Different genetic factors influence specific symptom dimensions of DSM-IV major depression

2013 ◽  
Vol 17 (1) ◽  
pp. 18-18 ◽  
Keyword(s):  
Major Depression ◽  
Genetic Factors ◽  
Specific Symptom ◽  
Symptom Dimensions ◽  
Dsm Iv

Toward a Comprehensive Symptom-Based Model of Psychopathology

2017 ◽  
pp. 260-286
Author(s):  
David Watson ◽  
Michael W. O’Hara
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Eating Disorders ◽  
Major Depression ◽  
Personality Disorder ◽  
Posttraumatic Stress ◽  
Discriminant Validity ◽  
Specific Symptom ◽  
Symptom Dimensions ◽  
Dsm 5 ◽  
Convergent And Discriminant Validity

This chapter reviews major findings reported in earlier chapters. First, previous findings confirm the existence of specific symptom dimensions that are highly robust and that show strong convergent and discriminant validity. Second, they establish the existence of multiple symptom dimensions within several disorders. Third, they demonstrate that these specific symptom dimensions have differential criterion validity, differential diagnostic specificity, and differential incremental validity. These symptom data can be used to improve various DSM diagnoses, such as major depression and posttraumatic stress disorder. More fundamentally, they provide the basis for a comprehensive symptom-based model of psychopathology. In addition to the IDAS-II, other instruments assess dimensions underlying sleep disorders, eating disorders, schizotypy, personality disorder, and hypochondriasis. These instruments jointly provide broad coverage of the 19 diagnostic classes contained in DSM-5. These measures support movement away from disorder-based models of psychopathology to ones focused on homogeneous symptom dimensions.

scholarly journals Evidence for Multiple Genetic Factors Underlying DSM-IV Criteria for Major Depression

2013 ◽  
Vol 70 (6) ◽  
pp. 599 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Steven H. Aggen ◽  
Michael C. Neale
Keyword(s):  
Major Depression ◽  
Genetic Factors ◽  
Dsm Iv

scholarly journals The structure of the symptoms of major depression: exploratory and confirmatory factor analysis in depressed Han Chinese women

2013 ◽  
Vol 44 (7) ◽  
pp. 1391-1401 ◽  
Author(s):  
Y. Li ◽  
S. Aggen ◽  
S. Shi ◽  
J. Gao ◽  
Y. Li ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Major Depression ◽  
Chinese Women ◽  
Han Chinese ◽  
Psychiatric Interview ◽  
Symptom Dimensions ◽  
Psychiatric Syndrome ◽  
Dsm Iv

BackgroundThe symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature of this important psychiatric syndrome?MethodSymptoms at lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor analysis (CFA) were performed in Mplus in random split-half samples.ResultsThe preliminary EFA results were consistently supported by the findings from CFA. Analyses of the nine DSM-IV MD symptomatic A criteria revealed two factors loading on: (i) general depressive symptoms; and (ii) guilt/suicidal ideation. Examining 14 disaggregated DSM-IV criteria revealed three factors reflecting: (i) weight/appetite disturbance; (ii) general depressive symptoms; and (iii) sleep disturbance. Using all symptoms (n = 27), we identified five factors that reflected: (i) weight/appetite symptoms; (ii) general retarded depressive symptoms; (iii) atypical vegetative symptoms; (iv) suicidality/hopelessness; and (v) symptoms of agitation and anxiety.ConclusionsMD is a clinically complex syndrome with several underlying correlated symptom dimensions. In addition to a general depressive symptom factor, a complete picture must include factors reflecting typical/atypical vegetative symptoms, cognitive symptoms (hopelessness/suicidal ideation), and an agitated symptom factor characterized by anxiety, guilt, helplessness and irritability. Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen in Western populations suggest that our results are likely to be broadly representative of the human depressive syndrome.

Symptom dimensions of major depression in a large community-based cohort

2021 ◽  
pp. 1-8
Author(s):  
Michael Wainberg ◽  
Peter Zhukovsky ◽  
Sean L. Hill ◽  
Daniel Felsky ◽  
Aristotle Voineskos ◽  
...  
Keyword(s):  
Primary Care ◽  
Major Depression ◽  
Risk Scores ◽  
Polygenic Risk Score ◽  
Psychiatric Diagnoses ◽  
Uk Biobank ◽  
Community Based ◽  
Symptom Dimensions ◽  
Polygenic Risk ◽  
Large Community

Abstract Background Our understanding of major depression is complicated by substantial heterogeneity in disease presentation, which can be disentangled by data-driven analyses of depressive symptom dimensions. We aimed to determine the clinical portrait of such symptom dimensions among individuals in the community. Methods This cross-sectional study consisted of 25 261 self-reported White UK Biobank participants with major depression. Nine questions from the UK Biobank Mental Health Questionnaire encompassing depressive symptoms were decomposed into underlying factors or ‘symptom dimensions’ via factor analysis, which were then tested for association with psychiatric diagnoses and polygenic risk scores for major depressive disorder (MDD), bipolar disorder and schizophrenia. Replication was performed among 655 self-reported non-White participants, across sexes, and among 7190 individuals with an ICD-10 code for MDD from linked inpatient or primary care records. Results Four broad symptom dimensions were identified, encompassing negative cognition, functional impairment, insomnia and atypical symptoms. These dimensions replicated across ancestries, sexes and individuals with inpatient or primary care MDD diagnoses, and were also consistent among 43 090 self-reported White participants with undiagnosed self-reported depression. Every dimension was associated with increased risk of nearly every psychiatric diagnosis and polygenic risk score. However, while certain psychiatric diagnoses were disproportionately associated with specific symptom dimensions, the three polygenic risk scores did not show the same specificity of associations. Conclusions An analysis of questionnaire data from a large community-based cohort reveals four replicable symptom dimensions of depression with distinct clinical, but not genetic, correlates.

Evaluation of Functionality in Families with Depressed Patient by Using the FFS - Poster Prezentation

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
T. Maria-Silvia
Keyword(s):  
Major Depression ◽  
Depressive Disorder ◽  
Positive Affect ◽  
Psychiatric Patients ◽  
Normal Families ◽  
Control Group ◽  
World Population ◽  
Dsm Iv ◽  
The Individual ◽  
Family Functionality

Depression is a disorder of representation and regulation of mood and emotion; it affects 5% of world population, in a year. Unlike normal loss and sadness feelings, major depression is persistant and it interferes significantly with thoughts, behaviour, emotions, activity and health of the individual. If untreated, depression can lead to suicide. Using family therapy in treating psychiatric patients is a must due to the significance that a family holds in individual and society life.Objective:Assesing family functionality in families with a member diagnosed according to DSM IV TR with depressive disorder; depression intensity was assesed with HDRS.Methods:A sample of 3o families (71 members); FFS assesses the most important and consistent five functioning areas: positive affect, comunication, conflicts, worries and rituals.Results:Values obtained in each of the 40 questions of the scale can give information on variables affecting the increase or decrease in subscales values. Positive affect 35,07, communication 37, conflicts 15,11, worries 40,77, rituals 45,03. The reuslts were compared to those obtained by assessin normal families from a control group of 132 families (323 members).Conclusions:Differences were noticed. Values obtained in our study represent the standard of functioning of families with a depressed member.

DSM-IV “major depression”: Are more stringent criteria needed?

Depression ◽  
1993 ◽  
Vol 1 (1) ◽  
pp. 24-28 ◽  
Author(s):  
James H. Kocsis
Keyword(s):  
Major Depression ◽  
Dsm Iv

Major Depression and Generalised Anxiety Disorder

1996 ◽  
Vol 168 (S30) ◽  
pp. 68-75 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Anxiety Disorder ◽  
Major Depression ◽  
Environmental Risk ◽  
Genetic Factors ◽  
Environmental Risk Factors ◽  
Generalised Anxiety Disorder ◽  
Increase Risk ◽  
Twin Models ◽  
One Year

In both clinical and epidemiological samples, major depression (MD) and generalised anxiety disorder (GAD) display substantial comorbidity. In a prior analysis of lifetime MD and GAD in female twins, the same genetic factors were shown to influence the liability to MD and to GAD. A follow-up interview in the same twin cohort examined one-year prevalence for MD and GAD (diagnosed using a one-month minimum duration of illness). Bivariate twin models were fitted using the program Mx. High levels of comorbidity were observed between MD and GAD. The best-fitting twin models, when GAD was diagnosed with or without a diagnostic hierarchy, found a genetic correlation of unity between the two disorders. The correlation in environmental risk factors was +0.70 when GAD was diagnosed non-hierarchically, but zero when hierarchical diagnoses were used. Our findings provide further support for the hypothesis that in women, MD and GAD are the result of the same genetic factors. Environmental risk factors that predispose to ‘pure’ GAD episodes may be relatively distinct from those that increase risk for MD.

scholarly journals The genetic epidemiology of personality disorders

2010 ◽  
Vol 12 (1) ◽  
pp. 103-114 ◽  
Keyword(s):  
Personality Disorders ◽  
Genetic Factors ◽  
Association Studies ◽  
Molecular Genetic ◽  
Cluster Structure ◽  
Epidemiologic Studies ◽  
Axis Ii ◽  
Candidate Gene Association ◽  
Axis I ◽  
Dsm Iv

Genetic epidemiologic studies indicate that all ten personality disorders (PDs) classified on the DSM-IV axis II are modestly to moderately heritable. Shared environmental and nonadditive genetic factors are of minor or no importance. No sex differences have been identified, Multivariate studies suggest that the extensive comorbidity between the PDs can be explained by three common genetic and environmental risk factors. The genetic factors do not reflect the DSM-IV cluster structure, but rather: i) broad vulnerability to PD pathology or negative emotionality; ii) high impulsivity/low agreeableness; and iii) introversion. Common genetic and environmental liability factors contribute to comorbidity between pairs or clusters of axis I and axis II disorders. Molecular genetic studies of PDs, mostly candidate gene association studies, indicate that genes linked to neurotransmitter pathways, especially in the serotonergic and dopaminergic systems, are involved. Future studies, using newer methods like genome-wide association, might take advantage of the use of endophenotypes.

Sign in / Sign up

Export Citation Format

Share Document