scholarly journals Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT

RMD Open ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e001424
Author(s):  
Nienke J Kleinrensink ◽  
Wouter Foppen ◽  
Iris Ten Katen ◽  
Pieternella H van der Veen ◽  
Bo de Klerk ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Metabolic Activity ◽  
Structural Damage ◽  
Plantar Fascia ◽  
Whole Body ◽  
Mri Findings ◽  
Imaging Results ◽  
Pet Ct ◽  
Mri Scans ◽  
Structural Disease

ObjectiveTo compare the Heel Enthesitis MRI Scoring model (HEMRIS) with clinical and PET/CT outcomes in patients with cutaneous psoriasis (Pso), psoriatic arthritis (PsA) or ankylosing spondylitis (AS).MethodsThis prospective, observational study included 38 patients with Pso, PsA and AS. Patients were included regardless of presence or absence of clinical heel enthesitis. MRI-scans of both ankles and a whole-body 18F-FDG PET/CT were acquired. MRIs were assessed for enthesitis by two independent and blinded observers according to the HEMRIS. A physician, blinded for imaging results, performed clinical evaluations of enthesitis at the Achilles tendon and plantar fascia.ResultsIn total, 146 entheses were scored according to the HEMRIS and clinically assessed for enthesitis (6 entheses were clinically affected). In Achilles tendons with clinical enthesitis, the HEMRIS structural damage score was significantly higher, compared to Achilles tendons without clinical enthesitis (respective median scores 1.0 and 0.5; p=0.04). In clinically unaffected entheses, HEMRIS abnormalities occurred in 44/70 (63%) of Achilles tendons and in 23/70 (33%) of plantar fascia. At the Achilles tendon, local metabolic activity measured on PET/CT was weakly associated with the structural (rs=0.25, p=0.03) and total HEMRIS (rs=0.26, p=0.03).ConclusionThis study revealed a high prevalence of subclinical HEMRIS abnormalities and discrepancy between HEMRIS and clinical and PET/CT findings. This may suggest that the HEMRIS is a sensitive method for detection of inflammatory and structural disease of enthesitis at the Achilles tendon and plantar fascia, although the clinical significance of these MRI findings remains to be determined in longitudinal studies.

Imaging metastatic prostate cancer with 18F-DCFBC PET/CT (DCFBC) and 18F-NaF PET/CT (NaF).

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 231-231
Author(s):  
Farhad Fakhrejahani ◽  
Maria Liza Lindenberg ◽  
Ethan S. Bargvall ◽  
Esther Mena ◽  
Baris Turkbey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Soft Tissue ◽  
Functional Imaging ◽  
Metastatic Prostate Cancer ◽  
Whole Body ◽  
Inverse Association ◽  
Non Invasive ◽  
Imaging Results ◽  
Pet Ct ◽  
Antiandrogen Therapy

231 Background: Conventional imaging of advanced prostate cancer (computerized tomography and nuclear bone scintigraphy) is limited and indicates a need for a more specific molecular imaging probe. DCFBC is a radiolabeled PET agent that binds with high affinity to prostate specific membrane antigen (PSMA), which is overexpressed in almost all prostate cancers and through whole-body non-invasive functional imaging, may provide new information on the expression of PSMA. We compare the uptake of DCFBC in bone with respect to NaF PET/CT in metastatic prostate cancer patients. DCFBC has added capability to detect soft tissue metastasis whereas NaF is confined to secondary effects of bone disease. Methods: Subjects with known or suspected prostate cancer metastasis underwent DCFBC PET/CT imaging performed at 1 hour and 2 hours after IV bolus injection of 8 mCi of DCFBC. Patients also underwent a whole body NaF PET/CT scan within 3 weeks of DCFBC PET/CT to assess for bone metastases. Patients received 3 mCi of NaF IV bolus and then were imaged 1hour post injection. PSA levels and antiandrogen therapy status were obtained at the time of DCFBC imaging. Results: Fifteen patients have been preliminarily analyzed. PSA ranged from < .01 to 4379 ng/mL. NaF identified bone lesions in 10 patients but matching focal DCFBC uptake was only seen in 3 patients. DCFBC additionally showed lymph node metastasis in 1of these 3 patient. There were 5 patients without focal abnormal bone uptake on NaF or DCFBC. In this group, 4 of 5 patients had focal DCFBC uptake in lymph nodes or soft tissue lesions. Ten patients were on some form of androgen deprivation therapy (ADT). For those on ADT, 7 of 10 patients had positive findings on NaF, compared to 2 of 10 patients on DCFBC. Conclusions: DCFBC uptake in bone metastasis does not routinely correspond to focal NaF uptake which could be due to distinct mechanisms of tracer uptake and tumor biology. There is an inverse association in focal bone findings when comparing each tracer on antiandrogen therapy. Through whole-body non-invasive functional imaging and further study, DCFBC may prove useful in characterizing prostate cancer based on PSMA expression. Clinical trial information: NCT02190279.

Alveolar echinococcosis: correlation between hepatic MRI findings and FDG-PET/CT metabolic activity

2014 ◽  
Vol 40 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Amel Azizi ◽  
Oleg Blagosklonov ◽  
Ahmed Lounis ◽  
Louis Berthet ◽  
Dominique-Angèle Vuitton ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Fdg Pet ◽  
Alveolar Echinococcosis ◽  
Mri Findings ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method

2020 ◽  
Author(s):  
Abudusalamu Aini ◽  
Maiweilidan Yimingjiang ◽  
Aimaiti Yasen ◽  
Bo Ran ◽  
Tiemin Jiang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Metabolic Activity ◽  
Sampling Method ◽  
Alveolar Echinococcosis ◽  
Basic Research ◽  
Necrotic Lesion ◽  
Surgical Removal ◽  
Position Emission Tomography ◽  
Imaging Results ◽  
Pet Ct

Abstract Background: Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery and obtaining liver samples for basic research targeting immunology. However, little is known about quantification of LME range and its’ metabolic activity regarding different lesion types. Materials and Methods: A prospective analysis of LME from consecutive surgical AE cases with relevant imaging results was performed. Patients (n=39) received abdominal computed tomography (CT) and position emission tomography/computed tomography using 18F-fluodeoxyglucose (18F-FDG-PET/CT) within one week prior to surgery. Tumor to background ratios (TBRs) of standard uptake value (SUV) in PET/CT was calculated for corresponding LME regions. Multi-site sampling method (MSS, n=26) was introduced to obtain histological slides from LME at different levels off the lesion to evaluate immune cell infiltrative ranges quantitatively. At last, data was statistically analyzed from the perspective of different lesion types. Results: Altogether six major lesion categories have been identified based on different morphology and calcification pattern (A: non-calcified uniform density lesion; B: diffuse calcified solid lesion; C: half necrotic and half solid lesion with minor calcification; D: half necrotic and half solid lesion with obvious calcification; E: subtotal necrotic lesion with minor calcification; F: total necrotic lesion with obvious calcification). Statistical significances were resulted from TBRs calculation (A>B, A>D, A>F, BB+D+F, etc.). Less calcified lesions were evidenced with higher TBRs, however, not much was valuable for necrosis. The 95% CI of LME ranges were (10.0, 12.1) mm and (9.9, 14.0) mm by PET/CT and MSS. And, weak regressions between TBRs and LME ranges indicated by PET/CT or MSS (r2 respectively were 0.2436 and 0.3171) were observed. Conclusions: PET/CT showed distinct TBRs for different lesion types with heterogenic calcification. PET/CT and MSS had similar discoverability for LME ranges, which also varied among different lesion types. Higher activity meant wider LME range within certain limit. This pioneering study would be able to provide references for both surgical removal of lesions and sample acquisitions more accurately for basic research targeted to immunology.

scholarly journals Prospective Comparison of 18-FDG PET/CT and Whole-Body MRI with Diffusion-Weighted Imaging in the Evaluation of Treatment Response of Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplant

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1938
Author(s):  
Charles Mesguich ◽  
Valérie Latrabe ◽  
Cyrille Hulin ◽  
Axelle Lascaux ◽  
Laurence Bordenave ◽  
...  
Keyword(s):  
Treatment Response ◽  
Fdg Pet ◽  
Diffusion Weighted Imaging ◽  
Whole Body ◽  
Newly Diagnosed ◽  
Whole Body Mri ◽  
Post Induction ◽  
Imaging Results ◽  
Pet Ct ◽  
Fdg Pet Ct

To compare the prognostic values of 18-FDG PET/CT (FDG-PET) and Whole-Body MRI with Diffusion-Weighted Imaging (WB-DW-MRI) in the evaluation of treatment response of Multiple Myeloma (MM) patients eligible for ASCT. Thirty patients with newly diagnosed MM prospectively underwent FDG-PET and WB-DW-MRI at baseline, after induction chemotherapy and after ASCT. Response on WB-DW-MRI was evaluated with the MY-RADS criteria. FDG-PET was considered positive if residual uptake was superior to liver uptake. Imaging results were not used for treatment modification. The impact of imaging results on PFS was analyzed. After a median follow-up of 32 months, 10 patients relapsed. With WB-DW-MRI, post-induction examination was positive in 3/25 and post-ASCT examination was positive in 3/27 patients. However, neither study showed prognostic impact on PFS. FDG-PET was positive in 5/22 post-induction and 3/26 patients post-ASCT, respectively. Positivity of FDG-PET, post-induction or post-ASCT, was associated with a shorter PFS (post-induction: median PFS 19 months vs. not reached, log-rank p = 0.0089; post-ASCT: median PFS 18 months vs. not reached, log-rank p = 0.0005). Preliminary results from this small, single-center, prospective study show that, whether performed post-induction or post-ASCT, FDG-PET has a higher prognostic value than WB-DW-MRI for treatment response evaluation of newly diagnosed MM.

scholarly journals Characterizing active and inactive brown adipose tissue in adult humans using PET-CT and MR imaging

2016 ◽  
Vol 311 (1) ◽  
pp. E95-E104 ◽  
Author(s):  
Aliya Gifford ◽  
Theodore F. Towse ◽  
Ronald C. Walker ◽  
Malcolm J. Avison ◽  
E. Brian Welch
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Whole Body ◽  
Subcutaneous White Adipose Tissue ◽  
Brown Adipose ◽  
Pet Ct ◽  
Adult Humans ◽  
Mri Scans ◽  
Whole Body Metabolism

Activated brown adipose tissue (BAT) plays an important role in thermogenesis and whole body metabolism in mammals. Positron emission tomography (PET)-computed tomography (CT) imaging has identified depots of BAT in adult humans, igniting scientific interest. The purpose of this study is to characterize both active and inactive supraclavicular BAT in adults and compare the values to those of subcutaneous white adipose tissue (WAT). We obtained [18F]fluorodeoxyglucose ([18F]FDG) PET-CT and magnetic resonance imaging (MRI) scans of 25 healthy adults. Unlike [18F]FDG PET, which can detect only active BAT, MRI is capable of detecting both active and inactive BAT. The MRI-derived fat signal fraction (FSF) of active BAT was significantly lower than that of inactive BAT (means ± SD; 60.2 ± 7.6 vs. 62.4 ± 6.8%, respectively). This change in tissue morphology was also reflected as a significant increase in Hounsfield units (HU; −69.4 ± 11.5 vs. −74.5 ± 9.7 HU, respectively). Additionally, the CT HU, MRI FSF, and MRI R2* values are significantly different between BAT and WAT, regardless of the activation status of BAT. To the best of our knowledge, this is the first study to quantify PET-CT and MRI FSF measurements and utilize a semiautomated algorithm to identify inactive and active BAT in the same adult subjects. Our findings support the use of these metrics to characterize and distinguish between BAT and WAT and lay the foundation for future MRI analysis with the hope that some day MRI-based delineation of BAT can stand on its own.

scholarly journals Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method

2020 ◽  
Author(s):  
Abudusalamu Aini ◽  
Maiweilidan Yimingjiang ◽  
Aimaiti Yasen ◽  
Bo Ran ◽  
Tiemin Jiang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Metabolic Activity ◽  
Sampling Method ◽  
Alveolar Echinococcosis ◽  
Basic Research ◽  
Necrotic Lesion ◽  
Surgical Removal ◽  
Position Emission Tomography ◽  
Imaging Results ◽  
Pet Ct

Abstract Background: Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery and obtaining liver samples for basic research targeting immunology. However, little is known about quantification of LME range and its’ metabolic activity regarding different lesion types.Methods: A prospective analysis of LME from consecutive surgical AE cases with relevant imaging results was performed. Patients (n=39) received abdominal computed tomography (CT) and position emission tomography/computed tomography using 18F-fluodeoxyglucose (18F-FDG-PET/CT) within one week prior to surgery. Tumor to background ratios (TBRs) of standard uptake value (SUV) in PET/CT was calculated for corresponding LME regions. Multi-site sampling method (MSS, n=26) was introduced to obtain histological slides from LME at different levels off the lesion to evaluate immune cell infiltrative ranges quantitatively. At last, data was statistically analyzed from the perspective of different lesion types.Results: Altogether six major lesion categories have been identified based on different morphology and calcification pattern (A: non-calcified uniform density lesion; B: diffuse calcified solid lesion; C: half necrotic and half solid lesion with minor calcification; D: half necrotic and half solid lesion with obvious calcification; E: subtotal necrotic lesion with minor calcification; F: total necrotic lesion with obvious calcification). Statistical significances were resulted from TBRs calculation (A>B, A>D, A>F, B<C, B<E, A+C+E>B+D+F, etc.). Less calcified lesions were evidenced with higher TBRs, however, not much was valuable for necrosis. The 95% CI of LME ranges were (10.0, 12.1) mm and (9.9, 14.0) mm by PET/CT and MSS. And, weak regressions between TBRs and LME ranges indicated by PET/CT or MSS (r2 respectively were 0.2436 and 0.3171) were observed.Conclusions: PET/CT showed distinct TBRs for different lesion types with heterogenic calcification. PET/CT and MSS had similar discoverability for LME ranges, which also varied among different lesion types. Higher activity meant wider LME range within certain limit. This pioneering study would be able to provide references for both surgical removal of lesions and sample acquisitions more accurately for basic research targeted to immunology.

Whole-Body Diffusion-Weighted Magnetic Resonance Imaging Is a New Sensitive Non-Invasive Method for Staging and Monitoring Chemotherapy Response of Malignant Lymphoma Including Indolent Lymphoma Compared with FDG-PET/CT

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4147-4147
Author(s):  
Shinji Kishi ◽  
Tatsuro Tsuchida ◽  
Takahiro Yamauchi ◽  
Naoko Hosono ◽  
Satoshi Ikegaya ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Fdg Pet ◽  
Therapeutic Response ◽  
Cell Lymphoma ◽  
Whole Body ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Pet Ct ◽  
Weighted Magnetic Resonance Imaging ◽  
Fdg Pet Ct

Abstract Abstract 4147 Whole-body diffusion-weighted magnetic resonance imaging (DWI-MRI) provides functional information and is able to highlight oncological lesions, but the usefulness has not been established in malignant lymphoma especially for monitoring therapeutic response. Positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) is a useful imaging producer for tumor staging and therapy monitoring that can visualize active tumor tissue including malignant lymphoma. The spatial resolution of FDG-PET is limited, and low accuracy rates in diabetic patients and those with low grade lymphoma have been reported. We prospectively studied the utility of DWI-MRI with T2 imaging and apparent diffusion coefficient (ADC) for staging and monitoring therapeutic responses in patients with malignant lymphoma compared with FDG-PET/CT. Twenty-eight patients with malignant lymphoma (16 patients with diffuse large B cell lymphoma: DLBCL, 7 with follicular Lymphoma: FL, 3 with aggressive T cell lymphoma: TCL and 2 with Hodgkin lymphoma: HL, including one diabetic patient) received both MRI and FDG-PET examination before (n=28), after 2 courses of chemotherapy (n=25) and one month after the end of chemotherapy (n=9). MRI examination was performed with a 3-Tesla MR system (Signa Excite, Generel Electrics). Whole-body DWI-MRI was performed with echo planar imaging sequence with short T1 inversion recovery (STIR) fat suppression. ADC measurement was performed based on the region of interest (ROI) method. ROI was placed on the lesion showing the highest standardized uptake value (SUV) on FDG-PET/CT scanner (Discovery LS, General Electrics) in each patient, and crucial parameters of the ADC and SUV were compared. Based on staging by PET/CT, 4 patients were clinical stage I, 8 were stage II, 7 were stage III and 9 were stage IV. DWI-MRI findings alone matched PET/CT in 22 patients (79%), whereas these findings combined with T2 imaging increased match in 26 patients (93%). Regarding the early response to chemotherapy, 19 of 25 patients (76%) were considered to show CR on PET/CT and the DWI findings matched PET/CT 23 patients (92%). To evaluate the final response after chemotherapy, 7 of 9 patients (78%) were considered to show CR on PET/CT and the DWI findings matched PET/CT in 8 of 9 patients (89%). Of these nine, one patient with DLBCL who did not show a match was a false positive on PET/CT. In all patients with TCL and HL, the DWI-MRI findings combined with T2 imaging matched PET/CT findings for staging and therapeutic response. Interestingly, the ADC values on DWI-MRI did not differ between DLBCL and FL (0.77 +/− 0.23 and 0.70 +/− 0.08, p=0.99, mean +/− SD respectively), whereas the SUV values of DLBCL on PET/CT were higher than those of FL (14.5 +/− 6.97 and 6.09 +/− 2.54, p < 0.0005, mean +/− SD respectively), suggesting the DWI-MRI could detect the lymphoma lesion more accurately than PET/CT in patients with indolent lymphoma such as FL. We conclude that whole-body DWI-MRI combined with T2 imaging and ADC analysis could be promising sensitive method for staging and therapeutic response evaluation in patients with malignant lymphoma. Disclosures: No relevant conflicts of interest to declare.

Utility of 11C choline PET CT and MRI in relapsed prostate cancer (PC).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16586-e16586
Author(s):  
Thomas H Tarter ◽  
Benjamin Esparaz ◽  
David Lieber ◽  
Adam Zorn ◽  
Jon Locke ◽  
...  
Keyword(s):  
Predictive Value ◽  
Intracellular Transport ◽  
Whole Body ◽  
Ct Scans ◽  
Pelvic Mri ◽  
Choline Pet ◽  
Pet Ct ◽  
Mri Scans ◽  
Pet Scans ◽  
Ct And Mri

e16586 Background: Choline intracellular transport is upregulated in PC, and it is phosphorylated by choline kinase and becomes trapped within PC cells. 11 C Choline has t½ life of 20.4 minutes and emits positrons detectable by PET. Retrospective studies of 11 C choline PET CT in (PC) have been reported. In this original prospective study, we calculated the performance of 11C choline with whole body PET CT and pelvic PET MRI in patients (pts) with biochemical PC relapse. Methods: From November 2014- June 2016, 101 pts with biochemical PC relapse underwent 11C choline PET CT and pelvic PET MRI. Scans were read in blinded fashion. Tissue was obtained from area of 11 C Choline positivity and correlated with scan results. Results: Sixty-two pts (61%) were included in the analysis. 49 pts were excluded due to non-compliance with protocol. 11C choline PET CT and pelvic MRI showed a sensitivity of 92.5%, specificity of 45.5%, positive predictive value of 75.5%, and negative predictive value of 76.9%. Of 37 pts with positive 11C choline PET scans and confirmation of PC, 12 (32%) had positive 11C choline PET scans and negative CT and MRI scans; 7 (18%) had positive C11 choline and CT scans and negative MRI scans; 12 (32%) had positive 11C choline and MRI scans and negative CT scans, and 9 (24%) had positive 11C choline, CT and MRI scans. Mean PSA level in this group of 37 pts was 9.86 ng/mL (range 0.4 – 107.9 ng/mL), and 7 (19%) of the pts had PSA levels < 2 ng/mL. Conclusions: 11C choline PET improves detection of relapsed PC over CT and MRI scans. 11C choline PET pelvic MRI improves detection over 11C choline PET CT.

PET/CT

2005 ◽  
Vol 44 (S 01) ◽  
pp. S51-S57 ◽  
Author(s):  
T. Beyer ◽  
G. Brix
Keyword(s):  
Diagnostic Accuracy ◽  
Radiation Exposure ◽  
Dose Reduction ◽  
Pet Imaging ◽  
Clinical Studies ◽  
Review Article ◽  
Whole Body ◽  
High Radiation ◽  
Radiation Burden ◽  
Pet Ct

Summary:Clinical studies demonstrate a gain in diagnostic accuracy by employing combined PET/CT instead of separate CT and PET imaging. However, whole-body PET/CT examinations result in a comparatively high radiation burden to patients and thus require a proper justification and optimization to avoid repeated exposure or over-exposure of patients. This review article summarizes relevant data concerning radiation exposure of patients resulting from the different components of a combined PET/CT examination and presents different imaging strategies that can help to balance the diagnostic needs and the radiation protection requirements. In addition various dose reduction measures are discussed, some of which can be adopted from CT practice, while others mandate modifications to the existing hardand software of PET/CT systems.

Reducing [ 18 F]FDG activity levels for whole-body PET/CT examinations of children

2020 ◽  
Author(s):  
H Kertesz ◽  
T Beyer ◽  
T Traub-Weidinger ◽  
J Cal-Gonzalez ◽  
M Hacker ◽  
...  
Keyword(s):  
Whole Body ◽  
Activity Levels ◽  
Pet Ct
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