IQ in late adolescence/early adulthood, risk factors in middle age and later all-cause mortality in men: the Vietnam Experience Study

Adolescent girls have always been a relevant presence in the juvenile justice system but have received limited attention from researchers. In response to the dearth of studies on female juvenile offenders, federal study groups and reviewers have called for more research to advance our understanding of the risk factors for antisocial behavior among adolescent girls. To date, however, much of the research on antisocial behavior in adolescent girls has had relatively serious methodological limitations, including relying on correlational or cross-sectional designs and focusing on a limited range of risk factors (e.g., family or school). The current study addressed these limitations by longitudinally examining how risks assessed in early adolescence across multiple domains of youths' social ecology (i.e., individual, family, peer, school, and neighborhood) predicted antisocial behaviors in late adolescence and early adulthood for both females and males. A representative national sample of 1,033 youths and their caregivers completed structured interviews that assessed risk factors in early adolescence, and these risk factors were used to predict subsequent antisocial behaviors. Results of path analyses indicated that peer relationship variables and low levels of academic commitment were most predictive of male antisocial behavior in late adolescence, while physical abuse and age were most predictive of female antisocial behavior in late adolescence. However, most of these same variables no longer predicated antisocial behavior in early adulthood. Overall, the findings suggest that treatments for antisocial behavior should be flexible enough to target the risks that are most salient for male and female youths.

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Homelessness in early adulthood and biomedical risk factors by middle-age: the 1970 British Cohort Study

Journal of Epidemiology & Community Health ◽

10.1136/jech-2021-217457 ◽

2021 ◽

pp. jech-2021-217457

Author(s):

James W White ◽

Mark Hamer ◽

G David Batty

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Cohort Study ◽

Heart Disease ◽

Mental Health Problems ◽

Middle Age ◽

Early Adulthood ◽

Premature Mortality ◽

Glycated Haemoglobin ◽

Birth Cohort Study

BackgroundHomelessness has been linked to premature mortality but the relationship with biomedical risk factors is uncertain.MethodsWe analysed data from 8581 participants in the 1970 British Birth Cohort Study. Homelessness and type of experience were self-reported at 30 years of age. Nine biomarkers outcomes were collected at 46 years of age: body mass index (BMI), blood pressure, total and high-density cholesterol, triglycerides, glycated haemoglobin, C-reactive protein (CRP), insulin-like growth factor 1 and we computed the 10-year risk for coronary heart disease.ResultsBy 30 years of age, 5.8% of participants had been homeless with sofa surfing the most common experience (4.3%). Homelessness was associated with socioeconomic disadvantage, mental health problems and substance use in early adulthood, but these differences were not expressed in biomarkers. After accounting for early adulthood characteristics, residing in a bed and breakfast was associated with a higher BMI (0.59, 95% CI 0.13 to 1.05) and CRP (0.16, 95% CI 0.04 to 0.29), squatting with a lower BMI (−1.69, 95% CI –3.08 to −0.21) and rough sleeping with a higher 10-year risk of coronary heart disease (0.03, 95% CI 0.01 to 0.05).ConclusionsExposure to homelessness in early adulthood was essentially unrelated to biomarkers in middle age. Inconsistent links were found for specific types of experience.

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The development of fears from early adolesence to young adulthood: a multivariate study

Psychological Medicine ◽

10.1017/s0033291708002936 ◽

2008 ◽

Vol 38 (12) ◽

pp. 1759-1769 ◽

Cited By ~ 22

Author(s):

K. S. Kendler ◽

C. O. Gardner ◽

P. Annas ◽

P. Lichtenstein

Keyword(s):

Risk Factors ◽

Environmental Risk ◽

Common Factor ◽

Early Adulthood ◽

Late Adolescence ◽

Environmental Risk Factors ◽

Genetic Effects ◽

Animal Blood ◽

Time Specific ◽

The Impact

BackgroundCommon fears change over development. Genetic and environmental risk factors for fears are partly shared across fears and partly fear-specific. The nature of the changes in common and fear-specific genetic and environmental risk factors over time is unknown.MethodSelf-reported fears were obtained at ages 13–14, 16–17 and 19–20 from 2404 twins in the Swedish Twin Study of Child and Adolescent Development. A multivariate longitudinal twin analysis was conducted with Mx.ResultsEighteen individual items formed four fear factors: animal, blood-injury, situational, and social. The best-fit model had no quantitative or qualitative sex effects or shared environmental effects, but included a strong common factor with a stable cross-time structure with highest loadings on situational and lowest loadings on social fears. New common and fear-specific genetic risk factors emerged over development. With increasing age, genetic effects declined in overall importance and became more fear-specific. Cross-time continuity in specific genetic effects was highest for animal and lowest for social fears. Social fears had a ‘burst’ of specific genetic effects in late adolescence. Individual-specific environmental factors impacted both on the general fear factor and on specific fears. Compared to genetic effects, the impact of the unique environment was more time-specific.ConclusionsGenetic and environmental risk factors for individual fears are partly mediated through a common fear factor and are partly fear-specific in their effect. The developmental pattern of these risk factors is complex and dynamic with new common and specific genetic effects arising in late adolescence and early adulthood.

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Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

European Journal of Epidemiology ◽

10.1007/s10654-021-00732-w ◽

2021 ◽

Vol 36 (3) ◽

pp. 287-298

Author(s):

Jonathan Bergman ◽

Marcel Ballin ◽

Anna Nordström ◽

Peter Nordström

Keyword(s):

Risk Factors ◽

Down Syndrome ◽

Long Term Care ◽

Care Facility ◽

Prescription Medication ◽

Term Care ◽

Term Care Facility ◽

Long Term Care Facility ◽

All Cause Mortality

AbstractWe conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60–69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40–49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19.

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Socialization processes within adolescents’ relationships with parents and peers predicting couples’ intimate partner violence in adulthood: A social learning perspective

Development and Psychopathology ◽

10.1017/s0954579421000602 ◽

2021 ◽

pp. 1-14

Author(s):

Thao Ha ◽

Mark J. Van Ryzin ◽

Kit K. Elam

Keyword(s):

Risk Factors ◽

Substance Use ◽

Partner Violence ◽

Violent Behavior ◽

Early Adulthood ◽

Intimate Partner ◽

High Risk Sexual Behavior ◽

Self Reports ◽

Socialization Processes ◽

Risk Sexual Behavior

Abstract Previous studies have established that individual characteristics such as violent behavior, substance use, and high-risk sexual behavior, as well as negative relationships with parents and friends, are all risk factors for intimate partner violence (IPV). In this longitudinal prospective study, we investigated whether violent behavior, substance use, and high-risk sexual behavior in early adulthood (ages 22–23 years) mediated the link between family conflict and coercive relationship talk with friends in adolescence (ages 16–17 years) and dyadic IPV in adulthood (ages 28–30 years). A total of 998 individuals participated in multimethod assessments, including observations of interactions with parents and friends. Data from multiple reporters were used for variables of interest including court records, parental and self-reports of violence, self-reports of high-sexual-risk behaviors and substance use, and self- and romantic partner-reports of IPV. Longitudinal mediation analyses showed that violent behavior during early adulthood mediated the link between coercive relationship talk with friends in adolescence and dyadic IPV in adulthood. No other mediation paths were found and there was no evidence of gender differences. Results are discussed with attention to the interpersonal socialization processes by which IPV emerges relative to individual risk factors.

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Leisure time physical activity throughout adulthood is associated with lower medicare costs: evidence from the linked NIH-AARP diet and health study cohort

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2021-001038 ◽

2021 ◽

Vol 7 (1) ◽

pp. e001038

Author(s):

Diarmuid Coughlan ◽

Pedro F Saint-Maurice ◽

Susan A Carlson ◽

Janet Fulton ◽

Charles E Matthews

Keyword(s):

Physical Activity ◽

Healthcare Costs ◽

Middle Age ◽

Leisure Time Physical Activity ◽

Early Adulthood ◽

Later Life ◽

Health Study ◽

Activity Levels ◽

Physical Activity Levels ◽

Medicare Costs

BackgroundThere is limited information about the association between long-term leisure time physical activity (LTPA) participation and healthcare costs. The purpose of this study was to investigate the association between LTPA over adulthood with later life healthcare costs in the USA.MethodsUsing Medicare claims data (between 1999 and 2008) linked to the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, we examined associations between nine trajectories of physical activity participation throughout adulthood with Medicare costs.ResultsCompared with adults who were consistently inactive from adolescence into middle age, average annual healthcare costs were significantly lower for maintainers, adults who maintained moderate (–US$1350 (95% CI: –US$2009 to –US$690) or −15.9% (95% CI: −23.6% to −8.1%)) or high physical activity levels (–US$1200 (95% CI: –US$1777 to –US$622) or −14.1% (95% CI: −20.9% to −7.3%)) and increasers, adults who increased physical activity levels in early adulthood (–US$1874 (95% CI: US$2691 to –US$1057) or −22.0% (95% CI: −31.6% to −12.4%)) or in middle age (–US$824 (95% CI: –US$1580 to –US$69 or −9.7% (95% CI −18.6% to −0.8%)). For the four trajectories where physical activity decreased, the only significant difference was for adults who increased physical activity levels during early adulthood with a decline in middle age (–US$861 (95% CI:–US$1678 to –US$45) or −10.1% (95% CI: −19.7% to −0.5%)).ConclusionOur analyses suggest the healthcare cost burden in later life could be reduced through promotion efforts supporting physical activity participation throughout adulthood.

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Long-term survival after Carpentier-Edwards Perimount aortic valve replacement in Western Denmark: a multi-centre observational study

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-021-01506-x ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Lytfi Krasniqi ◽

Mads P. Kronby ◽

Lars P. S. Riber

Keyword(s):

Risk Factors ◽

Aortic Valve ◽

Aortic Valve Replacement ◽

Valve Replacement ◽

Significant Risk ◽

Valve Prosthesis ◽

Term Survival ◽

Long Term Survival ◽

All Cause Mortality

Abstract Background This study describes the long-term survival, risk of reoperation and clinical outcomes of patients undergoing solitary surgical aortic valve replacement (SAVR) with a Carpentier-Edwards Perimount (CE-P) bioprosthetic in Western Denmark. The renewed interest in SAVR is based on the questioning regarding the long-term survival since new aortic replacement technique such as transcatheter aortic-valve replacement (TAVR) probably have shorter durability, why assessment of long-term survival could be a key issue for patients. Methods From November 1999 to November 2013 a cohort of a total of 1604 patients with a median age of 73 years (IQR: 69–78) undergoing solitary SAVR with CE-P in Western Denmark was obtained November 2018 from the Western Danish Heart Registry (WDHR). The primary endpoint was long-term survival from all-cause mortality. Secondary endpoints were survival free from major adverse cardiovascular and cerebral events (MACCE), risk of reoperation, cause of late death, patient-prothesis mismatch, risk of AMI, stroke, pacemaker or ICD implantation and postoperative atrial fibrillation (POAF). Time-to-event analysis was performed with Kaplan-Meier curve, cumulative incidence function was performed with Nelson-Aalen cumulative hazard estimates. Cox regression was applied to detect risk factors for death and reoperation. Results In-hospital mortality was 2.7% and 30-day mortality at 3.4%. The 5-, 10- and 15-year survival from all-cause mortality was 77, 52 and 24%, respectively. Survival without MACCE was 80% after 10 years. Significant risk factors of mortality were small valves, smoking and EuroSCORE II ≥4%. The risk of reoperation was < 5% after 7.5 years and significant risk factors were valve prosthesis-patient mismatch and EuroSCORE II ≥4%. Conclusions Patients undergoing aortic valve replacement with a Carpentier-Edwards Perimount valve shows a very satisfying long-term survival. Future research should aim to investigate biological valves long-term durability for comparison of different SAVR to different TAVR in long perspective.

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Prediction of All-Cause Mortality Using an Echocardiography-Based Risk Score in Hemodialysis Patients

Cardiorenal Medicine ◽

10.1159/000507727 ◽

2020 ◽

pp. 1-11

Author(s):

Jing Zhu ◽

Chao Tang ◽

Han Ouyang ◽

Huaying Shen ◽

Tao You ◽

...

Keyword(s):

Risk Factors ◽

Cox Model ◽

Prognostic Score ◽

Basic Model ◽

Risk Of Mortality ◽

All Cause Mortality ◽

Cardiac Valve Regurgitation ◽

Stage Renal Disease ◽

End Stage ◽

Esrd Patients

Aim: To derive an echocardiography-based prognostic score for a 3-year risk of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Methods: 173 ESRD patients hospitalized in the second affiliated hospital of Soochow University from January 1, 2010, to July 31, 2016, were enrolled and followed up for 3 years. All subjects began to receive HD from recruitment. Baseline clinical and echocardiographic parameters were collected and screened for risk factors using univariate and multivariate analysis. The prognostic value of echocardiographic indexes was determined by concordance indexes and reclassification assay. Restricted cubic spline models (RCS) and forest plots were employed to visualize the association between risk factors and all-cause mortality. A multivariate nomogram including the identified factors was developed to estimate the prognosis. Results: After multivariate adjustment for advanced age, hypertension, diabetes, and decreased hemoglobin (Hb), echocardiographic indexes including left atrial diameter index (LADI), cardiac valvular calcification, and moderate to severe cardiac valve regurgitation were independently associated with the risk of 3-year mortality in HD patients. RCS showed that age, Hb, and LADI were positively associated with the risk of mortality. Adding multiple echocardiographic indexes to a basic model containing age, hypertension, diabetes, and Hb increased the concordance index and improved reclassification. A multivariate Cox model-derived nomogram showed the association between each factor and mortality by the end of follow-up. Conclusions: Echocardiographic indexes showed independent predictive power for mortality in ESRD patients and may constitute a promising prognostic tool in this population.

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