Effects of Echinocandins in Combination with Nikkomycin Z against Invasive Candida albicans Bloodstream Isolates and the fks Mutants
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ABSTRACT We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, <0.5). Enhanced survival was observed in an immunocompromised murine model (log-rank test, P < 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.
2011 ◽
Vol 56
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pp. 208-217
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2016 ◽
Vol 60
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pp. 6179-6188
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2014 ◽
Vol 59
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pp. 1341-1343
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2012 ◽
Vol 57
(1)
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pp. 445-451
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2016 ◽
Vol 60
(5)
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pp. 3152-3155
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2014 ◽
Vol 58
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pp. 7606-7610
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