Psychiatric in-patients from Salford: the current problem and future demand.

Tuberculosis (TB) is a global health disaster and is a wide-reaching hitch. The improper use of antibiotics in chemotherapy of TB patients led to the current problem of tuberculosis therapy which gives rise to Multi-Drug Resistant (MDR) strains. Nitrogen heterocycles including azole compounds are an important class of therapeutic agent with electron-rich property. Azole-based derivatives easily bind with the enzymes and receptors in organisms through noncovalent interactions, thereby possessing various applications in medicinal chemistry. Research on azoles derivatives have been expansively carried out and have become one of the extremely active area in recent years and the progress is quite rapid. A genuine attempt to review chemistry of azoles and to describe various azole-based compounds synthesized in the last two decades having promising antitubercular potential is described in the present article. It is hopeful that azole compounds may continue to serve as an important direction for the exploitation of azole-based antitubercular drugs with better curative effect, lower toxicity, less side effects, especially fewer resistances and so on.

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FRI0431 PROFILE OF INFECTIOUS SPONDYLODISCITIS ACCORDING TO THE SITE: UNIFOCAL VERSUS MULTIFOCAL

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4844 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 814.3-814

Author(s):

A. Ben Tekaya ◽

L. Ben Ammar ◽

M. Ben Hammamia ◽

O. Saidane ◽

S. Bouden ◽

...

Keyword(s):

Current Problem ◽

Common Factor ◽

Cord Compression ◽

Posterior Arch ◽

Significant Difference ◽

Infectious Spondylodiscitis ◽

Vertebral Biopsy ◽

Inflammatory Syndrome ◽

Different Levels ◽

A Current

Background:Infectious spondylodiscitis is a therapeutic emergency and is a current problem. It can affect the different levels of the spine. Multifocal forms, touching several floors, however remain rare.Objectives:To compare the clinical, biological, radiological and therapeutic aspects of unifocal versus multifocal spondylodiscitis.Methods:This is a retrospective study of 113 patients admitted to our service over a period of 20 years [1998-2018]. The diagnosis of spondylodiscitis was made on the basis of clinical, biological, radiological and bacteriological data. We have divided our population into two groups: unifocal and multifocal spondylodiscitis.Results:Spondylodiscitis was more frequently unifocal (75.2%) than multifocal (24.8%). The average age of the patients was 55.8 years. There were 62 men and 51 women. There was no difference in age and sex between the two groups (p=0.5 and p=0.8, respectively).Diabetes was more frequent in the group of multifocal spondylodiscitis but with no statistically significant difference (p=0.4). No statistically significant difference between the two groups regarding the start mode (p=0.7), the schedule (p=0.3), the presence of neurological signs (p=0.7), fever (p = 0.2), impaired general condition (p=0.6) and biological inflammatory syndrome (p=0.6).Cervical and dorsal spine involvement was more common in multifocal spondylodiscitis (p = 0.02 and p = 0.01; respectively). There were 11 spondylodiscitis involving 2 floors (cervical and dorsal: 2 cases, cervical and lumbar: 3 cases, dorsal and lumbar: 6 cases) and 3 spondylodiscitis involving 3 floors.Radiologically, the presence of vertebral fracture and involvement of the posterior arch was more frequent during the multifocal form (p=0.03 and p=0.001; respectively). The frequency of para-vertebral abscesses, epiduritis and the presence of spinal cord compression were similar in the two groups (p=0.6; p=0.7 and p=0.2, respectively).Tuberculosis was more frequent during the multifocal form (p = 0.05) and brucellosis during the unifocal form (p = 0.03). Disco-vertebral biopsy was performed in 79 cases. It was more often contributory during multifocal spondylodiscitis (p = 0.03).The occurrence of immediate complications was more frequent in multifocal spondylodiscitis but with no statistically significant difference (p=0.2).Conclusion:Multifocal sppondylodiscitis is seen mainly in immunocompromised subjects. Our study found that diabetes is the most common factor in immunosuppression. Note also the predominance of involvement of the posterior elements, tuberculous origin and immediate complications.Disclosure of Interests:None declared

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The protein challenge: matching future demand and supply in Indonesia

Biofuels Bioproducts and Biorefining ◽

10.1002/bbb.2176 ◽

2021 ◽

Author(s):

Yessie W Sari ◽

Widyarani ◽

Johan P M Sanders ◽

Hero J Heeres

Keyword(s):

Demand And Supply ◽

Future Demand

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Employment Trends in Geography, Part 3: Future Demand Conditions

The Professional Geographer ◽

10.1111/j.0033-0124.1995.00336.x ◽

1995 ◽

Vol 47 (3) ◽

pp. 336-346 ◽

Cited By ~ 3

Author(s):

Patricia Gober ◽

Amy K. Glasmeier ◽

James M. Goodman ◽

David A. Plane ◽

Howard A. Stafford ◽

...

Keyword(s):

Employment Trends ◽

Future Demand

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Influence of Alkalinity and Ambient Temperature on Long-Term Properties of GFRP Reinforcement

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.760.213 ◽

2018 ◽

Vol 760 ◽

pp. 213-218

Author(s):

František Girgle ◽

Lenka Bodnárová ◽

Ondřej Januš ◽

Vojtěch Kostiha

Keyword(s):

Tensile Strength ◽

Ambient Temperature ◽

Mechanical Characteristics ◽

Current Problem ◽

Concrete Structures ◽

Experimental Program ◽

Glass Fibres ◽

Metallic Reinforcement ◽

Gfrp Reinforcement

The article deals with the current problem of determining long-term reliability of non-metallic reinforcement in concrete structures. The alkaline environment of concrete with a pH higher than 12.0 affects the glass fibres degradative, whereas this degradation presents by reduction of their mechanical characteristics, resulting in a decrease in the tensile strength of the whole composite. The article summarizes the results of the ongoing experimental program so far, which aims to quantify this influence.

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SOCIAL STRUCTURE AND EDUCATIONAL LEVEL OF TEACHERS OF THE UZBEKISTAN SSR

Journal of look to the past ◽

10.26739/2181-9599-2021-7-6 ◽

2021 ◽

Vol 4 (7) ◽

pp. 34-43

Author(s):

Muysin Dusaliev ◽

Keyword(s):

Public Education ◽

Education System ◽

Educational Level ◽

Primary Schools ◽

Current Problem ◽

Educational Institutions ◽

Religious Schools ◽

Soviet Government ◽

Public Education System ◽

The Impact

The article highlights the problems and needs of the population for education as a result of the concentration of the Soviet government on the formation of a public education system in the spirit of its socialist ideas by creating new Soviet schools and increasing their number.In November 1918,the Soviet government of Turkestan decided to separate church from state and school from church. Although the existing private old religious schools were not completely banned by this decision, the creation of new Soviet schools and the increase in their number became more and more important. It is clear that this is a sign that the system is completely politicized. The schools were divided into two levels: the first level educational institutions included the first three classes, and the second level consisted of four classes. There was also a high school with three classes. Under the conditions of that time, more primary schools were opened in the country.This article discusses the current problem in the Soviet-era public education system under the Soviet government from 1994 to 1991, as well as the impact of this problem on today's education system

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The Role of Immigrants in Solving the Problem of the Shortage of Skilled Labor in Germany

Scientific Research and Development Modern Communication Studies ◽

10.12737/2587-9103-2021-43-46 ◽

2021 ◽

Vol 10 (1) ◽

pp. 43-46

Author(s):

N. Krutova-Soliman

Keyword(s):

Current Problem ◽

Professional Activity ◽

Federal Republic Of Germany ◽

Multicultural Society ◽

Skilled Workers ◽

Business World ◽

State Security ◽

Activity Component ◽

Integration Of Immigrants

The article is devoted to the current problem of the shortage of qualified labor in the Federal Republic of Germany and the question of whether the country's economy is acquiring potential specialists for the labor market from among immigrants. The author emphasizes that without successful integration of immigrants, it is impossible not only to acquire human capital for the country's economy, but also there is a real threat to state security in Germany. The article examines what qualities or system of qualities immigrants should acquire in order to increase the level of professional activity component of their ability to integrate into the host country's society, specifies the goals of pedagogical communication in this process and the importance of the adoption of the Skilled Workers Immigration Act (Fachkräfteeinwanderungsgesetz). The author comes to the conclusion that the professional and activity component formed by the immigrant demonstrates its full integration into the business world and multicultural society of Germany.

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QUALITY OF LIFE ASSESSMENT IN PATIENTS WITH ARTERIAL HYPERTENSION (LITERATURE REVIEW)

10.12731/2658-4034-2021-12-1-2-178-184 ◽

2021 ◽

Author(s):

OLGA MOSKALENKO ◽

ROMAN YASKEVICH

Keyword(s):

Quality Of Life ◽

Arterial Hypertension ◽

Current Problem ◽

Life Assessment ◽

Review Of The Literature ◽

Quality Of Life Assessment ◽

The Common ◽

The Individual ◽

Satisfactory Quality

A review of the literature on the current problem of medicine is presented. Arterial hypertension is one of the common chronic diseases for which the current goal of therapy is not recovery, but improvement of circulatory function with a satisfactory quality of life. The study of QOL and the factors influencing it can contribute to an increase in the individual effectiveness of treatment and complex rehabilitation of patients suffering from this pathology.

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