Evaluation of Bacteriophage Cocktails Alone and in Combination with Daptomycin Against Daptomycin-Nonsusceptible
Enterococcus faecium
Keyword(s):
Enterococcus faecium ( E. fcm ) is a significant multidrug-resistant pathogen. Bacteriophage cocktails are being proposed to complement antibiotic therapy. After a screen of 8 E. fcm strains against 4 phages, two phages(113, 9184) with the broadest host ranges were chosen for further experiments. Transmission electron microscopy, whole-genome sequencing, comparative genome analyses, and time-kill analyses were performed. Daptomycin(DAP) plus phage cocktail(113:myophage;9184:siphopage) showed bactericidal activity in most regimens, while DAP addition prevented phage 9184 resistance against daptomycin non-susceptible E. fcm .
2020 ◽
Vol 75
(7)
◽
pp. 1895-1905
◽
2011 ◽
Vol 55
(5)
◽
pp. 2137-2145
◽
2020 ◽
Vol 13
(3)
◽
pp. 1068-1072
1971 ◽
Vol 29
◽
pp. 204-205
1967 ◽
Vol 25
◽
pp. 364-365
1974 ◽
Vol 32
◽
pp. 514-515
1978 ◽
Vol 36
(2)
◽
pp. 82-83
◽
1974 ◽
Vol 32
◽
pp. 546-547
1977 ◽
Vol 35
◽
pp. 460-461
1982 ◽
Vol 40
◽
pp. 262-265