scholarly journals Study on Qi Deficiency Syndrome Identification Modes of Coronary Heart Disease Based on Metabolomic Biomarkers

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Qi Shi ◽  
Huihui Zhao ◽  
Jianxin Chen ◽  
Youlin Li ◽  
Zhongfeng Li ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Deficiency Syndrome ◽  
Healthy People ◽  
Dynamic Responses ◽  
Plasma Metabolites ◽  
Incidence And Mortality ◽  
Exogenous Factors ◽  
Concentration Changes ◽  
Endogenous Metabolites

Coronary heart disease (CHD) is one of the most important types of heart disease because of its high incidence and mortality. With the era of systems biology bursting into reality, the analysis of the whole biological systems whether they are cells, tissues, organs, or the whole organisms has now become the norm of biological researches. Metabolomics is the branch of science concerned with the quantitative understandings of the metabolite complement of integrated living systems and their dynamic responses to the changes of both endogenous and exogenous factors. The aim of this study is to discuss the characteristics of plasma metabolites in CHD patients and CHD Qi deficiency syndrome patients and explore the composition and concentration changes of the plasma metabolomic biomarkers. The results show that 25 characteristic metabolites related to the CHD patients comparing with the healthy people, and 4 identifiable variables had significant differences between Qi deficiency and non-Qi deficiency patients. On the basis of identifying the different plasma endogenous metabolites between CHD patients and healthy people, we further prompted the metabolic rules, pathogenesis, and biological essence in Qi deficiency syndrome patients.

Recognition Patterns Construction of Coronary Heart Disease Patients with Qi Deficiency Syndrome Based on Artificial Neural Network

2011 ◽  
Vol 393-395 ◽  
pp. 916-920 ◽  
Author(s):  
Qi Shi ◽  
Hui Hui Zhao ◽  
Jian Xin Chen ◽  
Yi Yang ◽  
Cheng Long Zheng ◽  
...  
Keyword(s):  
Neural Network ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Deficiency Syndrome ◽  
Modern Medicine ◽  
Biological Parameters ◽  
Recognition Pattern ◽  
Incidence And Mortality ◽  
High Incidence ◽  
Artificial Neural

Coronary heart disease (CHD), called “thoracic obstruction” in TCM, is one of the most important types of heart disease for its high incidence and mortality. The methods of syndrome studies in TCM can not be completely in accordance with these of modern medicine because of the complexity itself. In this paper, we investigated the ability of Artificial Neural Networks (ANNs) to predict CHD patients with or without qi deficiency syndrome. Predictions with Multilayer Perceptron Neural Network (MPLNN, one type of the ANNS), we obtained recognition patterns made up of eight biological parameters. The accuracy of this recognition pattern was 82.2%, and the accuracy of validation pattern was 80.0%.

Genetic Polymorphisms, LDL-C and sdLDL-C Help Optimize Coronary Heart Disease (CHD) Therapy

2021 ◽  
Author(s):  
Ruozhu Dai ◽  
Huilin Zhuo ◽  
Wei Wang ◽  
Xinjun Wang ◽  
Xiaoyu Zhao
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Genetic Polymorphisms ◽  
Therapy Monitoring ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Healthy People ◽  
Risk Indicator ◽  
Before And After ◽  
A Prospective Study

Abstract Background: Low-density lipoprotein cholesterol (LDL-C) and small, dense LDL-C (sdLDL-C) are important risk indicator of coronary heart disease (CHD), but their application in therapy monitoring of CHD is still far from being elucidated. Following the concept of precision medicine, we investigated whether the scientific medication based on medication-sensitive genes can reverse the LDL-C and sdLDL-C status in human bloodstream, so as to reveal the possibility of them as a monitoring indicator of CHD efficacy.Methods: A prospective study of CHD cohort containing 208 Chinese CHD patients (158 males and 50 females) and 20 healthy people (14 males and 6 females) was recruited. LDL-C and its subfractions were detected before and after treatment. Polymorphism of medication-sensitive genes, including SLCO1B1 (rs4149056, 521T>C), CYP2C19*2 (rs4244285, c.681G>A), and CYP2C19*3 (rs4986893, c.636G>A) were detected for medication guidance.Results: Nearly half of Chinese CHD patients (47.60%, 99/208) had genetic polymorphisms with homozygous or heterozygous mutations within these three genes. LDL-1 and LDL-2, subfractions of LDL-C, had a 100% positive rate in CHD patients and healthy people. However, sdLDL-C components of LDL-5 to LDL-7 were only enrichment in CHD patients. Moreover, the mean amount of sdLDL-C subfractions in CHD patients was significantly higher than that in healthy people. Among 180 patients with treatment remission, 81.67% (n=147) of CHD patients had decreased LDL-C, while 61.67% (n=111) of patients had decreased sdLDL-C.Conclusion: sdLDL-C has better accuracy on CHD screening than LDL-C, while LDL-C was more suitable for CHD therapy monitoring. Combined medication-sensitive genes polymorphism, LDL-C and sdLDL-C detection would optimize the treatment strategy for CHD patients.

scholarly journals Fish Consumption and Coronary Heart Disease: A Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2278
Author(s):  
Bo Zhang ◽  
Ke Xiong ◽  
Jing Cai ◽  
Aiguo Ma
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Dose Response ◽  
Fish Consumption ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Response Analysis ◽  
Summary Estimate ◽  
Incidence And Mortality ◽  
The Impact

Epidemiological studies on the impact of fish consumption on coronary heart disease (CHD) incidence have shown inconsistent results. In addition, in terms of CHD mortality, although previous meta-analyses showed that fish consumption reduces the risk of CHD, six newly incorporated studies show that fish consumption has no impact on CHD. Therefore, the results still need to be verified. The purpose of this study is to quantitatively evaluate the impact of fish consumption on CHD incidence and mortality. Relevant studies were identified from PubMed, Web of Science, and Embase databases up to October 2019. The multivariate-adjusted relative risks (RRs) for the highest versus the lowest fish consumption categories and the 95% confidence intervals were computed with a random-effect model. A restricted cubic spline regression model was used to assess the dose–response relationship between fish consumption and CHD incidence and mortality. Forty prospective cohort studies were incorporated into research. Among them, 22 studies investigated the association between fish consumption and CHD incidence (28,261 cases and 918,783 participants), and the summary estimate showed that higher fish consumption was significantly associated with a lower CHD incidence [RR: 0.91, 95% CI: (0.84, 0.97); I2 = 47.4%]. Twenty-seven studies investigated the association between fish consumption and CHD mortality (10,568 events and 1,139,553 participants), and the summary estimate showed that higher fish intake was significantly associated with a lower CHD mortality [RR: 0.85, 95% CI: (0.77, 0.94); I2 = 51.3%]. The dose–response analysis showed that the CHD incidence and mortality were reduced by 4%, respectively, with a 20 g/day increment in fish consumption. This meta-analysis indicates that fish consumption is associated with a lower CHD incidence and mortality.

Abstract WP192: Secular Trends in the Incidence, Mortality and Survival Rates of Cardiovascular Disease in a General Japanese Population: the Hisayama Study, 1961-2009

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jun Hata ◽  
Toshiharu Ninomiya ◽  
Yasufumi Doi ◽  
Yoichiro Hirakawa ◽  
Masayo Fukuhara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Survival Rates ◽  
The Past ◽  
Past Half Century ◽  
Incidence And Mortality ◽  
Clear Change ◽  
Past Half

Background: Changes in lifestyle and advances in medical technology during the past half century have been likely to affect the incidence and mortality of cardiovascular diseases and the prevalence of their risk factors in Japan. Methods: We established 5 cohorts consisting of residents of the town of Hisayama, Fukuoka, Japan, aged 40 years or older without a history of cardiovascular disease in 1961, 1974, 1983, 1993, and 2002. Each cohort was followed up for 7 years. Results: The age-adjusted incidence and mortality rates of ischemic stroke decreased significantly in men and women over the past half century. These decreasing trends were the greatest in the earlier period (from the 1960s to the 1970s) and slowed down in the recent period (from the 1980s to the 2000s). The incidence and mortality of intracerebral hemorrhage decreased significantly in men but not in women. The incidence and mortality of coronary heart disease decreased in women, but did not show a clear change in men. Five-year survival rates of stroke and acute myocardial infarction increased significantly with time. While the prevalence of hypertension did not show a drastic secular change, the proportion of individuals with antihypertensive treatment increased consistently, and mean systolic and diastolic blood pressures among hypertensive participants significantly decreased over the study period. On the other hand, the prevalence of glucose intolerance, hypercholesterolemia, and obesity increased steeply. Conclusions: The incidence and mortality rates of ischemic stroke in both sexes, intracerebral hemorrhage in men, and coronary heart disease in women decreased significantly, probably owing to better management of hypertension. However, the decreasing trends in ischemic stroke slowed down recently and there was no clear change for coronary heart disease in men, probably because the benefits of hypertension control were negated by increasing prevalence of metabolic risk factors. In addition to strict control of hypertension, urgent management of metabolic disorders is needed for further prevention of cardiovascular disease in Japan.

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