β-Catenin Interacts with MyoD and Regulates Its Transcription Activity
2008 ◽
Vol 28
(9)
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pp. 2941-2951
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Keyword(s):
ABSTRACT Wnt regulation of muscle development is thought to be mediated by the β-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that β-catenin, not TCF/LEF, is required for muscle differentiation. We showed that β-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when β-catenin is deficient or the interaction between MyoD and β-catenin is disrupted. These results demonstrate that β-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.
1995 ◽
Vol 15
(5)
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pp. 2707-2718
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2008 ◽
Vol 19
(6)
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pp. 2389-2401
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2001 ◽
Vol 183
(13)
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pp. 4090-4093
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Keyword(s):
2000 ◽
Vol 275
(27)
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pp. 20239-20242
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