scholarly journals Antimicrobial Susceptibility Patterns of Brachyspira Species Isolated from Swine Herds in the United States

2016 ◽  
Vol 54 (8) ◽  
pp. 2109-2119 ◽  
Author(s):  
Nandita S. Mirajkar ◽  
Peter R. Davies ◽  
Connie J. Gebhart
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
North American ◽  
Bacterial Species ◽  
The United States ◽  
Swine Dysentery ◽  
Content Type ◽  
Brachyspira Pilosicoli ◽  
Swine Herds ◽  
And Control

Outbreaks of swine dysentery, caused byBrachyspira hyodysenteriaeand the recently discovered “Brachyspira hampsonii,” have reoccurred in North American swine herds since the late 2000s. Additionally, multipleBrachyspiraspecies have been increasingly isolated by North American diagnostic laboratories. In Europe, the reliance on antimicrobial therapy for control of swine dysentery has been followed by reports of antimicrobial resistance over time. The objectives of our study were to determine the antimicrobial susceptibility trends of fourBrachyspiraspecies originating from U.S. swine herds and to investigate their associations with the bacterial species, genotypes, and epidemiological origins of the isolates. We evaluated the susceptibility ofB. hyodysenteriae,B. hampsonii,Brachyspira pilosicoli, andBrachyspira murdochiito tiamulin, valnemulin, doxycycline, lincomycin, and tylosin by broth microdilution and that to carbadox by agar dilution. In general,Brachyspiraspecies showed high susceptibility to tiamulin, valnemulin, and carbadox, heterogeneous susceptibility to doxycycline, and low susceptibility to lincomycin and tylosin. A trend of decreasing antimicrobial susceptibility by species was observed (B. hampsonii>B. hyodysenteriae>B. murdochii>B. pilosicoli). In general,Brachyspiraisolates from the United States were more susceptible to these antimicrobials than were isolates from other countries. Decreased antimicrobial susceptibility was associated with the genotype, stage of production, and production system from which the isolate originated, which highlights the roles of biosecurity and husbandry in disease prevention and control. Finally, this study also highlights the urgent need for Clinical and Laboratory Standards Institute-approved clinical breakpoints forBrachyspiraspecies, to facilitate informed therapeutic and control strategies.

scholarly journals Antimicrobial Susceptibility to Azithromycin among Salmonella enterica Isolates from the United States

2011 ◽  
Vol 55 (9) ◽  
pp. 3985-3989 ◽  
Author(s):  
Maria Sjölund-Karlsson ◽  
Kevin Joyce ◽  
Karen Blickenstaff ◽  
Takiyah Ball ◽  
Jovita Haro ◽  
...  
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Antimicrobial Agents ◽  
The United States ◽  
Outcome Data ◽  
Content Type ◽  
Susceptibility Data ◽  
Retail Meat ◽  
Clinical Breakpoints

ABSTRACTDue to emerging resistance to traditional antimicrobial agents, such as ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol, azithromycin is increasingly used for the treatment of invasiveSalmonellainfections. In the present study, 696 isolates of non-TyphiSalmonellacollected from humans, food animals, and retail meats in the United States were investigated for antimicrobial susceptibility to azithromycin. Seventy-twoSalmonella entericaserotype Typhi isolates from humans were also tested. For each isolate, MICs of azithromycin and 15 other antimicrobial agents were determined by broth microdilution. Among the non-TyphiSalmonellaisolates, azithromycin MICs among human isolates ranged from 1 to 32 μg/ml, whereas the MICs among the animal and retail meat isolates ranged from 2 to 16 μg/ml and 4 to 16 μg/ml, respectively. AmongSalmonellaserotype Typhi isolates, the azithromycin MICs ranged from 4 to 16 μg/ml. The highest MIC observed in the present study was 32 μg/ml, and it was detected in three human isolates belonging to serotypes Kentucky, Montevideo, and Paratyphi A. Based on our findings, we propose an epidemiological cutoff value (ECOFF) for wild-typeSalmonellaof ≤16 μg/ml of azithromycin. The susceptibility data provided could be used in combination with clinical outcome data to determine tentative clinical breakpoints for azithromycin andSalmonella enterica.

scholarly journals Antimicrobial Susceptibility and Clonality of Clinical Ureaplasma Isolates in the United States

2016 ◽  
Vol 60 (8) ◽  
pp. 4793-4798 ◽  
Author(s):  
Javier Fernández ◽  
Melissa J. Karau ◽  
Scott A. Cunningham ◽  
Kerryl E. Greenwood-Quaintance ◽  
Robin Patel
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Antimicrobial Agents ◽  
Ureaplasma Urealyticum ◽  
Resistance Mechanism ◽  
The United States ◽  
Resistance Mechanisms ◽  
Resistant Isolate ◽  
Limited Information ◽  
Content Type

ABSTRACTUreaplasma urealyticumandUreaplasma parvumare pathogens involved in urogenital tract and intrauterine infections and also in systemic diseases in newborns and immunosuppressed patients. There is limited information on the antimicrobial susceptibility and clonality of these species. In this study, we report the susceptibility of 250 contemporary isolates ofUreaplasma(202U. parvumand 48U. urealyticumisolates) recovered at Mayo Clinic, Rochester, MN. MICs of doxycycline, azithromycin, ciprofloxacin, tetracycline, erythromycin, and levofloxacin were determined by broth microdilution, with MICS of the last three interpreted according to CLSI guidelines. Levofloxacin resistance was found in 6.4% and 5.2% ofU. parvumandU. urealyticumisolates, respectively, while 27.2% and 68.8% of isolates, respectively, showed ciprofloxacin MICs of ≥4 μg/ml. The resistance mechanism of levofloxacin-resistant isolates was due to mutations inparC, with the Ser83Leu substitution being most frequent, followed by Glu87Lys. No macrolide resistance was found among the 250 isolates studied; a singleU. parvumisolate was tetracycline resistant.tet(M) was found in 10U. parvumisolates, including the single tetracycline-resistant isolate, as well as in 9 isolates which had low tetracycline and doxycycline MICs. Multilocus sequence typing (MLST) performed on a selection of 46 isolates showed high diversity within the clinicalUreaplasmaisolates studied, regardless of antimicrobial susceptibility. The present work extends previous knowledge regarding susceptibility to antimicrobial agents, resistance mechanisms, and clonality ofUreaplasmaspecies in the United States.

scholarly journals Global Dissemination ofblaKPCinto Bacterial Species beyond Klebsiella pneumoniae andIn VitroSusceptibility to Ceftazidime-Avibactam and Aztreonam-Avibactam

2016 ◽  
Vol 60 (8) ◽  
pp. 4490-4500 ◽  
Author(s):  
Krystyna M. Kazmierczak ◽  
Douglas J. Biedenbach ◽  
Meredith Hackel ◽  
Sharon Rabine ◽  
Boudewijn L. M. de Jonge ◽  
...  
Keyword(s):  
United States ◽  
Klebsiella Pneumoniae ◽  
Molecular Mechanisms ◽  
Bacterial Species ◽  
The United States ◽  
Asia Pacific ◽  
Gram Negative ◽  
Content Type ◽  
Global Problem

ABSTRACTTheKlebsiella pneumoniaecarbapenemase (KPC), first described in the United States in 1996, is now a widespread global problem in several Gram-negative species. A worldwide surveillance study collected Gram-negative pathogens from 202 global sites in 40 countries during 2012 to 2014 and determined susceptibility to β-lactams and other class agents by broth microdilution testing. Molecular mechanisms of β-lactam resistance among carbapenem-nonsusceptibleEnterobacteriaceaeandPseudomonas aeruginosawere determined using PCR and sequencing. Genes encoding KPC enzymes were found in 586 isolates from 22 countries (76 medical centers), including countries in the Asia-Pacific region (32 isolates), Europe (264 isolates), Latin America (210 isolates), and the Middle East (19 isolates, Israel only) and the United States (61 isolates). The majority of isolates wereK. pneumoniae(83.4%); however, KPC was detected in 13 additional species. KPC-2 (69.6%) was more common than KPC-3 (29.5%), with regional variation observed. A novel KPC variant, KPC-18 (KPC-3[V8I]), was identified during the study. Few antimicrobial agents tested remained effectivein vitroagainst KPC-producing isolates, with ceftazidime-avibactam (MIC90, 4 μg/ml), aztreonam-avibactam (MIC90, 0.5 μg/ml), and tigecycline (MIC90, 2 μg/ml) retaining the greatest activity againstEnterobacteriaceaecocarrying KPC and other β-lactamases, whereas colistin (MIC90, 2 μg/ml) demonstrated the greatestin vitroactivity against KPC-positiveP. aeruginosa. This analysis of surveillance data demonstrated that KPC is widely disseminated. KPC was found in multiple species ofEnterobacteriaceaeandP. aeruginosaand has now become a global problem.

scholarly journals Swine Dysentery

2016 ◽  
Vol 54 (1) ◽  
pp. 22-31 ◽  
Author(s):  
E. R. Burrough
Keyword(s):  
United States ◽  
Risk Factors ◽  
Laboratory Diagnosis ◽  
The United States ◽  
Enteric Disease ◽  
Treatment Control ◽  
Swine Dysentery ◽  
The World ◽  
Industry Consolidation ◽  
And Control

Swine dysentery is a severe enteric disease in pigs, which is characterized by bloody to mucoid diarrhea and associated with reduced growth performance and variable mortality. This disease is most often observed in grower–finisher pigs, wherein susceptible pigs develop a significant mucohemorrhagic typhlocolitis following infection with strongly hemolytic spirochetes of the genus Brachyspira. While swine dysentery is endemic in many parts of the world, the disease had essentially disappeared in much of the United States by the mid-1990s as a result of industry consolidation and effective treatment, control, and elimination methods. However, since 2007, there has been a reported increase in laboratory diagnosis of swine dysentery in parts of North America along with the detection of novel pathogenic Brachyspira spp worldwide. Accordingly, there has been a renewed interest in swine dysentery and Brachyspira spp infections in pigs, particularly in areas where the disease was previously eliminated. This review provides an overview of knowledge on the etiology, pathogenesis, and diagnosis of swine dysentery, with insights into risk factors and control.

Canada-US tariff troubles may flare more broadly

2018 ◽  
Keyword(s):  
United States ◽  
Foreign Trade ◽  
Free Trade ◽  
North American ◽  
Foreign Relations ◽  
Free Trade Agreement ◽  
Trade Agreement ◽  
The United States ◽  
Short Term ◽  
Content Type

Significance Canada has a temporary exemption, but Trump is calling for North American Free Trade Agreement (NAFTA) renegotiations to be completed speedily. The NAFTA and tariffs issues have, therefore, become fused, raising questions about the outlook for Canada-US foreign relations. Impacts In the short term, Canadian steel companies may benefit from reduced foreign providers’ presence in the United States. Canada’s NAFTA negotiators will not respond to the Trump team’s threat to impose tariffs. Canadian businesses will begin to migrate south to take advantage of the new and more competitive US tax regime. Canada’s efforts to diversify its foreign trade and decrease US dependence will further accelerate, but still face hurdles.

scholarly journals Genome Sequence of the Corynebacterium pseudotuberculosis Cp316 Strain, Isolated from the Abscess of a Californian Horse

2012 ◽  
Vol 194 (23) ◽  
pp. 6620-6621 ◽  
Author(s):  
Rommel Thiago Jucá Ramos ◽  
Artur Silva ◽  
Adriana Ribeiro Carneiro ◽  
Anne Cybelle Pinto ◽  
Siomar de Castro Soares ◽  
...  
Keyword(s):  
United States ◽  
Genome Sequence ◽  
North American ◽  
Complete Genome ◽  
The United States ◽  
Corynebacterium Pseudotuberculosis ◽  
Economic Losses ◽  
Content Type ◽  
Veterinary Importance

ABSTRACTThe bacteriumCorynebacterium pseudotuberculosisis of major veterinary importance because it affects livestock, particularly sheep, goats, and horses, in several countries, including Australia, Brazil, the United States, and Canada, resulting in significant economic losses. In the present study, we describe the complete genome of theCorynebacterium pseudotuberculosisCp316 strain, biovar equi, isolated from the abscess of a North American horse.

New jerseys: exploring the influence of NBA team jersey sponsorships on teams and sponsors

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sara Shoffner ◽  
Mark Slavich ◽  
Gi-Yong Koo
Keyword(s):  
United States ◽  
North American ◽  
Design Methodology ◽  
The United States ◽  
National Basketball Association ◽  
Future Research ◽  
Sport Sponsorship ◽  
Content Type ◽  
Sport League ◽  
The Impact

PurposeIn 2017, the National Basketball Association (NBA) became the first major professional North American sport league to adopt jersey sponsorship. While professional leagues across the globe have allowed this practice for decades, the NBA's decision marked what may be the start of a new trend in North American sport sponsorship. With this in mind, the current study sought to assess the impact of fans' perceptions of these sponsorships on sponsor- and team-related outcomes.Design/methodology/approachAn online sample of 301 NBA fans across the United States was conducted through Amazon's MTurk.FindingsResults exhibited the importance of sponsorship authenticity, which maintained the strongest influence on sponsor- and team-related outcomes. Brand–team fit, sponsorship familiarity and sponsorship identification were also assessed, with mixed results for each factor.Originality/valueResults of these findings related to sponsorship authenticity and consequent practical and theoretical implications are discussed, and areas for future research are provided.

Canada’s new government will survive for now

2019 ◽  
Keyword(s):  
United States ◽  
Prime Minister ◽  
The United States ◽  
Content Type ◽  
Opposition Party ◽  
And Control ◽  
Opposition Parties

Significance Parliament elected a new speaker and the governor general delivered the government’s traditional throne speech, which sets out its legislative priorities. Prime Minister Justin Trudeau’s Liberals have been returned to parliament by voters as a minority administration after federal elections in October. Impacts Opposition parties are likely to give Trudeau a couple of years in office before pursuing a no-confidence motion. The Trans Mountain pipeline will be built and eventually transferred to indigenous ownership and control. Additional policing, tax and pensions powers will be devolved to Alberta and Saskatchewan, given separatist sentiment there. The Conservatives, the largest opposition party, could decide to change their leader in April 2020. Should the United States enact the USMCA trade deal, Canada’s parliament would pass it speedily.

scholarly journals Surveillance for Antimicrobial Susceptibility among Clinical Isolates of Pseudomonas aeruginosa and Acinetobacter baumannii from Hospitalized Patients in the United States, 1998 to 2001

2003 ◽  
Vol 47 (5) ◽  
pp. 1681-1688 ◽  
Author(s):  
James A. Karlowsky ◽  
Deborah C. Draghi ◽  
Mark E. Jones ◽  
Clyde Thornsberry ◽  
Ian R. Friedland ◽  
...  
Keyword(s):  
United States ◽  
Pseudomonas Aeruginosa ◽  
Multidrug Resistance ◽  
Acinetobacter Baumannii ◽  
Antimicrobial Susceptibility ◽  
Bacterial Species ◽  
The United States ◽  
Hospitalized Patients ◽  
Icu Patients ◽  
Clinical Specimens

ABSTRACT Pseudomonas aeruginosa and Acinetobacter baumannii are the most prevalent nonfermentative bacterial species isolated from clinical specimens of hospitalized patients. A surveillance study of 65 laboratories in the United States from 1998 to 2001 found >90% of isolates of P. aeruginosa from hospitalized patients to be susceptible to amikacin and piperacillin-tazobactam; 80 to 90% of isolates to be susceptible to cefepime, ceftazidime, imipenem, and meropenem; and 70 to 80% of isolates to be susceptible to ciprofloxacin, gentamicin, levofloxacin, and ticarcillin-clavulanate. From 1998 to 2001, decreases in antimicrobial susceptibility (percents) among non-intensive-care-unit (non-ICU) inpatients and ICU patients, respectively, were greatest for ciprofloxacin (6.1 and 6.5), levofloxacin (6.6 and 3.5), and ceftazidime (4.8 and 3.3). Combined 1998 to 2001 results for A. baumannii isolated from non-ICU inpatients and ICU patients, respectively, demonstrated that >90% of isolates tested were susceptible to imipenem (96.5 and 96.6%) and meropenem (91.6 and 91.7%); fewer isolates from both non-ICU inpatients and ICU patients were susceptible to amikacin and ticarcillin-clavulanate (70 to 80% susceptible); and <60% of isolates were susceptible to ceftazidime, ciprofloxacin, gentamicin, or levofloxacin. From 1998 to 2001, rates of multidrug resistance (resistance to at least three of the drugs ceftazidime, ciprofloxacin, gentamicin, and imipenem) showed small increases among P. aeruginosa strains isolated from non-ICU inpatients (5.5 to 7.0%) and ICU patients (7.4 to 9.1%). From 1998 to 2001, rates of multidrug resistance among A. baumannii strains isolated from non-ICU inpatients (27.6 to 32.5%) and ICU patients (11.6 to 24.2%) were higher and more variable than those observed for P. aeruginosa. Isolates concurrently susceptible, intermediate, or resistant to both imipenem and meropenem accounted for 89.8 and 91.2% of P. aeruginosa and A. baumannii isolates, respectively, studied from 1998 to 2001. In conclusion, for aminoglycosides and most β-lactams susceptibility rates for P. aeruginosa and A. baumannii were constant or decreased only marginally (≤3%) from 1998 to 2001. Greater decreases in susceptibility rates were, however, observed for fluoroquinolones and ceftazidime among P. aeruginosa isolates.

scholarly journals IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis

2016 ◽  
Vol 60 (10) ◽  
pp. 6418-6421 ◽  
Author(s):  
Nyssa Dixon ◽  
Randal C. Fowler ◽  
A. Yoshizumi ◽  
Tsukasa Horiyama ◽  
Y. Ishii ◽  
...  
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Proteus Mirabilis ◽  
Susceptibility Testing ◽  
Gene Cassette ◽  
The United States ◽  
Antimicrobial Susceptibility Testing ◽  
Content Type ◽  
Lactamase Gene

ABSTRACTA novel metallo-β-lactamase gene,blaIMP-27, was identified in unrelatedProteus mirabilisisolates from two geographically distinct locations in the United States. Both isolates harborblaIMP-27as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.

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