◽  
Daniel Wendt ◽  
Guojun Hou ◽  
Hermann Wendt ◽  
Matthias Thielmann ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Strain Rate ◽  
Heart Valves ◽  
Aortic Wall ◽  
Peak Flow ◽  
Fluid Dynamic ◽  
Maximum Velocity ◽  
Jet Flow ◽  
Clinical Results

Objective Currently, sutureless heart valves (SHV) reveal good clinical results during aortic valve replacement. The aim of this study was to evaluate the fluid dynamics of the ATS 3F Enable SHV in the ascending aorta and their influence on the aortic wall in an in vitro setup. Methods A two-dimensional particle image velocimetry study with an image rate of 15 Hz was conducted to evaluate the fluid dynamics of the SHV in the aortic flow field. The prosthesis (diameter, 23 mm) was placed inside a silicone mock aorta under pulsatile flow conditions. Velocities, vorticity, and strain rate were obtained and calculated with a fixed frequency (70 Hz) at constant stroke volume (70 mL). Results 3F Enable showed a jet flow type profile with a maximum velocity of 1.01 ± 0.13 m/s during peak flow phase (PFP). The jet flow was surrounded by ambilateral vortices with a slightly higher percentage of clockwise than counterclockwise vorticity (377 ± 57/s vs 389 ± 76/s), strain rate (370 ± 79/s for elongation vs — 370 ± 102/s for contraction) was nearly similar. The point-of-interest analysis revealed a higher velocity for bottom compared with upper aortic wall (0.28 ± 0.07 m/s vs 0.31 ± 0.06 m/s, P = 0.024). All values were lower during acceleration and deceleration phase compared with PFP. Conclusions The peak flow of the 3F Enable SHV seems to be little higher compared with native aortic valves, thus simulating nearly physiologic conditions. Vorticity and strain rate are high during PFP and low during other phases and might have an influence on the aortic wall as well.

An in Vitro Model of Neural Trauma: Device Characterization and Calcium Response to Mechanical Stretch

2001 ◽  
Vol 123 (3) ◽  
pp. 247-255 ◽  
Author(s):  
Donna M. Geddes ◽  
Robert S. Cargill
Keyword(s):  
Strain Rate ◽  
In Vitro Model ◽  
Mechanical Stretch ◽  
Neural Cells ◽  
Novel Device ◽  
Loop Feedback ◽  
Closed Loop Feedback ◽  
Cellular Tolerance ◽  
Vitro Model

An in vitro model for neural trauma was characterized and validated. The model is based on a novel device that is capable of applying high strain rate, homogeneous, and equibiaxial deformation to neural cells in culture. The deformation waveform is fully arbitrary and controlled via closed-loop feedback. Intracellular calcium [Ca2+]i alterations were recorded in real time throughout the imposed strain with an epifluorescent microscopy system. Peak change in [Ca2+]i, recovery of [Ca2+]i, and percent responding NG108-15 cells were shown to be dependent on strain rate (1−1 to 10−1) and magnitude (0.1 to 0.3 Green’s Strain). These measures were also shown to depend significantly on the interaction between strain rate and magnitude. This model for neural trauma is a robust system that can be used to investigate the cellular tolerance and response to traumatic brain injury.

Heat Transfer for Laminar Flow in Spiral Ducts of Rectangular Cross Section

2005 ◽  
Vol 127 (3) ◽  
pp. 352-356 ◽  
Author(s):  
Michael W. Egner ◽  
Louis C. Burmeister
Keyword(s):  
Heat Transfer ◽  
Nusselt Number ◽  
Laminar Flow ◽  
Cross Section ◽  
Rectangular Cross Section ◽  
Three Dimensional ◽  
Radius Of Curvature ◽  
Dean Number ◽  
Aspect Ratios ◽  
Small Pitch

Laminar flow and heat transfer in three-dimensional spiral ducts of rectangular cross section with aspect ratios of 1, 4, and 8 were determined by making use of the FLUENT computational fluid dynamics program. The peripherally averaged Nusselt number is presented as a function of distance from the inlet and of the Dean number. Fully developed values of the Nusselt number for a constant-radius-of-curvature duct, either toroidal or helical with small pitch, can be used to predict those quantities for the spiral duct in postentry regions. These results are applicable to spiral-plate heat exchangers.

Computational and Experimental Investigation of the Vertical Flash Tank Separator Part 1: Effect of Parameters on Separation Efficiency

2019 ◽  
Vol 27 (01) ◽  
pp. 1950005 ◽  
Author(s):  
Raid Ahmed Mahmood ◽  
David Buttsworth ◽  
Ray Malpress
Keyword(s):  
Separation Efficiency ◽  
Fluid Dynamic ◽  
Effective Area ◽  
Working Fluid ◽  
Cfd Simulations ◽  
Liquid Separation ◽  
Two Phase ◽  
Flash Tank ◽  
Tank Design ◽  
The Heat Transfer Coefficient

The flash tank separator is one of the most important components that can be used to improve the performance of a refrigeration cycle by separating the liquid from the gas–liquid two-phase flow and providing the evaporator with only liquid refrigerant. This technique increases the effective area and enhances the heat transfer coefficient in the evaporator. To optimize the size of the vertical flash tank separator for obtaining high separation efficiency, the effect of the size of the vertical flash tank separator needs to be considered. This paper investigates the effect of the size on the liquid separation efficiency of the vertical flash tank separator. This paper also assesses the usefulness of Computational Fluid Dynamic (CFD) in flash tank design, and this is achieved through experiments and simulations on a range of relevant configurations using water as the working fluid. The results revealed that the size has a significant effect on the liquid separation efficiency, as the highest value was achieved by the largest size (VFT-V5). The CFD simulations give a good agreement with the experiments; all the simulations underestimated the liquid separation efficiency by approximately 0.02 over the range of conditions tested.

scholarly journals Deformation in the Vicinity of Ice Divides

1983 ◽  
Vol 29 (103) ◽  
pp. 357-373 ◽  
Author(s):  
Charles F. Raymond
Keyword(s):  
Finite Elements ◽  
Laminar Flow ◽  
Velocity Profile ◽  
Strain Rate ◽  
Shear Strain ◽  
Vertical Velocity ◽  
Flow Theory ◽  
Numerical Calculations ◽  
Shear Strain Rate ◽  
Horizontal Shear

AbstractNumerical calculations by finite elements show that the variation of horizontal velocity with depth in the vicinity of a symmetric, isothermal, non-slipping ice ridge deforming on a flat bed is approximately consistent with prediction from laminar flow theory except in a zone within about four ice thicknesses of the divide. Within this near-divide zone horizontal shear strain-rate is less concentrated near the bottom and downward velocity is less rapid in comparison to the flanks. The profiles over depth of horizontal and vertical velocity approach being linear and parabolic respectively. Calculations for various surface elevation profiles show these velocity profile shapes are insensitive to the ice-sheet geometry.

scholarly journals 3D Perfusable Hydrogel Recapitulating the Cancer Dynamic Environment to in Vitro Investigate Metastatic Colonization

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2467
Author(s):  
Chiara Vitale ◽  
Arianna Fedi ◽  
Alessandra Marrella ◽  
Gabriele Varani ◽  
Marco Fato ◽  
...  
Keyword(s):  
Single Channel ◽  
Fluid Dynamic ◽  
Dynamic Environment ◽  
Metastatic Breast ◽  
Polymeric Matrix ◽  
The Body ◽  
Secondary Site ◽  
Circulation System ◽  
Metastatic Cascade

Metastasis is a dynamic process involving the dissemination of circulating tumor cells (CTCs) through blood flow to distant tissues within the body. Nevertheless, the development of an in vitro platform that dissects the crucial steps of metastatic cascade still remains a challenge. We here developed an in vitro model of extravasation composed of (i) a single channel-based 3D cell laden hydrogel representative of the metastatic site, (ii) a circulation system recapitulating the bloodstream where CTCs can flow. Two polymers (i.e., fibrin and alginate) were tested and compared in terms of mechanical and biochemical proprieties. Computational fluid-dynamic (CFD) simulations were also performed to predict the fluid dynamics within the polymeric matrix and, consequently, the optimal culture conditions. Next, once the platform was validated through perfusion tests by fluidically connecting the hydrogels with the external circuit, highly metastatic breast cancer cells (MDA-MB-231) were injected and exposed to physiological wall shear stress (WSS) conditions (5 Dyn/cm2) to assess their migration toward the hydrogel. Results indicated that CTCs arrested and colonized the polymeric matrix, showing that this platform can be an effective fluidic system to model the first steps occurring during the metastatic cascade as well as a potential tool to in vitro elucidate the contribution of hemodynamics on cancer dissemination to a secondary site.

Effects of Fe3O4/Water Nanofluid on the Efficiency of a Curved Pipe

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Milad Kelidari ◽  
Ali Jabari Moghadam
Keyword(s):  
Mass Flow Rate ◽  
Mass Flow ◽  
Flow Rate ◽  
Volume Concentration ◽  
Volume Fraction ◽  
Working Fluid ◽  
Radius Of Curvature ◽  
Dean Number ◽  
Curved Pipe ◽  
Overall Efficiency

Different-radius of curvature pipes are experimentally investigated using distilled water and Fe3O4–water nanofluid with two different values of the nanoparticle volume fraction as the working fluids. The mass flow rate is approximately varied from 0.2 to 0.7 kg/min (in the range of laminar flow); the wall heat flux is nearly kept constant. The experimental results reveal that utilizing the nanofluid increases the convection heat transfer coefficient and Nusselt number in comparison to water; these outcomes are also observed when the radius of curvature is decreased and/or the mass flow rate is increased (equivalently, a rise in Dean number). The resultant pressure gradient is, however, intensified by an increase in the volume concentration of nanoparticles and/or by a rise in Dean number. For any particular working fluid, there is an optimum mass flow rate, which maximizes the system efficiency. The overall efficiency can be introduced to include hydrodynamic as well as thermal characteristics of nanofluids in various geometrical conditions. For each radius of curvature, the same overall efficiency may be achieved for two magnitudes of nanofluid volume concentration.

CFD Assessment and Experimental Investigation of the Liquid Separation Efficiency Enhancements in a Vertical Gravity Separator

2020 ◽  
Vol 28 (03) ◽  
pp. 2050021
Author(s):  
Raid Ahmed Mahmood
Keyword(s):  
Separation Efficiency ◽  
Flow Direction ◽  
Fluid Dynamic ◽  
Working Fluid ◽  
Cfd Simulations ◽  
Liquid Separation ◽  
Flash Tank ◽  
Tank Design ◽  
Vertical Gravity ◽  
Design Options

Three design enhancement options for a vertical gravitational flash tank separator were proposed and investigated in this work. Computational Fluid Dynamic (CFD) was used to assess the optimum configurations of the vertical gravitational flash tank separator. A series of experiments were performed to test the CFD proposed configurations of the enhancement design options. This paper also assessed the usefulness of CFD in flash tank design, and this is achieved through experiments and simulations on a range of relevant configurations using water as the working fluid. The results revealed that the combination of the inlet flow direction and extractor had a significant effect on the performance of the vertical flash tank separator which increased by 2%. The results also revealed that there was a good agreement between the CFD simulations and experiments; the CFD simulations underestimated the liquid separation efficiency by approximately 0.02 over the range of conditions tested.

Sign in / Sign up

Export Citation Format

Share Document