Blood Glucose and Glucoregulatory Hormone Responses to Solid and Liquid Carbohydrate Ingestion During Exercise

1998 ◽  
Vol 8 (1) ◽  
pp. 70-83 ◽  
Author(s):  
Robert A. Robergs ◽  
Susie B. McMinn ◽  
Cristine Mermier ◽  
Guy Leadbetter ◽  
Brent Ruby ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Plasma Glucose ◽  
Exercise Performance ◽  
Serum Glucose ◽  
Solid Food ◽  
Total Work ◽  
Carbohydrate Ingestion ◽  
Added Water ◽  
Hormone Responses ◽  
Ad Libitum

This study was conducted to compare blood glucose and glucoregulatory hormone responses to the ingestion of solid and liquid carbohydrate (CHO) during prolonged cycling, followed by 30 min of isokinetic cycling. Eight male cyclists randomly completed three cycling trials (LC = liquid CHO, SCE = solid CHO with water equal to LC, SCA = solid CHO + ad libitum water). Each subject cycled for 120 min at 65% of VO2max with CHO ingestion (0.6 g CHO/kg/hr) at 0, 30, 60, 90, and 120 min. Subjects then completed a 30-min maximal isokinetic ride at 90 rpm. There was no significant (p < .05) difference between the trials for plasma glucose, insulin, glucagon, glycerol, lactate, RER, HR, VO2 RPE, and total work performed during the isokinetic ride. However, serum glucose was significantly lower in the SCE and SCA trials compared to LC at 80 min. The ingestion of a solid food containing CHO. protein, and fat with added water produced similar blood glucose, metabolic, glucoregulatory hormone, and exercise performance responses to those seen with the ingestion of liquid CHO.

Improvements in exercise performance: effects of carbohydrate feedings and diet

1987 ◽  
Vol 62 (3) ◽  
pp. 983-988 ◽  
Author(s):  
P. D. Neufer ◽  
D. L. Costill ◽  
M. G. Flynn ◽  
J. P. Kirwan ◽  
J. B. Mitchell ◽  
...  
Keyword(s):  
Muscle Glycogen ◽  
Exercise Performance ◽  
Cycle Ergometer ◽  
Serum Glucose ◽  
O2 Consumption ◽  
Total Work ◽  
Vo2 Max ◽  
Fed State ◽  
Performance Effects ◽  
Muscle Glycogen Concentration

In an effort to determine the effects of carbohydrate (CHO) feedings immediately before exercise in both the fasted and fed state, 10 well-trained male cyclists [maximum O2 consumption (VO2 max), 4.35 +/- 0.11 l/min)] performed 45 min of cycling at 77% VO2 max followed by a 15-min performance ride on an isokinetic cycle ergometer. After a 12-h fast, subjects ingested 45 g of liquid carbohydrate (LCHO), solid carbohydrate confectionery bar (SCHO), or placebo (P) 5 min before exercise. An additional trial was performed in which a high-CHO meal (200 g) taken 4 h before exercise was combined with a confectionery bar feeding (M + SCHO) immediately before the activity. At 10 min of exercise, serum glucose values were elevated by 18 and 24% during SCHO and LCHO, respectively, compared with P. At 0 and 45 min no significant differences were observed in muscle glycogen concentration or total use between the four trials. Total work produced during the final 15 min of exercise was significantly greater (P less than 0.05) during M + SCHO (194,735 +/- 9,448 N X m), compared with all other trials and significantly greater (P less than 0.05) during LCHO and SCHO (175,204 +/- 11,780 and 176,013 +/- 10,465 N X m, respectively) than trial P (159,143 +/- 11,407 N X m). These results suggest that, under conditions when CHO stores are less than optimal, exercise performance is enhanced with the ingestion of 45 g of CHO 5 min before 1 h of intense cycling.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Blood glucose concentration measured in EDTA/F plasma and serum in a referral clinical laboratory in Nepal

2021 ◽  
Vol 11 (1) ◽  
pp. 1837-1841
Author(s):  
Vivek Pant ◽  
Keyoor Gautam ◽  
Santosh Pradhan ◽  
Devish Pyakurel ◽  
Abha Shrestha
Keyword(s):  
Blood Glucose ◽  
Sodium Fluoride ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Clinical Laboratory ◽  
Blood Glucose Concentration ◽  
Serum Glucose ◽  
Relative Reduction ◽  
The Difference ◽  
Glucose Estimation

Background: Sodium fluoride tubes or serum separator tubes are mostly used for blood glucose estimation in the clinical laboratories of Nepal. The study aimed to investigate the stability of glucose in samples collected in serum separator tubes and sodium fluoride/sodium ethylenediaminetetraacetic tubes by comparing the glucose concentration at 30 minutes and 4 hours collected and handled differently to simulate prolonged sample transport between venipunctures, centrifugation, and measurement.Materials and Methods: Samples were collected from healthy volunteers into two different serum separator tubes and two different sodium fluoride/sodium ethylenediaminetetraacetic tubes. Glucose concentration was measured at 30 minutes after venipuncture and compared with results from the same samples analyzed at four hours and with the results from tubes centrifuged with a delay of 4 hours. Differences between baseline and respective delayed analyzed glucose values for each tube type were tested using the Student’s paired t-test and Deming regression.Results: When comparing plasma glucose at 30 minutes, glycolysis caused a relative reduction of the glucose concentration in serum at 30 minutes of 3.1 %, which is only slightly less than at 4 hours (3.7 %). This is still substantially more than the reduction in plasma at 4 hours (1.3 %). Surprisingly, the difference between plasma glucose at 30 minutes and serum glucose at 4 hours was only 1.9% which is not clinically significant.Conclusions: The Na-F/Na2 EDTA tubes and serum separator tubes can be used interchangeably for analysis of blood glucose up to 4 hours if centrifuged within 30 minutes.

scholarly journals Single-dose prednisolone alters endocrine and haematologic responses and exercise performance in men

2019 ◽  
Vol 8 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Alexander Tacey ◽  
Lewan Parker ◽  
Bu B Yeap ◽  
John Joseph ◽  
Ee M Lim ◽  
...  
Keyword(s):  
Heart Rate ◽  
Single Dose ◽  
Blood Glucose ◽  
Exercise Performance ◽  
High Intensity ◽  
Cycling Performance ◽  
Total Work ◽  
Post Exercise ◽  
High Intensity Interval ◽  
Interval Cycling

The aim of this study was to investigate the effect of a single dose of prednisolone on (A) high-intensity interval cycling performance and (B) post-exercise metabolic, hormonal and haematological responses. Nine young men participated in this double-blind, randomised, cross-over study. The participants completed exercise sessions (4 × 4 min cycling bouts at 90–95% of peak heart rate), 12 h after ingesting prednisolone (20 mg) or placebo. Work load was adjusted to maintain the same relative heart rate between the sessions. Exercise performance was measured as total work performed. Blood samples were taken at rest, immediately post exercise and up to 3 h post exercise. Prednisolone ingestion decreased total work performed by 5% (P < 0.05). Baseline blood glucose was elevated following prednisolone compared to placebo (P < 0.001). Three hours post exercise, blood glucose in the prednisolone trial was reduced to a level equivalent to the baseline concentration in the placebo trial (P > 0.05). Prednisolone suppressed the increase in blood lactate immediately post exercise (P < 0.05). Total white blood cell count was elevated at all time-points with prednisolone (P < 0.01). Androgens and sex hormone-binding globulin were elevated immediately after exercise, irrespective of prednisolone or placebo. In contrast, prednisolone significantly reduced the ratio of testosterone/luteinizing hormone (P < 0.01). Acute prednisolone treatment impairs high-intensity interval cycling performance and alters metabolic and haematological parameters in healthy young men. Exercise may be an effective tool to minimise the effect of prednisolone on blood glucose levels.

Hypoglycemic Emergencies

1992 ◽  
Vol 3 (2) ◽  
pp. 361-369
Author(s):  
Kathryn Mulcahy
Keyword(s):  
Optimal Control ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Warning Signs ◽  
Loss Of Consciousness ◽  
Carbohydrate Ingestion ◽  
Prompt Treatment ◽  
Simple Carbohydrate

Optimal control of blood glucose requires a balance of diet, exercise, and in some cases, medications. Many factors can cause a state of imbalance, resulting in extremes of glucose control. Hypoglycemia is defined generally as a blood glucose level lower than 50 mg/dL. Although the causes of hypoglycemic episodes are diverse, the management is always aimed at normalizing the plasma glucose concentration. Treatment ranges from simple carbohydrate ingestion in mild to moderate cases to intravenous administration of glucose when the reaction is severe and loss of consciousness occurs. Recognition of warning signs and prompt treatment is essential in all cases

Update on Carbohydrate: Solid versus Liquid

1994 ◽  
Vol 4 (2) ◽  
pp. 80-88 ◽  
Author(s):  
Ellen Coleman
Keyword(s):  
Blood Glucose ◽  
Endurance Exercise ◽  
Glycogen Synthesis ◽  
Liver Glycogen ◽  
Serum Glucose ◽  
Carbohydrate Utilization ◽  
Carbohydrate Ingestion ◽  
Glucose Levels ◽  
Muscle Glycogen Synthesis ◽  
And Performance

Athletes often train or compete in athletic events that significantly reduce muscle and liver glycogen reserves. Carbohydrate ingestion before or during endurance exercise enhances performance by maintaining blood glucose levels and carbohydrate utilization. Also, an adequate intake of carbohydrate following endurance exercise helps to restore muscle and liver glycogen. This paper reviews the physiologic and performance benefits of solid versus liquid carbohydrate feedings before, during, and following endurance exercise. Solid and liquid carbohydrates are equally effective in raising blood glucose and enhancing performance when consumed during endurance exercise. Also, both forms of carbohydrate are similarly beneficial in promoting muscle glycogen synthesis after exercise. It is unclear whether solid and liquid carbohydrate feedings have the same effect on serum glucose and performance when consumed before exercise. Although limited research suggests that a low glycemic solid carbohydrate may represent the best preexercise meal choice, further research is needed to support this hypothesis.

Effect of Offering Concentrate Rations with Different Energy Densities on Calf Performance

1993 ◽  
Vol 1993 ◽  
pp. 209-209 ◽  
Author(s):  
R.J. Fallon ◽  
J.R. Twigge
Keyword(s):  
Energy Density ◽  
Rapid Growth ◽  
High Energy ◽  
Solid Food ◽  
Milk Replacer ◽  
Successful Transition ◽  
Calf Performance ◽  
Ad Libitum

The primary aim of the calf rearer is to ensure a successful transition from non ruminant to ruminant status while achieving rapid growth and an early intake of solid food. Newbold, Blake and Hagges (1991), found that increasing the concentration of ME in either the starter or milk replacer will not promote more rapid growth, but will simply reduce the rate of starter consumption. This present study investigated the extent to which the energy density of a calf starter ration affected starter intake and liveweight gain in calves receiving a fixed allowance of a high energy milk replacer with ad libitum access to solid calf starter rations.

scholarly journals Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles Based on Protamine Zinc Insulin in the Rabbit

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 375
Author(s):  
Saori Deguchi ◽  
Fumihiko Ogata ◽  
Takumi Isaka ◽  
Hiroko Otake ◽  
Yosuke Nakazawa ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Plasma Glucose ◽  
Polyacrylic Acid ◽  
Rabbit Model ◽  
Postprandial Hyperglycemia ◽  
Postprandial Blood Glucose ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Protamine Zinc Insulin ◽  
Bead Mill

Postprandial hyperglycemia, a so-called blood glucose spike, is associated with enhanced risks of diabetes mellitus (DM) and its complications. In this study, we attempted to design nanoparticles (NPs) of protamine zinc insulin (PZI) by the bead mill method, and prepare ophthalmic formulations based on the PZI-NPs with (nPZI/P) or without polyacrylic acid (nPZI). In addition, we investigated whether the instillation of the newly developed nPZI and nPZI/P can prevent postprandial hyperglycemia in a rabbit model involving the oral glucose tolerance test (OGTT). The particle size of PZI was decreased by the bead mill to a range for both nPZI and nPZI/P of 80–550 nm with no observable aggregation for 6 d. Neither nPZI nor nPZI/P caused any noticeable corneal toxicity. The plasma INS levels in rabbits instilled with nPZI were significantly higher than in rabbits instilled with INS suspensions (commercially available formulations, CA-INS), and the plasma INS levels were further enhanced with the amount of polyacrylic acid in the nPZI/P. In addition, the rapid rise in plasma glucose levels in OGTT-treated rabbits was prevented by a single instillation of nPZI/P, which was significantly more effective at attenuating postprandial hyperglycemia (blood glucose spike) in comparison with nPZI. In conclusion, we designed nPZI/P, and show that a single instillation before OGTT attenuates the rapid enhancement of plasma glucose levels. These findings suggest a better management strategy for the postprandial blood glucose spike, which is an important target of DM therapy.

scholarly journals Cytokine changes after a marathon race

2001 ◽  
Vol 91 (1) ◽  
pp. 109-114 ◽  
Author(s):  
David C. Nieman ◽  
Dru A. Henson ◽  
Lucille L. Smith ◽  
Alan C. Utter ◽  
Debra M. Vinci ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Plasma Glucose ◽  
Plasma Levels ◽  
Major Effect ◽  
Double Blind ◽  
Plasma Cytokine ◽  
Carbohydrate Ingestion ◽  
Marathon Race ◽  
Gender And Age ◽  
Anti Inflammatory

The influence of carbohydrate (1 l/h of a 6% carbohydrate beverage), gender, and age on pro- and anti-inflammatory plasma cytokine and hormone changes was studied in 98 runners for 1.5 h after two competitive marathon races. The marathoner runners were randomly assigned to carbohydrate (C, n = 48) and placebo (P, n = 50) groups, with beverages administered during the races in a double-blind fashion using color codes. Plasma glucose was higher and cortisol was lower in the C than in the P group after the race ( P < 0.001). For all subjects combined, plasma levels of interleukin (IL)-10, IL-1 receptor antagonist (IL-1ra), IL-6, and IL-8 rose significantly immediately after the race and remained above prerace levels 1.5 h later. The pattern of change in all cytokines did not differ significantly between the 12 women and 86 men in the study and the 23 subjects ≥50 yr of age and the 75 subjects <50 yr of age. The pattern of change in IL-10, IL-1ra, and IL-8, but not IL-6, differed significantly between the C and the P group, with higher postrace values measured for IL-10 (109% higher) and IL-1ra (212%) in the P group and for IL-8 (42%) in the C group. In conclusion, plasma levels of IL-10, IL-1ra, IL-6, and IL-8 rose strongly in runners after a competitive marathon, and this was not influenced by age or gender. Carbohydrate ingestion, however, had a major effect in attenuating increases in cortisol and two anti-inflammatory cytokines, IL-10 and IL-1ra.

Nutritive value of Albizia lebbek supplements for growing sheep

1992 ◽  
Vol 32 (3) ◽  
pp. 273 ◽  
Author(s):  
i Dwatmadj ◽  
E Teleni ◽  
AR Bird ◽  
JB Lowry
Keyword(s):  
Plasma Glucose ◽  
Nutritive Value ◽  
Environmental Temperature ◽  
Daily Maximum ◽  
Albizia Lebbeck ◽  
N Retention ◽  
Grass Hay ◽  
Ad Libitum ◽  
Dietary Treatments ◽  
Albizia Lebbek

This study was undertaken to evaluate the effect of supplements of siris (Albizia lebbeck) flowers and leaves on Merino wethers fed Mitchell grass hay (Astrebla spp.). Three groups, each of 6 sheep, were fed the following diets: hammermilled Mitchell grass hay ad libitum (M); M + 181 g DM/day of siris flowers (MF), and M + 216 g DM/day of siris leaves (ML). The experiment, conducted over 17 days, measured feed intake and digestibility, nitrogen (N) retention, and plasma glucose and urea concentrations. The total DM intakes by MF and ML sheep were significantly (P<0.01) higher than those in M sheep. As a result of the supplement of siris flowers, the digestibility of the MF diet was highest (P<0.01). Sheep fed the M diet showed negative N retention, while MF and ML sheep showed positive N retention. The increased (P<0.01) N retention in the MF and ML sheep was associated with increased (P<0.01) urinary N excretion. The improved nutritional state of MF and ML sheep was associated with increases in plasma glucose and urea concentrations. Environmental temperature, which reached a mean daily maximum of 31.3�C, did not interact with the dietary treatments.

Short-term effects of milkshake containing polydextrose and maltodextrin on subjective feelings of appetite, energy intake and blood glucose in healthy females

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
İsmail Mücahit Alptekin ◽  
Ece Erdoğan ◽  
Aylin İşler ◽  
Esma Cansu Yanalak ◽  
Funda Pınar Çakiroğlu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Energy Intake ◽  
Postprandial Blood Glucose ◽  
Dietary Fibers ◽  
Analog Scale ◽  
Short Term ◽  
Content Type ◽  
Ad Libitum ◽  
Desire To Eat ◽  
Healthy Females

Purpose Previous studies have reported that dietary fibers such as polydextrose and maltodextrin can reduce food intake; however, the studies on the differences of this effect are insufficient. The purpose of this paper is to compare the effects of dietary fibers maltodextrin and polydextrose on alterations of short-term satiety, energy intake and postprandial blood glucose in healthy females. Design/methodology/approach This study was designed as a randomized, crossover and double blind research. For this purpose, 21 healthy females consumed a milkshake containing 0 g (control), 15 g polydextrose (PDX) and 15 g maltodextrin (MDX), and an ad libitum lunch meal was served 150 min later. Subjective appetite scores (hunger, satiety, prospective food consumption and desire to eat) were measured using a visual analog scale. Appetite scores and blood glucose were measured before preload and once per 15 min after milkshake consumption. Findings Visual analog scale scores showed that PDX had an improved effect on satiety and hunger feelings. Compared to the control, dietary fiber increased the Area Under Curve (AUC) scores of satiety (p < 0.001) and decreased the AUC scores of hunger (p < 0.001), prospective food consumption (p < 0.001) and desire to eat (p < 0.001). Energy intake during ad libitum meal was significantly lower in PDX (Control: 862 (54.3) Kcal versus PDX: 679 (35.4) Kcal and MDX: 780 (49.3) Kcal. Moreover, the blood glucose levels were significantly lower in MDX. Originality/value This study conducted with healthy females demonstrated that PDX was more effective in inducing satiety during subsequent food intake, and that postprandial blood glucose were within more healthy levels in MDX.

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