Genodermatoses with behavioural sequelae

2021 ◽  
pp. postgradmedj-2020-139539
Author(s):  
Lamiaa Hamie ◽  
Edward Eid ◽  
Joanna Khalil ◽  
Rayah Touma Sawaya ◽  
Ossama Abbas ◽  
...  
Keyword(s):  
Early Recognition ◽  
Treatment Strategies ◽  
Mental Health Disorders ◽  
History Taking ◽  
Behavioural Disorders ◽  
Childhood Mental Health ◽  
Increased Risk ◽  
Health Disorders ◽  
The Individual ◽  
Psychiatric Screening

Children with genodermatoses are at an increased risk of developing behavioural disorders which may impart lasting damage on the individual and their family members. As such, early recognition of childhood mental health disorders via meticulous history taking, thorough physical examination, and disorder-specific testing is of paramount importance for timely and effective intervention. If carried out properly, prompt psychiatric screening and intervention can effectively mitigate, prevent or even reverse, the psychiatric sequela in question. To that end, this review aims to inform the concerned physician of the manifestations and treatment strategies relevant to the psychological sequelae of genodermatoses.

The non-specific nature of mental health and structural brain outcomes following childhood trauma

2021 ◽  
pp. 1-10
Author(s):  
Theresa K. Haidl ◽  
Dennis M. Hedderich ◽  
Marlene Rosen ◽  
Nathalie Kaiser ◽  
Mauro Seves ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Childhood Trauma ◽  
Brain Structure ◽  
Mental Health Disorders ◽  
Recent Onset ◽  
Increased Risk ◽  
Health Disorders ◽  
Structural Brain

Abstract Background Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by structural brain changes. Our aim was to explore whether (i) a predictive CT pattern for transdiagnostic psychopathology exists, and whether (ii) CT can differentiate between distinct diagnosis-dependent psychopathology. Furthermore, we aimed to identify the association between CT, psychopathology and brain structure. Methods We used multivariate pattern analysis in data from 643 participants of the Personalised Prognostic Tools for Early Psychosis Management study (PRONIA), including healthy controls (HC), recent onset psychosis (ROP), recent onset depression (ROD), and patients clinically at high-risk for psychosis (CHR). Participants completed structured interviews and self-report measures including the Childhood Trauma Questionnaire, SCID diagnostic interview, BDI-II, PANSS, Schizophrenia Proneness Instrument, Structured Interview for Prodromal Symptoms and structural MRI, analyzed by voxel-based morphometry. Results (i) Patients and HC could be distinguished by their CT pattern with a reasonable precision [balanced accuracy of 71.2% (sensitivity = 72.1%, specificity = 70.4%, p ≤ 0.001]. (ii) Subdomains ‘emotional neglect’ and ‘emotional abuse’ were most predictive for CHR and ROP, while in ROD ‘physical abuse’ and ‘sexual abuse’ were most important. The CT pattern was significantly associated with the severity of depressive symptoms in ROD, ROP, and CHR, as well as with the PANSS total and negative domain scores in the CHR patients. No associations between group-separating CT patterns and brain structure were found. Conclusions These results indicate that CT poses a transdiagnostic risk factor for mental health disorders, possibly related to depressive symptoms. While differences in the quality of CT exposure exist, diagnostic differentiation was not possible suggesting a multi-factorial pathogenesis.

The Architecture and Early Findings of a Working SMS-Based System for Individuals with Mild to Moderate Depression

2013 ◽  
pp. 20-32
Author(s):  
Elizabeth M. LaRue ◽  
Hassan A. Karimi ◽  
Ann M. Mitchell ◽  
Joy Y. Zang
Keyword(s):  
Health Care Professionals ◽  
Emotional State ◽  
Mental Health Disorders ◽  
Emotional Reaction ◽  
Text Messages ◽  
Mobile Technologies ◽  
The World ◽  
Health Disorders ◽  
The Individual

Depression is one of the leading mental health disorders in the world. With an exponential rate of growth, the disease will soon surpass the ability of health care professionals to monitor and treat individuals. The use of mobile technologies offers new insights into disease progression, real-time emotional reaction data collection, and care in vivo. This chapter describes the architecture of a software system that continuously monitors an individual’s emotional state through SMS and responds to the individual with supportive text messages. Along with early findings from the working system, the development of the emotional state queries and responses is described.

scholarly journals Management of mental health disorders and central nervous system sequelae in HIV-positive children and adolescents

2014 ◽  
Vol 15 (3) ◽  
pp. 81-96 ◽  
Author(s):  
R Nassen ◽  
K Donald ◽  
K Walker ◽  
S Paruk ◽  
M Vujovic ◽  
...  
Keyword(s):  
Mental Health ◽  
Central Nervous System ◽  
Nervous System ◽  
Mental Disorders ◽  
Children And Adolescents ◽  
Mental Health Disorders ◽  
Hiv Positive ◽  
Increased Risk ◽  
Health Disorders ◽  
The Impact

HIV-positive children and adolescents are at increased risk of both central nervous system (CNS) sequelae and mental disorders owing to a number of factors, including the impact of HIV infection on the brain, social determinants of health (e.g. poverty and orphanhood) and psychosocial stressors related to living with HIV. Every effort should be made to identify perinatally HIV-infected children and initiate them on antiretroviral therapy early in life. HIV clinicians should ideally screen for mental health and neurocognitive problems, as part of the routine monitoring of children attending antiretroviral clinics. This guideline is intended as a reference tool for HIV clinicians to support the early identification, screening and management of mental health disorders and/or CNS impairment in children and adolescents. This guideline covers mental disorders (section 1) and HIV-associated neurocognitive disorders (section 2) among children and adolescents.  

Therapie des Typ-2-Diabetes

2020 ◽  
Vol 145 (09) ◽  
pp. 593-600
Author(s):  
Dirk Müller-Wieland ◽  
Nikolaus Marx
Keyword(s):  
Cardiovascular Risk ◽  
Treatment Strategies ◽  
Patient Profile ◽  
Typ 2 Diabetes ◽  
Increased Risk ◽  
Cardiovascular Endpoint ◽  
The Individual ◽  
Very High ◽  
Hba1c Levels

AbstractNew joint clinical recommendations for the treatment of patients with type 2 diabetes of the european (EASD) and american (ADA) diabetes associations and the european society for cardiology (ESC) implement the evidence from clinical cardiovascular endpoint studies into daily clinical practice. The individual patient profile and it´s cardiovascular risk rather than HbA1c levels alone dominate treatment strategies. In case of high oder very high cardiovascular risk GLP-1-receptor agonists or SGLT-2-inhibitors are the preferred choice, the latter especially in patients with chronic heart failure or increased risk, respectively.

Sign in / Sign up

Export Citation Format

Share Document