scholarly journals Engineering Complexity in Bacterial Regulatory Circuits for Biotechnological Applications

mSystems ◽  
2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Cauã Antunes Westmann ◽  
María-Eugenia Guazzaroni ◽  
Rafael Silva-Rocha
Keyword(s):  
High Performance ◽  
New Technologies ◽  
Biotechnological Applications ◽  
On Demand ◽  
The Past ◽  
Regulatory Circuits ◽  
Short Palindromic Repeat ◽  
Regulatory Complexity ◽  
Dna Editing ◽  
Microbial Systems

ABSTRACT Engineering microbial systems allows the generation of new technologies having significant impact in the biotechnological industry and on human health. In the past few years, several synthetic biology approaches have been implemented in bacteria to allow precise engineering of novel regulatory circuits for several applications. The advent of high-throughput technologies and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-based DNA editing techniques have been pivotal in this process. Yet, despite the tremendous advances experienced recently, there are still a number of bottlenecks that need to be overcome in order to generate high-performance redesigned living machines, and the use of novel computer-aided approaches would be essential for this task. In this perspective, we discuss some of the main advances in the field of microbial engineering and the new technologies and approaches that should allow the construction of on demand synthetic microbial factories through the redesign of regulatory complexity.

scholarly journals It’s Time to Talk About HPC Storage: Perspectives on the Past and Future

2021 ◽  
Author(s):  
Bradley Settlemyer ◽  
George Amvrosiadis ◽  
Philip Carns ◽  
Robert Ross
Keyword(s):  
Artificial Intelligence ◽  
High Performance ◽  
New Technologies ◽  
Storage Systems ◽  
Storage System ◽  
Status Quo ◽  
Future Research ◽  
The Past ◽  
Experimental Data Analysis ◽  
Performance Computing

High-performance computing (HPC) storage systems are a key component of the success of HPC to date. Recently, we have seen major developments in storage-related technologies, as well as changes to how HPC platforms are used, especially in relation to artificial intelligence and experimental data analysis workloads. These developments merit a revisit of HPC storage system architectural designs. In this paper we discuss the drivers, identify key challenges to status quo posed by these developments, and discuss directions future research might take to unlock the potential of new technologies for the breadth of HPC applications.

The Recent Revolution in High Performance Computing

MRS Bulletin ◽  
1997 ◽  
Vol 22 (10) ◽  
pp. 5-6
Author(s):  
Horst D. Simon
Keyword(s):  
High Performance Computing ◽  
High Performance ◽  
New Technologies ◽  
New Technology ◽  
Parallel Architecture ◽  
Time Frame ◽  
Good News ◽  
Computing Industry ◽  
Time And Energy ◽  
Performance Computing

Recent events in the high-performance computing industry have concerned scientists and the general public regarding a crisis or a lack of leadership in the field. That concern is understandable considering the industry's history from 1993 to 1996. Cray Research, the historic leader in supercomputing technology, was unable to survive financially as an independent company and was acquired by Silicon Graphics. Two ambitious new companies that introduced new technologies in the late 1980s and early 1990s—Thinking Machines and Kendall Square Research—were commercial failures and went out of business. And Intel, which introduced its Paragon supercomputer in 1994, discontinued production only two years later.During the same time frame, scientists who had finished the laborious task of writing scientific codes to run on vector parallel supercomputers learned that those codes would have to be rewritten if they were to run on the next-generation, highly parallel architecture. Scientists who are not yet involved in high-performance computing are understandably hesitant about committing their time and energy to such an apparently unstable enterprise.However, beneath the commercial chaos of the last several years, a technological revolution has been occurring. The good news is that the revolution is over, leading to five to ten years of predictable stability, steady improvements in system performance, and increased productivity for scientific applications. It is time for scientists who were sitting on the fence to jump in and reap the benefits of the new technology.

Performance Management Transformation

2020 ◽  
Keyword(s):  
Organizational Performance ◽  
Performance Management ◽  
High Performance ◽  
Best Practice ◽  
Call To Action ◽  
Daily Work ◽  
The Past ◽  
Great Debate ◽  
The Subject ◽  
New Research

No other talent process has been the subject of such great debate and emotion as performance management (PM). For decades, different strategies have been tried to improve PM processes, yielding an endless cycle of reform to capture the next “flavor-of-the-day” PM trend. The past 5 years, however, have brought novel thinking that is different from past trends. Companies are reducing their formal processes, driving performance-based cultures, and embedding effective PM behavior into daily work rather than relying on annual reviews to drive these. Through case studies provided from leading organizations, this book illustrates the range of PM processes that companies are using today. These show a shift away from adopting someone else’s best practice; instead, companies are designing bespoke PM processes that fit their specific strategy, climate, and needs. Leading PM thought leaders offer their views about the state of PM today, what we have learned and where we need to focus future efforts, including provocative new research that shows what matters most in driving high performance. This book is a call to action for talent management professionals to go beyond traditional best practice and provide thought leadership in designing PM processes and systems that will enhance both individual and organizational performance.

scholarly journals The Digitalization of the European Agri-Food Cooperative Sector. Determining Factors to Embrace Information and Communication Technologies

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 514
Author(s):  
Javier Jorge-Vázquez ◽  
Mª Peana Chivite-Cebolla ◽  
Francisco Salinas-Ramos
Keyword(s):  
Information And Communication Technologies ◽  
High Performance ◽  
New Technologies ◽  
Communication Technologies ◽  
Political Agenda ◽  
Food Sector ◽  
Technological Adoption ◽  
Synthetic Index ◽  
Determining Factors ◽  
Information And Communication

The digitization of the agri-food sector is a strategic priority in the political agenda of European institutions. The opportunity to improve the competitiveness and efficiency of the sector offered by new technologies comes together with its potential to face new economic and environmental challenges. This research aims to analyze the level of digitalization of the European agri-food cooperative sector from the construction of a composite synthetic index. Such an index is to be based on a diverse set of variables related to electronic commerce and the services offered through the internet. It also evaluates how European cooperatives influence the degree of technological adoption depending on their size or the wealth of the country where they carry out their activity. The empirical analytical method is thus used, through the analysis of frequencies and correlations. The results obtained reveal the existence of a suboptimal and heterogeneous degree of digitization of European agri-food cooperatives, clearly conditioned by their size and the wealth of the country where they operate. In this situation, it is recommended to promote public policies that guarantee high-performance digital connectivity, an improvement in training in digital skills and the promotion of cooperative integration processes.

Fused Ambipolar Aza-isoindigos with NIR absorption

2021 ◽  
Author(s):  
Liping Yao ◽  
Danlei Zhu ◽  
Hailiang Liao ◽  
Sheik Haseena ◽  
Mahesh kumar Ravva ◽  
...  
Keyword(s):  
Organic Semiconductors ◽  
High Performance ◽  
Low Cost ◽  
Light Weight ◽  
The Past ◽  
Pi Conjugated ◽  
Nir Absorption ◽  
Conjugated Organic Semiconductors

Due to their advantages of low-cost, light-weight, and mechanical flexibility, much attention has been focused on pi-conjugated organic semiconductors. In the past decade, although many materials with high performance has...

scholarly journals 3D Printing of High Viscosity Reinforced Silicone Elastomers

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2239
Author(s):  
Nicholas Rodriguez ◽  
Samantha Ruelas ◽  
Jean-Baptiste Forien ◽  
Nikola Dudukovic ◽  
Josh DeOtte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
New Technologies ◽  
Three Dimensional ◽  
High Viscosity ◽  
Layer By Layer ◽  
Silicone Elastomers ◽  
Uv Curable ◽  
Octet Truss ◽  
Tunable Mechanical Properties

Recent advances in additive manufacturing, specifically direct ink writing (DIW) and ink-jetting, have enabled the production of elastomeric silicone parts with deterministic control over the structure, shape, and mechanical properties. These new technologies offer rapid prototyping advantages and find applications in various fields, including biomedical devices, prosthetics, metamaterials, and soft robotics. Stereolithography (SLA) is a complementary approach with the ability to print with finer features and potentially higher throughput. However, all high-performance silicone elastomers are composites of polysiloxane networks reinforced with particulate filler, and consequently, silicone resins tend to have high viscosities (gel- or paste-like), which complicates or completely inhibits the layer-by-layer recoating process central to most SLA technologies. Herein, the design and build of a digital light projection SLA printer suitable for handling high-viscosity resins is demonstrated. Further, a series of UV-curable silicone resins with thiol-ene crosslinking and reinforced by a combination of fumed silica and MQ resins are also described. The resulting silicone elastomers are shown to have tunable mechanical properties, with 100–350% elongation and ultimate tensile strength from 1 to 2.5 MPa. Three-dimensional printed features of 0.4 mm were achieved, and complexity is demonstrated by octet-truss lattices that display negative stiffness.

scholarly journals Analysis of the Mycosporine-Like Amino Acid (MAA) Pattern of the Salt Marsh Red Alga Bostrychia scorpioides

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 321
Author(s):  
Maria Orfanoudaki ◽  
Anja Hartmann ◽  
Julia Mayr ◽  
Félix L. Figueroa ◽  
Julia Vega ◽  
...  
Keyword(s):  
Amino Acids ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Red Alga ◽  
Array Detector ◽  
Diode Array ◽  
Diode Array Detector ◽  
The Past ◽  
Specific Species

This study presents the validation of a high-performance liquid chromatography diode array detector (HPLC-DAD) method for the determination of different mycosporine-like amino acids (MAAs) in the red alga Bostrychia scorpioides. The investigated MAAs, named bostrychines, have only been found in this specific species so far. The developed HPLC-DAD method was successfully applied for the quantification of the major MAAs in Bostrychia scorpioides extracts, collected from four different countries in Europe showing only minor differences between the investigated samples. In the past, several Bostrychia spp. have been reported to include cryptic species, and in some cases such as B. calliptera, B. simpliciuscula, and B. moritziana, the polyphyly was supported by differences in their MAA composition. The uniformity in the MAA composition of the investigated B. scorpioides samples is in agreement with the reported monophyly of this Bostrychia sp.

scholarly journals Ship Handling in Unprotected Waters: A Review of New Technologies in Escort Tugs to Improve Safety

2021 ◽  
Vol 2 (1) ◽  
pp. 46-62
Author(s):  
Santiago Iglesias-Baniela ◽  
Juan Vinagre-Ríos ◽  
José M. Pérez-Canosa
Keyword(s):  
High Performance ◽  
New Technologies ◽  
Weather Conditions ◽  
Hull Form ◽  
Best Available Technologies ◽  
Adverse Weather Conditions ◽  
Adverse Weather ◽  
New Type ◽  
Technological Challenge ◽  
And Performance

It is a well-known fact that the 1989 Exxon Valdez disaster caused the escort towing of laden tankers in many coastal areas of the world to become compulsory. In order to implement a new type of escort towing, specially designed to be employed in very adverse weather conditions, considerable changes in the hull form of escort tugs had to be made to improve their stability and performance. Since traditional winch and ropes technologies were only effective in calm waters, tugs had to be fitted with new devices. These improvements allowed the remodeled tugs to counterbalance the strong forces generated by the maneuvers in open waters. The aim of this paper is to perform a comprehensive literature review of the new high-performance automatic dynamic winches. Furthermore, a thorough analysis of the best available technologies regarding towline, essential to properly exploit the new winches, will be carried out. Through this review, the way in which the escort towing industry has faced this technological challenge is shown.

scholarly journals Key Performance Indicators for an Energy Community Based on Sustainable Technologies

2021 ◽  
Vol 13 (16) ◽  
pp. 8789
Author(s):  
Giovanni Bianco ◽  
Barbara Bonvini ◽  
Stefano Bracco ◽  
Federico Delfino ◽  
Paola Laiolo ◽  
...  
Keyword(s):  
Performance Indicators ◽  
Urban Areas ◽  
High Performance ◽  
Power Plants ◽  
New Technologies ◽  
Storage Systems ◽  
Clean Energy ◽  
Key Performance Indicators ◽  
Energy Performance ◽  
Green Energy

As reported in the “Clean energy for all Europeans package” set by the EU, a sustainable transition from fossil fuels towards cleaner energy is necessary to improve the quality of life of citizens and the livability in cities. The exploitation of renewable sources, the improvement of energy performance in buildings and the need for cutting-edge national energy and climate plans represent important and urgent topics to be faced in order to implement the sustainability concept in urban areas. In addition, the spread of polygeneration microgrids and the recent development of energy communities enable a massive installation of renewable power plants, high-performance small-size cogeneration units, and electrical storage systems; moreover, properly designed local energy production systems make it possible to optimize the exploitation of green energy sources and reduce both energy supply costs and emissions. In the present paper, a set of key performance indicators is introduced in order to evaluate and compare different energy communities both from a technical and environmental point of view. The proposed methodology was used in order to assess and compare two sites characterized by the presence of sustainable energy infrastructures: the Savona Campus of the University of Genoa in Italy, where a polygeneration microgrid has been in operation since 2014 and new technologies will be installed in the near future, and the SPEED2030 District, an urban area near the Campus where renewable energy power plants (solar and wind), cogeneration units fed by hydrogen and storage systems are planned to be installed.

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