scholarly journals EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2

2020 ◽  
Vol 79 (7) ◽  
pp. 851-858 ◽  
Author(s):  
Robert BM Landewé ◽  
Pedro M Machado ◽  
Féline Kroon ◽  
Hans WJ Bijlsma ◽  
Gerd R Burmester ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Musculoskeletal Diseases ◽  
Task Force ◽  
New Developments ◽  
Social Distancing ◽  
Eular Recommendations ◽  
Starting Point ◽  
Potential Impact ◽  
Prevention Of Infections

The provisional EULAR recommendations address several aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus, and the disease caused by SARS-CoV-2, COVID-19 and are meant for patients with rheumatic and musculoskeletal diseases (RMD) and their caregivers. A task force of 20 members was convened by EULAR that met several times by videoconferencing in April 2020. The task force finally agreed on five overarching principles and 13 recommendations covering four generic themes: (1) General measures and prevention of SARS-CoV-2 infection. (2) The management of RMD when local measures of social distancing are in effect. (3) The management of COVID-19 in the context of RMD. (4) The prevention of infections other than SARS-CoV-2. EULAR considers this set of recommendations as a ‘living document’ and a starting point, which will be updated as soon as promising new developments with potential impact on the care of patients with RMD become available.

scholarly journals 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis

2018 ◽  
Vol 77 (9) ◽  
pp. 1251-1260 ◽  
Author(s):  
Anne-Kathrin Rausch Osthoff ◽  
Karin Niedermann ◽  
Jürgen Braun ◽  
Jo Adams ◽  
Nina Brodin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Arthritis ◽  
Musculoskeletal Diseases ◽  
Task Force ◽  
The Public ◽  
Knee Oa ◽  
Eular Recommendations ◽  
Patient Representatives ◽  
Research And Education ◽  
Level Of Agreement

Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. We evaluated if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice. The EULAR standardised operating procedures for the development of recommendations were followed. A task force (TF) (including rheumatologists, other medical specialists and physicians, health professionals, patient-representatives, methodologists) from 16 countries met twice. In the first TF meeting, 13 research questions to support a systematic literature review (SLR) were identified and defined. In the second meeting, the SLR evidence was presented and discussed before the recommendations, research agenda and education agenda were formulated. The TF developed and agreed on four overarching principles and 10 recommendations for PA in people with iA and OA. The mean level of agreement between the TF members ranged between 9.8 and 8.8. Given the evidence for its effectiveness, feasibility and safety, PA is advocated as integral part of standard care throughout the course of these diseases. Finally, the TF agreed on related research and education agendas. Evidence and expert opinion inform these recommendations to provide guidance in the development, conduct and evaluation of PA-interventions and promotion in people with iA and OA. It is advised that these recommendations should be implemented considering individual needs and national health systems.

scholarly journals EULAR recommendations for vaccination in paediatric patients with rheumatic diseases

2011 ◽  
Vol 70 (10) ◽  
pp. 1704-1712 ◽  
Author(s):  
M W Heijstek ◽  
L M Ott de Bruin ◽  
M Bijl ◽  
R Borrow ◽  
F van der Klis ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Task Force ◽  
Guideline Development ◽  
Scoring Systems ◽  
Level Of Evidence ◽  
Eular Recommendations ◽  
American College Of Rheumatology ◽  
Paediatric Patients ◽  
Prevention Of Infections

Evidence-based recommendations for vaccination of paediatric patients with rheumatic diseases (PaedRD) were developed by following the EULAR standardised procedures for guideline development. The EULAR task force consisted of (paediatric) rheumatologists/immunologists, one expert in vaccine evaluation, one expert in public health and infectious disease control, and one epidemiologist. A systematic literature review was conducted in MEDLINE, EMBASE, and abstracts of the EULAR and American College of Rheumatology meetings of 2008/9. The level of evidence and strength of recommendation were based on customary scoring systems. Delphi voting was applied to assess the level of agreement between task force members. 107 papers and eight abstracts were used. The majority of papers considered seasonal influenza (41) or pneumococcal (23) vaccination. 26 studies were performed specifically in paediatric patients, and the majority in adult rheumatoid arthritis and systemic lupus erythematosus patients. Fifteen recommendations were developed with an overall agreement of 91.7%. More research is needed on the safety and immunogenicity of (live-attenuated) vaccination in PaedRD, particularly in those using biologicals, and the effect of vaccination on prevention of infections.

Updated picture of SARS-CoV-2 variants and mutations

Diagnosis ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giuseppe Lippi ◽  
Camilla Mattiuzzi ◽  
Brandon M. Henry
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Preventive Measures ◽  
Definitive Treatment ◽  
Social Distancing ◽  
Viral Spread ◽  
Limited Efficacy ◽  
Highly Virulent ◽  
New Mutations

Abstract The worldwide burden of coronavirus disease 2019 (COVID-19) is still unremittingly prosecuting, with nearly 300 million infections and over 5.3 million deaths recorded so far since the origin of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic at the end of the year 2019. The fight against this new highly virulent beta coronavirus appears one of the most strenuous and long challenges that humanity has ever faced, since a definitive treatment has not been identified so far. The adoption of potentially useful physical preventive measures such as lockdowns, social distancing and face masking seems only partially effective for mitigating viral spread, though efficacy and continuation of such measures on the long term is questionable, due to many social and economic reasons. Many COVID-19 vaccines have been developed and are now widely used, though their effectiveness is challenged by several aspects such as low uptake and limited efficacy in some specific populations, as well as by continuous emergence of new mutations in the SARS-CoV-2 genome, accompanying the origin and spread of new variants, which in turn may contribute to further decrease the effectiveness of current vaccines and treatments. This article is hence aimed to provide an updated picture of SARS-CoV-2 variants and mutations that have emerged from November 2019 to present time (i.e., early December 2021).

scholarly journals The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology

2017 ◽  
Vol 76 (12) ◽  
pp. 1974-1979 ◽  
Author(s):  
Ingrid Möller ◽  
Iustina Janta ◽  
Marina Backhaus ◽  
Sarah Ohrndorf ◽  
David A Bong ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
Task Force ◽  
Nominal Group Technique ◽  
Nominal Group ◽  
Anatomic Structure ◽  
Scanning Method ◽  
European League Against Rheumatism ◽  
The Us ◽  
Technological Developments ◽  
Probe Placement

BackgroundIn 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an update of these guidelines.ObjectivesTo update the existing MSUS guidelines in rheumatology as well as to extend their scope to other anatomic structures relevant for rheumatology.MethodsThe project consisted of the following steps: (1) a systematic literature review of MSUS evaluable structures; (2) a Delphi survey among rheumatologist and radiologist experts in MSUS to select MS and non-MS anatomic structures evaluable by US that are relevant to rheumatology, to select abnormalities evaluable by US and to prioritise these pathologies for rheumatology and (3) a nominal group technique to achieve consensus on the US scanning procedures and to produce an electronic illustrated manual (ie, App of these procedures).ResultsStructures from nine MS and non-MS areas (ie, shoulder, elbow, wrist and hand, hip, knee, ankle and foot, peripheral nerves, salivary glands and vessels) were selected for MSUS in rheumatic and musculoskeletal diseases (RMD) and their detailed scanning procedures (ie, patient position, probe placement, scanning method and bony/other landmarks) were used to produce the App. In addition, US evaluable abnormalities present in RMD for each anatomic structure and their relevance for rheumatology were agreed on by the MSUS experts.ConclusionsThis task force has produced a consensus-based comprehensive and practical framework on standardised procedures for MSUS imaging in rheumatology.

scholarly journals Delaying the COVID-19 epidemic in Australia: Evaluating the effectiveness of international travel bans

2020 ◽  
Author(s):  
Adeshina I. Adekunle ◽  
Michael Meehan ◽  
Dianna Rojas ◽  
James Trauer ◽  
Emma McBryde
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
International Travel ◽  
Control Measures ◽  
Social Distancing ◽  
Novel Virus

AbstractFollowing the outbreak of novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) or COVID-19 in Wuhan, China late 2019, different countries have put in place interventions such as travel ban, proper hygiene, and social distancing to slow the spread of this novel virus. We evaluated the effects of travel bans in the Australia context and projected the epidemic until May 2020. Our modelling results closely align with observed cases in Australia indicating the need for maintaining or improving on the control measures to slow down the virus.

EDUKASI MASYARAKAT MELALUI AKTIVITAS RELAWAN NON MEDIS DALAM MEMUTUS RANTAI PENYEBARAN COVID-19 DI LINGKUNGAN CAKRANEGARA UTARA

2020 ◽  
Vol 2 (1) ◽  
pp. 150
Author(s):  
Maruni Wiwin Diarti ◽  
Yunan Jiwintarum ◽  
Awan Dramawan
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Social Distancing

Coronavirus Disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). WHO sudah menetapkan Covid-19 sebagai pandemi. Virus Covid-19 umumnya ditransmisikan melalui kontak fisik erat dan percikan (droplet) dari saluran pernapasan, sedangkan transmisi melalui udara (airborne) dapat terjadi saat melakukan prosedur medis yang menghasilkan aerosol.  Cakranegara Utara merupakan salah satu kelurahan di Kota Mataram yang sampai dengan bulan Agustus 2020 masih ditetapkan sebagai Zona merah.  Peran masyarakat diakui cukup penting untuk menekan kasus Covid-19 yang terus bertambah.  Relawan non medis merupakan kelompok mahasiswa yang peduli terhadap Covid-19.  Pendekatan edukasi masyarakat melalui aktivitas relawan non medis dalam kegiatan pengabdian masyarakat ini diharapkan dapat mencegah penyebaran Covid 19 di lingkungan Cakranegara Utara. Metode yang digunakan dalam Edukasi Masyarakat melalui aktivitas relawan non medis dalam memutus rantai penularan Covid-19 melalui ceramah, metode diskusi dan metode demonstrasi. Untuk mengetahui keberhasilan edukasi pada masyarakat melalui aktivitas relawan non medis ini dilakukan pretest dan posttest pada masyarakat. Hasil menunjukkan terjadi peningkatan pengetahuan masyarakat mengenai cara cuci tangan yang benar (WHO), Covid-19 dan pencegahannya dan Edukasi masyarakat melalui aktivitas relawan non medis dapat meningkatkan pengetahuan masyarakat tentang tentang cara mencuci tangan dengan benar (WHO), Covid-19 dan cara pencegahannya, social distancing dan manfaat pengunaan masker untuk memutus rantai penularan Covid-19.

scholarly journals Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis

2020 ◽  
pp. annrheumdis-2019-216656 ◽  
Author(s):  
Andreas Kerschbaumer ◽  
Alexandre Sepriano ◽  
Josef S Smolen ◽  
Désirée van der Heijde ◽  
Maxime Dougados ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Residual Disease ◽  
Task Force ◽  
Certolizumab Pegol ◽  
Evidence Base ◽  
Janus Kinase ◽  
Cochrane Library ◽  
Literature Research ◽  
Eular Recommendations ◽  
Factor Inhibitor

ObjectivesTo inform the 2019 update of the European League against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA).MethodsA systematic literature research (SLR) to investigate the efficacy of any disease-modifying antirheumatic drug (DMARD) (conventional synthetic (cs)DMARD, biological (b) and biosimilar DMARD, targeted synthetic (ts)DMARD) or glucocorticoid (GC) therapy in patients with RA was done by searching MEDLINE, Embase and the Cochrane Library for articles published between 2016 and 8 March 2019.Results234 abstracts were selected for detailed assessment, with 136 finally included. They comprised the efficacy of bDMARDs versus placebo or other bDMARDs, efficacy of Janus kinase (JAK) inhibitors (JAKi) across different patient populations and head-to-head of different bDMARDs versus JAKi or other bDMARDs. Switching of bDMARDs to other bDMARDs or tsDMARDs, strategic trials and tapering studies of bDMARDs, csDMARDs and JAKi were assessed. The drugs evaluated included abatacept, adalimumab, ABT-122, baricitinib, certolizumab pegol, SBI-087, CNTO6785, decernotinib, etanercept, filgotinib, golimumab, GCs, GS-9876, guselkumab, hydroxychloroquine, infliximab, leflunomide, mavrilimumab, methotrexate, olokizumab, otilimab, peficitinib, rituximab, sarilumab, salazopyrine, secukinumab, sirukumab, tacrolimus, tocilizumab, tofacitinib, tregalizumab, upadacitinib, ustekinumab and vobarilizumab. The efficacy of many bDMARDs and tsDMARDs was shown. Switching to another tumour necrosis factor inhibitor (TNFi) or non-TNFi bDMARDs after TNFi treatment failure is efficacious. Tapering of DMARDs is possible in patients achieving long-standing stringent clinical remission; in patients with residual disease activity (including patients in LDA) the risk of flares is increased during the tapering. Biosimilars are non-inferior to their reference products.ConclusionThis SLR informed the task force regarding the evidence base of various therapeutic regimen for the development of the update of EULAR’s RA management recommendation.

scholarly journals EULAR points to consider for the development, evaluation and implementation of mobile health applications aiding self-management in people living with rheumatic and musculoskeletal diseases

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e001014 ◽  
Author(s):  
Aurélie Najm ◽  
Elena Nikiphorou ◽  
Marie Kostine ◽  
Christophe Richez ◽  
John D Pauling ◽  
...  
Keyword(s):  
Mobile Health ◽  
Online Survey ◽  
Musculoskeletal Diseases ◽  
Task Force ◽  
Cost Benefit ◽  
Self Management ◽  
Mobile Health Applications ◽  
Development Evaluation ◽  
Level Of Agreement ◽  
Health Applications

BackgroundMobile health applications (apps) are available to enable people with rheumatic and musculoskeletal diseases (RMDs) to better self-manage their health. However, guidance on the development and evaluation of such apps is lacking.ObjectivesThe objective of this EULAR task force was to establish points to consider (PtC) for the development, evaluation and implementation of apps for self-management of RMDs.MethodsA systematic literature review of app content and development strategies was conducted, followed by patient focus group and an online survey. Based on this information and along with task force expert opinion, PtC were formulated in a face-to-face meeting by a multidisciplinary task force panel of experts, including two patient research partners. The level of agreement among the panel in regard to each PtC was established by anonymous online voting.ResultsThree overarching principles and 10 PtC were formulated. Three PtC are related to patient safety, considered as a critical issue by the panel. Three are related to relevance of the content and functionalities. The requirement for transparency around app development and funding sources, along with involvement of relevant health professionals, were also raised. Ease of app access across ages and abilities was highlighted, in addition to considering the cost benefit of apps from the outset. The level of agreement was from 8.8 to 9.9 out of 10.ConclusionThese EULAR PtC provide guidance on important aspects that should be considered for the development, evaluation and implementation of existing and new apps.

scholarly journals Social Distancing to Mitigate COVID-19 Risks Is Associated With COVID-19 Discriminatory Attitudes Among People Living with HIV

2020 ◽  
Vol 54 (10) ◽  
pp. 728-737
Author(s):  
Marcie Berman ◽  
Lisa A Eaton ◽  
Ryan J Watson ◽  
J L Andrepont ◽  
Seth Kalichman
Keyword(s):  
Social Sciences ◽  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Ongoing Study ◽  
People Living With Hiv ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Immune Systems ◽  
Social Distancing ◽  
Living With Hiv

Abstract Background Severe acute respiratory syndrome coronavirus-2, the virus that causes COVID-19, is an emerging pandemic with heightened concerns for people with compromised immune systems, including people living with HIV. Purpose In the absence of a vaccine, public health messaging to mitigate risks for COVID-19 primarily focuses on social distancing. Because people living with HIV commonly experience mistreatment associated with HIV, their response to social distancing may be complicated by psychosocial attitudes associated with COVID-19. Methods To evaluate these relationships, we conducted a rapid-response, cross-sectional survey with people living with HIV (N = 149) to assess social distancing practices, COVID-19 discriminatory attitudes, COVID-19 xenophobic attitudes, HIV microaggressions, and concern over contracting COVID-19. Data were collected from participants enrolled in a larger ongoing study between March 30, 2020 and April 17, 2020. Results Results indicated that choosing to socially distance to reduce COVID-19 exposure was associated with COVID-19 discriminatory attitudes, concerns of contracting COVID-19, and identifying as transgender. Likewise, social distancing imposed by others (e.g., cancelations and restrictions) was associated with concerns of contracting COVID-19. Conclusions Findings demonstrate that social distancing measures are related to concerns of contracting the virus and discriminatory attitudes toward those who are presumed to be living with COVID-19. These potentially negative psychosocial attitudes toward people perceived to have COVID-19 echo the discriminatory actions and attitudes that we continue to observe in HIV social sciences research.

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