scholarly journals Safety and immunogenicity of a live oral bivalent typhoid fever (Salmonella typhi Ty21a)-cholera (Vibrio cholerae CVD 103-HgR) vaccine in healthy adults.

1995 ◽  
Vol 63 (4) ◽  
pp. 1336-1339 ◽  
Author(s):  
S J Cryz ◽  
J U Que ◽  
M M Levine ◽  
G Wiedermann ◽  
H Kollaritsch
Keyword(s):  
Typhoid Fever ◽  
Vibrio Cholerae ◽  
Salmonella Typhi ◽  
Healthy Adults ◽  
Cholera Vibrio

Biochemical studies on the production of neuraminidase by environmental isolates of Vibrio cholerae non-O1 from Bulgaria

2011 ◽  
Vol 57 (7) ◽  
pp. 606-610 ◽  
Author(s):  
Rumyana Eneva ◽  
Stephan Engibarov ◽  
Tanya Strateva ◽  
Radoslav Abrashev ◽  
Ignat Abrashev
Keyword(s):  
Vibrio Cholerae ◽  
Pathogenic Bacteria ◽  
Environmental Isolates ◽  
Anaerobic Conditions ◽  
Temperature Optimum ◽  
Ph Optimum ◽  
Cholera Vibrio ◽  
Key Factor ◽  
Aeration Conditions ◽  
The One

Neuraminidase is a key factor in the infectious process of many viruses and pathogenic bacteria. The neuraminidase enzyme secreted by the etiological agent of cholera — Vibrio cholerae О1 — is well studied in contrast with the one produced by non-O1/non-O139 V. cholerae. Environmental non-O1/non-O139 V. cholerae isolates from Bulgaria were screened for production of neuraminidase. The presence of the neuraminidase gene nanH was detected in 18.5% of the strains. Тhe strain showing highest activity (30 U/mL), V. cholerae non-O1/13, was used to investigate the enzyme production in several media and at different aeration conditions. The highest production of extracellular neuraminidase was observed under microaerophilic conditions, which is possibly related to its role in the infection of intestine epithelium, where the oxygen content is low. On the other hand, this is another advantage of the microbe in such microaerophilic environments as sediments and lake mud. The highest production of intracellular neuraminidase was observed at anaerobic conditions. The ratio of extracellular to intracellular neuraminidase production in V. cholerae was investigated. The temperature optimum of the enzyme was determined to be 50 °C and the pH optimum to be 5.6–5.8.

scholarly journals Stool shedding of Salmonella Typhi in children with blood culture-confirmed typhoid fever

2020 ◽  
Vol 101 ◽  
pp. 123
Author(s):  
M. Srinivasan ◽  
S. Giri ◽  
S. Kulandaipalayam Natarajan ◽  
N. Kumar ◽  
V.R. Mohan ◽  
...  
Keyword(s):  
Blood Culture ◽  
Typhoid Fever ◽  
Salmonella Typhi

scholarly journals Typh fevers: a combination of Typhoid and Typhus

2017 ◽  
Vol 8 (6) ◽  
pp. 40-41
Author(s):  
Robin George Manappallil
Keyword(s):  
Typhoid Fever ◽  
Similar Pattern ◽  
Salmonella Typhi ◽  
Young Lady ◽  
Medical Sciences ◽  
Rickettsial Infection ◽  
History Of ◽  
Typhus Fever

Typhoid fever is caused by Salmonella typhi, while typhus fever is a rickettsial infection. In both cases the patients present with almost similar pattern of illness and are often misdiagnosed. This is the case of a young lady who presented with 10 days history of fever and was diagnosed to have typhoid fever. She continued to be febrile despite ceftriaxone therapy. She was later found to have a typhus coinfection and improved with addition of doxycycline.Asian Journal of Medical Sciences Vol.8(6) 2017 40-41

scholarly journals MLVA-TYPING OF CLINICAL STAMPS OF GENETICALLY CHANGED VIBRIO CHOLERAE BIOTYPE EL TOR INSULATED IN RUSSIA AND UKRAINE IN THE PERIOD OF SEVENTH PANDEMIC CHOLERA

2018 ◽  
pp. 37-43
Author(s):  
I. V. Savelieva ◽  
A. N. Kulichenko ◽  
V. N. Saveliev ◽  
D. A. Kovalev ◽  
O. V. Vasilieva ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Vibrio Cholerae ◽  
Genetically Modified ◽  
Cholera Vibrio ◽  
Separate Branch ◽  
Comparative Aspect ◽  
The Russian Federation ◽  
Time Periods ◽  
El Tor ◽  
Mlva Typing

Aim. Conduct in a comparative aspect MLVA-typing of genetically altered cholera vibrio biovar El Tor, isolated from patients during the epidemic (1994) and outbreaks (1993, 1998) in Dagestan with isolates in Mariupol (Ukraine) in 1994-2011 in Moscow (2010, 2012), India (1964, 2006, 2007), Bangladesh 1991, 1994, 2001, 2004) and to establish Phylogenetic connections between strains of cholera vibrios isolated in different years in these territories, to ascertain the source of their drift. Materials and methods. MLVA-tyP-ing was carried out in PCR at 5 variable loci of 35 clinical strains of genetically modified Vibrio cholerae byotyPe El Tor. The obtained amPlicon was studied in the system of automatic caPillary electroPhoresis ExPerion («Bio Rad Laboratories», USA). For Phylogenetic analysis, along with MLVA-genotyPes, 35 strains of Vibrio cholerae from the Institute's collection used Published genotyPes of strains isolated in India, Bangladesh, Haiti. Results. The investigated strains of cholera vibrio are referred to 21 MLVA-tyPes, divided into 2 main clades and 1 seParate branch with clonal clusters and subclusters, each of which contains closely related strains of cholera vibrio genovariants having a different degree of Phylogenetic relationshiP - full or Partial identity of allelic Profiles of five variable loci. The sources of drift of genetically modified Vibrio cholerae byotyPe El Tor to Russia and Ukraine from disadvantaged cholera of India, Bangladesh, Azerbaijan and the countries of the Middle East have been established. Conclusion. The obtained data testify to the PolymorPhism of MLVA-tyPes of genetically altered strains of cholera vibrio of the biologist El Tor, evolved in different years and caused ePidemics or outbreaks of cholera in different territories during different time Periods of the course of the seventh cholera Pandemic, and also suggest the Polyclonal origin of the Vibrio cholerae biovar El Tor and the source of their drift to the territory of the Russian Federation and Ukraine.

scholarly journals Massive Lower Gastrointestinal Bleed caused by Typhoid Ulcer: Conservative Management

2017 ◽  
Vol 7 (2) ◽  
pp. 176-177 ◽  
Author(s):  
Apoorv Goel ◽  
Roli Bansal
Keyword(s):  
Typhoid Fever ◽  
Conservative Management ◽  
Salmonella Typhi ◽  
Young Female ◽  
High Grade ◽  
High Grade Fever ◽  
Gram Negative ◽  
Gastrointestinal Bleed ◽  
Lower Gastrointestinal Bleed ◽  
Gi Bleed

ABSTRACT Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article Goel A, Bansal R. Massive Lower Gastrointestinal Bleed caused by Typhoid Ulcer: Conservative Management. Euroasian J Hepato-Gastroenterol 2017;7(2):176-177.

scholarly journals Typhoid fever: a review

2017 ◽  
Vol 4 (2) ◽  
pp. 300 ◽  
Author(s):  
Uttam Kumar Paul ◽  
Arup Bandyopadhyay
Keyword(s):  
Typhoid Fever ◽  
Paediatric Population ◽  
Salmonella Typhi ◽  
Third Generation ◽  
Once Daily ◽  
Contaminated Food ◽  
Adults And Children ◽  
Third Line ◽  
Flagellar Antigen ◽  
Third Generation Cephalosporins

Typhoid fever is still a deadly disease in developing countries, particularly in India. Although, the paediatric population is mostly affected by this disease, yet the disease is an important cause of morbidity and mortality in adult populations also. In India, most of the cases of typhoid fever are diagnosed clinically, or at the most by the Widal test which is not fool proof. The disease typhoid fever is an orally transmitted communicable infectious disease caused by the bacteria Salmonella typhi. It is usually caused by consuming impure water and contaminated food. Salmonella typhi is serologically positive for lipopolysaccharide antigens O9 and O12, protein flagellar antigen Hd, and polysaccharide capsular antigen Vi. S. typhi Vi-positive strains are more infectious and virulent than Vi-negative strains. Following the incubation period of 7 to 14 days, there is onset of fever and malaise. The fever is then accompanied by chills, headache, malaise, anorexia, nausea, vague abdominal discomfort, dry cough and myalgia. These are followed by coated tongue, tender abdomen, hepatomegaly, and splenomegaly. Azithromycin (10mg/kg) given once daily for seven days has proven effective in the treatment of typhoid fever in some adults and children. A dose of 1g per day for five days was also found to be more effective in most adults. Of the third generation cephalosporins, oral Cefixime (15-20mg per kg per day, for adults, 100-200mg twice daily) has been widely used. Intravenous third generation cephalosporins (ceftriaxone, cefotaxime) are effective. Aztreonam and imipenem are potential third line drugs.

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