scholarly journals Immunodeficiency associated with tumour pathology: Good’s syndrome

2019 ◽  
Vol 12 (3) ◽  
pp. e227970
Author(s):  
Javier Barrios Recio ◽  
Alejandra Perez Rodriguez ◽  
Ariel Callero ◽  
Juan Antonio Martinez Tadeo
Keyword(s):  
Image Analysis ◽  
Respiratory Symptoms ◽  
Anterior Mediastinum ◽  
Substitution Therapy ◽  
Good’S Syndrome ◽  
Tumour Pathology ◽  
Thymic Neoplasm ◽  
Low Prevalence ◽  
Slow Growing ◽  
Multiple Episodes

The Good’s syndrome (GS) is a low prevalence entity where thymoma often is associated with immunodeficiency. Patients may start presenting recurrent rhinosinusal infections, bronchopulmonary infections, haematological alterations and diarrhoea, secondary to immunodeficiency. They can also present respiratory symptoms and parathymic syndromes derived from the existence of thymoma, a slow-growing neoplasm located in the anterior mediastinum. We present the case of a 76-year-old man diagnosed with thymoma by image analysis, which had presented multiple episodes of pneumonia and two admissions to the hospital for diarrhoea of weeks of evolution. After finishing the study, the patient is diagnosed of GS. In this case, thymectomy prevented the appearance of parathymic syndrome, but without any effect on immunodeficiency symptoms. To decrease repeat infections, substitution therapy with immunoglobulins was started. The prognosis will depend mainly on the recurrent infectious and to a lesser extent on the thymic neoplasm.

scholarly journals Thymoangiolipoma: A rare histologic variant of thymolipoma in a patient with myasthenia gravis

Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097921
Author(s):  
Mohammad Hossein Anbardar ◽  
Fatemeh Amirmoezi ◽  
Armin Amirian
Keyword(s):  
Myasthenia Gravis ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
High Serum ◽  
Anterior Mediastinal Mass ◽  
Spiral Computed ◽  
Thymic Tissue ◽  
Radiologic Evaluation ◽  
Thymic Neoplasm ◽  
Slow Growing

Thymoangiolipoma is a rare, slow-growing, benign thymic neoplasm that arises from the anterior mediastinum. A 61-year-old man with the chief complaint of right eye ptosis and high serum acetylcholine receptor antibody level is presented here. The spiral computed tomography of the chest revealed a hypodense mass in the anterior mediastinum. Microscopic examination showed admixture of adipose tissue, thymic tissue and blood vessels with the diagnosis of thymoangiolipoma. Thymoangiolipoma is a rare histologic variant of thymolipoma which can be associated with myasthenia gravis and must be considered as a differential diagnosis in anterior mediastinal mass with fat density in radiologic evaluation.

scholarly journals THYMOMA: A RARE CAUSE OF MEDIASTINAL TUMOR IN CHILDREN

2016 ◽  
Vol 65 (4) ◽  
pp. 382-385
Author(s):  
Andreea Durlan ◽  
◽  
Cristina Oana Marginean ◽  
Maria Despina Baghiu ◽  
Alina Grama ◽  
...  
Keyword(s):  
Pediatric Cardiology ◽  
Specific Treatment ◽  
Anterior Mediastinum ◽  
Solid Mass ◽  
Partial Removal ◽  
Mediastinal Tumors ◽  
Cardiology Clinic ◽  
Diagnostic Difficulties ◽  
Vascular Structures ◽  
Thymic Neoplasm

Thymoma is a thymic neoplasm composed of epithelial cells, rarely seen in children. Approximately two-thirds of mediastinal tumors in children are asymptomatic. The diagnosis is suspected following the compression of the tumor mass on the airways. We present the case of a male patient, age 7 years and 8 months, who presented at the emergency room accusing fatigue at rest or minimum effort, dry cough, intense dyspnea, orthopnea, tachypnea, chest pain, being transferred to the Pediatric Cardiology Clinic in Tirgu Mures with the following diagnoses: fluid pericarditis, right pleural effusion and cardiac tamponade. Chest computer tomography examination is carried out, describing a solid mass of 100/89/111 mm in the anterior mediastinum, partially incorporating the thymus and the vascular structures of the middle mediastinum. Pericardectomy is practiced with partial removal of the tumor and extensive tumor cytoreduction and the histopathologic examination is B3 Thymoma. Specific treatment is initiated according to the Tymoma VENUTA protocol, followed by adjuvant radiotherapy, with clinical and radiological remission. The particularity of the case is the fact that thymoma is a rare tumor on the patient’s age, creating diagnostic difficulties, has no complications during treatment, with favorable evolution, with clinical and radiological remission at 1.9 years after.

scholarly journals Primary Thymus Tumors: Retrospective Case Analysis at a Reference Center in Latin America, 2011 – 2019

2020 ◽  
Author(s):  
Diego F. Scarpetta-Gonzalez ◽  
Eliana Isabel Morales ◽  
Luz Fernanda Sua ◽  
Mauricio Velásquez ◽  
Saveria Sanguiovanni ◽  
...  
Keyword(s):  
Cushing Syndrome ◽  
Survival Rates ◽  
Anterior Mediastinum ◽  
High Survival ◽  
Male Population ◽  
Retrospective Case ◽  
Mediastinal Tumors ◽  
Thymic Neoplasm ◽  
Improve Patient ◽  
Thymic Tumors

Abstract BackgroundThymic tumors are unusual neoplasms, representing 0.2% to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear around the fourth and fifth decades of life without gender predilection. Up to 30% of patients are asymptomatic, therefore many are incidentally diagnosed. Radical thymectomy is the treatment of choice with high survival rates when detected in the early stages. Methods This was a retrospective descriptive study, including 18 adult patients’ diagnosis of thymic neoplasm, who were managed with surgical resection from 2011 to 2019. Information about demographics, clinical characteristics, imaging findings, surgical and medical management, plus histological findings was obtained and reported. Results18 patients with thymic tumors were included, of which specific histologic studies reveled thymomas, carcinomas, neuroendocrine tumors, thymolipoma and thymic cyst. Mean age was 52.7 years, with a predominance of male population. The main symptom was dyspnea, followed by cough and chest pain. Paraneoplastic syndromes such as myasthenia gravis, aplastic anemia and Cushing syndrome were reported. 89% of cases were treated by radical thymectomy alone, while only 2 cases required chemotherapy and radiotherapy. There were no surgical complications. Mean hospital stay length was 11. 9 days, with only 1 mortality during hospital admission. 5-year survival rate was 81%. Conclusions The treatment of choice is radical thymectomy, which has been shown to positively impact patient mortality. Early detection is key to improve patient outcomes.

Mediastinal Mature Teratomas Penetrating the Chest Wall

2021 ◽  
Vol 2021 ◽  
Author(s):  
Abdelfettah Zidane ◽  
Ikram Samri ◽  
Adil Arsalane
Keyword(s):  
Chronic Inflammation ◽  
Chest Wall ◽  
Surgical Resection ◽  
Rare Case ◽  
Surgical Planning ◽  
Anterior Mediastinum ◽  
Complete Resection ◽  
En Bloc ◽  
Slow Growing

Mediastinal mature teratomas (MMT) are benign and slow-growing tumors in the anterior mediastinum, which can reach a huge size. Surgical resection is often challenging, however, with proper surgical planning, complete resection is feasible with good outcomes. we report a rare case of MMT penetrating the chest wall as a result of chronic inflammation successfully treated with en bloc surgical resection.

scholarly journals Prevalence of Respiratory Symptoms among Quarry Workers in Brunei Darussalam

2021 ◽  
Author(s):  
Ashish Trivedi ◽  
Alice S.C Lai ◽  
Mahmud Tasim ◽  
Nik A.A Tuah
Keyword(s):  
Respiratory Symptoms ◽  
Respiratory Illnesses ◽  
Work Settings ◽  
Preventative Measures ◽  
Brunei Darussalam ◽  
Long Latency ◽  
Related Quality ◽  
Health Related ◽  
St George's Respiratory Questionnaire ◽  
Low Prevalence

Background: The mining and quarrying industry is considered a hazardous work sector due to occupational exposure to quarry dust and particulate matter, resulting in workers' respiratory illnesses. These occupational respiratory illnesses tend to have a long latency before the diagnosis is made, and therefore early detection of respiratory symptoms is crucial to prevent the development of chronic irreversible respiratory conditions. This study aimed to assess quarry workers' self-reported respiratory symptoms and their health-related quality of life (HRQOL) in Brunei. Methods: A descriptive study using a convenient sampling method was involving 23 quarry workers from three quarry companies in Brunei. The data were collected using the adapted St. George's Respiratory Questionnaire (SGRQ), which was self-administered to all participants. Data were analyzed using descriptive statistics. Results: Cough was the most typical reported symptom (26.1%) among quarry workers, followed by cough with phlegm (8.6%), shortness of breath (4.3%), and chest discomfort (4.3%). The mean total SGRQ score was 7.51 (±11.70), while the sub-domain scores for symptoms, activity, and impact were 10.60 (±12.37), 6.30 (±11.43), and 7.35 (±15.87), respectively. Conclusion: The key findings revealed that there was a low prevalence of respiratory symptoms in quarry workers. Prevalence of respiratory symptoms was higher among workers who were smokers, those who were exposed to quarry materials, and those who had been employed longer. The study's findings can be utilized by health professionals to plan, implement and evaluate preventative measures for mining and quarrying work settings.

scholarly journals Primary small cell neuroendocrine carcinoma of the anterior mediastinum presenting with trepopnea

2018 ◽  
Vol 11 (1) ◽  
pp. e225014
Author(s):  
Mohamed Iliyas ◽  
Das Dona ◽  
Uma Devi ◽  
Naseem Noorunnisa
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Outpatient Care ◽  
Delayed Diagnosis ◽  
Anterior Mediastinum ◽  
Small Cell ◽  
Common Symptom ◽  
Small Cell Neuroendocrine Carcinoma ◽  
X Ray ◽  
Chest X Ray ◽  
Slow Growing

We report the case of an elderly man who had visited many physicians with breathlessness and was treated in an outpatient care. The cause of breathlessness was not evaluated, which turned out to be a slow-growing tumour in the mediastinum. Later, we diagnosed it to be a case of neuroendocrine carcinoma arising from the anterior mediastinum. The patient had succumbed to death because of the delayed diagnosis. A simple chest X-ray could have helped to make an early diagnosis. This case is reported with the intention to bring into light the effect of delayed diagnosis of a rare disease presenting with a very common symptom.

scholarly journals Extensive mediastinal thymolipoma mimicking pulmonary edema

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Mohamed Farah Yusuf Mohamud ◽  
Mohamed Abdi Ahmed ◽  
Ibrahim Hussein Ali
Keyword(s):  
Soft Tissue ◽  
World Literature ◽  
Surgical Excision ◽  
Mass Effect ◽  
Anterior Mediastinum ◽  
Chest Tightness ◽  
Progressive Dyspnea ◽  
The World ◽  
Slow Growing ◽  
Radiological Examinations

Abstract Thymolipoma is a rare benign slow-growing encapsulated tumor of anterior mediastinum that accounts for 2–9% of all thymic neoplasms. About 30–50% of them are asymptomatic and found incidentally. Less than 200 cases have been published in the world literature so far. Here we report a case of thymolipoma of an adult female presented with progressive dyspnea, chest tightness and non-productive chough for 2-month duration. All blood investigations were normal. Radiological examinations suggested the presence of fat and soft tissue within the tumor without invading the neighboring structures. We concluded that the only curative treatment of thymolipoma is surgical excision. Unfortunately, the patient did not give consent despite telling her the outcomes if we do not do the surgical procedure, and a week later she passed away due to respiratory distress secondary to the mass effect of the tumor.

Low Prevalence of Pertussis Among Children Admitted With Respiratory Symptoms During Respiratory Syncytial Virus Season

2006 ◽  
Vol 27 (1) ◽  
pp. 95-97 ◽  
Author(s):  
George K. Siberry ◽  
Nicholas R. Paquette ◽  
Tracy L. Ross ◽  
Trish M Perl ◽  
Alexandra Valsamakis
Keyword(s):  
Polymerase Chain Reaction ◽  
Respiratory Syncytial Virus ◽  
Bordetella Pertussis ◽  
Respiratory Symptoms ◽  
Chain Reaction ◽  
Pcr Screening ◽  
Respiratory Syncytial Virus Season ◽  
Polymerase Chain ◽  
Syncytial Virus ◽  
Low Prevalence

Pertussis may go unrecognized during respiratory syncytial virus (RSV) epidemics. Nosocomially transmitted pertussis can be severe in infants. Polymerase chain reaction (PCR) screening may identify infants with pertussis on admission, allowing for preemptive isolation. In a random sample, 1 (0.6%) of 166 children admitted to the hospital during RSV season were Bordetella pertussis PCR positive during a nonepidemic period. These data show that screening may not be useful when pertussis prevalence is low.

scholarly journals Prevalence of bronchial asthma and respiratory symptoms in a group of students from grodno. An example of standardized epidemiological survey

2014 ◽  
Vol 8 (3) ◽  
pp. 4-10
Author(s):  
Oleg Ahiyevets
Keyword(s):  
Prevalence Rate ◽  
Respiratory Symptoms ◽  
Respiratory Health ◽  
Epidemiological Survey ◽  
Population Based ◽  
Electronic Version ◽  
Asthma Prevalence ◽  
Cross Sectional ◽  
Asthmatic Bronchitis ◽  
Low Prevalence

Introduction: Due to an insufficient knowledge of the real asthma prevalence rate among children and adults in Belarus, we conducted a population-based respiratory health survey.Aim of the study: The study aimed at estimating the prevalence rate of asthma and major respiratory symptoms among students of the Grodno Region (Western Belarus).Material and methods: The cross-sectional study was conducted in 2014 and included 833 students aged 20-40 (young adults). Physician-diagnosed respiratory diseases and symptoms were ascertained using electronic version of the ISAAC questionnaire (web LimeSurvey).Results: The prevalence of asthma was 2.88% (physician-diagnosed). The obstructive (asthmatic) bronchitis (without established diagnosis of asthma) was found in 5.04% of the respondents. A chronic respiratory symptom occurring in the past 12 months and suggestive of asthma included attacks of dyspnea at rest, cough (5.88%) or in previous periods (8.88%), and wheezing in the chest (one of the most characteristic symptoms of asthma) - 8.04%, which may indicate a higher prevalence of asthma among patients. Wheezing and wheeze without diagnosed asthma, colds or infections were reported in a small number of cases (about 1.0%). 32 respondents (3.84%) can be attributed to the group of risk for asthma due to the presence of specific respiratory symptoms.Conclusions: The findings show a low prevalence of physician-diagnosed asthma among students of Western Belarus. Relatively low prevalence of allergic disorders among respondents of Belarus suggest underdiagnosis of allergic diseases, in particular of asthma. Presumably, cases of asthma might be diagnosed as spastic bronchitis, “obstructive bronchitis”, “asthmatic bronchitis”, a traditional label for clinical manifestation of asthma in medical practice in the region.

scholarly journals Primary thymus tumors: retrospective case analysis at a reference center in Latin America, 2011–2019

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Diego F. Scarpetta-Gonzalez ◽  
Eliana Isabel Morales ◽  
Luz Fernanda Sua ◽  
Mauricio Velásquez ◽  
Saveria Sangiovanni ◽  
...  
Keyword(s):  
Cushing Syndrome ◽  
Survival Rates ◽  
Anterior Mediastinum ◽  
High Survival ◽  
Male Population ◽  
Retrospective Case ◽  
Mediastinal Tumors ◽  
Thymic Neoplasm ◽  
Improve Patient ◽  
Thymic Tumors

Abstract Background Thymic tumors are unusual neoplasms, representing 0.2 to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear around the fourth and fifth decades of life without gender predilection. Up to 30% of patients are asymptomatic, therefore many are incidentally diagnosed. Radical thymectomy is the treatment of choice with high survival rates when detected in the early stages. Methods This was a retrospective descriptive study, including 18 adult patients’ diagnosis of thymic neoplasm, who were managed with surgical resection from 2011 to 2019. Information about demographics, clinical characteristics, imaging findings, surgical and medical management, plus histological findings was obtained and reported. Results 18 patients with thymic tumors were included, of which specific histologic studies reveled thymomas, carcinomas, neuroendocrine tumors, thymolipoma and thymic cyst. Mean age was 52.7 years, with a predominance of male population. The main symptom was dyspnea, followed by cough and chest pain. Paraneoplastic syndromes such as myasthenia gravis, aplastic anemia and Cushing syndrome were reported. 89% of cases were treated by radical thymectomy alone, while only 2 cases required chemotherapy and radiotherapy. There were no surgical complications. Mean hospital stay length was 11. 9 days, with only 1 mortality during hospital admission. 5-year survival rate was 81%. Conclusions The treatment of choice is radical thymectomy, which has been shown to positively impact patient mortality. Early detection is key to improve patient outcomes.

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