Synthesis, Stability and Selection Study of Oil-in-Water Nanoemulsions Containing Nigella Sativa L. Essential Oil

2017 ◽  
Author(s):  
Aybala Usta ◽  
Muhammad Rahman ◽  
Ramazan Asmatulu
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Nigella Sativa ◽  
Local Treatment ◽  
Water Soluble ◽  
Surface Charges ◽  
Oil In Water ◽  
Targeted Drug ◽  
The Stability ◽  
Triton X

Targeted drug delivery has a great importance in cancer treatment and is in interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behaviors where they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs into hydrogels is not practical in terms of poor drug solubility and burst drug release because of this. At this point, an oil phase can be considered as a drug carrying agent, and entrapment of this oil phase into hydrogel would make it possible for in-situ injection of dissolved drug in oil phase. Oil in water (O/W)-type nanoemulsions were prepared using black seed oil, which is known to cause apoptosis via p-53 dependent mechanism, water and Triton X-100, Span-80 surfactant combinations. Three different oil percentage and three different surfactant percentage were tested, and stability behaviors of nanoemulsions were investigated and compared. Dynamic light scattering analysis and zeta potential measurements were conducted for determination of particles sizes and surface charges of the nanoemulsions. The most stable nanoemulsion along with having smallest diameter and lowest polydispersity index (PDI) was used for further studies. Results indicated that using both hydrophilic and hydrophobic surfactants together increased the stability of nanoemulsions compared to those using either of them.

Highly Porous, Water-Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

2011 ◽  
Vol 17 (45) ◽  
pp. 12802-12808 ◽  
Author(s):  
Fuping Dong ◽  
Wanping Guo ◽  
Jae-Ho Bae ◽  
Sun-Hee Kim ◽  
Chang-Sik Ha
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Water Soluble ◽  
Targeted Drug ◽  
Highly Porous

scholarly journals Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 5294-5303 ◽  
Author(s):  
Meng-Yu Fei ◽  
Meng-Meng Song ◽  
Pei Wang ◽  
Gao-zong Pang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mr Imaging ◽  
Targeted Drug Delivery ◽  
Water Soluble ◽  
Ultrasonic Technique ◽  
One Step ◽  
Targeted Drug

Water-soluble Fe3O4@F127@FA nanoclusters were prepared by a facile ultrasonic-treated method for MR imaging and targeted drug delivery.

scholarly journals Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 68 ◽  
Author(s):  
Sang Hoon Lee ◽  
Rajiv Bajracharya ◽  
Jeong Youn Min ◽  
Ji-Won Han ◽  
Byeong Ju Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Local Treatment ◽  
Delivery Systems ◽  
Therapeutic Benefits ◽  
Colonic Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck

2005 ◽  
Vol 13 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Anjan Nan ◽  
Hamidreza Ghandehari ◽  
Carla Hebert ◽  
Hessam Siavash ◽  
Nikolaos Nikitakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Head And Neck ◽  
Targeted Drug Delivery ◽  
Squamous Carcinoma ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Targeted Drug

scholarly journals Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review

2015 ◽  
Vol 3 (02) ◽  
pp. 37-57
Author(s):  
Komal . ◽  
Ujjwal Nautiyal ◽  
Ramandeep , Anita Devi Singh ◽  
Anita Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Local Treatment ◽  
Systemic Delivery ◽  
Colonic Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as the small intestine, and neither the bioactive agent should be degraded in either of the dissolution sites but only released and absorbed once the system reaches the colon. Different approaches are designed based on prodrug formulation, pHsensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review article discusses, in brief, introduction to targeted drug delivery system, anatomy and physiology of the colon and approaches utilized in the colon targeted drug delivery system.

EFFECT OF CROSSLINKER AMOUNT ON HYBRID HYDROGELS SWELLING AND DRUG RELEASE

2021 ◽  
Author(s):  
Maja Markovic ◽  
◽  
Vesna Panic ◽  
Julijana Tadic ◽  
Rada Pjanovic
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Water Soluble ◽  
Soluble Model ◽  
Hybrid Hydrogels ◽  
Poorly Water Soluble ◽  
Targeted Drug ◽  
Model Drug

Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly water- soluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.

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