Review: anger and hostility increase risk of coronary heart disease events in healthy people and those with existing CHD

Abstract Background: Low-density lipoprotein cholesterol (LDL-C) and small, dense LDL-C (sdLDL-C) are important risk indicator of coronary heart disease (CHD), but their application in therapy monitoring of CHD is still far from being elucidated. Following the concept of precision medicine, we investigated whether the scientific medication based on medication-sensitive genes can reverse the LDL-C and sdLDL-C status in human bloodstream, so as to reveal the possibility of them as a monitoring indicator of CHD efficacy.Methods: A prospective study of CHD cohort containing 208 Chinese CHD patients (158 males and 50 females) and 20 healthy people (14 males and 6 females) was recruited. LDL-C and its subfractions were detected before and after treatment. Polymorphism of medication-sensitive genes, including SLCO1B1 (rs4149056, 521T>C), CYP2C19*2 (rs4244285, c.681G>A), and CYP2C19*3 (rs4986893, c.636G>A) were detected for medication guidance.Results: Nearly half of Chinese CHD patients (47.60%, 99/208) had genetic polymorphisms with homozygous or heterozygous mutations within these three genes. LDL-1 and LDL-2, subfractions of LDL-C, had a 100% positive rate in CHD patients and healthy people. However, sdLDL-C components of LDL-5 to LDL-7 were only enrichment in CHD patients. Moreover, the mean amount of sdLDL-C subfractions in CHD patients was significantly higher than that in healthy people. Among 180 patients with treatment remission, 81.67% (n=147) of CHD patients had decreased LDL-C, while 61.67% (n=111) of patients had decreased sdLDL-C.Conclusion: sdLDL-C has better accuracy on CHD screening than LDL-C, while LDL-C was more suitable for CHD therapy monitoring. Combined medication-sensitive genes polymorphism, LDL-C and sdLDL-C detection would optimize the treatment strategy for CHD patients.

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Long working hours may increase risk of coronary heart disease

American Journal of Industrial Medicine ◽

10.1002/ajim.22367 ◽

2014 ◽

Vol 57 (11) ◽

pp. 1227-1234 ◽

Cited By ~ 13

Author(s):

Mo-Yeol Kang ◽

Soo-Hun Cho ◽

Min-Sang Yoo ◽

Taeshik Kim ◽

Yun-Chul Hong

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Working Hours ◽

Long Working Hours ◽

Increase Risk

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L162v Polymorphism of Par-Α Gene, A603g Polymorphism of Tissue Factor Gene and Risk of Coronary Heart Disease in Russian Population

Journal of Bioinformatics and Diabetes ◽

10.14302/issn.2374-9431.jbd-19-2788 ◽

2019 ◽

Vol 1 (4) ◽

pp. 1-11

Author(s):

E.G. Sergeeva ◽

O.A. Berkovich ◽

Z.I. Ionova ◽

M.I. Zaraisky ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Tissue Factor ◽

Restriction Analysis ◽

Russian Population ◽

Control Group ◽

Factor Gene ◽

Chd Risk ◽

Increased Risk ◽

Increase Risk

Purpose The goal of this study is to determine the association of L162V polymorphism of PPAR-alpha gene, A603G polymorphism of tissue factor gene and the risk of coronary heart disease development in Russian population. Materials and Methods A clinical and genetic study of 414 patients with CHD and 220 people of comparable age without CHD which amounted to a control group was performed. L162L and L162V genotypes of L162V polymorphism of PPAR-α gene, A603A, A603G and G603G genotypes of A603G polymorphism of tissue factor gene were determined by polymerase chain reaction followed by restriction analysis. Results A carriage of L162V genotype and V allele of PPAR-α gene was associated with an increase risk of CHD in 2,13 times (L162V genotype) and in 2,21 times (V allele), with an increase in risk of CHD before the age of 45 years in 4,68 times (L162V genotype) and in 3,88 times (V allele). Significantly higher in patients with CHD compared with the general population and in patients with a carriage of G603G genotype and G allele of tissue factor gene was associated with the increase of CHD risk in 2,68 times (G603G genotype) and in 4,37 times (G allele), occurred more frequently in patients with debut of disease at age of 45 years and younger. The level of tissue factor was significantly higher in patients with CHD – carriers G603G genotype compared with carriers A603A genotype (217,9±15,2 pg/ml and 152,6±30,4 pg/ml, respectively, p=0,04). A carriage of the combination of L162V and G603G genotypes was associated with an increased risk of CHD in 3,04 times. Conclusion A carriage of V allele of L162V polymorphism of PPAR-α gene and G allele of A603G polymorphism of tissue factor gene, as well as their pair combination are associated with an increased CHD risk, especially at age 45 years or less.

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PLANT STEROLS LOWER CHOLESTEROL, BUT INCREASE RISK FOR CORONARY HEART DISEASE

OnLine Journal of Biological Sciences ◽

10.3844/ojbsci.2014.167.169 ◽

2014 ◽

Vol 14 (3) ◽

pp. 167-169 ◽

Cited By ~ 5

Author(s):

Zoë Harcombe ◽

Julien S. Baker

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Plant Sterols ◽

Increase Risk

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Progress Toward Achieving National Targets for Reducing Coronary Heart Disease and Stroke Mortality: A County‐Level Perspective

Journal of the American Heart Association ◽

10.1161/jaha.120.019562 ◽

2021 ◽

Vol 10 (4) ◽

Author(s):

Adam S. Vaughan ◽

Rebecca C. Woodruff ◽

Christina M. Shay ◽

Fleetwood Loustalot ◽

Michele Casper

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

American Heart Association ◽

American Heart ◽

Heart Association ◽

Vital Statistics ◽

Healthy People ◽

County Level ◽

Death Rates ◽

Stroke Death

Background The American Heart Association and Healthy People 2020 established objectives to reduce coronary heart disease (CHD) and stroke death rates by 20% by the year 2020, with 2007 as the baseline year. We examined county‐level achievement of the targeted reduction in CHD and stroke death rates from 2007 to 2017. Methods and Results Applying a hierarchical Bayesian model to National Vital Statistics data, we estimated annual age‐standardized county‐level death rates and the corresponding percentage change during 2007 to 2017 for those aged 35 to 64 and ≥65 years and by urban‐rural classification. For those aged ≥35 years, 56.1% (95% credible interval [CI], 54.1%–57.7%) and 39.8% (95% CI, 36.9%–42.7%) of counties achieved a 20% reduction in CHD and stroke death rates, respectively. For both CHD and stroke, the proportions of counties achieving a 20% reduction were lower for those aged 35 to 64 years than for those aged ≥65 years (CHD: 32.2% [95% CI, 29.4%–35.6%] and 64.1% [95% CI, 62.3%–65.7%]), respectively; stroke: 17.9% [95% CI, 13.9%–22.2%] and 45.6% [95% CI, 42.8%–48.3%]). Counties achieving a 20% reduction in death rates were more commonly urban counties (except stroke death rates for those aged ≥65 years). Conclusions Our analysis found substantial, but uneven, achievement of the targeted 20% reduction in CHD and stroke death rates, defined by the American Heart Association and Healthy People. The large proportion of counties not achieving the targeted reduction suggests a renewed focus on CHD and stroke prevention and treatment, especially among younger adults living outside of urban centers. These county‐level patterns provide a foundation for robust responses by clinicians, public health professionals, and communities.

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Study on Qi Deficiency Syndrome Identification Modes of Coronary Heart Disease Based on Metabolomic Biomarkers

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/281829 ◽

2014 ◽

Vol 2014 ◽

pp. 1-15 ◽

Cited By ~ 7

Author(s):

Qi Shi ◽

Huihui Zhao ◽

Jianxin Chen ◽

Youlin Li ◽

Zhongfeng Li ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Deficiency Syndrome ◽

Healthy People ◽

Dynamic Responses ◽

Plasma Metabolites ◽

Incidence And Mortality ◽

Exogenous Factors ◽

Concentration Changes ◽

Endogenous Metabolites

Coronary heart disease (CHD) is one of the most important types of heart disease because of its high incidence and mortality. With the era of systems biology bursting into reality, the analysis of the whole biological systems whether they are cells, tissues, organs, or the whole organisms has now become the norm of biological researches. Metabolomics is the branch of science concerned with the quantitative understandings of the metabolite complement of integrated living systems and their dynamic responses to the changes of both endogenous and exogenous factors. The aim of this study is to discuss the characteristics of plasma metabolites in CHD patients and CHD Qi deficiency syndrome patients and explore the composition and concentration changes of the plasma metabolomic biomarkers. The results show that 25 characteristic metabolites related to the CHD patients comparing with the healthy people, and 4 identifiable variables had significant differences between Qi deficiency and non-Qi deficiency patients. On the basis of identifying the different plasma endogenous metabolites between CHD patients and healthy people, we further prompted the metabolic rules, pathogenesis, and biological essence in Qi deficiency syndrome patients.

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