SAT0442 Waist Circumference Is The Anthropometric Variable More Related To Clinical Severity in Women with Knee Osteoarthritis with Synovial Effussion

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 831.2-831
Author(s):  
C. Orellana ◽  
J. Calvet ◽  
A. Caixàs ◽  
N. Navarro ◽  
M. Arévalo ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Knee Osteoarthritis ◽  
Clinical Severity ◽  
Anthropometric Variable

scholarly journals Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
María García-Manrique ◽  
Joan Calvet ◽  
Cristóbal Orellana ◽  
Antoni Berenguer-Llergo ◽  
Silvia Garcia-Cirera ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Correlation Coefficient ◽  
Inflammatory Markers ◽  
Partial Correlation ◽  
Statistical Significance ◽  
Clinical Severity ◽  
Joint Effusion ◽  
Cross Sectional ◽  
Partial Correlation Coefficient

AbstractSeveral cytokines and adipokines are related to clinical severity and progression in knee osteoarthritis. The aim of this study was to evaluate the associations of IL-8 with clinical severity and with local and systemic adipokines and cytokines. This is a Cross-sectional study including 115 women with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, symptoms duration and body mass index were collected. Radiographic severity was evaluated according to Kellgren–Lawrence. Pain and disability were assessed by Lequesne and Knee injury and Osteoarthritis Outcome Score pain, symptoms and function scales. Three inflammatory markers and five adipokines were measured by ELISA in serum and synovial fluid. Partial correlation coefficient (PCC) and corresponding 95% confidence interval were used to evaluate association. Synovial fluid IL-8 was significantly associated with clinical severity scales. After controlling for potential confounders, associations measured by a Partial Correlation Coefficient (PCC) remained essentially unaltered for Lequesne (PCC = 0.237), KOOS pain (PCC = − 0.201) and KOOS symptoms (PCC = − 0.209), KOOS function (PCC = − 0.185), although the later did not reach statistical significance. Also in synovial fluid samples, associations were found between IL-8 and TNF (PCC = 0.334), IL6 (PCC = 0.461), osteopontin (PCC = 0.575), visfatin (PCC = 0.194) and resistin (PCC = 0.182), although significance was not achieved for the later after statistical control for confounders. None of these associations were detected in serum. In conclusion, IL-8 was associated with clinical severity, inflammatory markers and adipokines in synovial fluid, but not in blood. Although the reported associations are weak to moderate in magnitude, these findings reinforce the notion that local and not systemic inflammation is more relevant to clinical severity in knee OA women with joint effusion.

scholarly journals Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study

2008 ◽  
Vol 68 (4) ◽  
pp. 490-496 ◽  
Author(s):  
L S Lohmander ◽  
M Gerhardsson de Verdier ◽  
J Rollof ◽  
P M Nilsson ◽  
G Engström
Keyword(s):  
Cohort Study ◽  
Waist Circumference ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Hip Osteoarthritis ◽  
Population Based ◽  
Normal Weight ◽  
Men And Women ◽  
Relative Risks ◽  
Percentage Of Body Fat

Objective:To determine in a prospective population-based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis.Materials and methods:Body mass index (BMI), waist circumference, waist–hip ratio (WHR), weight and percentage of body fat (BF%) were measured at baseline in 11 026 men and 16 934 women from the general population. The incidence of osteoarthritis over 11 years was monitored by linkage with the Swedish hospital discharge register.Results:471 individuals had knee osteoarthritis and 551 had hip osteoarthritis. After adjustment for age, sex, smoking and physical activity, the relative risks (RR) of knee osteoarthritis (fourth vs first quartile) were 8.1 (95% CI 5.3 to 12.4) for BMI, 6.7 (4.5 to 9.9) for waist circumference, 6.5 (4.6 to 9.43) for weight, 3.6 (2.6 to 5.0) for BF% and 2.2 (1.7 to 3.0) for WHR. Corresponding RR for hip osteoarthritis were 2.6 (2.0 to 3.4) for BMI, 3.0 (2.3 to 4.0) for weight, 2.5 (1.9 to 3.3) for waist, 1.3 (0.99 to 1.6) for WHR and 1.5 (1.2 to 2.0) for BF%.Conclusion:All measures of overweight were associated with the incidence of knee osteoarthritis, with the strongest relative risk gradient observed for BMI. The incidence of hip osteoarthritis showed smaller but significant differences between normal weight and obesity. Our results support a major link between overweight and biomechanics in increasing the risk of knee and hip osteoarthritis in men and women.

scholarly journals The Association of an Increasing Waist Circumference and Risk of Incident Low Physical Function in Adults with Knee Osteoarthritis

2020 ◽  
Vol 47 (10) ◽  
pp. 1550-1556
Author(s):  
Meredith B. Christiansen ◽  
Louise M. Thoma ◽  
Hiral Master ◽  
Dana Voinier ◽  
Daniel K. White
Keyword(s):  
Waist Circumference ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Disease Risk ◽  
World Health ◽  
Risk Category ◽  
Study Enrollment ◽  
Calculated Risk ◽  
Osteoarthritis Initiative ◽  
Health Organization

Objective.To investigate an 8-year change in waist circumference (WC) with the risk of incident low physical function over 1 year in adults with, or at risk of, knee osteoarthritis (OA).Methods.Data from the Osteoarthritis Initiative were used. Change in WC was measured from study enrollment (0 month) to the 96-month visit and classified as Increase (≥ 5cm gain) or Maintain (< 5cm gain). We identified World Health Organization (WHO) risk category based on WC at study enrollment as Large WC (males ≥ 102 cm, females ≥ 88 cm) or Small WC (males < 102 cm, females < 88 cm). The outcome was incident low physical function (≥ 28 Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale) at the 108-month visit. To investigate the association of the 8-year change in WC with the risk of low physical function, we calculated risk ratios (95% CI) and adjusted for potential confounders. We repeated the analyses stratified by the WHO disease risk category.Results.The Increase WC group had 1.43 (95% CI 1.04–1.96) times the risk of incident low physical function compared to adults in the Maintain WC group. Adults with a Large WC at baseline who increased WC had 1.55 (95% CI 1.00–2.37) times the risk of incident low physical function compared to those who maintained WC. Adults with a Small WC at baseline who increased WC had 1.97 (95% CI 0.84–4.63) times the risk compared to those who maintained WC.Conclusion.Increasing WC increases the risk of incident low physical function in the following year. Maintaining WC may mitigate developing low physical function.

Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis

Biomarkers ◽  
2012 ◽  
Vol 18 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Jie Xiao ◽  
Xiang-Rui Wang ◽  
Kong-Zu Hu ◽  
Mao-Qiang Li ◽  
Jian-Wei Chen ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Clinical Severity ◽  
Fetuin A

S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis

Biomarkers ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Li-chun Wang ◽  
Hong-ying Zhang ◽  
Lin Shao ◽  
Lin Chen ◽  
Ze-han Liu ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Clinical Severity

scholarly journals Association of Trimethylamine N-Oxide (TMAO) with the Clinical Severity of Hidradenitis Suppurativa (Acne Inversa)

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1997
Author(s):  
Luigi Barrea ◽  
Giovanna Muscogiuri ◽  
Gabriella Pugliese ◽  
Giulia de Alteriis ◽  
Maria Maisto ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Total Energy ◽  
Energy Intake ◽  
Hidradenitis Suppurativa ◽  
Metabolic Diseases ◽  
Total Energy Intake ◽  
Clinical Severity ◽  
Control Group ◽  
Acne Inversa ◽  
Lower Phase

In this case-control, cross-sectional, observational study, we evaluated circulating trimethylamine n-oxide (TMAO) levels, a gut-derived metabolite associated with inflammation and cardiometabolic risk, in patients with hidradenitis suppurativa (HS), a highly disabling inflammatory skin disease associated with an elevated prevalence of comorbidities, especially cardiovascular and metabolic diseases. In this study, we enrolled 35 naive-treatment patients with HS and 35 controls, matched for sex, age, and body mass index (BMI). HS Sartorius score was 49.0 (33.0–75.0), while according to the Harley system 12 and 23 patients presented grade 1 and grade 2 severity, respectively. HS patients had a lower adherence to the Mediterranean diet (MD) (p = 0.002), lower phase angle (PhA) (p < 0.001), and higher circulating TMAO levels (p < 0.001) than the control group. HS patients with grade 2 rather than grade 1 of Harley grade severity showed a higher BMI (p = 0.007), waist circumference (p = 0.016), total energy intake (p = 0.005), and lower PhA (p < 0.001) and adherence to the MD (p = 0.003). Of interest, patients with Hurley grade 2 of severity exhibited higher circulating TMAO levels (p < 0.001) compared to grade 1. Circulating TMAO levels showed a positive correlation with HS Sartorius score even after adjustment for confounding covariates, including BMI, waist circumference, adherence to the MD, total energy intake, and PhA (r = 0.570, p = 0.001). Using a linear regression model, circulating TMAO levels and PhA were the main predictors of the clinical severity of HS.

scholarly journals Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis

Cartilage ◽  
2020 ◽  
pp. 194760352090477 ◽  
Author(s):  
Cristóbal Orellana ◽  
Joan Calvet ◽  
Antoni Berenguer-Llergo ◽  
Néstor Albiñana ◽  
María García Manrique ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Osteoarthritis ◽  
Inflammatory Markers ◽  
Cross Sectional Study ◽  
Clinical Severity ◽  
Womac Pain ◽  
Obese Women ◽  
Cross Sectional ◽  
Total Pain ◽  
Tnf Α

Objective Different adipokines have been reported to play a role in the development, progression, and severity of knee osteoarthritis, but this association may be mediated by obesity. The aim of this study was to evaluate separately the associations of leptin and adiponectin with clinical severity and inflammatory markers in nonobese and obese women with knee osteoarthritis. Design Cross-sectional study with systematic inclusion of 115 women with symptomatic primary knee osteoarthritis. Age, physical exercise, symptoms duration, and body mass index were collected. Radiographic severity was evaluated according to Kellgren-Lawrence scale. Pain and disability were assessed by WOMAC-total, -pain, -function subscales. Two adipokines (leptin and adiponectin) and 3 inflammatory markers (TNF-α, hsCRP, and IL-6) were measured by ELISA in synovial fluid and serum. Results Synovial fluid adiponectin was associated with WOMAC pain, function, and total and with synovial fluid IL-6 in nonobese female knee osteoarthritis after controlling by confounders (partial correlation coefficient [PCC] = 0.395, 0.387, 0.427, and 0.649, respectively). Synovial fluid and serum leptin were significantly associated with IL-6 (PCC = 0.354) after controlling by confounders but associations with clinical severity and the rest of inflammatory markers were mitigated after control. Conclusions Adiponectin in synovial fluid was associated with clinical severity and local inflammatory markers in knee osteoarthritis women, while leptin relation was attenuated when controlled by confounders.

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