scholarly journals Maternal education and language development at 2 years corrected age in children born very preterm: results from a European population-based cohort study

2020 ◽  
Vol 74 (4) ◽  
pp. 346-353 ◽  
Author(s):  
Mariane Sentenac ◽  
Samantha Johnson ◽  
Marie-Laure Charkaluk ◽  
Anna-Veera Sëppanen ◽  
Ulrika Aden ◽  
...  
Keyword(s):  
Language Development ◽  
Maternal Education ◽  
Short Form ◽  
Population Based ◽  
Expressive Vocabulary ◽  
Perinatal Risk ◽  
Adjusted Risk ◽  
Very Preterm ◽  
Clinical Records ◽  
The Impact

BackgroundSocioeconomic factors influence language development in the general population, but the association remains poorly documented in children born very preterm (VPT). We assessed the impact of maternal education on language development in children born VPT and effect modification by perinatal risk.MethodsData were from the Effective Perinatal Intensive Care in Europe (EPICE) population-based cohort of children born <32 weeks’ gestational age (GA) in 2011/2012. Regions from six countries (Estonia, France, Germany, Italy, Sweden and UK) used a validated short form MacArthur Developmental Communicative Inventories Checklist to assess language at 2 years corrected age. Perinatal variables were collected from clinical records. We assessed expressive language delay (ELD), defined as (a) not combining words; and (b) expressive vocabulary <10th percentile of norms for age and sex. Perinatal risk (low, moderate and high) was determined using GA, small for GA and neonatal morbidities. We estimated adjusted risk ratios (aRR) of ELD by maternal education with inverse weighting to account for non-response bias.ResultsOf 2741 children, 24.6% were not combining words and 39.7% had a low expressive vocabulary. Low maternal education (lower secondary or less compared with a bachelor’s degree or more) increased risks of ELD: not combining words: aRR=1.52 (95% CI 1.36 to 1.69); low expressive vocabulary: aRR=1.25 (1.04 to 1.51). For children with low perinatal risk, the aRR were 1.88 (1.26 to 2.80) and 1.44 (1.06 to 1.95), respectively, compared with those with high perinatal risks: 1.36 (1.10 to 1.67) and 1.11 (0.97 to 1.27), respectively.ConclusionLow maternal education affects ELD for children born VPT, although the association appears attenuated among those with highest perinatal risk.

scholarly journals Renin–angiotensin system blocker use and the risk of acute kidney injury after colorectal cancer surgery: a population-based cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e032964
Author(s):  
Charlotte Slagelse ◽  
H Gammelager ◽  
Lene Hjerrild Iversen ◽  
Kathleen D Liu ◽  
Henrik T Toft Sørensen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Acute Kidney Injury ◽  
Cohort Study ◽  
Angiotensin Receptor Blockers ◽  
Kidney Injury ◽  
Population Based ◽  
Adjusted Risk ◽  
Increased Risk ◽  
The Impact ◽  
Postoperative Aki

ObjectivesIt is unknown whether preoperative use of ACE inhibitors (ACE-I) or angiotensin receptor blockers (ARBs) affects the risk of acute kidney injury (AKI) after colorectal cancer (CRC) surgery. We assessed the impact of preoperative ACE-I/ARB use on risk of AKI after CRC surgery.DesignObservational cohort study. Patients were divided into three exposure groups—current, former and non-users—through reimbursed prescriptions within 365 days before the surgery. AKI within 7 days after surgery was defined according to the current Kidney Disease Improving Global Outcome consensus criteria.SettingPopulation-based Danish medical databases.ParticipantsA total of 9932 patients undergoing incident CRC surgery during 2005–2014 in northern Denmark were included through the Danish Colorectal Cancer Group Database.Outcome measureWe computed cumulative incidence proportions (risk) of AKI with 95% CIs for current, former and non-users of ACE-I/ARB, including death as a competing risk. We compared current and former users with non-users by computing adjusted risk ratios (aRRs) using log-binomial regression adjusted for demographics, comorbidities and CRC-related characteristics. We stratified the analyses of ACE-I/ARB users to address any difference in impact within relevant subgroups.ResultsTwenty-one per cent were ACE-I/ARB current users, 6.4% former users and 72.3% non-users. The 7-day postoperative AKI risk for current, former and non-users was 26.4% (95% CI 24.6% to 28.3%), 25.2% (21.9% to 28.6%) and 17.8% (17.0% to 18.7%), respectively. The aRRs of AKI were 1.20 (1.09 to 1.32) and 1.16 (1.01 to 1.34) for current and former users, compared with non-users. The relative risk of AKI in current compared with non-users was consistent in all subgroups, except for higher aRR in patients with a history of hypertension.ConclusionsBeing a current or former user of ACE-I/ARBs is associated with an increased risk of postoperative AKI compared with non-users. Although it may not be a drug effect, users of ACE-I/ARBs should be considered a risk group for postoperative AKI.

A long-term predictive validity study: Can the CDI Short Form be used to predict language and early literacy skills four years later?

2012 ◽  
Vol 40 (4) ◽  
pp. 821-835 ◽  
Author(s):  
DILARA DENIZ CAN ◽  
MARIKA GINSBURG-BLOCK ◽  
ROBERTA MICHNICK GOLINKOFF ◽  
KATHRYN HIRSH-PASEK
Keyword(s):  
Language Development ◽  
Early Literacy ◽  
Predictive Validity ◽  
Phonemic Awareness ◽  
Short Form ◽  
Parent Report ◽  
Literacy Skills ◽  
Hierarchical Regression ◽  
Expressive Vocabulary ◽  
Decoding Skills

ABSTRACTThis longitudinal study examined the predictive validity of the MacArthur Communicative Developmental Inventories-Short Form (CDI-SF), a parent report questionnaire about children's language development (Fenson, Pethick, Renda, Cox, Dale & Reznick, 2000). Data were first gathered from parents on the CDI-SF vocabulary scores for seventy-six children (mean age=1 ; 10). Four years later (mean age=6 ; 1), children were assessed on language outcomes (expressive vocabulary, syntax, semantics and pragmatics) and code-related skills, including phonemic awareness, word recognition and decoding skills. Hierarchical regression analyses revealed that early expressive vocabulary accounted for 17% of the variance in picture vocabulary, 11% of the variance in syntax, and 7% of the variance in semantics, while not accounting for any variance in pragmatics in kindergarten. CDI-SF scores did not predict code-related skills in kindergarten. The importance of early vocabulary skills for later language development and CDI-SF as a valuable research tool are discussed.

scholarly journals Does community-based distribution of HIV self-tests increase uptake of HIV testing? Results of pair-matched cluster randomised trial in Zambia

2021 ◽  
Vol 6 (Suppl 4) ◽  
pp. e004543 ◽  
Author(s):  
Melissa Neuman ◽  
Bernadette Hensen ◽  
Alwyn Mwinga ◽  
Namwinga Chintu ◽  
Katherine L Fielding ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Randomised Trial ◽  
Population Based ◽  
Cluster Randomised Trial ◽  
Distribution Models ◽  
Community Based ◽  
Adjusted Risk ◽  
Cluster Randomised ◽  
Catchment Areas ◽  
The Impact

ObjectivesEnding HIV by 2030 is a global priority. Achieving this requires alternative HIV testing strategies, such as HIV self-testing (HIVST) to reach all individuals with HIV testing services (HTS). We present the results of a trial evaluating the impact of community-based distribution of HIVST in community and facility settings on the uptake of HTS in rural and urban Zambia.DesignPair-matched cluster randomised trial.MethodsIn catchment areas of government health facilities, OraQuick HIVST kits were distributed by community-based distributors (CBDs) over 12 months in 2016–2017. Within matched pairs, clusters were randomised to receive the HIVST intervention or standard of care (SOC). Individuals aged ≥16 years were eligible for HIVST. Within communities, CBDs offered HIVST in high traffic areas, door to door and at healthcare facilities. The primary outcome was self-reported recent testing within the previous 12 months measured using a population-based survey.ResultsIn six intervention clusters (population 148 541), 60 CBDs distributed 65 585 HIVST kits. A recent test was reported by 66% (1622/2465) in the intervention arm compared with 60% (1456/2429) in SOC arm (adjusted risk ratio 1.08, 95% CI 0.94 to 1.24; p=0.15). Uptake of the HIVST intervention was low: 24% of respondents in the intervention arm (585/2493) used an HIVST kit in the previous 12 months. No social harms were identified during implementation.ConclusionDespite distributing a large number of HIVST kits, we found no evidence that this community-based HIVST distribution intervention increased HTS uptake. Other models of HIVST distribution, including secondary distribution and community-designed distribution models, provide alternative strategies to reach target populations.Trial registration numberClinicalTrials.gov Registry (NCT02793804).

scholarly journals Sociodemographic Differences in Prenatal Diagnosis of Chromosomal Anomalies: A Population-Based Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Michele Santoro ◽  
Lorena Mezzasalma ◽  
Alessio Coi ◽  
Silvia Baldacci ◽  
Lucia Pasquini ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Prenatal Diagnosis ◽  
Maternal Education ◽  
Geographic Origin ◽  
Population Based ◽  
Termination Of Pregnancy ◽  
Chromosomal Anomalies ◽  
Essential Information ◽  
Maternal Characteristics ◽  
The Impact

Background: In Europe, about 76% of cases of chromosomal anomalies are prenatally diagnosed. Prenatal diagnosis allows more efficient planning of postnatal treatment and helps parents for an informed decision about the continuation of pregnancy. The main aim of this study was to evaluate whether the sociodemographic maternal characteristics affect the probability of prenatal diagnosis of chromosomal anomalies.Methods: Cases of chromosomal anomalies in the period 2005–2017 came from the population-based registry of congenital anomalies of Tuscany (Italy). Differences in the proportion of cases prenatally diagnosed were investigated through the following maternal characteristics: education, geographic origin and occupation. The association between cases of termination of pregnancy after prenatal diagnosis and maternal characteristics was also analysed. Odds Ratios (OR) adjusted by maternal age were calculated using logistic regression models. Results were provided for all cases of chromosomal anomalies and for Down syndrome cases.Results: A total of 1,419 cases were included in the study. Cases prenatally diagnosed were 1,186 (83.6%). We observed a higher proportion of cases not prenatally diagnosed among cases with low maternal education compared to those with high maternal education (OR = 2.16, p &lt; 0.001) and in women from high migratory outflow countries, compared to the Italian ones (OR = 2.85, p &lt; 0.001). For prenatally diagnosed Down syndrome cases, we observed a higher proportion of termination of pregnancy for women with low education level (OR = 4.36, p = 0.023).Conclusions: In our study evidence of differences in the probability of prenatal diagnosis of chromosomal anomalies associated with maternal education and geographic origin was found. Population-based studies investigating sociodemographic disparities can provide essential information for targeted public health programs. Further studies are recommended to monitor the impact of the increasing availability of non-invasive screening tests.

scholarly journals The Association between Difficulty Seeing and Physical Activity among 17,777 Adults Residing in Spain

2019 ◽  
Vol 16 (21) ◽  
pp. 4267 ◽  
Author(s):  
Guillermo F. López-Sánchez ◽  
Igor Grabovac ◽  
Damiano Pizzol ◽  
Lin Yang ◽  
Lee Smith
Keyword(s):  
Physical Activity ◽  
Contact Lenses ◽  
Low Vision ◽  
Short Form ◽  
Population Based ◽  
National Health Survey ◽  
Cross Sectional ◽  
Reduced Physical Activity ◽  
Obesity Hypertension ◽  
The Impact

This is the first representative population-based study exploring the association between difficulty seeing (i.e., low vision) and physical activity in Spain. Cross-sectional data from the Spanish National Health Survey 2017 were analysed (n = 17,777, ≥15 years; 52% females). Difficulty seeing was self-reported in response to the question ‘‘Do you have difficulty seeing?” The international physical activity questionnaire (IPAQ) short form was used to measure level of physical activity. Multivariable logistic regression was used to assess associations overall and by age group (15–49, 50–64, ≥65 years). Covariates included in the analysis were sex, age, education, marital status, use of glasses or contact lenses, cataracts, diabetes, obesity, hypertension, smoking and alcohol consumption. The overall prevalence of difficulty seeing was 11%, and the overall prevalence of participating in less than 600 metabolic equivalent (MET)-min/week of physical activity was 30.2%. After adjustment for covariates, difficulty seeing was associated with significantly higher odds of performing less than 600 MET-min/week of physical activity with the odds ratio (OR) = 1.222 (95% confidence interval = 1.099–1.357). Considering the impact on health and quality of life due to reduced physical activity in people with difficulty seeing, at least 600 MET-min/week of physical activity should be promoted to this population.

scholarly journals Comorbidities at Diagnosis, Survival, and Cause of Death in Patients with Chronic Lymphocytic Leukemia: A Population-Based Study

2021 ◽  
Vol 18 (2) ◽  
pp. 701
Author(s):  
Alicia Villavicencio ◽  
Marta Solans ◽  
Lluís Zacarías-Pons ◽  
Anna Vidal ◽  
Montse Puigdemont ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Relative Survival ◽  
Organ Damage ◽  
Population Based ◽  
Lymphocytic Leukemia ◽  
Common Disease ◽  
Population Based Study ◽  
Comorbidity Index ◽  
Clinical Records ◽  
The Impact

This study aimed to examine the prevalence of comorbidities in patients diagnosed with chronic lymphocytic leukemia (CLL), and to assess its influence on survival and cause-specific mortality at a population-based level. Incident CLL cases diagnosed in the Girona province (Spain) during 2008–2016 were extracted from the Girona Cancer Registry. Rai stage and presence of comorbidities at diagnosis, further categorized using the Charlson comorbidity index (CCI), were obtained from clinical records. Observed (OS) and relative survival (RS) were estimated and Cox’s proportional hazard models were used to explore the impact of comorbidity on mortality. Among the 400 cases included in the study, 380 (99.5%) presented at least one comorbidity at CLL diagnosis, with diabetes without end organ damage (21%) being the most common disease. 5-year OS and RS were 68.8 (95% CI: 64.4–73.6) and 99.5 (95% CI 3.13–106.0), respectively, which decreased markedly with increasing CCI, particularly in patients with CCI ≥ 3. Multivariate analysis identified no statistically significant association between the CCI and overall CLL-related or CLL-unrelated mortality. In conclusion, a high CCI score negatively influenced the OS and RS of CLL patients, yet its effect on mortality was statistically non-significant when also considering age and the Rai stage.

Maternal Determinants Mediating the Impact of Household Poverty on the Nutritional Status of Children Under 5 Years of Age in Bangladesh

2021 ◽  
pp. 037957212199901
Author(s):  
Probir Kumar Ghosh ◽  
Pritimoy Das ◽  
Doli Rani Goswam ◽  
Ausraful Islam ◽  
Sukanta Chowdhury ◽  
...  
Keyword(s):  
Higher Education ◽  
Nutritional Status ◽  
Maternal Education ◽  
Prevalence Ratio ◽  
Household Wealth ◽  
Population Based ◽  
Maternal Factors ◽  
Household Poverty ◽  
Maternal Determinants ◽  
The Impact

Objectives: We explored the maternal determinants that mediate the effect of household poverty on childhood undernutrition. Methods: We used the population-based Bangladesh Demographic Health Survey data from 2014 for demographic characteristics, child and maternal factors. Results: Of the 7173 under-5 children, 3456 (48.2%) had undernutrition. The prevalence of undernutrition was less common in wealthy households (poorest vs richest: adjusted prevalence ratio [aPR] = 1.37), mothers having history of antenatal care (ANC) visits (no visit vs ≥4 visits: aPR = 1.22), maternal higher education (no education vs higher education: aPR = 1.54), and mothers with good nutritional status (underweight vs healthy: aPR = 1.13). The risk of undernutrition (37.1%) was attributed to household wealth, mediated 55% by maternal factors; of which 20% by maternal education, 21% by ANC visits, and 14% by maternal nutritional status. Conclusions: Our study findings outlined higher maternal education, ≥4 ANC visits and maternal good nutritional status in mediating the impact of household wealth on childhood nutrition.

Burdens of parents with epileptic children - Results of a study using a short-form of the German version of the Impact-on-Family-Scale

2012 ◽  
Vol 43 (02) ◽  
Author(s):  
L Dehn ◽  
E Korn-Merker ◽  
M Pfäfflin ◽  
H Fischbach ◽  
M Frantz ◽  
...  
Keyword(s):  
Short Form ◽  
German Version ◽  
Epileptic Children ◽  
Impact On Family ◽  
The Impact

Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study

2021 ◽  
Vol 184 (1) ◽  
pp. 19-28
Author(s):  
Alexander A Leung ◽  
Janice L Pasieka ◽  
Martin D Hyrcza ◽  
Danièle Pacaud ◽  
Yuan Dong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Administrative Data ◽  
Laboratory Data ◽  
Population Based ◽  
Incidence Rates ◽  
Primary Objective ◽  
Administrative Databases ◽  
Secondary Objective ◽  
True Frequency ◽  
Clinical Records

Objective Despite the significant morbidity and mortality associated with pheochromocytoma and paraganglioma, little is known about their epidemiology. The primary objective was to determine the incidence of pheochromocytoma and paraganglioma in an ethnically diverse population. A secondary objective was to develop and validate algorithms for case detection using laboratory and administrative data. Design Population-based cohort study in Alberta, Canada from 2012 to 2019. Methods Patients with pheochromocytoma or paraganglioma were identified using linked administrative databases and clinical records. Annual incidence rates per 100 000 people were calculated and stratified according to age and sex. Algorithms to identify pheochromocytoma and paraganglioma, based on laboratory and administrative data, were evaluated. Results A total of 239 patients with pheochromocytoma or paraganglioma (collectively with 251 tumors) were identified from a population of 5 196 368 people over a period of 7 years. The overall incidence of pheochromocytoma or paraganglioma was 0.66 cases per 100 000 people per year. The frequency of pheochromocytoma and paraganglioma increased with age and was highest in individuals aged 60–79 years (8.85 and 14.68 cases per 100 000 people per year for males and females, respectively). An algorithm based on laboratory data (metanephrine >two-fold or normetanephrine >three-fold higher than the upper limit of normal) closely approximated the true frequency of pheochromocytoma and paraganglioma with an estimated incidence of 0.54 cases per 100 000 people per year. Conslusion The incidence of pheochromocytoma and paraganglioma in an unselected population of western Canada was unexpectedly higher than rates reported from other areas of the world.

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