MprF-Mediated Lysinylation of Phospholipids in Staphylococcus aureus Leads to Protection against Oxygen-Independent Neutrophil Killing
2003 ◽
Vol 71
(1)
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pp. 546-549
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Keyword(s):
ABSTRACT Staphylococcus aureus achieves resistance to defensins and similar cationic antimicrobial peptides (CAMPs) by modifying anionic membrane lipids via MprF with l-lysine, which leads to repulsion of these host defense molecules. S. aureus ΔmprF, which lacks the modification, was very efficiently killed by neutrophil defensins and CAMP-producing leukocytes, even when oxygen-dependent killing was disrupted, but was as susceptible as wild-type bacteria to inactivation by myeloperoxidase or human monocytes lacking defensins. These results demonstrate the impact and specificity of MprF-mediated CAMP resistance and underscore the role of defensin-like peptides in innate host defense.
2011 ◽
Vol 55
(9)
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pp. 4012-4018
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2020 ◽
Keyword(s):
2013 ◽
Vol 57
(11)
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pp. 5658-5664
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2000 ◽
Vol 66
(8)
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pp. 3151-3159
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Keyword(s):
Keyword(s):
2010 ◽
Vol 59
(5)
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pp. 521-527
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Keyword(s):