scholarly journals Haemoglobin-H disease presenting with microcytic hypochromic anaemia in an 81 year old woman.

1993 ◽  
Vol 69 (818) ◽  
pp. 930-931
Author(s):  
O. M. Jolobe
Keyword(s):  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

Reticulocyte Parameters in Microcytic Hypochromic Anaemias Using Beckman Coulter DxH800 – A Study from Kerala, India

2021 ◽  
Vol 8 (14) ◽  
pp. 888-892
Author(s):  
Blessy Mary Thomas ◽  
Sheila Das ◽  
Sunil Antony ◽  
Alice David
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Response To Therapy ◽  
Control Group ◽  
Blood Samples ◽  
Deficiency Anaemia ◽  
Chronic Disorder ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

BACKGROUND Microcytic hypochromic anaemia is commonly due to iron deficiency, anaemia of chronic disorder [ACD] and thalassaemic syndromes. Reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anaemias and monitoring bone marrow response to therapy METHODS All samples were selected from routine blood counts, and sent for investigation of anaemia, over a period of two years. These samples were run on the DxH800 (Beckman Coulter). 385 cases were selected for the study. Blood analysis for all these cases had been requested by general practitioners to investigate anaemia. These blood samples had been collected in ethylenediaminetetraacetic acid (EDTA) anticoagulant vacutainers and processed within 2 hours of collection. Determination of red cell and reticulocyte parameters in all blood samples, was performed using the Beckman Coulter 7-part analyser [Unicell DxH 800]. RESULTS Of the 156 cases of microcytic hypochromic anaemia studied, iron deficiency anaemia (IDA) was present in 91 cases, anaemia of chronic disorder (ACD) in 50 cases, beta thalassemia trait (BTT) in 15 cases. Of the 50 ACD cases, 37 were associated with IDA. The control group comprised of 229 adult medical students (143 women and 103 men) with a median age of 18.84 ± 0.98 years. We also had 4 cases of other haemoglobinopathies, which were microcytic hypochromic, but were not included in our study as the number of cases was too less to be analysed. CONCLUSIONS New reticulocyte parameters are useful for evaluation of iron status and diagnosing iron deficiency anaemias. They also are reliable parameters for recognising subsets of anaemic patients thereby improving the management of anaemia. KEYWORDS Reticulocyte, Microcytic, Hypochromic, Anaemia, Beckman Coulter

scholarly journals PICA with microcytic hypochromic anaemia and hookworm infestation: A case report

2014 ◽  
Vol 5 (9) ◽  
pp. 585
Author(s):  
Bilkisu Ilah Garba ◽  
MS Aminu ◽  
SO Onazi ◽  
B Edem ◽  
T Kolawole ◽  
...  
Keyword(s):  
Case Report ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

scholarly journals Severe Microcytic Anaemia due to Chrohn's Disease - An Uncommon Presentation

2013 ◽  
Vol 21 (2) ◽  
pp. 101-104
Author(s):  
Md Abul Kalam Azad ◽  
Monzoor Quader ◽  
Mohammad Ferdous Ur Rahaman ◽  
Md Abdur Rahim ◽  
Aklima Khanam ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Uncommon Presentation ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Uncommon Disease ◽  
Significant Clinical Improvement ◽  
Subacute Intestinal Obstruction ◽  
One Year ◽  
Diagnostic Work ◽  
Medical University

Crohn’s disease is an uncommon disease. Most common presentation is abdominal pain, diarrhea and weight loss. It may present as subacute or even acute intestinal obstruction. Crohn’s disease is very rare in Bangladesh. Here we report a case of Crohn’s disease where the initial presentation was severe microcytic hypochromic anaemia. Who had repeated blood transfusion for one year. Initially cause was not detected. Later on he presented with subacute intestinal obstruction. After all diagnostic work up no definitive diagnosis could be found. So laparotomy was done in Bangabandhu Shiekh Mujib Medical University (BSMMU). Histopathology report was suggestive of Crohn’s disease and he was on mesalazine with significant clinical improvement. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13620 Bangladesh J Medicine 2010; 21: 101-104

scholarly journals Sehgal index and its comparison with Mentzer's index and Green and King index in assessment of peripheral blood smear with marked anisopoikilocytosis

2020 ◽  
Vol 8 (8) ◽  
pp. 2972
Author(s):  
Naincy Rastogi ◽  
Arvind S. Bhake
Keyword(s):  
Developing Countries ◽  
Peripheral Blood ◽  
Predictive Value ◽  
Complete Blood Count ◽  
Blood Film ◽  
Beta Thalassemia ◽  
Cell Parameters ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Youden’S Index

Background: Mild microcytic hypochromic anaemias due to iron deficiency (IDA) and beta thalassemia trait(β-TT) continue to be a cause of significant burden to the society, particularly in the poorer developing countries. The objective of the present study was to study the RBC based indices in patients of marked anisopoikilocytosis in determining the etiology of it, to standardize few automated red cell parameters, and also objective grading of RBC morphology on peripheral smear and interpreting its utility in indicating a diagnosis. Also, to establish a relation between value of RBC indices with that of degree of anisocytosis.Methods: A total of 500 patients diagnosed with mild microcytic hypochromic anaemia on complete blood count and peripheral blood film were included in the study. Hb, RBC count, MCV, MCH and RDW obtained from the electronic cell counter were used to calculate discrimination indices by various mathematical formulae. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden’s index (YI) were calculated.Results: Green and King index demonstrated the lowest sensitivity of 70.51%. Mentzer index demonstrated the highest specificity of 96.80%. The highest and lowest PPV were found for Mentzer index (97.09%) and Sehgal index (92.81%) respectively. Sehgal’s index demonstrated the highest NPV of 95.96% and lowest NPV was exhibited by G and K (87.9%). The highest and the lowest values for Youden’s index were shown by Sehgal’s index (87.82%) and G and K index (68.47%).Conclusions: Sehgal’s index followed by Mentzer index are highly sensitive and reasonably specific in differentiating β-TT from IDA and none of the indices is 100% sensitive and specific. Though HbA2 estimation is the gold standard for diagnosing β-TT, in developing countries, Sehgal index followed by Mentzer et al, index can be used to screen mild microcytic hypochromic anaemia cases to eliminate as many false positive cases as possible to reduce the financial cost.

scholarly journals A Mesothelial Inclusion Cyst Presenting in a 40-Year-Old Woman as Abdominal Pain and Bloating – A Rare Diagnosis

2020 ◽  
Author(s):  
Sonia Canadas ◽  
Rita Fernandes ◽  
Hugo Almeida ◽  
João Santiago Correia
Keyword(s):  
Abdominal Pain ◽  
Abdominal Mass ◽  
Tumour Marker ◽  
Ca 125 ◽  
Inclusion Cyst ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
History Of ◽  
Cystic Abdominal Mass ◽  
Work Up

Cystic mesotheliomas (also called mesothelial inclusion cysts) are rare benign neoplasms that occur more often in young women. Symptoms are usually non-specific, demanding a thorough work-up. We report a case of a 40-year-old female patient with 2 prior caesarean sections presenting with a 3-month history of abdominal pain. Laboratory tests revealed microcytic hypochromic anaemia and an elevated tumour marker CA-125. An investigation identified a large cystic abdominal mass, mostly in the left side of the abdomen. A laparotomy was performed with total resection of the lesion. Histological assessment resulted in a diagnosis of a mesothelial inclusion cyst. The patient had no recurrence after 3 years.

Hematological Changes in Dogs Affected with Canine Babesiosis

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
A. K. Bilwal ◽  
G. C. Mandali ◽  
A. C. Patel
Keyword(s):  
Blood Cell ◽  
Haemoglobin Concentration ◽  
Canine Babesiosis ◽  
Corpuscular Haemoglobin ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Mean Corpuscular Haemoglobin ◽  
Wbc Count ◽  
Hematological Changes ◽  
Hematological Evaluation

Canine babesiosis caused by tick-borne organisms of the genus Babesia, is one of the most significant disease worldwide. The aim of this study was to determine the haematological changes in dogs naturally infected with Babesia. The hematological evaluation included haemoglobin (Hb), red blood cell (RBC) count, platelets, white blood cell (WBC) count, differential leucocyte count (DLC), packet cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC). The haematological findings in most of these dogs revealed microcytic hypochromic anaemia, lowered platelet count and 75% cases had 24% decreased PCV. The results of the study showed that Babesia infection in dogs caused anaemia and thrombocytopenia.

MORPHOLOGICAL EVALUATION OF ANAEMIA CASES IN DIFFERENT AGE GROUPS IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

2020 ◽  
pp. 59-60
Author(s):  
Arti Gupta ◽  
Pankaj Kumar Gupta ◽  
Pushpendra Kumar Gupta ◽  
Abhishree Geda
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Developed Countries ◽  
Reproductive Age ◽  
Care Hospital ◽  
Age Group ◽  
Adult Females ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Developing And Developed Countries

Introduction: Anaemia is prevalent clinical condition in both developing and developed countries so it needs constant evaluation. As morphological study of red blood cell is initial and cheep tool for approach to causative factors here is an attempt to evaluate morphological distribution of anaemia. Aims and objectives: 1-To study distribution of anaemia in different age and sex category. 2-To determine morphological pattern of anaemia in all age groups. Material and Methods: A total of 752 anaemic samples were studied by peripheral smear examination, Samples were also run in automated cell counter to nd red cell parameters WHO Criteria were used as cut off for haemoglobin concentration Results: Among Seven hundred fty two cases , paediatric age group include 92 cases (12.23%), adult male aged 12 to 65 years include 160 patients (21.27%) , adult female aged 12 to 65 years was 476 ( 63.29%) and elderly patients more than 65 years was 24 (3.19%).Among all 752 cases 311 patients (41.3%) were having microcytic hypochromic anaemia Conclusion: To conclude in our study maximum numbers of cases are observed in adult females in reproductive age group. In both adult females and children maximum number of cases is having microcytic hypochromic anaemia due to iron deciency. So it is important to focus on screening, early dietary modication and supplemental therapy to reduce anaemia prevalence in the developing and developed countries.

scholarly journals Rare presentation of iron deficiency anaemia with cerebral venous sinus thrombosis in a middle-aged woman

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-225851 ◽  
Author(s):  
Amna Bibi ◽  
Chathuri Liyanapthirana ◽  
Sajjad Khan
Keyword(s):  
Iron Deficiency ◽  
Sinus Thrombosis ◽  
Anticoagulation Therapy ◽  
Cerebral Venous Sinus Thrombosis ◽  
Good Prognosis ◽  
Rare Presentation ◽  
Aged Woman ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Middle Aged Woman

This is a case of a female patient presented with a mild headache associated with recurrent episodes of nausea and vomiting, confusion and right-sided hemiparesis, diagnosed of haemorrhagic venous infarction from the thrombosis of left transverse and sigmoid sinus and probably the left vein of Labbe. She had severe microcytic hypochromic anaemia due to iron deficiency, without any other risk factors for cerebral venous thrombosis such as trauma history, infections, coagulation disorders or autoimmune diseases. She had a good prognosis after iron supplementation and anticoagulation therapy.

scholarly journals Studies of the toxicity of copper to pigs

1966 ◽  
Vol 20 (2) ◽  
pp. 135-148 ◽  
Author(s):  
N. F. Suttle ◽  
C. F. Mills
Keyword(s):  
Live Weight ◽  
Hemoglobin Concentration ◽  
Aspartate Transaminase ◽  
Transaminase Activity ◽  
Large White ◽  
Growth Depression ◽  
Litter Mate ◽  
Small Risk ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

1. Six groups of four litter-mate female Large White pigs of about 17 kg live weight were allocated according to a 2×2 factorial design in each of two experiments in which rations containing 0 or 750 ppm copper were offered with either 0 and 500 ppm zinc, or 0 and 750 ppm iron. 2. Severity of toxicosis was assessed by determining aspartate transaminase activity in serum, observing the incidence of jaundice and determining the hemoglobin concentration in whole blood and Cu concentration in serum and liver. 3. Addition of 750 ppm Cu to the diet caused toxicity in nine out of twelve animals; it was most severe after about 4 weeks when two-to five-fold increases in serum Cu and aspartate transaminase levels were found and seven pigs were jaundiced. Serum Cu and aspartate transaminase concentrations and degrees of jaundice were apparently interrelated and returned to normal levels after 6 weeks, suggesting adaptation to the high Cu intake. Growth depression and a microcytic hypochromic anaemia persisted. 4. Addition of 500 ppm Zn or 750 ppm Fe in the presence of 750 ppm Cu eliminated jaundice and produced serum Cu and aspartate transaminase concentrations similar to control values after 4 weeks. Only supplementary Fe afforded protection against anaemia. 5. Variability in the response of the pig to Cu supplements could be partly due to variations in the intake of Fe and Zn. The addition of Fe and Zn supplements to pig diets supplemented with Cu would probably reduce the small risk of causing Cu poisoning.

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