Measurement properties of the ASAS Health Index: results of a global study in patients with axial and peripheral spondyloarthritis

ObjectivesTo evaluate construct validity, interpretability, reliability and responsiveness as well as determination of cut-off points for good and poor health within the original English version and the 18 translations of the disease-specific Assessment of Spondyloarthritis international Society Health Index (ASAS HI) in 23 countries worldwide in patients with spondyloarthritis (SpA).MethodsA representative sample of patients with SpA fulfilling the ASAS classification criteria for axial (axSpA) or peripheral SpA was used. The construct validity of the ASAS HI was tested using Spearman correlation with several standard health outcomes for axSpA. Test–retest reliability was assessed by intraclass correlation coefficients (ICCs) in patients with stable disease (interval 4–7 days). In patients who required an escalation of therapy because of high disease activity, responsiveness was tested after 2–24weeks using standardised response mean (SRM).ResultsAmong the 1548 patients, 64.9% were men, with a mean (SD) age 42.0 (13.4) years. Construct validity ranged from low (age: 0.10) to high (Bath AnkylosingSpondylitisFunctioning Index: 0.71). Internal consistency was high (Cronbach’s α of 0.93). The reliability among 578 patients was good (ICC=0.87 (95% CI 0.84 to 0.89)). Responsiveness among 246 patients was moderate-large (SRM=−0.44 for non-steroidal anti-inflammatory drugs, −0.69 for conventional synthetic disease-modifying antirheumatic drug and −0.85 for tumour necrosis factor inhibitor). The smallest detectable change was 3.0. Values ≤5.0 have balanced specificity to distinguish good health as opposed to moderate health, and values ≥12.0 are specific to represent poor health as opposed to moderate health.ConclusionsThe ASAS HI proved to be valid, reliable and responsive. It can be used to evaluate the impact of SpA and its treatment on functioning and health. Furthermore, comparison of disease impact between populations is possible.

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Infant with Clefts Observation Outcomes Instrument (iCOO): A New Outcome for Infants and Young Children with Orofacial Clefts

The Cleft Palate-Craniofacial Journal ◽

10.1177/10556656211040307 ◽

2021 ◽

pp. 105566562110403

Author(s):

Todd C. Edwards ◽

Carrie L. Heike ◽

Kathleen A. Kapp-Simon ◽

Salene M. Jones ◽

Brian G. Leroux ◽

...

Keyword(s):

Cleft Lip ◽

Intraclass Correlation ◽

Primary Caregivers ◽

Correlation Coefficients ◽

Measurement Properties ◽

Cross Sectional ◽

Scale Scores ◽

Health Domains ◽

And Function ◽

The Impact

Objective We evaluated the measurement properties for item and domain scores of the Infant with Clefts Observation Outcomes Instrument (iCOO). Design Cross-sectional (before lip surgery) and longitudinal study (preoperative baseline and 2 days and 2 months after lip surgery). Setting Three academic craniofacial centers and national online advertisements. Participants Primary caregivers with an infant with cleft lip with or without cleft palate (CL ± P) scheduled to undergo primary lip repair. There were 133 primary caregivers at baseline, 115 at 2 days postsurgery, and 112 at 2 months postsurgery. Main Outcome Measure(s) Caregiver observation items ( n = 61) and global impression of health and function items ( n = 8) across eight health domains. Results Mean age at surgery was 6.0 months (range 2.7-11.8 months). Five of eight iCOO domains have scale scores, with Cronbach’s alphas ranging from 0.67 to 0.87. Except for the Facial Skin and Mouth domain, iCOO scales had acceptable intraclass correlation coefficients (ICCs) ranging from 0.76 to 0.84. The internal consistency of the Global Impression items across all domains was 0.90 and had acceptable ICCs (range 0.76-0.91). Sixteen out of 20 (nonscale) items had acceptable ICCs (range 0.66-0.96). As anticipated, iCOO scores 2 days postoperatively were generally lower than baseline and scores 2 months postsurgery were consistent with baseline or higher. The iCOO took approximately 10 min to complete. Conclusions The iCOO meets measurement standards and may be used for assessing the impact of cleft-related treatments in clinical research and care. More research is needed on its use in various treatment contexts.

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Functional Index-3: A Valid and Reliable Functional Outcome Assessment Measure in Patients With Dermatomyositis and Polymyositis

The Journal of Rheumatology ◽

10.3899/jrheum.191374 ◽

2020 ◽

Vol 48 (1) ◽

pp. 94-100 ◽

Cited By ~ 2

Author(s):

Floranne C. Ernste ◽

Christopher Chong ◽

Cynthia S. Crowson ◽

Tanaz A. Kermani ◽

Orla Ni Mhuircheartaigh ◽

...

Keyword(s):

Construct Validity ◽

Interrater Reliability ◽

Intraclass Correlation ◽

Health Assessment ◽

Correlation Coefficients ◽

Measurement Properties ◽

Muscle Endurance ◽

Spearman Correlation ◽

Intrarater Reliability ◽

Functional Index

Objective.Patients with dermatomyositis (DM) and polymyositis (PM) have reduced muscle endurance.The aim of this study was to streamline the Functional Index-2 (FI-2) by developing the Functional Index-3 (FI-3) and to evaluate its measurement properties, content and construct validity, and intra- and interrater reliability.Methods.A dataset of the previously performed and validated FI-2 (n = 63) was analyzed for internal redundancy, floor, and ceiling effects. The content of the FI-2 was revised into the FI-3. Construct validity and intrarater reliability of FI-3 were tested on 43 DM and PM patients at 2 rheumatology centers. Interrater reliability was tested in 25 patients. The construct validity was compared with the Myositis Activities Profile (MAP), Health Assessment Questionnaire (HAQ), and Borg CR-10 using Spearman correlation coefficient.Results.Spearman correlation coefficients of 63 patients performing FI-3 revealed moderate to high correlations between shoulder flexion and hip flexion tasks and similar correlations with MAP and HAQ scores; there were lower correlations for neck flexion task. All FI-3 tasks had very low to moderate correlations with the Borg scale. Intraclass correlation coefficients (ICC) of FI-3 tasks for intrarater reliability (n = 25) were moderate to good (0.88–0.98). ICC of FI-3 tasks for interrater reliability (n = 17) were fair to good (range 0.83–0.96).Conclusion.The FI-3 is an efficient and valid method for clinically assessing muscle endurance in DM and PM patients. FI-3 construct validity is supported by the significant correlations between functional tasks and the MAP, HAQ, and Borg CR-10 scores.

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The Short Musculoskeletal Function Assessment: a study of the reliability, construct validity and responsiveness in patients sustaining trauma

Clinical Rehabilitation ◽

10.1177/0269215519828152 ◽

2019 ◽

Vol 33 (5) ◽

pp. 923-935 ◽

Cited By ~ 3

Author(s):

Max W de Graaf ◽

Inge HF Reininga ◽

Klaus W Wendt ◽

Erik Heineman ◽

Mostafa El Moumni

Keyword(s):

Construct Validity ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Detectable Change ◽

Post Injury ◽

Physical Trauma ◽

Short Musculoskeletal Function Assessment ◽

Smallest Detectable Change ◽

Musculoskeletal Function ◽

Function Assessment

Objective: To assess test–retest reliability, construct validity and responsiveness of the Dutch Short Musculoskeletal Function Assessment (SMFA-NL) in patients who sustained acute physical trauma. Design: A longitudinal cohort study. Setting: A level 1 trauma center in The Netherlands. Subjects: Patients who required hospital admission after sustaining an acute physical trauma. Intervention: Patients completed the SMFA-NL at six weeks, eight weeks and six months post-injury. Main measure: The measures used were The Dutch Short Musculoskeletal Function Assessment. Test–retest reliability (between six and eight weeks post-injury) using intraclass correlation coefficients, the smallest detectable change and Bland and Altman plots. Construct validity (six weeks post-injury) and responsiveness (between six weeks and six months post-injury) were evaluated using the hypothesis testing method. Results: A total of 248 patients (mean age: 46.5, SD: 13.4) participated, 145 patients completed the retest questionnaires (eight weeks) and 160 patients completed the responsiveness questionnaires (six months). The intraclass correlation coefficients indicated good to excellent reliability on all subscales (0.80 to 0.98). The smallest detectable change was 17.4 for the Upper Extremity Dysfunction subscale, 11.0 for the Lower Extremity Dysfunction subscales, 13.9 for the Problems with Daily Activities subscale and 16.5 for the Mental and Emotional Problems subscale. At group level, the smallest detectable change ranged from 1.48 to 1.96. A total of 86% of the construct validity hypotheses and 79% of the responsiveness hypotheses were confirmed. Conclusion: This study showed that the SMFA-NL has good to excellent reliability, sufficient construct validity and is able to detect change in physical function over time.

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Assessing the Measurement Properties of the Fitbit Zip® Among Adults Living With HIV

Journal of Physical Activity and Health ◽

10.1123/jpah.2019-0242 ◽

2020 ◽

Vol 17 (3) ◽

pp. 293-305

Author(s):

Matthieu Dagenais ◽

Nancy M. Salbach ◽

Dina Brooks ◽

Kelly K. O’Brien

Keyword(s):

Physical Activity ◽

Construct Validity ◽

A Priori ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Measurement Properties ◽

Activity Questionnaires ◽

Walking Speeds ◽

Living With Hiv ◽

Walk Tests

Purpose: To assess the criterion and construct validity of the Fitbit Zip® to measure physical activity among adults living with HIV. Methods: Participants were video recorded completing 2 walk tests while wearing the Fitbit Zip® and completed 3 self-reported physical activity questionnaires 1 week later. The authors calculated intraclass correlation coefficients (ICCs) to determine agreement between the number of steps taken and distance walked (Fitbit Zip®) with the visual count of number of steps taken and actual distance walked (walk tests). The authors tested 15 a priori hypotheses about predicted associations between questionnaire scores and physical activity measured by the Fitbit Zip®. Results: Among the 34 participants, there was “excellent” agreement between the number of steps taken measured by the Fitbit Zip® and visually counted number of steps taken (ICC = .99) and number of steps taken at slow (ICC = .75), moderate (ICC = .85), and fast (ICC = .78) walking speeds. There was “poor” agreement between the Fitbit Zip® recorded distance and actual determined distance walked (ICC = .20). Three (20%) construct validity hypotheses were confirmed. Conclusions: The Fitbit Zip® demonstrated criterion validity for its ability to measure number of steps taken but not distance walked, and did not demonstrate construct validity for measuring physical activity among adults with HIV.

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Abstract P303: Association of Overweight/Obesity and Self Reported Health Status in Hispanics: A Comparison with Non Hispanic Whites

Circulation ◽

10.1161/circ.127.suppl_12.ap303 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Connie Ingram ◽

Maria Canossa-Terris ◽

Mary Comerford ◽

Paul Kurlansky

Keyword(s):

Logistic Regression ◽

Health Status ◽

Good Health ◽

Overweight And Obesity ◽

Poor Health ◽

Self Perception ◽

Heart Research ◽

Major Health Problem ◽

Perception Of Health ◽

The Impact

Introduction The growing global prevalence of obesity is recognized as an important risk for cardiovascular disease. Understanding self perception of weight as it pertains to health is critical to the success of weight reduction programs. The impact of ethnicity on this association has not been examined. Methods The sample included 927 Hispanic (H) and 72 Non-Hispanics white (NHW) adults who received free cardiovascular screening from Florida Heart Research Institute. Overweight and obesity were measured by Body Mass Index. Self-perceived health status was characterized as excellent, very good, good, fair or poor health. Logistic regression was used to determine independent risk factors for perceived fair-poor health, as well as for excellent, very good health. Odds ratios and 95% Confidence Intervals were calculated. Results Both H and NHW overweight/obese subjects tended to view their health as good, very good or excellent: H (overweight 81.1%/obese 73%) and NHW (89.3%/66.7%). Logistic regression revealed the following independent correlates of self-perceived very good or excellent health: NHW (OR 3.618, CI 2.126, 6.157, p<0.001) and exercise (OR 1.640;CI 1.186, 2.268; p=0.003). Hypertension (OR 0.392; CI 0.246, 0.625; p<0.001), overweight (OR 0.551, CI0.386, 0.785, p=0.001) and obesity (OR 0.431, CI 0.288, 0.644; p<0.001) were all negatively associated with very good/excellent status. Conclusions Although it is not surprising that participation in regular exercise is associated with a better self-perception of health status, or that hypertension and obesity is correlated with a worse self-assessed health status, there are two striking findings that emerge from this data: 1. The vast majority of both H and NHW subjects do not perceive either overweight or obesity to be a major health problem. 2. Hispanics have a significantly worse self-perception of health status even after controlling for associated factors.This information provides a critical foundation for overcoming fundamental barriers to effective patient education_a critical first step in addressing the current epidemic of obesity in ethnically diverse populations.

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Measurement properties of the Musculoskeletal Health Questionnaire (MSK-HQ): a between country comparison

10.21203/rs.2.19546/v3 ◽

2020 ◽

Author(s):

David Høyrup Christiansen ◽

Gareth McCray ◽

Trine Nøhr Winding ◽

Johan Hviid Andersen ◽

Kent Jacob Nielsen ◽

...

Keyword(s):

Measurement Error ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Roc Curves ◽

Measurement Properties ◽

Activity Levels ◽

Health Questionnaire ◽

Musculoskeletal Health ◽

Random Measurement Error ◽

The Uk

Abstract Background: The Musculoskeletal Health Questionnaire (MSK-HQ) has been developed to measure musculoskeletal health status across musculoskeletal conditions and settings. However, the MSK-HQ needs to be further evaluated across settings and different languages.Objective: The objective of the study was to evaluate and compare measurement properties of the MSK-HQ across Danish (DK) and English (UK) cohorts of patients from primary care physiotherapy services with musculoskeletal pain. Methods: MSK-HQ was translated into Danish according to international guidelines. Measurement invariance was assessed by differential item functioning (DIF) analyses. Test-retest reliability, measurement error, responsiveness and minimal clinically important change (MCIC) were evaluated and compared between DK (n=153) and UK (n=166) cohorts. Results: The Danish version demonstrated acceptable face and construct validity. Out of the 14 MSK-HQ items, three items showed DIF for language (pain/stiffness at night, understanding condition and confidence in managing symptoms) and three items showed DIF for pain location (walking, washing/dressing and physical activity levels). Intraclass Correlation Coefficients for test-retest were 0.86 (95% CI 0.81 to 0.91) for DK cohort and 0.77 (95% CI 0.49 to 0.90) for the UK cohort. The systematic measurement error was 1.6 and 3.9 points for the DK and UK cohorts respectively, with random measurement error being 8.6 and 9.9 points. Receiver operating characteristic (ROC) curves of the change scores against patients’ own judgment at 3 months exceeded 0.70 in both cohorts. Absolute and relative MCIC estimates were 8-10 points and 26% for the DK cohort and 6-8 points and 29% for the UK cohort.Conclusions: The measurement properties of MSK-HQ were acceptable across countries, but seem more suited for group than individual level evaluation. Researchers and clinicians should be aware that some discrepancy exits and should take the observed measurement error into account when evaluating change in scores over time.

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The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencing

Scientific Reports ◽

10.1038/s41598-019-51948-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Gabriel N. Valbuena ◽

Sophia Apostolidou ◽

Rhiannon Roberts ◽

Julie Barnes ◽

Wendy Alderton ◽

...

Keyword(s):

Chronic Disease ◽

Rna Sequencing ◽

Small Rna ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Critical Factor ◽

Alternative Methods ◽

Small Rna Sequencing ◽

Diagnosis And Prognosis ◽

The Impact

Abstract Understanding the normal temporal variation of serum molecules is a critical factor for identifying useful candidate biomarkers for the diagnosis and prognosis of chronic disease. Using small RNA sequencing in a longitudinal study of 66 women with no history of cancer, we determined the distribution and dynamics (via intraclass correlation coefficients, ICCs) of the miRNA profile over 3 time points sampled across 2–5 years in the course of the screening trial, UKCTOCS. We were able to define a subset of longitudinally stable miRNAs (ICC >0.75) that were individually discriminating of women who had no cancer over the study period. These miRNAs were dominated by those originating from the C14MC cluster that is subject to maternal imprinting. This assessment was not significantly affected by common confounders such as age, BMI or time to centrifugation nor alternative methods to data normalisation. Our analysis provides important benchmark data supporting the development of miRNA biomarkers for the impact of life-course exposure as well as diagnosis and prognostication of chronic disease.

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Reliability and Validity of the Sedentary Behavior Questionnaire (SBQ) for Adults

Journal of Physical Activity and Health ◽

10.1123/jpah.7.6.697 ◽

2010 ◽

Vol 7 (6) ◽

pp. 697-705 ◽

Cited By ~ 162

Author(s):

Dori E. Rosenberg ◽

Gregory J. Norman ◽

Nicole Wagner ◽

Kevin Patrick ◽

Karen J. Calfas ◽

...

Keyword(s):

Sedentary Behavior ◽

Intraclass Correlation ◽

Reliability And Validity ◽

Correlation Coefficients ◽

Population Surveillance ◽

Sitting Time ◽

Measurement Properties ◽

Sedentary Behaviors ◽

Partial Correlations ◽

Overweight Adults

Background:Sedentary behavior is related to obesity, but measures of sedentary behaviors are lacking for adults. The purpose of this study was to examine the reliability and validity of the Sedentary Behavior Questionnaire (SBQ) among overweight adults.Methods:Participants were 49 adults for the 2 week test-retest reliability study (67% female, 53% white, mean age = 20) and 401 overweight women (mean age = 41, 61% white) and 441 overweight men (mean age = 44, 81% white) for the validity study. The SBQ consisted of reports of time spent in 9 sedentary behaviors. Outcomes for validity included accelerometer measured inactivity, sitting time (International Physical Activity Questionnaire), and BMI. Intraclass correlation coefficients (ICCs) assessed reliability and partial correlations assessed validity.Results:ICCs were acceptable for all items and the total scale (range = .51–.93). For men, there were significant relationships of SBQ items with IPAQ sitting time and BMI. For women, there were relationships between the SBQ and accelerometer inactivity minutes, IPAQ sitting time, and BMI.Conclusions:The SBQ has acceptable measurement properties for use among overweight adults. Specific measures of sedentary behavior should be included in studies and population surveillance.

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Measuring participation in people with spondyloarthritis using the social role participation questionnaire

Annals of the Rheumatic Diseases ◽

10.1136/ard.2010.149211 ◽

2011 ◽

Vol 70 (10) ◽

pp. 1765-1769 ◽

Cited By ~ 11

Author(s):

Aileen M Davis ◽

Marvilyn P Palaganas ◽

Elizabeth M Badley ◽

Dafna D Gladman ◽

Robert D Inman ◽

...

Keyword(s):

Depressive Symptoms ◽

Ankylosing Spondylitis ◽

Construct Validity ◽

Disease Severity ◽

Social Role ◽

Correlation Coefficients ◽

Measurement Properties ◽

Illness Intrusiveness ◽

Scaling Properties ◽

The Social

ObjectivesPeople with spondyloarthritis (SpA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) have identified the importance of understanding how their disease and its treatment impacts on their social roles. This requires a reliable and valid standardised measure, and this study evaluates these measurement properties of the Social Role Participation Questionnaire (SRPQ).Methods109 participants (44 with AS, 65 with PsA) completed questionnaires on demographics, participation measures (SRPQ, Keele Assessment of Participation (KAP), Late Life Disability Instrument (LLDI)), disease severity (physician global) and activity (pain, fatigue, Bath Ankylosing Spondylitis Disease Activity Index), psychological measures (depressive symptoms (Hospital Anxiety and Depression Scale), Illness Intrusiveness)) and function (Health Assessment Questionnaire, Bath Ankylosing Spondylitis Functional Index). After testing scaling properties, test-retest reliability of the SRPQ was evaluated using intraclass correlation coefficients (ICC) and hypotheses of construct validity were evaluated using correlation coefficients.ResultsPatients with AS had a mean age of 40 years and 65% were male, whereas patients with PsA had a mean age of 53 years and 63% were male. Although there were some differences between AS and PsA participants in their social role participation, scaling properties were good for both groups. ICCs were >0.90 for the satisfaction subscales of the SRPQ. For construct validity, SRPQ satisfaction subscales were moderately correlated with the KAP and LLDI (0.64–0.78), and less satisfaction was associated with higher disease severity and activity, more depressive symptoms, more illness intrusiveness and more disability (coefficients −0.67 to −0.88).ConclusionSocial role participation is an important concept for people with SpA, and the SRPQ is a reliable and valid measure for use with people with AS and PsA.

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Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method

The Journal of Rheumatology ◽

10.3899/jrheum.161583 ◽

2017 ◽

Vol 45 (1) ◽

pp. 70-77 ◽

Cited By ~ 10

Author(s):

Pernille Hededal ◽

Mikkel Østergaard ◽

Inge Juul Sørensen ◽

Anne Gitte Loft ◽

Jens S. Hindrup ◽

...

Keyword(s):

Sacroiliac Joint ◽

Controlled Trial ◽

Linear Regression Analysis ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Scoring Methods ◽

Double Blind ◽

Smallest Detectable Change ◽

Observed Score ◽

Very High

Objective.To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods.Methods.Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)].Results.Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83–0.88 and 0.85–0.97; change 0.33–0.78), while high to very high for semicoronal scoring methods (baseline 0.90–0.92 and 0.93–0.97; change 0.77–0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R2 = 0.93 and 0.88; change: R2 = 0.82 and 0.87, respectively), while lower for the global method (baseline: R2 = 0.79; change: R2 = 0.54). The SDC-HOS were 9.8–18.6% and 5.9–10.7% for the semiaxial and semicoronal methods, respectively.Conclusion.Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.

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