Targeted Gene Disruption of the 14-α Sterol Demethylase (cyp51A) in Aspergillus fumigatus and Its Role in Azole Drug Susceptibility
2005 ◽
Vol 49
(6)
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pp. 2536-2538
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ABSTRACT The role of Aspergillus fumigatus 14α-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.
2003 ◽
Vol 47
(3)
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pp. 1120-1124
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2011 ◽
Vol 55
(12)
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pp. 5459-5468
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Keyword(s):
2021 ◽
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2000 ◽
Vol 13
(10)
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pp. 1145-1155
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Keyword(s):
2000 ◽
Vol 66
(12)
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pp. 5182-5185
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2004 ◽
Vol 48
(8)
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pp. 3203-3206
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