scholarly journals Early ultrastructural changes of antral mucosa with aspirin in the absence of Helicobacter pylori.

1995 ◽  
Vol 48 (11) ◽  
pp. 994-997 ◽  
Author(s):  
C J McCarthy ◽  
E Sweeney ◽  
C O'Morain
Keyword(s):  
Helicobacter Pylori ◽  
Ultrastructural Changes ◽  
Antral Mucosa

scholarly journals Gastrin and the Moderate Hypergastrinemias

2021 ◽  
Vol 22 (13) ◽  
pp. 6977
Author(s):  
Jens F. Rehfeld
Keyword(s):  
Helicobacter Pylori ◽  
Plasma Concentrations ◽  
Antral Mucosa ◽  
Serum Concentrations ◽  
Health Issues ◽  
Gastrin Secretion ◽  
Mucosal Growth ◽  
Early Phases ◽  
Molecular Nature ◽  
Concentration Levels

The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first premise the normal biogenesis of gastrin in the antral mucosa, but also mentions the extraantral expression. Subsequently, the molecular nature and concentration levels of gastrin in serum or plasma are overviewed. Third, assays for accurate measurements of plasma or serum concentrations are commented. Finally, the problem of moderate hypergastrinemia due to Helicobacter pylori infections and/or treatment with proton-pump inhibitors (PPI) is discussed. The review concludes that accurate measurement of the true concentrations of bioactive gastrins in plasma is important. Moreover, it suggests that moderate hypergastrinemias are also essential health issues that require serious attention.

scholarly journals Helicobacter pylori Infection and the Patterns of Gastric Mucin Expression in Children

2020 ◽  
Vol 9 (12) ◽  
pp. 4030
Author(s):  
Ana-Maria Teodora Domșa ◽  
Raluca Lupușoru ◽  
Dan Gheban ◽  
Alexandra Buruiană-Simic ◽  
Bogdan Alexandru Gheban ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Risk Factor ◽  
Monoclonal Antibodies ◽  
Chronic Inflammation ◽  
Gastric Carcinogenesis ◽  
Antral Mucosa ◽  
Mucin Expression ◽  
Muc2 Expression ◽  
H Pylori ◽  
The Impact

Background: The updated model for the mechanism of gastric carcinogenesis demonstrates that Helicobacter pylori (H. pylori) is a risk factor in every step of the process. The expression of certain gastric mucins is altered by H. pylori infection in adult patients. The aim of our research was to assess the impact of H. pylori infection on the expression of secretory mucins in the pediatric antral mucosa. Methods: Slides were stained with monoclonal antibodies for MUC5AC, MUC6 and MUC2, digitalized and scored using both a semiquantitative and a quantitative approach. Results: The expression of MUC5AC was significantly lower in infected children. Also, MUC2 expression was more pronounced in infected children. MUC6 expression did not differentiate between infected and noninfected children. Additionally, the presence of chronic inflammation significantly altered the expression of MUC6 and MUC2. The expression of MUC6 was significantly higher in patients with gastric atrophy. Conclusion: The minor differences in mucin expression at distinct ages might stem from different H. pylori exposure periods. Further research is needed to determine the particular patterns of expression according to age and to evaluate the effects of the interaction between H. pylori and mucins in the progression of the gastric carcinogenesis cascade.

Long-term effects of Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients

2000 ◽  
Vol 12 (7) ◽  
pp. 719-725 ◽  
Author(s):  
Frank Zerbib ◽  
Christine Lenk ◽  
Bassem Sawan ◽  
Rémy Cayla ◽  
Nathalie Broutet ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Antral Mucosa ◽  
Long Term Effects ◽  
Helicobacter Pylori Eradication

scholarly journals Chronic gastritis and Helicobacter pylori in digestive form of Chagas' disease

1993 ◽  
Vol 35 (2) ◽  
pp. 117-121 ◽  
Author(s):  
A. J. A. Barbosa ◽  
D. M. M. Queiroz ◽  
A. M. M. F. Nogueira ◽  
M. J. A. Roquette Reis ◽  
E. N. Mendes ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Chagas Disease ◽  
Chronic Gastritis ◽  
Antral Mucosa ◽  
Common Cause ◽  
Superficial Gastritis ◽  
H Pylori ◽  
Inflammatory Changes

Patients with the digestive form of Chagas'disease frequently present chronic gastritis. As the microorganism Helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. Seventeen chagasics, with megaesophagus and or megacolon were studied. Fragments from two different regions of antral mucosa were obtained by endoscopy, fixed in 4% neutral formaldehyde and embedded in paraffin. The sections were stained by haematoxylin and eosin for histology analysis, and by carbolfuchsin for H. pylori identification. H. pylori was found in 16 (94.1%) chagasic patients, all of them presenting chronic gastritis. Superficial gastritis was seen in 9 (52.9%) while atrophic gastritis was present in 8 (47.1%) patients. H. pylori was present on gastric mucosa of 8 (100%) patients with atrophic gastritis and of 8 (88.8%) patients with superficial gastritis. We concluded that the microorganism H. pylori should be considered a possible factor connected with the etiopathogenesis of chronic superficial and atrophic gastritis frequently observed in patients with the digestive form of Chagas' disease.

scholarly journals Lactoferrin Levels in the Gastric Tissue ofHelicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yaşar Doğan ◽  
Tülay Erkan ◽  
Zerrin Önal ◽  
Merve Usta ◽  
Gülen Doğusoy ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Antral Mucosa ◽  
Gastric Tissue ◽  
Negative Controls

Aim. To determine gastric tissue lactoferrin (Lf) levels ofHelicobacter pylori-(Hp-) positive and -negative patients and its effect on anemia.Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.Results. The study included 64 cases (average: years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were % and , respectively. Hp-negative cases showed significantly different values of % and , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were /dL and /mL, but these were comparable with Hp-negative cases (/dL and /mL).Conclusions.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

scholarly journals Association of Helicobacter pylori infection with nodular antritis and follicular gastritis

2006 ◽  
Vol 63 (3) ◽  
pp. 313-315 ◽  
Author(s):  
Ratko Tomasevic ◽  
Gradimir Golubovic ◽  
Miroslav Kiurski ◽  
Dragana Stankovic ◽  
Radoje Doder ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Case Report ◽  
Chronic Gastritis ◽  
Upper Gastrointestinal Endoscopy ◽  
Antral Mucosa ◽  
Urease Test ◽  
Sydney System ◽  
H Pylori ◽  
The Relationship ◽  
Upper Gastrointestinal

Introduction. Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic complaints and was diagnosed as having nodular antritis, but also underwent urease test and hystopathologic examination of antral mucosa, to determine the presence and density of H. pylori infection and the presence and severity of gastritis. After a course of anti H. pylori treatment, dyspepsia improved and new biopsy specimens obtained two months and six months afterwards revealed no pathological findings. Conclusion. The case report supported the association of H. pylori infection of lymphoid follicles with nodular gastric mucosis.

scholarly journals Particular Morphological Features in the Diagnosis of Pediatric Helicobacter pylori Gastritis: A Morphometry-Based Study

2020 ◽  
Vol 9 (11) ◽  
pp. 3639
Author(s):  
Ana-Maria Teodora Domșa ◽  
Dan Gheban ◽  
Camelia Lazăr ◽  
Bogdan Pop ◽  
Cristina Maria Borzan
Keyword(s):  
Helicobacter Pylori ◽  
Cross Sections ◽  
Antral Mucosa ◽  
Background Current ◽  
Histological Changes ◽  
Mucosal Thickness ◽  
Gastric Biopsies ◽  
Glandular Structures ◽  
H Pylori ◽  
Helicobacter Pylori Gastritis

Background: Current pediatric guidelines recommend the use of the Updated Sydney Classification for gastritis to assess histological changes caused by Helicobacter pylori (H. pylori) infection. The purpose of this study was to investigate the morphometric alterations of the antral mucosa in relation to pediatric H. pylori infection. Methods: A total of 65 cases were considered eligible. Apart from scoring the biopsies according to the recommendations, foveolar hyperplasia (FH) was assessed. The following measurements were performed on digital slides: total mucosal thickness, foveolar and glandular length, number of glandular cross sections per 40X field, glandular diameter, and distance between glands. Results: The thickness of the antral mucosa increased along with the bacterial density and the intensity of inflammation in H. pylori-infected children (p < 0.05). FH was significantly associated with the presence of H. pylori (p < 0.001) and also exhibited a greater length of the foveolar and glandular structures and an increased glandular diameter (p < 0.05), but without influencing the thickness of the mucosa. Conclusions: Our results reinforce the fact that FH is not only an important histologic characteristic of gastropathy, but is also a significant change observed in H. pylori infection in children and may be considered for reporting when evaluating pediatric gastric biopsies.

Relationship between mucosal levels of Helicobacter pylori-specific IgA, interleukin-8 and gastric inflammation

1999 ◽  
Vol 96 (4) ◽  
pp. 409-414 ◽  
Author(s):  
Q. B. ZHANG ◽  
G. ETOLHI ◽  
J. B. DAWODU ◽  
C. G. GEMMELL ◽  
R. I. RUSSELL
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Inverse Correlation ◽  
Interleukin 8 ◽  
Antral Mucosa ◽  
Significant Difference ◽  
Iga Antibodies ◽  
Iga Response ◽  
Non Ulcer Dyspepsia ◽  
H Pylori

Mucosal IgA is important in local immune defence. Helicobacter pylori induces a specific IgA response in antral mucosa, but its immunopathology is unknown. Interleukin-8 (IL-8) has been suggested to be important in H. pylori-induced inflammation. Current information on the relationship between H. pylori-induced IgA and mucosal inflammation is limited. To investigate possible associations between mucosal-specific IgA, the toxinogenicity of H. pylori, mucosal levels of IL-8 and gastric inflammation, 52 endoscoped patients were studied. These comprised 28 patients with peptic ulcer and 24 with non-ulcer dyspepsia. Of these patients, 38 had H. pylori infection: 28 with peptic ulcer and 10 with non-ulcer dyspepsia. Antral biopsies were taken for histology, H. pylori culture and measurement of mucosal levels of IL-8 (pg/mg) and specific IgA (A450×1000) by ELISA. Mucosal H. pylori IgA was detectable in 35 out of 38 patients with H. pylori infection, with a median (interquartile) level of 220 (147, 531) units. There was no significant difference in mucosal levels of the IgA antibodies between patients infected with cytotoxin-positive or cagA-positive strains of H. pylori and those with toxin-negative or cagA-negative strains. The IgA levels in those patients with severe neutrophil infiltration were lower than in those with mild or moderate infiltration (P< 0.05). There was a weak inverse correlation between antral mucosal IgA and IL-8 in infected patients (r = -0.36; P = 0.04). H. pylori infection induced a significant local mucosal IgA response in most infected patients. The level of IgA antibodies does not appear to be correlated with the toxinogenicity of H. pylori. However, patients with severe active inflammation appear to have decreased levels of IgA. An inverse correlation between mucosal IL-8 and IgA may suggest that IL-8-induced inflammation compromises the mucosal IgA defence and renders the mucosa susceptible to further damage.

Sign in / Sign up

Export Citation Format

Share Document