Effect of intense THz pulses on expression of genes associated with skin cancer and inflammatory skin conditions

2014 ◽  
Author(s):  
Lyubov V. Titova ◽  
Ayesheshim K. Ayesheshim ◽  
David Purschke ◽  
Andrey Golubov ◽  
Rocio Rodriguez-Juarez ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Expression Of Genes ◽  
Inflammatory Skin ◽  
Skin Conditions

Investigations on T cell transmigration in a human skin-on-chip (SoC) model

Lab on a Chip ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 1527-1539
Author(s):  
Xiaoou Ren ◽  
Anthony E. Getschman ◽  
Samuel Hwang ◽  
Brian F. Volkman ◽  
Thomas Klonisch ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Human Skin ◽  
Drug Candidates ◽  
New Drug ◽  
Human T Lymphocytes ◽  
Quantitative Studies ◽  
Inflammatory Skin ◽  
Skin Conditions ◽  
On Chip

Our skin-on-chip (SoC) model uniquely enabled quantitative studies of transendothelial and transepithelial migration of human T lymphocytes under mimicked inflammatory skin conditions and was used to test new drug candidates.

scholarly journals Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer

2006 ◽  
Vol 26 (22) ◽  
pp. 8515-8526 ◽  
Author(s):  
Judith Jans ◽  
George A. Garinis ◽  
Wouter Schul ◽  
Adri van Oudenaren ◽  
Michael Moorhouse ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Biological Effects ◽  
Mouse Skin ◽  
Cell Type ◽  
Cell Type Specificity ◽  
Basal Keratinocytes ◽  
Expression Of Genes ◽  
Pyrimidine Dimers ◽  
Response To Stress

ABSTRACT Cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs) comprise major UV-induced photolesions. If left unrepaired, these lesions can induce mutations and skin cancer, which is facilitated by UV-induced immunosuppression. Yet the contribution of lesion and cell type specificity to the harmful biological effects of UV exposure remains currently unclear. Using a series of photolyase-transgenic mice to ubiquitously remove either CPDs or 6-4PPs from all cells in the mouse skin or selectively from basal keratinocytes, we show that the majority of UV-induced acute effects to require the presence of CPDs in basal keratinocytes in the mouse skin. At the fundamental level of gene expression, CPDs induce the expression of genes associated with repair and recombinational processing of DNA damage, as well as apoptosis and a response to stress. At the organismal level, photolyase-mediated removal of CPDs, but not 6-4PPs, from the genome of only basal keratinocytes substantially diminishes the incidence of skin tumors; however, it does not affect the UVB-mediated immunosuppression. Taken together, these findings reveal a differential role of basal keratinocytes in these processes, providing novel insights into the skin's acute and chronic responses to UV in a lesion- and cell-type-specific manner.

Skin Cancer Incidence in Organ Transplant Recipients Referred for Benign Skin Conditions

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sakil Chundydyal ◽  
Joyce Y. Cheng ◽  
Mike Wang ◽  
Fang-Yong Li ◽  
Oscar R. Colegio
Keyword(s):  
Skin Cancer ◽  
Cancer Incidence ◽  
Organ Transplant ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Skin Conditions

Dermatology

2020 ◽  
pp. 559-616
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
General Practice ◽  
Skin Cancer ◽  
Fungal Infection ◽  
Sweat Gland ◽  
Skin Infection ◽  
Skin Tumours ◽  
Nail Changes ◽  
Skin Erythema ◽  
Keratinization Disorders ◽  
Skin Conditions

This chapter in the Oxford Handbook of General Practice explores dermatology in general practice. It covers skin assessment, treatment of skin conditions, changes in skin colour and eruptions, itching and blistering of the skin, erythema, pigmentation disorder, hair and sweat gland problems, nail changes, and atopic and other eczemas. It discusses ulcers, urticaria, angio-oedema, acne, psoriasis, lichen planus, keratinization disorders, pityriasis, and seborrhoeic warts. It examines sunlight and the skin, benign skin tumours, and skin cancer. It also explores bacterial skin infection, viral skin infection, fungal infection, and infestation.

Mammalian Target of Rapamycin in Inflammatory Skin Conditions

2014 ◽  
Vol 12 (2) ◽  
pp. 341-350 ◽  
Author(s):  
A. Balato ◽  
R. Di Caprio ◽  
S. Lembo ◽  
M. Mattii ◽  
M. Megna ◽  
...  
Keyword(s):  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Inflammatory Skin ◽  
Skin Conditions

scholarly journals Non-Contact Dermatoscope with Ultra-Bright Light Source and Liquid Lens-Based Autofocus Function

2019 ◽  
Vol 9 (11) ◽  
pp. 2177 ◽  
Author(s):  
Dierk Fricke ◽  
Evgeniia Denker ◽  
Annice Heratizadeh ◽  
Thomas Werfel ◽  
Merve Wollweber ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Skin Cancer ◽  
Bright Light ◽  
Point Of View ◽  
Large Field ◽  
Skin Cancer Screening ◽  
Ambient Lighting ◽  
Contact Devices ◽  
Skin Conditions ◽  
Color Reproducibility

Dermatoscopes are routinely used in skin cancer screening but are rarely employed for the diagnosis of other skin conditions. Broader application is promising from a diagnostic point of view as biopsies for differential diagnosis may be avoided but it requires non-contact devices allowing a comparably large field of view that are not commercially available today. Autofocus and color reproducibility are specific challenges for the development of dermatoscopy for application beyond cancer screening. We present a prototype for such a system including solutions for autofocus and color reproducibility independent of ambient lighting. System performance includes sufficiently high feature resolution of up to 30 µm and feature size scaling fulfilling the requirements to apply the device in regular skin cancer screening.

Dermoscopy and confocal microscopy correlates in inflammatory skin conditions

2013 ◽  
Vol 8 (3) ◽  
pp. 241-248 ◽  
Author(s):  
Marina Agozzino ◽  
Alexandre Guichard ◽  
Marco Ardigò
Keyword(s):  
Confocal Microscopy ◽  
Inflammatory Skin ◽  
Skin Conditions

scholarly journals A study of the knowledge, attitude and behavior among patients with psoriasis vulgaris during the COVID-19 lockdown period

2021 ◽  
Vol 9 (10) ◽  
pp. 3120
Author(s):  
Sukanya G. ◽  
Richa Jotwani ◽  
Manoharan D. ◽  
Shreya Srinivasan
Keyword(s):  
General Population ◽  
Disease Severity ◽  
Psychosocial Stress ◽  
Financial Constraints ◽  
Psoriasis Vulgaris ◽  
Treatment Compliance ◽  
Inflammatory Skin ◽  
Skin Conditions ◽  
The Right ◽  
And Behavior

Background: Patients with psoriasis may have been directly impacted by the COVID-19 lockdown and this may have had a significant effect on disease severity and treatment compliance. This study aims to investigate the knowledge, attitude and the behavioral practices of patients with psoriasis during the lockdown period.Methods: A self-assessed questionnaire was employed for the purpose of this study and was answered by 100 patients of clinically diagnosed psoriasis.Results: Although several patients were aware of their condition and its implications, a significant number of responders were found to have a faulty treatment compliance due to the COVID-19 lockdown.Conclusions: To our knowledge, this is the first study that evaluates the knowledge, attitude and behaviour during the COVID-19 lockdown period of individuals who have been clinically diagnosed with psoriasis. This study raises the possibility that the sustained psychosocial stress induced by the current pandemic can potentially lead to exacerbations or onset of common inflammatory skin conditions like psoriasis. The overall compliance to dermatologic therapy was slightly poor as there were frequent concerns regarding the safety of visiting a hospital or a doctor as well as possible financial constraints. As per this study, there is an urgent need to convey the right information about managing psoriasis during the COVID-19 pandemic among both the general population and patients alike. 

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