Problematic External Wound Healing after ACL-Reconstructive Surgery

2002 ◽  
Vol 7 (3) ◽  
pp. 36-37
Author(s):  
Joseph J. Piccininni ◽  
Malissa Martin ◽  
Sheila Curry
Keyword(s):  
Wound Healing ◽  
Reconstructive Surgery ◽  
External Wound

scholarly journals Management of Chronic Non-Healing Wound using Ayurvedic drugs - A Case Study

2020 ◽  
Vol 11 (2) ◽  
pp. 337-341
Author(s):  
Hemanta Kumar Panigrahi
Keyword(s):  
Wound Healing ◽  
Subcutaneous Tissue ◽  
Oral Intake ◽  
Central Research Institute ◽  
Central Research ◽  
Ayurvedic Drugs ◽  
Superficial Wound ◽  
Healing Wound ◽  
Skin Loss ◽  
External Wound

Sushruta in 1st part of his compendium described about wound healing its types etc. as Vranitopasaniya adhyaya. Ayurveda described so many compound medicines and oil for oral administration and topical application to accelerate the wound healing. But this is not scientifically validated. So there is always a search for finding a newer and better medicine for wound healing. I am presenting a case of 42 year old married male with complain of superficial external wound with mild pain,  mal odour  and not healing  since 45 days in spite of taking allopathic conventional treatment in his lower limb. The study was done in my outpatient department of Central Research institute for cardiovascular disease, Punjabi Bagh, New Delhi. On examination it was found that surface area of superficial wound is 22.5 sq. cm. having full thickness, skin loss involving necrosis of subcutaneous tissue extended down to underlying fascia. Necessary laboratory investigations were done prior to initiate the treatment. The wound was irrigated with Panchvalkala kasaya and dressing with Jatyadi Tail was done daily followed by oral intake of Triphala guggulu 500mg twice in a day and Amalaki churna 6gm twice in a day was administered orally for 28th days. Periodic follow up was done on 0, 7, 14, and in 28 days. This regimen was found to be effective in faster wound epithelialization, and reducing wound exudates. There was no evidence of any allergic reaction as well as no evidence showing any adverse event on the wound.

scholarly journals A Role for Postoperative Negative Pressure Wound Therapy in Multitissue Hand Injuries

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hyung Sup Shim ◽  
Ji Seon Choi ◽  
Sang Wha Kim
Keyword(s):  
Wound Healing ◽  
Reconstructive Surgery ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Injury Severity ◽  
Hand Injury ◽  
Wound Therapy ◽  
The Mean ◽  
Group 2 ◽  
Functional Position

In this study, we compared outcomes in patients with acute hand injury, who were managed with or without negative pressure wound therapy (NPWT) after reconstructive surgery. All of the patients who sustained acute and multitissue injuries of the hand were identified. After reconstructive surgery, a conventional dressing was applied in Group 1 and NPWT was applied in Group 2. The dressing and NPWT were changed every 3 days. The mean age and Hand Injury Severity Scoring System score of both groups were not significantly different. Disabilities of the Arm, Shoulder, and Hand (DASH) scores were evaluated 1 month after all the sutures were removed and 1 year postoperatively, which were both significantly lower in Group 2. Applying NPWT to the hand promoted wound healing by reducing edema, stabilizing the wound, and providing immobilization in a functional position. Early wound healing and decreased complications enabled early rehabilitation, which led to successful functional recovery, both objectively and subjectively.

Results of auricular helical rim reconstruction with post-auricular tube flap

2016 ◽  
Vol 88 (1) ◽  
Author(s):  
Aleksandra Iljin ◽  
Edward Lewandowicz ◽  
Bogusław Antoszewski ◽  
Tomasz Zieliński
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
Reconstructive Surgery ◽  
Aesthetic Surgery ◽  
Venous Congestion ◽  
Long Term Results ◽  
Postoperative Results ◽  
Delayed Wound Healing ◽  
Complete Restoration

Abstractwas to present our experience with post-auricular tube flap (ptf) and clinical evaluation of the results following auricular helical rim reconstruction with this technique in patients after trauma.We analyzed the results in 12 patients who underwent three-staged auricular helical rim reconstruction with ptf following trauma in the Department of Plastic, Reconstructive and Aesthetic Surgery between 2005-2014. The patients were followed-up for at least 1 year. We evaluated early and long-term results after surgery including plastic surgeon’s and patient’s opinion.Postoperative results were satisfactory (very good) in 10 cases, both in the opinion of the plastic surgeon and patients. Transient venous congestion of the helix occurred in two cases (16.6%). This complication did not have any influence on estimation of the results after surgery. Delayed wound healing in the poles of the reconstructed helical edge, as well as non-aesthetic helical scars with imperfections of helical rim, were seen in another two patients (16.6%).1. Post-auricular tube flap reconstructions after helical rim trauma allowed for complete restoration of contour, size and orientation of the helix and the whole operated ear, which confirms the efficiency of the applied technique. 2. Reconstructive surgery with post-auricular tube flap in patients with auricular helical rim defects contributed to postoperative satisfaction in both patients and doctors’ estimations.

Agrobacteriumtumefaciens, A Promoter of Wound Healing in Betulaalleghaniensis

1975 ◽  
Vol 5 (4) ◽  
pp. 722-730 ◽  
Author(s):  
Robert A. Blanchette ◽  
Edward M. Sharon
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Healing Process ◽  
Yellow Birch ◽  
Natural Defense ◽  
Defense Reactions ◽  
Fivefold Increase ◽  
Antagonistic Microorganisms ◽  
Clear Plastic ◽  
External Wound

Agrobacteriumtumefaciens (E. F. Smith and Town.) Conn, was evaluated as a promoter of wound healing on mechanically inflicted basal wounds on 50 greenhouse-grown and 45 field-grown yellow birch, Betulaalleghaniensis Britt. Inoculated and noninoculated wounds were wrapped with a clear plastic wrap. The healing process of external wound closure by callus and internal compartmentalization of tissues extant before wounding was observed. Treated wounds showed a fourfold to fivefold increase in wound closure after 30 days for greenhouse-grown trees and after 45 days for field-grown trees. Effects of internal defense reactions that occur after injury were histologically examined. Compartmentalization of the wounded tissue was stimulated by treatment with A. tumefaciens. Abundant vessel plugging and an enhanced zone of cells, which formed after wounding, served to compartmentalize the wound. Although the effect of A. tumefaciens against antagonistic microorganisms is uncertain, the natural defense reactions of the tree were intensified while accelerating wound closure.

scholarly journals Corticoids as a treatment to control complications arising after reconstructive surgery of the skin: a case report

2017 ◽  
Vol 62 (No. 7) ◽  
pp. 406-409
Author(s):  
C. Serrano ◽  
A. Ortilles ◽  
A. Diaz ◽  
A. Whyte
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Surgical Procedures ◽  
Granulation Tissue ◽  
Reconstructive Surgery ◽  
Skin Grafting ◽  
Topical Administration ◽  
Topical Corticosteroids ◽  
Control Tissue ◽  
Before And After

Corticosteroids are not indicated in wound healing, but the intralesional and topical administration of these agents has been described to control tissue overgrowth in humans. The aim of the present study was to assess the use of topical corticosteroids to control pre- and post-surgical tissue overgrowth in a 5-year-old male Belgian shepherd weighing 33.5 kg. We report successful use of topical administration of corticosteroids to treat granulation tissue overgrowth before and after skin grafting. Corticosteroids are a safe and easy way to treat this complication and can be used to prepare a healthy granulation tissue bed before performing surgical procedures to cover large defects in dogs.

scholarly journals Polymeric Materials for Hemostatic Wound Healing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2127
Author(s):  
Suvash Ghimire ◽  
Pritha Sarkar ◽  
Kasey Rigby ◽  
Aditya Maan ◽  
Santanu Mukherjee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Visual Inspection ◽  
First Responders ◽  
Polymeric Materials ◽  
Severe Bleeding ◽  
Military Operations ◽  
Manual Pressure ◽  
External Wound ◽  
Wounded Area

Hemorrhage is one of the greatest threats to life on the battlefield, accounting for 50% of total deaths. Nearly 86% of combat deaths occur within the first 30 min after wounding. While external wound injuries can be treated mostly using visual inspection, abdominal or internal hemorrhages are more challenging to treat with regular hemostatic dressings because of deep wounds and points of injury that cannot be located properly. The need to treat trauma wounds from limbs, abdomen, liver, stomach, colon, spleen, arterial, venous, and/or parenchymal hemorrhage accompanied by severe bleeding requires an immediate solution that the first responders can apply to reduce rapid exsanguinations from external wounds, including in military operations. This necessitates the development of a unique, easy-to-use, FDA-approved hemostatic treatment that can deliver the agent in less than 30 s and stop bleeding within the first 1 to 2 min at the point of injury without application of manual pressure on the wounded area.

Aspects of Nanomaterials in Wound Healing

2018 ◽  
Vol 16 (1) ◽  
pp. 26-41 ◽  
Author(s):  
Srijita Chakrabarti ◽  
Pronobesh Chattopadhyay ◽  
Johirul Islam ◽  
Subhabrata Ray ◽  
Pakalapati Srinivas Raju ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Wound Care ◽  
Healing Process ◽  
Wound Management ◽  
Wound Healing Process ◽  
Cell Type Specificity ◽  
Normal Wound Healing ◽  
Nanofibrous Scaffolds ◽  
External Wound

Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, influencing the cost of treatment. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diversified categories of wounds such as acute and chronic wounds. However, nanotechnology-based diagnostics and treatments have achieved a new horizon in the arena of wound care due to its ability to deliver a plethora of therapeutics into the target site, and to target the complexity of the normal wound-healing process, cell type specificity, and plethora of regulating molecules as well as pathophysiology of chronic wounds. The emerging concepts of nanobiomaterials such as nanoparticles, nanoemulsion, nanofibrous scaffolds, graphene-based nanocomposites, etc., and nano-sized biomaterials like peptides/proteins, DNA/RNA, oligosaccharides have a vast application in the arena of wound care. Multi-functional, unique nano-wound care formulations have acquired major attention by facilitating the wound healing process. In this review, emphasis has been given to different types of nanomaterials used in external wound healing (chronic cutaneous wound healing); the concepts of basic mechanisms of wound healing process and the promising strategies that can help in the field of wound management.

scholarly journals Acceleration of Wound Healing byα-gal Nanoparticles Interacting with the Natural Anti-Gal Antibody

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Uri Galili
Keyword(s):  
Wound Healing ◽  
Biological Function ◽  
Healing Time ◽  
Complement Cascade ◽  
Skin Wounds ◽  
Nerve Injuries ◽  
Human Immunoglobulins ◽  
Surgical Incisions ◽  
External Wound ◽  
Carbohydrate Ligand

Application ofα-gal nanoparticles to wounds and burns induces accelerated healing by harnessing the natural anti-Gal antibody which constitutes ~1% of human immunoglobulins.α-gal nanoparticles present multipleα-gal epitopes (Galα1-3Galβ1-4GlcNAc-R), the carbohydrate ligand of anti-Gal. Studiedα-gal nanoparticles were comprised of glycolipids withα-gal epitopes, phospholipids, and cholesterol. Binding of anti-Gal toα-gal nanoparticles in wounds activates the complement cascade, resulting in formation of chemotactic complement cleavage peptides that induce rapid recruitment of many macrophages. The Fc/Fcγreceptors interaction between anti-Gal coatingα-gal nanoparticles and the recruited macrophages activates macrophages to produce cytokines/growth factors that promote wound healing and recruit stem cells. Studies of wound healing byα-gal nanoparticles were feasible inα1,3galactosyltransferase knockout mice and pigs. In contrast to other nonprimate mammals, these mice and pigs lack theα-gal epitope, and thus they are not immunotolerant to it and produce anti-Gal. Treatment of skin wounds and burns withα-gal nanoparticles resulted in 40–60% decrease in healing time in comparison with control wounds treated with saline. This accelerated healing is associated with increased recruitment of macrophages and extensive angiogenesis in wounds, faster regrowth of epidermis, and regeneration of the dermis. The accelerated healing further decreases and may completely eliminate fibrosis and scar formation in wounds. Since healing of internal injuries is mediated by mechanisms similar to those in external wound healing, it is suggested thatα-gal nanoparticles treatment may also improve regeneration and restoration of biological function following internal injuries such as surgical incisions, myocardial ischemia following infarction, and nerve injuries.

scholarly journals The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing

2018 ◽  
Vol 10 (1) ◽  
pp. 58-64
Author(s):  
HARIYANTO IH ◽  
INARAH FAJRIATY ◽  
TANTO WIJAYA ◽  
MUHAMMAD HAFIZH
Keyword(s):  
Wound Healing ◽  
Extraction Yield ◽  
Drying Rate ◽  
High Humidity ◽  
Phytochemical Screening ◽  
West Kalimantan ◽  
Impatiens Balsamina ◽  
The People ◽  
External Wound ◽  
Wound Healing Activity

Hariyanto IH, Fajriaty I, Wijaya T, Hafizh M. 2018. The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing. Nusantara Bioscience 10: 58-64. Pacar air or garden balsam (Impatiens balsamina L.) is a herb plant that grows wildly in high humidity areas. The leaves of I. balsamina are used by the people in Bengkulu, Indonesia, as herbal medicine to treat wounds. I. balsamina grows abundantly in West Borneo due to the proper conditions. This study aimed to determine the wound healing activity of I. balsamina as an ethnomedicine plant and standardize its extract. The leaves of I. balsamina was macerated with 96% ethanol. The extraction yield was 20.3%, the solubility of the extract in water and ethanol was 15.77% and 41.41%, respectively, the drying rate was 23.02%, and the extracted density was 0.8136 g/mL. The extract of I. balsamina contained polyphenols, flavonoids, saponins, tannins, quinones, steroids, and terpenoids based on the phytochemical screening. Anatomical and histological pathology tests showed that the leaves extract had the potential to heal the external wound.

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

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