Possible relationship between antiphospholipid antibodies and embolic events in infective endocarditis

ObjectiveAntiphospholipid (aPL) antibodies may activate platelets and contribute to vegetation growth and embolisation in infective endocarditis (IE). We aimed to determine the value of aPL as predictors of embolic events (EE) in IE.MethodsWe studied 186 patients with definite IE (Duke-Li criteria, all types of IE) from the Nanc-IE prospective registry (2007–2012) who all had a frozen blood sample and at least one imaging procedure to detect asymptomatic or confirm symptomatic EE. Anticardiolipin (aCL) and anti-β2-glycoprotein I (β2GPI) antibodies (IgG and IgM) were assessed after the end of patients’ inclusion. The relationship between antibodies and the detection of EE after IE diagnosis were studied with Kaplan-Meier and Cox multivariate analyses.ResultsAt least one EE was detected in 118 (63%) patients (52 cerebral, 95 other locations) after IE diagnosis in 80 (time interval between IE and EE diagnosis: 5.9±11.3 days). At least one aPL antibody was found in 31 patients (17%).Detection of EE over time after IE diagnosis was more frequent among patients with anti-β2GPI IgM (log-rank P=0.0036) and that of cerebral embolisms, among patients with aCL IgM and anti-β2GPI IgM (log-rank P=0.002 and P<0.0001, respectively).Factors predictive of EE were anti-β2GPI IgM (HR=3.45 (1.47–8.08), P=0.0045), creatinine (2.74 (1.55–4.84), P=0.0005) and vegetation size (2.41 (1.41–4.12), P=0.0014). Those of cerebral embolism were aCL IgM (2.84 (1.22–6.62), P=0.016) and anti-β2GPI IgM (4.77 (1.79–12.74), P=0.0018).ConclusionThe presence of aCL and anti-β2GPI IgM was associated with EE, particularly cerebral ones, and could contribute to assess the embolic risk of IE.

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Hubungan Perilaku Perdagangan Investor Dengan Volume Perdagangan Di Bursa Efek Indonesia

Jurnal Manajemen Teori dan Terapan | Journal of Theory and Applied Management ◽

10.20473/jmtt.v2i1.2377 ◽

2009 ◽

Vol 2 (1) ◽

Author(s):

Ghazali Syamni

Keyword(s):

Trading Volume ◽

Stock Exchange ◽

Time Interval ◽

Time Intervals ◽

Using Data ◽

Changes Over Time ◽

Relationship Of ◽

The Relationship ◽

Order Pattern ◽

Over Time

This paper examines the relationship of behavior trading investor using data detailed transaction history-corporate edition demand and order history in Indonesia Stock Exchange during period of March, April and May 2005. Peculiarly, behavior placing of investor order at trading volume. The result of this paper indicates that trading volume order pattern to have pattern U shape. The pattern happened that investors have strong desires to places order at the opening and close of compared to in trading periods. While the largest orders are of market at the opening indicates that investor is more conservatively when opening, where many orders when opening has not happened transaction to match. In placing order both of investor does similar strategy. By definition, informed investors’ orders more large than uninformed investors. If comparison of order examined hence both investors behavior relatively changes over time. But, statistically shows there is not ratio significant. This implies behavior trading of informed investors and uninformed investors stable relative over time. The result from regression analysis indicates that informed investors to correlate at trading volume in all time intervals, but not all uninformed investors correlates in every time interval. This imply investor order inform is more can explain trading volume pattern compared to uninformed investor order in Indonesia Stock Exchange. Finally, result of regression also finds that order status match has greater role determines trading volume pattern intraday especially informed buy match and informed sale match. While amend, open and withdraw unable to have role to determine intraday trading volume pattern.

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Surgical treatment for infective endocarditis over three decades: a nationwide study

European Heart Journal ◽

10.1093/ehjci/ehaa946.2016 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

A Dalsgaard Jensen ◽

M.H Smerup ◽

H Bundgaard ◽

J.H Butt ◽

N.E Bruun ◽

...

Keyword(s):

Infective Endocarditis ◽

Mortality Risk ◽

Temporal Trends ◽

Valve Surgery ◽

Annual Number ◽

Nationwide Study ◽

Kaplan Meier ◽

Number Of Patients ◽

First Time ◽

Over Time

Abstract Background An increasing number of patients with infective endocarditis (IE) are treated surgically over time. It is important to know how this affects patient outcome. Current studies are mainly from tertiary centres which may bias estimations of outcomes. We have therefore conducted a nationwide study of surgical outcomes during admission for IE over three decades. Purpose We set out to examine temporal trends in use of valve surgery for IE and these patients' characteristics and related outcomes in Denmark in the period 1998–2017. Methods Using Danish nationwide registries, we included patients with first-time IE (1998–2017). The study population was categorized into four groups of five-year intervals (1998–2002, 2003–2007, 2008–2012, 2012–2017). Annual number of patients with IE and the proportion who underwent valve surgery during admission were reported. Kaplan-Meier estimates and multivariable logistic regression analyses were used to compare the associated 30-day mortality risk between calendar periods. Kaplan-Meier estimates and multivariable adjusted Cox proportional hazard analyses were used compare the associated 1-year mortality risk between calendar periods. Results A total of 8,455 patients with first-time IE were identified in the period of 1998–2017 of which 1,906 (22.5%) underwent valve surgery (1998–2002; N=320, 2003–2007; N=468, 2008–2012; N=528, 2013–2017; N=595). The proportion of patients who underwent surgery was 21.5% in 1998 and 19.4% in 2017 (P=0.02 for trend). See figure. For patients undergoing surgery, the median age and proportion of males increased from 58.3 years (P25-P75: 48.2–67.4) and 69.1% to 66.7 years (P25-P75: 55.2–73.0) and 73.1% in 1998–2002 and 2013–2017, respectively. Patients had an increasing burden of comorbidities including diabetes (10.3% to 14.3%), hypertension (16.9% to 37.5%) and renal disease (9.1% to 9.6%) across calendar periods. The 30-day mortality risk for patients with IE who underwent valve surgery was 10.0% (1998–2002), 10.8% (2003–2007), 6.4% (2008–2012) and 8.5% (2013–2017), respectively (P=0.09). One-year mortality risk for patients with IE who underwent valve surgery was 16.7% (1998–2002), 21.2% (2003–2007), 15.2% (2008–2012) and 16.6% (2013–2017), respectively (P=0.08). The declining 30-day and 1-year mortality was statistically significant over time when adjusting for patient characteristics (P=0.01 and P≤0.0001, respectively). Conclusion From a nationwide, unselected cohort of patients with first-time IE, around 1/5 undergo surgery during admission. Surgical IE-cases are older and sicker now compared to 10–20 years ago. In spite of this, there was a trend towards a decreased associated 30-day and 1-year mortality over time. Our data show a lower rate of surgery in IE than in most prior studies and we believe that this is due to the nationwide, unselected nature of our study. Infective endocarditis and surgery Funding Acknowledgement Type of funding source: None

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In a Prospective Inceptional Cohort Study of Children with Thrombosis, a Persistently Positive Dilute Russell Viper Venom Time Is Associated with Thrombus Progression or Recurrence and Multiple Antiphospholipid Antibodies

Blood ◽

10.1182/blood.v112.11.527.527 ◽

2008 ◽

Vol 112 (11) ◽

pp. 527-527 ◽

Cited By ~ 1

Author(s):

Hannah A Hathaway ◽

Emily L. Joachim ◽

Linda Jacobson ◽

Chris G. Bombardier ◽

Neil A Goldenberg ◽

...

Keyword(s):

Cohort Study ◽

Antiphospholipid Antibodies ◽

Protein S ◽

Clot Lysis ◽

Acute Thrombosis ◽

Duration Of Therapy ◽

Glycoprotein I ◽

Thrombotic Diseases ◽

Relationship Of ◽

The Relationship

Abstract BACKGROUND: Antiphospholipid antibodies (APA) that persist ≥12 weeks in adults with acute thrombosis are predictive of thrombus recurrence. The significance of APA in children with thrombosis is unclear. This study was developed to examine the relationship of a persistently positive lupus anticoagulant (≥ 12 weeks), assessed by the dilute Russell Viper Venom Time (dRVVT), to adverse thrombus outcomes including progression or recurrence. In addition, the relationship of a persistently positive dRVVT to the prevalence and titer of several other APA in children with thrombosis were examined. METHODS: Data from a consented prospective inceptional cohort study of pediatric thrombosis and thrombophilia (COMIRB 05–0339) were extracted for this analytic project. Eligibility included age ≤ 21 years at presentation, objectively confirmed thrombus, dRVVT within 4 weeks of presentation and repeated ≥ 12 weeks later. Patients with a persistently positive dRVVT (ratio of Screen/Confirm ≥1.2) were classified as having antiphospholipid syndrome (APS positive), and those with a negative dRVVT were classified as APS negative. Twelve or more weeks from presentation, patient plasmas were tested in ELISA assays for the presence and titer of IgM and IgG antibodies directed against protein C (PC), protein S (PS), prothrombin (II), β-2-Glycoprotein I (B2GPI), and cardiolipin (ACA). A euglobulin clot lysis assay (ELT) and hexagonal (II) phase phospholipid assay (STACLOT LA, Diagnostica Stago, Inc.) were also performed. RESULTS: The cohort included 122 cases with thrombosis. Of these, 35 failed eligibility due to transient dRVVT positivity or lack of blood sampling within the specified time period. Of the remaining 87 patients, 43 were APS positive and 44 were APS negative. APS positivity was associated with longer duration of therapy (p<0.001) and multiple autoantibodies at ≥ 12 weeks from presentation (p=0.04). APS was associated with higher titers of several antibodies, including those directed against: B2GPI (IgG, p=0.01), II (IgG, p=0.02), PC (IgG, p=0.03; IgM, p<0.001). Despite the longer duration of therapy for these patients, APS was highly associated with thrombus progression or recurrence (47% in APS positive versus 8% in APS negative, p=0.001). Thrombus progression or recurrence was further associated with positivity for ACA IgM, Anti-II IgM and the STACLOT LA (p=0.02 for each), and additionally with higher titers of antibodies against B2GPI (IgG, p=0.03), II (IgM, p=0.05), PC (IgM, p=0.04), and PS (IgM, p=0.03). CONCLUSION: In this pediatric prospective inceptional cohort study, APS (defined as a persistence of positive dRVVT 12 weeks or greater in children affected with thrombosis), was found in more than one third of children and was associated with higher prevalence and titers of several APA. In spite of longer duration of therapy, children with APS had a significantly higher rate of thrombus progression or recurrence. APA testing in children with thrombosis is important to predict outcomes. Future clinical trials must consider APS status in evaluating risk-stratified therapy for thrombotic diseases in children.

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Antiphospholipid Antibodies in Patients with Covid-19: Trend Over Time

10.21203/rs.3.rs-652861/v1 ◽

2021 ◽

Author(s):

Silvia Mancuso ◽

Simona Truglia ◽

Maurizio Sorice ◽

Cristiano Alessandri ◽

Flavia Pasquali ◽

...

Keyword(s):

Antiphospholipid Antibodies ◽

Lupus Anticoagulant ◽

Anticardiolipin Antibodies ◽

Risk Of Death ◽

Glycoprotein I ◽

D Dimer ◽

Over Time

Abstract Purpose Aim of the study was to investigate whether aPL positivity correlated with thrombosis in COVID-19 patients and whether it was transient or persistent. Methods We enrolled COVID-19 patients who underwent aPL tests: Lupus Anticoagulant (LA); IgM, IgG, IgA anticardiolipin antibodies (aCL); and IgM, IgG anti-β2-Glycoprotein-I antibodies (aβ2GPI). Results Twenty-eight out of 73 (38.4%) patients resulted positive for at least one aPL assay: 32.8% for IgA aCL, 6.8% for IgM aCL and 4.1% for IgM aβ2GPI. No patients tested positive for IgG aPL or LA at the first determination. Seven (9.6%) patients developed thrombotic events during hospitalization, with 4 of them resulting positive for aPL. In patients with thrombotic events during hospitalization the risk of death was increased 9-fold (LR+8.9, p=0.003). Patients with double positivity for aCL and aβ2GPI IgM had a LR+ of 6.3 to have thrombotic events (p=0.012) and a LR+ of 4.9 to have elevated D-dimer levels (p=0.027). In 10 out of 28 positive patients, aPL was detected in a second occasion at least 12-weeks apart and two patients confirmed the positivity. Conclusion Results suggest that double positivity for aCL and aβ2GPI IgM increases the risk of thrombosis in COVID-19, unlike IgA aCL positivity. APL positivity may be persistent, and it is advisable to monitor it over time.

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Sustainable Land Management, Wildfire Risk and the Role of Grazing in Mediterranean Urban-Rural Interfaces: A Regional Approach from Greece

Land ◽

10.3390/land9010021 ◽

2020 ◽

Vol 9 (1) ◽

pp. 21 ◽

Cited By ~ 2

Author(s):

Andrea Colantoni ◽

Gianluca Egidi ◽

Giovanni Quaranta ◽

Roberto D’Alessandro ◽

Sabato Vinci ◽

...

Keyword(s):

Urban Region ◽

Economic Damage ◽

Time Interval ◽

Indirect Measure ◽

Wildfire Risk ◽

Natural Land ◽

Fuel Accumulation ◽

The Relationship ◽

Over Time

Mediterranean regions are likely to be the most vulnerable areas to wildfires in Europe. In this context, land-use change has promoted land abandonment and the consequent accumulation of biomass (fuel) in (progressively less managed) forests and (non-forest) natural land, causing higher fire density and severity, economic damage, and land degradation. The expansion of Wildland-Urban Interfaces (WUIs) further affects fire density by negatively impacting peri-urban farming and livestock density. Assuming the role of grazing in controlling fuel accumulation in forests and non-forest natural land as an indirect measure of wildfire containment around large Mediterranean cities, our work focuses on the role of nomadic livestock, i.e., sheep and goats—the most abundant and traditional farm species in the area. The present study (i) investigates the relationship between fire frequency/extent and livestock decline at the regional level in Greece, (ii) explores changes over time in regional wildfire regimes, comparing Attica, a particularly vulnerable peri-urban region which includes Athens (the Greek capital city), with the rest of the country, and (iii) quantifies trends over time in livestock characteristics (population structure and dynamics) over a sufficiently long time interval (1961–2017) at the same spatial scale, with the aim to document the progressive reduction of nomadic livestock in peri-urban districts. A comprehensive analysis of statistical data, corroborated with a literature review, outlined the relationship between livestock decline over time and changes in specific wildfire characteristics at the regional scale, evidencing peculiar environmental conditions in Attica. In this region, a rapid decline of nomadic livestock was observed compared to in the rest of Greece, leading to a higher wildfire risk. The results of this study suggest that nomadic livestock contributes to sustainable management of peri-urban land, stimulating grazing that may prevent fuel accumulation in fringe woodlands.

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55. Infective Endocarditis After Surgical or Transcatheter Aortic Valve Replacement

Open Forum Infectious Diseases ◽

10.1093/ofid/ofab466.055 ◽

2021 ◽

Vol 8 (Supplement_1) ◽

pp. S38-S39

Author(s):

Aikaterini Papamanoli ◽

Brandon Muncan ◽

Puja Parikh ◽

Hal A Skopicki ◽

Andreas Kalogeropoulos

Keyword(s):

Infective Endocarditis ◽

Aortic Valve ◽

Aortic Valve Replacement ◽

Valve Replacement ◽

Surgical Aortic Valve Replacement ◽

Transcatheter Aortic Valve ◽

Kaplan Meier ◽

Aortic Valve Implantation ◽

Valve Implantation ◽

Over Time

Abstract Background Infective endocarditis (IE) can complicate both surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) with significant morbidity and mortality despite differing pathogenesis. In the presence of limited data from direct comparison studies and recent expansion of TAVI to younger and lower- risk patients, we compared the incidence and timing of IE in TAVI versus SAVR. Methods Using data from the TriNetX electronic health records network, we identified (1) a cohort of patients who underwent TAVI between January 2016 and December 2020 (CPT procedure code 1021150) and (2) a propensity score-matched cohort of patients who underwent SAVR (CPT procedure codes 1035167 or 1029693, without any associated transcatheter procedure). We examined the incidence of IE (captured with ICD-10 codes I33, I38, or I39) over a 5-year follow up period and matched the cohorts for demographic data and clinically relevant background history. We used Kaplan-Meier estimates and Cox proportional hazards models to compare incidence between matched cohorts. Results We identified 6,302 patients with TAVI and 6,302 matched patients with SAVR. The baseline characteristics of the cohorts were well balanced, Table 1. All standardized mean differences were < 0.05, indicating adequate matching between cohorts. The Kaplan-Meier mortality at 5 years was 38.0% in the TAVI vs. 22.0% in the SAVR cohort (log-rank P < 0.001). There were 290 cases with IE in the TAVI and 604 cases in the SAVR cohort. The corresponding 5-year event rates were 10.0% vs. 16.9% (log-rank P < 0.001), respectively, Figure 1. The risk ratio of TAVI vs. SAVR related IE over the entire 5-year period was 0.48 (95%CI 0.42 — 0.55; P < 0.001). However, the relative risk for IE was non-proportional between groups over the 5-year period, with an early pronounced incidence among SAVR relative to TAVI patients and gradual convergence of the hazard rates over time, Figure 2. Figure 1. Cumulative 5-Year Incidence (Kaplan-Meier Estimates) of Infective Endocarditis Among Matched Transcatheter Aortic Valve Implantation (TAVI) vs. Surgical Aortic Valve Replacement (SAVR) Recipients Figure 2. Risk of Infective Endocarditis in SAVR vs. TAVI Recipients Over Time Conclusion In this comparative study, the risk for IE was lower among TAVI vs. SAVR recipients, primarily due to the higher risk of IE during the early post-SAVR period. With increasing uptake of TAVI procedures, a better understanding of the temporal occurrence and pathophysiology of IE and application of effective treatment strategies in these patients is required. Disclosures All Authors: No reported disclosures

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The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02426-9 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Zeyuan Qiang ◽

Haofeng Zhang ◽

Shuai Jin ◽

Cao Yan ◽

Zhen Li ◽

...

Keyword(s):

Intrahepatic Cholangiocarcinoma ◽

Prognostic Value ◽

Multivariate Analyses ◽

Clinical Information ◽

Prognostic Biomarkers ◽

Expression Levels ◽

Arginase 1 ◽

Kaplan Meier ◽

Independent Risk Factors ◽

The Relationship

Abstract Background The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC). Methods Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete clinical information. Immunohistochemistry was used to assess the levels of Arg-1 and GPC-3 in ICC tissues. Univariate and multivariate analyses were conducted to identify independent risk factors in ICC. The relationship between Arg-1 and GPC-3 levels and patient survival was determined using the Kaplan-Meier method. Results High Arg-1 and GPC-3 expression levels were associated with poor prognosis in patients with ICC, and they could be as new prognostic biomarkers in ICC. Conclusion Arg-1 and GPC-3 can serve as independent prognostic biomarkers in ICC.

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Investment Traits and Intelligence in Adulthood

Journal of Individual Differences ◽

10.1027/1614-0001/a000101 ◽

2013 ◽

Vol 34 (2) ◽

pp. 82-89 ◽

Cited By ~ 5

Author(s):

Sophie von Stumm

Keyword(s):

Individual Differences ◽

Personality Traits ◽

Fluid Intelligence ◽

Need For Cognition ◽

Openness To Experience ◽

Intelligence Tests ◽

Crystallized Intelligence ◽

New Knowledge ◽

The Relationship ◽

Over Time

Intelligence-as-knowledge in adulthood is influenced by individual differences in intelligence-as-process (i.e., fluid intelligence) and in personality traits that determine when, where, and how people invest their intelligence over time. Here, the relationship between two investment traits (i.e., Openness to Experience and Need for Cognition), intelligence-as-process and intelligence-as-knowledge, as assessed by a battery of crystallized intelligence tests and a new knowledge measure, was examined. The results showed that (1) both investment traits were positively associated with intelligence-as-knowledge; (2) this effect was stronger for Openness to Experience than for Need for Cognition; and (3) associations between investment and intelligence-as-knowledge reduced when adjusting for intelligence-as-process but remained mostly significant.

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Power Values and Power Distance Moderate the Relationship Between Workplace Supervisory Power and Job Satisfaction

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000257 ◽

2020 ◽

Vol 19 (3) ◽

pp. 135-141

Author(s):

Kenneth D. Locke

Keyword(s):

Job Satisfaction ◽

Multilevel Modeling ◽

Power Distance ◽

European Social Survey ◽

Social Survey ◽

The Relationship ◽

Workplace Power ◽

Over Time

Abstract. Person–job (or needs–supplies) discrepancy/fit theories posit that job satisfaction depends on work supplying what employees want and thus expect associations between having supervisory power and job satisfaction to be more positive in individuals who value power and in societies that endorse power values and power distance (e.g., respecting/obeying superiors). Using multilevel modeling on 30,683 European Social Survey respondents from 31 countries revealed that overseeing supervisees was positively associated with job satisfaction, and as hypothesized, this association was stronger among individuals with stronger power values and in nations with greater levels of power values or power distance. The results suggest that workplace power can have a meaningful impact on job satisfaction, especially over time in individuals or societies that esteem power.

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Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000042 ◽

2010 ◽

Vol 57 (5) ◽

pp. 354-359 ◽

Cited By ~ 10

Author(s):

Melanie K. T. Takarangi ◽

Deryn Strange

Keyword(s):

Well Being ◽

The Other ◽

Personal Perspective ◽

Emotional Impact ◽

Potential Mechanism ◽

Negative Experiences ◽

Negative Memory ◽

The Relationship ◽

Negative Memories ◽

Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

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