scholarly journals Preliminary results of clinical use of colchicine in COVID-19 treatment

2021 ◽  
Vol 14 (7) ◽  
pp. e244482
Author(s):  
Rafael Silvestre Knack ◽  
Luis Carlos Losso ◽  
Renata Silvestre Knack ◽  
Talie Hanada
Keyword(s):  
Inflammatory Markers ◽  
Treatment Initiation ◽  
Clinical Use ◽  
Cytokine Storm ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Increased Risk ◽  
Pulmonary Impairment ◽  
Experimental Use

We report a case of the use of colchicine in a patient infected with SARS-CoV-2 virus. A 37-year-old man with COVID-19 presented with moderate symptoms, mild pulmonary impairment and elevated inflammatory markers, suggesting an increased risk of cytokine storm and possible worsening of clinical condition. Experimental use of colchicine resulted in an 85% decrease in C reactive protein levels 3 days after treatment initiation and a 182.6% decrease in interleukin-6 levels 8 days after treatment initiation. Due to the lack of effective therapies, it is important to search for potential compounds and compounds that focus on controlling the danger caused by systemic inflammation in COVID-19. Although further research is needed in the area of colchicine and viral infection, preliminary efficacy was observed.

scholarly journals Higher Levels of C-Reactive Protein and Ferritin in Patients with Overweight and Obesity and SARS-CoV-2-Related Pneumonia

Obesity Facts ◽  
2021 ◽  
pp. 1-7
Author(s):  
Silvia Bettini ◽  
Giovanni Bucca ◽  
Caterina Sensi ◽  
Chiara Dal Prà ◽  
Roberto Fabris ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Adipose Tissue ◽  
Hospital Stay ◽  
Invasive Mechanical Ventilation ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Cytokine Storm ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk

<b><i>Introduction:</i></b> Overweight and obesity are associated with a more severe COronaVirus Disease 19 (COVID-19). Adipose tissue-related chronic inflammation could be a promoter for the occurrence of the cytokine storm that predicts aggravation of COVID-19. The primary aim was to investigate if this increased risk for more severe COVID-19 was associated with a higher inflammatory response. <b><i>Methods:</i></b> We enrolled patients &#x3c;75 years old hospitalized in a medical COVID-19 ward with SARS-CoV-2-related pneumonia. Patients were classified according to BMI as normal weight, overweight, and obesity. Laboratory parameters were measured at admission and every second day during the hospital stay. <b><i>Results:</i></b> Ninety patients (64.4% males; median age 61 years) were enrolled. Invasive mechanical ventilation (IMV) was needed in 9% of the patients with normal weight, in 32.4% of the patients with overweight, and in 12.9% of the patients with obesity (<i>p</i> = 0.045). Maximal C-reactive protein (CRP) level during hospital stay was 92 (48–122) mg/L in patients with normal weight, 140 (82–265) mg/L in patients with overweight, and 117 (67–160) mg/L in patients with obesity (<i>p</i> = 0.037). Maximal ferritin values were 564 (403–1,379) μg/L in patients with a normal weight, 1,253 (754–2,532) μg/L in patients with overweight, and 828 (279–1,582) μg/L in patients with obesity (<i>p</i> = 0.015). <b><i>Conclusion:</i></b> Patients with overweight and obesity required more IMV and had higher peaks of CRP and ferritin than patients with normal weight during COVID-19.

C-Reactive Protein Levels Are Not Associated with Increased Risk for Colorectal Cancer in Women

2005 ◽  
Vol 142 (6) ◽  
pp. 425 ◽  
Author(s):  
Shumin M. Zhang ◽  
Julie E. Buring ◽  
I-Min Lee ◽  
Nancy R. Cook ◽  
Paul M. Ridker
Keyword(s):  
Colorectal Cancer ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Increased Risk

scholarly journals Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

2006 ◽  
Vol 155 (1) ◽  
pp. 137-142 ◽  
Author(s):  
D M Wunder ◽  
M Yared ◽  
N A Bersinger ◽  
D Widmer ◽  
R Kretschmer ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Inflammatory Markers ◽  
Free Testosterone ◽  
Serum Levels ◽  
Reproductive Age ◽  
Normal Body Mass Index ◽  
C Reactive Protein ◽  
Normal Cycle ◽  
Protein Levels ◽  
Reactive Protein

Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17β-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1–2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1–5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.

Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels

2007 ◽  
Vol 98 (11) ◽  
pp. 1088-1095 ◽  
Author(s):  
María José Martínez-Calatrava ◽  
José Luis González-Sánchez ◽  
María Teresa Martínez-Larrad ◽  
Milagros Pérez-Barba ◽  
Manuel Serrano-Ríos
Keyword(s):  
Total Variation ◽  
Interindividual Variability ◽  
Spanish Population ◽  
C Reactive Protein ◽  
Clinical Variables ◽  
Protein Levels ◽  
Reactive Protein ◽  
Increased Risk ◽  
The Common ◽  
Serum Crp

SummaryC-reactive protein (CRP) is a marker of systemic inflammation significantly associated with an increased risk of cardiovascular disease in the general population. The aim of our current work was to study those clinical and genetic variables potentially associated with interindividual variability in serum CRP levels. A random sample of 844 participants (450 women, mean age 55 years) from a study carried out on the general Spanish population (The Segovia Study) was studied. Our results showed that age, gender, waist circumference, leptin, impaired glucose tolerance and smoking were the clinical variables significantly associated with variations in serum CRP levels. Among those, leptin showed the strongest association, explaining 11% of the interindividual variability in circulating CRP levels (p < 0.001). To study the effect of genetic variants on serum CRP levels, 10 SNPs within the CRP locus were genotyped in 756 participants. Four of these SNPs (rs1417938, rs1800947, rs1130864, rs1205) were significantly associated with CRP levels after adjustment for clinical variables. Among the common haplotypes inferred from eight SNPs, two (CCATGCCT, p = 0.025; CTATCCTT, p = 0.004) explained 2.9% of the total variation in serum CRP. The results here reported show that 2.9% of the total variation in circulating CRP levels seems to be explained by genetics variations within CRP locus. Furthermore, serum leptin levels are strongly associated with serum CRP levels in our Spanish population.

Elevated C-reactive Protein Levels Independently Predict the Development of Prediabetes Markers in Subjects with Normal Glucose Regulation

2019 ◽  
Author(s):  
Katsuhito Kato ◽  
Toshiaki Otsuka ◽  
Yoshiyuki Saiki ◽  
Nobuyuki Kobayashi ◽  
Takayuki Nakamura ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Glucose Regulation ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Glucose Levels ◽  
Reactive Protein ◽  
Increased Risk ◽  
Normal Glucose ◽  
Normal Glucose Regulation ◽  
Hba1c Levels

Abstract Aims Prediabetes is a precursor of diabetes and increases the risk of cardiovascular disease. Individuals with prediabetes reportedly have higher C-reactive protein levels, which is a risk factor for diabetes, relative to individuals with normal glucose regulation. Inflammation may play a role in the very early-phase deterioration of glucose metabolism, although there is insufficient knowledge regarding this relationship. Thus, we examined the association between serum C-reactive protein level and the development of three prediabetes markers. Methods This study included 743 subjects with normal glucose regulation at baseline who completed oral glucose tolerance tests at baseline and after approximately 5 years. Subjects with a history of cardiovascular disease were excluded. Results During the 5-year follow-up, 55 subjects developed isolated impaired glucose tolerance (IGT; 2h-plasma glucose levels of 7.8–11.0 mmol/L), 24 subjects developed isolated impaired fasting glucose (IFG; fasting plasma glucose levels of 6.1–7.0 mmol/L), 3 subjects developed IFG plus IGT, and 53 subjects developed isolated elevated glycated hemoglobin levels (HbA1c; level of 41–47 mmol/mol). The multivariate analysis revealed that, relative to the lowest quartile, the highest serum C-reactive protein quartile was independently associated with an increased risk of developing isolated elevated HbA1c levels (odds ratio: 2.95, 95% confidence interval: 1.16–7.51, P=0.024) and marginally associated with an increased risk of developing impaired glucose tolerance plus diabetes. However, C-reactive protein levels were not associated with an increased risk of developing IFG. Conclusions Elevated serum C-reactive protein levels independently predicted elevated HbA1c levels, but not IFG.

scholarly journals The Effect of Non Surgical Periodontal Therapy on the Serum C Reactive Protein Levels in Generalized Chronic Periodontitis Patients: A Clinical Study

2014 ◽  
Vol 02 (03) ◽  
pp. 157-161
Author(s):  
Anish Manocha ◽  
Suresh DK ◽  
Shikha Gupta ◽  
Sharuti Yakhmi ◽  
Aashish Pandit
Keyword(s):  
Chronic Periodontitis ◽  
Inflammatory Markers ◽  
Serum Levels ◽  
Periodontal Therapy ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Crp ◽  
Age Range

Abstract Background: Although many studies have compared circulating IL-6 and CRP concentrations in periodontal patients and controls, a limited number of studies have compared systemic inflammatory markers at baseline and follow-up and also Data on whether periodontal therapy affects serum CRP levels are inconclusive. Aims and Objective: By the virtue of this study, an attempt was made to evaluate and compare the effect of non surgical periodontal therapy on serum C-Reactive Protein levels in Generalized chronic periodontitis patients. Material and Method: A total of thirty patients with Generalised chronic periodontitis, within the age range of 30-70 years, were selected and underwent non surgical periodontal therapy. Further, they were put on a two month follow up after post operative phase for evaluation and comparison of pre and post values. Results and Conclusion: The results of our study showed that non surgical periodontal therapy significantly reduces the serum levels of C-reactive protein along with other clinical parameters in patients with generalised chronic periodontitis.

Reducing Inflammation

2011 ◽  
Vol 6 (1) ◽  
pp. 21-23
Author(s):  
Nicole D. Gillespie ◽  
Thomas L. Lenz
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Marker ◽  
Saturated Fat ◽  
C Reactive Protein ◽  
Cholesterol Lowering ◽  
Protein Levels ◽  
Reactive Protein ◽  
Risks And Benefits ◽  
Increased Risk

An elevated C-reactive protein level is an inflammatory marker associated with an increased risk in cardiovascular disease. Regular long-term exercise, a cholesterol-lowering diet (a diet low in saturated fat and high in viscous fiber and plant sterols), and statin pharmacotherapy have all been shown to reduce C-reactive protein levels. The purpose of this article is to describe the research available regarding lowering of C-reactive protein levels and reducing incidence of cardiovascular disease. Specifically, the article will compare the use of statin therapy, regular physical activity, and a cholesterol-lowering diet. The effectiveness of each intervention will be evaluated along with the risks and benefits associated with treatment.

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