The Family History of Diabetes: Report of a Working Party Appointed by the College of General Practitioners

The article by Forrest, Menser, and Harley1 prompts us to report two further cases of diabetes in children whose mothers were infected with rubella while pregnant during the American epidemic of 1963 to 1964. The first patient, a boy, was born at term in January 1965, weighing only 2,200 gm. His mother had an illness diagnosed as rubella in the first week of gestation. The family history of diabetes consisted of maturity-onset disease in the paternal grandfather and also in the materal great-grandmother.

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Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes

Diabetologia ◽

10.1007/s00125-020-05342-x ◽

2020 ◽

Author(s):

Anna Parkkola ◽

◽

Maaret Turtinen ◽

Taina Härkönen ◽

Jorma Ilonen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Family History ◽

Positive Family History ◽

Newly Diagnosed ◽

Family History Of Diabetes ◽

The Family ◽

History Of

Abstract Aims/hypothesis Shared aetiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. We wanted to characterise the family history of type 2 diabetes and its possible effects on the phenotype and genotype of type 1 diabetes in affected children at diagnosis. Methods A total of 4993 children under the age of 15 years with newly diagnosed type 1 diabetes from the Finnish Pediatric Diabetes Register were recruited (56.6% boys, median age of 8.2 years) for a cross-sectional, observational, population-based investigation. The family history of diabetes at diagnosis was determined by a structured questionnaire, and markers of metabolic derangement, autoantibodies and HLA class II genetics at diagnosis were analysed. Results Two per cent of the children had an immediate family member and 36% had grandparents with type 2 diabetes. Fathers and grandfathers were affected by type 2 diabetes more often than mothers and grandmothers. The children with a positive family history for type 2 diabetes were older at the diagnosis of type 1 diabetes (p < 0.001), had higher BMI-for-age (p = 0.01) and more often tested negative for all diabetes-related autoantibodies (p = 0.02). Conclusions/interpretation Features associated with type 2 diabetes, such as higher body weight, older age at diagnosis and autoantibody negativity, are more frequently already present at the diagnosis of type 1 diabetes in children with a positive family history of type 2 diabetes. Graphical abstract

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Maturity-Onset Diabetes of Young Type 5: Diabetes with Extrapancreatic Features

Case Reports in Endocrinology ◽

10.1155/2021/8243471 ◽

2021 ◽

Vol 2021 ◽

pp. 1-3

Author(s):

Adnan Haider ◽

Oksana Symczyk ◽

Ayesha Hassan ◽

Muhammad Atif Khan ◽

Inderpreet Madahar ◽

...

Keyword(s):

Family History ◽

Tolerance Test ◽

Diabetes Patient ◽

Oral Glucose ◽

Maturity Onset Diabetes ◽

Family History Of Diabetes ◽

Onset Diabetes ◽

The Family ◽

History Of ◽

Renal Abnormalities

Objective. This case involves a new-onset diabetes patient diagnosed during pregnancy with the congenital dysplastic right kidney. Case Report. Clinical presentation, biochemical features, imaging in a patient with diabetes diagnosed during pregnancy, and congenital dysplastic right kidney. Discussion. We present a case of a 22-year-old female with the congenital dysplastic right kidney diagnosed with gestational diabetes mellitus after failing a 1-hour oral glucose tolerance test, requiring insulin during pregnancy. Because of the family history of diabetes and morphologic renal abnormalities at young ages on the maternal side of the family, our patient was evaluated for maturity-onset diabetes of adult and was found to have HNF-1β mutation. Conclusion. This case highlights the importance of considering the diagnosis of maturity-onset diabetes of young and particularly MODY-5 in individuals with extrapancreatic features. MODY-5 should also be considered in a patient undergoing renal transplant at young ages with a family history of morphologic renal abnormalities.

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P.3.032 Does the family history of diabetes has an effect on the glucose metabolism of the patients recieving atypical antipsychotics?

European Neuropsychopharmacology ◽

10.1016/s0924-977x(05)80968-x ◽

2005 ◽

Vol 15 ◽

pp. S468-S469

Keyword(s):

Family History ◽

Glucose Metabolism ◽

Atypical Antipsychotics ◽

Family History Of Diabetes ◽

The Family ◽

History Of

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Analisis faktor yang berhubungan dengan kadar gula darah sewaktu pada ibu hamil di kota Manado

Jurnal e-Biomedik ◽

10.35790/ebm.4.2.2016.14623 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Vincent H. Kosanto ◽

Nelly Mayulu ◽

Shirley E.S. Kawengian

Keyword(s):

Family History ◽

Pregnant Women ◽

Blood Sugar ◽

Cross Sectional ◽

Public Health Centre ◽

Family History Of Diabetes ◽

Random Blood Sugar ◽

The Family ◽

History Of ◽

Sugar Levels

Abstract: Random blood sugar levels (GDS) on pregnant women is the result of blood tests of pregnant women in circumstances immediately taken from the blood capillaries and measured with a digital measuring tools. GDS category based on consensus of Perkeni 2011: not DM: (<90 mg / dL); Not Sure DM: (90-199 mg / dL); DM: (≥200 mg / dL). GDS levels are influenced by several factors which is a history of diabetes in the family. Family history of diabetes may come from parents or grandparents. This research is an analytic cross sectional (cross-sectional). Which is implemented in September to November 2016 in Bahu, Paniki bawah, Ranotana- Weru, Kombos and Tuminting Public Health Centre. The Data were collected through questionnaires and examinations for GDS levels, then the data is processed with SPSS applications. Respondents who had a history of diabetes in the family at 13.5% and who had no history of diabetes in the family is 86.5%. Respondents were not DM is 51.9%, which is uncertain DM is 48.0% and there were no DM. Conclusion: The results of this study concluded that there was significant relationship between family history of diabetes with DM status on pregnant women in Manado with p = 0.046 (p <α = 0.05).Keywords: random blood sugar levels, history of diabetes, pregnant women. Abstrak: Kadar gula darah sewaktu (GDS) ibu hamil adalah hasil pemeriksaan darah ibu hamil dalam keadaan sesaat yang diambil dari darah kapiler dan diukur dengan alat ukur digital. Kategori GDS berdasarkan Konsensus Perkeni 2011 adalah: bukan DM : (<90 mg/dL); Belum pasti DM : (90-199 mg/dL); DM : ( . Kadar GDS dipengaruhi oleh beberapa faktor salah satunya adalah riwayat DM dalam keluarga. Riwayat DM keluarga ini dapat berasal dari orang tua maupun kakek atau nenek. Penelitian ini bersifat analitik dengan pendekatan potong lintang (cross sectional). Yang dilaksanakan pada periode September sampai November 2016 di Puskesmas Bahu, Paniki bawah, Ranotana- Weru, Kombos dan Tuminting. Data yang dikumpulkan melalui kuisioner dan pemeriksaan kadar GDS, kemudian data diolah dengan aplikasi SPSS. Responden yang memiliki riwayat DM dalam keluarga 13,5% dan yang tidak memiliki riwayat DM dalam keluarga 86,5%. Responden yang bukan DM 51,9%, yang belum pasti DM 48,0% dan tidak terdapat yang DM. Simpulan: Hasil penelitian ini menyimpulkan bahwa terdapat hubungan yang bermakna antara riwayat DM keluarga dengan status DM pada ibu hamil di Kota Manado dengan p=0,046(p<α=0,05). Kata kunci: kadar gula darah sewaktu, riwayat DM, ibu hamil

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Gestational Diabetes Mellitus (GDM) Risk for Declared Family History of Diabetes, in Combination with BMI Categories

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18136936 ◽

2021 ◽

Vol 18 (13) ◽

pp. 6936

Author(s):

Małgorzata Lewandowska

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Family History ◽

Gestational Diabetes ◽

Pregnant Women ◽

Fold Increase ◽

Family History Of Diabetes ◽

The Family ◽

History Of ◽

Independent Risk Factors

Whether categories of family history of diabetes can act as independent risk factors for gestational diabetes mellitus (GDM-1, -2) has not yet been established, and neither has it been established how categories of body mass index (BMI) affect these relationships. A group of 912 women without chronic diseases, recruited in the first trimester, was investigated: 125 (13.7%) women developed GDM-1 (treated with diet); 21 (2.3%) women developed GDM-2 (treated with insulin); and a control group consisted of 766 non-diabetic women. A multiple logistic regression was used to evaluate adjusted odds ratios (AOR (95% confidence intervals)) of GDM-1 and GDM-2 for declared diabetes in the parents or grandparents (separately). These relationships were investigated in the whole cohort and subgroups of pre-pregnancy BMI. (1) Some categories of the family history were independent risk factors of GDM-1 or GDM-2. Compared to ‘absence of diabetes in the family’, women with diabetes in the father had a 3.68-fold increase in GDM-1 risk (AOR-b = 3.68 (2.23–6.07)), and women with diabetes in the mother had a 2.13-fold increase in GDM-1 risk (AOR-b = 2.13 (1.1−4.14)) and a 4.73-fold increase in GDM-2 risk (AOR-b = 4.73 (1.26−17.77)). Women with diabetes in the grandmother had a 2.34-fold increase in GDM-1 risk (AOR-b = 2.34 (1.29−4.24)). (2) The cumulative assessment of diabetes in the parents and/or grandparents was not related to the intensification of the risk of GDM, except for the increased risk of GDM-1 for diabetes in both mother and grandmothers simultaneously (AOR-b = 8.80 (1.16−66.57)), however, this group was very small. (3) The analyses in the subgroups of BMI categories showed that diabetes in the father was also an independent risk factor of GDM in the subgroup of pregnant women with normal BMI. In the subgroups of overweight and/or obesity, the risk of GDM for paternal and maternal diabetes was approximately twice as high as compared to the results of pregnant women with normal BMIs. Additionally, apart from the maternal influence of diabetes, the results suggest a significant influence of diabetes in the father on the risk of GDM, even (interestingly) in lean pregnant women.

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