Indicators of dependence and efforts to quit vaping and smoking among youth in Canada, England and the USA

ObjectiveThe current study examined indicators of dependence among youth cigarette smokers and e-cigarette users in Canada, England and the USA, including changes between 2017 and 2019.MethodsData are from repeated cross-sectional online surveys conducted in 2017, 2018 and 2019 with national samples of youth aged 16–19 years, in Canada (n=12 018), England (n=11 362) and the USA (n=12 110). Measures included perceived addiction to cigarettes/e-cigarettes, frequency of experiencing strong urges to smoke/use an e-cigarette, plans to quit smoking/using e-cigarettes and past attempts to quit. Logistic regression models were fitted to examine differences between countries and changes over time.ResultsThe proportion of ever-users who vaped frequently was significantly higher in 2019 compared with 2017 for all outcomes in each country. Between 2017 and 2019, the proportion of past 30-day vapers reporting strong urges to vape on most days or more often increased in each country (Canada: 35.3%, adjusted OR (AOR) 1.69, 95% CI 1.20 to 2.38; England: 32.8%, AOR 1.55, 1.08 to 2.23; USA: 46.1%, AOR 1.88, 1.41 to 2.50), along with perceptions of being ‘a little’ or ‘very addicted’ to e-cigarettes (Canada: 48.3%, AOR 1.99, 1.44 to 2.75; England: 40.1%, AOR 1.44, 1.03 to 2.01; USA: 53.1%, AOR 1.99, 1.50 to 2.63). Indicators of dependence among smokers were consistently greater than e-cigarette users, although differences had narrowed by 2019, particularly in Canada and the USA.ConclusionsPrevalence of dependence symptoms among young e-cigarette users increased between 2017 and 2019, more so in Canada and the USA compared with England. Dependence symptom prevalence was lower for e-cigarettes than smoking; however, the gap has narrowed over time.

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Trends in e-cigarette brands, devices and the nicotine profile of products used by youth in England, Canada and the USA: 2017–2019

Tobacco Control ◽

10.1136/tobaccocontrol-2020-056371 ◽

2021 ◽

pp. tobaccocontrol-2020-056371

Author(s):

David Hammond ◽

Jessica L Reid ◽

Robin Burkhalter ◽

Richard J O'Connor ◽

Maciej L Goniewicz ◽

...

Keyword(s):

Regression Models ◽

Online Surveys ◽

Cross Sectional ◽

Nicotine Content ◽

Nicotine Concentration ◽

Patterns Of Use ◽

The Usa ◽

Over Time

BackgroundThe e-cigarette market has rapidly evolved, with a shift towards higher nicotine concentration and salt-based products, such as JUUL; however, the implications for youth vaping remain unclear.MethodsRepeat cross-sectional online surveys were conducted in 2017, 2018 and 2019, with national samples of youth aged 16–19 years recruited from commercial panels in Canada (n=12 018), England (n=11 362) and the USA (n=12 110). Regression models examined differences between countries and over time in the types of e-cigarette products used (design and nicotine content), reasons for using brands and differences in patterns of use, sociodemographics and dependence symptoms by brand/nicotine content.ResultsIn 2019, the use of pod- or cartridge-style e-cigarettes was greater in Canada and the USA than England, with Smok and JUUL the leading brands in all countries. In 2019, youth vapers in England were less likely to report using e-cigarettes with ≥2% nicotine (12.8%) compared with Canada (40.5%; adjusted OR (AOR)=4.96; 95% CI 3.51 to 7.01) and the USA (37.0%; AOR=3.99, 95% CI 2.79 to 5.71) and less likely to report using nicotine salt-based products (12.3%) compared with Canada (27.1%; AOR=2.77, 95% CI 1.93 to 3.99) and the USA (21.9%; AOR=2.00, 95% CI 1.36 to 2.95). In 2019, self-reported use of products with higher nicotine concentration was associated with significantly greater frequency of vaping, urges to vape and perceived vaping addiction (p<0.05 for all).ConclusionsThe use of high-nicotine salt-based products is associated with greater symptoms of dependence, including JUUL and other higher-nicotine brands. Greater use of high-nicotine salt-based products may account for recent increases in the frequency of vaping among youth in Canada and the USA.

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Gingivitis Susceptibility and its Relation to Periodontitis in Men

Journal of Dental Research ◽

10.1177/154405910608501213 ◽

2006 ◽

Vol 85 (12) ◽

pp. 1134-1137 ◽

Cited By ~ 17

Author(s):

T. Dietrich ◽

E. Krall Kaye ◽

M.E. Nunn ◽

T. Van Dyke ◽

R.I. Garcia

Keyword(s):

Regression Models ◽

Cross Sectional Study ◽

Multiple Logistic Regression ◽

Sectional Study ◽

Cross Sectional ◽

Bleeding On Probing ◽

Attachment Loss ◽

Logistic Regression Models ◽

Quit Smoking ◽

Former Smokers

The objective of this cross-sectional study was to evaluate whether gingivitis susceptibility is associated with periodontitis. We analyzed data of 462 men in the VA Dental Longitudinal Study aged 47 to 92 years who had never smoked or had quit smoking 5+ years previously. Multiple logistic regression models, with tooth-level bleeding on probing at sites with attachment loss ≤ 2 mm as the dependent variable, were derived with adjustment for plaque, calculus, crown coverage, age, income, education, marital status, body mass index, diabetes, and vitamin C intake, and stratification by age (< 65, 65+ years). Periodontitis and mean attachment loss were positively associated with bleeding on probing, with stronger associations among men < 65 years old (for periodontitis, OR 2.1; 95% CI 1.5, 3.1) than men 65+ years of age (OR 1.2; 95% CI 0.9, 1.6). Our results suggest that among never and former smokers, gingivitis susceptibility is higher among men with periodontitis compared with that in men without periodontitis.

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Has working-age morbidity been declining? Changes over time in survey measures of general health, chronic diseases, symptoms and biomarkers in England 1994–2014

BMJ Open ◽

10.1136/bmjopen-2019-032378 ◽

2020 ◽

Vol 10 (3) ◽

pp. e032378

Author(s):

Ben Baumberg Geiger

Keyword(s):

Chronic Disease ◽

Respiratory Health ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Data Limitations ◽

Working Age ◽

The Usa ◽

Morbidity Index ◽

Changes Over Time ◽

Over Time

ObjectivesAs life expectancy has increased in high-income countries, there has been a global debate about whether additional years of life are free from ill-health/disability. However, little attention has been given to changes over time in morbidity in theworking-agepopulation, particularly outside the USA, despite its importance for health monitoring and social policy. This study therefore asks: what are the changes over time in working-age morbidity in England over two decades?Design, setting and participantsWe use a high-quality annual cross-sectional survey, the Health Survey for England (HSE) 1994–2014. HSE uses a random sample of the English household population, with a combined sample size of over 140 000 people. We produce a newly harmonised version of HSE that maximises comparability over time, including new non-response weights. While HSE is used for monitoring population health, it has hitherto not used for investigating morbidity as a whole.Outcome measuresWe analyse all 39 measures that are fully comparable over time—including chronic disease diagnoses, symptomatology and a number of biomarkers—adjusting for gender and age.ResultsWe find a mixed picture: we see improving cardiovascular and respiratory health, but deteriorations in obesity, diabetes, some biomarkers and feelings of extreme anxiety/depression, alongside stability in moderate mental ill-health and musculoskeletal-related health. In several domains we also see stable or rising chronic diseasediagnoseseven wheresymptomatologyhas declined. While data limitations make it challenging to combine these measures into a single morbidity index, there is little systematic trend for declining morbidity to be seen in the measures that predict self-reported health most strongly.ConclusionsDespite considerable falls in working-age mortality—and the assumptions of many policy-makers that morbidity will follow mortality – there is no systematic improvement in overall working-age morbidity in England from 1994 to 2014.

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Abstract P251: Triggers of Temptations and Urges Do Not Change During a 12-Month Behavioral Intervention for Weight Loss

Circulation ◽

10.1161/circ.133.suppl_1.p251 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Lora E Burke ◽

Saul Shiffman ◽

Daniel Siewiorek ◽

Asim Smailagic ◽

Andrea Kriska ◽

...

Keyword(s):

Weight Loss ◽

Regression Models ◽

Behavioral Weight Loss ◽

Logistic Regression Models ◽

Behavioral Weight Loss Intervention ◽

Ecological Momentary ◽

Changes Over Time ◽

Second Period ◽

Momentary Assessment ◽

Over Time

Introduction: Ecological momentary assessment (EMA) assesses individuals’ behaviors and moods as they occur in their natural environment. We examined self-reported triggers of temptations/urges to eat and compared percent of times each trigger was reported as the top trigger in the 1st 6 mos. vs. the 2nd 6 mos. of a standard behavioral weight loss intervention. Hypothesis: The distribution of self-reported triggers of urges/temptations changes over time. Methods: We provided participants a smartphone app programmed to permit them to self-initiate completing EMA and report temptations/urges in real time. Questions included: What were the triggers for the temptation/urge? What was the top trigger? Only data from subjects reporting ≥ one urge/temptation were included in the analysis. For each trigger, generalized estimating equations were used to fit logistic regression models to test the hypothesis that proportion of urges/temptations including that trigger did not change between the 1st and 2 nd 6 mos. of EMA surveillance. Results: The sample ( N = 139) was 90.6% female, 82.7% White, 50.9±10.10 years of age with a BMI of 34.2±4.6 kg/m2. There were 3175 reported episodes of temptation/urges. During both 6-mo.periods, sight/smell of food was the most frequently reported trigger occurring in 34.8% of temptations/urges in the first 6 mos., increasing to 35.52% in the second 6-mos. This was followed by stress, hunger/thirst, and habit during both 6-mo. periods. There were no significant differences in the frequency or type of triggers over time, except for “out of nowhere”, which occurred less often in the second period (6.98% vs. 5.42%, p = .02). The triggers are plotted in order of most to least frequent for both periods in the figure below. Conclusions: Fewer temptations/urges were reported in the second 6 mos., which likely is attributed to a decrease in compliance by participants to EMA protocols. The sight/smell of food remained the most frequently reported trigger, which is a concern in an environment that is very food centric.

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The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population

Scientific Reports ◽

10.1038/s41598-021-96523-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Li Ran ◽

Qi Chen ◽

Jingyi Zhang ◽

Xinlong Tu ◽

Xiaodong Tan ◽

...

Keyword(s):

Sleep Quality ◽

Regression Models ◽

Joint Effect ◽

Cross Sectional Study ◽

Poor Sleep ◽

Sectional Study ◽

Additive Interaction ◽

Cross Sectional ◽

Logistic Regression Models ◽

Remote Rural Area

AbstractHypertension (HTN) and osteoarthritis (OA) are frequent in middle-aged and elderly people, and the co-occurrence of these two diseases is common. However, the pathogenesis of the multimorbidity of both diseases and the relation with sleep quality, hyperlipemia, and hyperglycemia is unclear. We conducted a cross-sectional study to make sense of the multimorbidity of HTN and OA and the relation with sleep quality, hyperlipemia, and hyperglycemia. The relation between sleep quality and OA and its joint effect with hyperlipemia or hyperglycemia was evaluated with logistic regression models. The additive interaction was assessed with the relative excess risk due to interaction (REEI), the attributable proportion (AP), and the synergy index (S). According to this research in a remote rural area, approximately 34.2% of HTN patients are accompanied with OA and 49.1% are suffering poor sleep. Both hyperlipemia/hyperglycemia and sleep quality were related to OA prevalence with crude ORs of 1.43 (95% CI 1.014–2.029) and 1.89 (95% CI 1.411–2.519, P < 0.001) respectively. An observed additive effect was found greater than the sum of the effects of sleep quality and hyperlipemia/hyperglycemia posed on OA prevalence alone. This additive interaction was observed in females (OR = 3.19, 95% CI 1.945–5.237) as well as males ≥ 65 years old (OR = 2.78, 95% CI 1.693–4.557), with RERI, AP, and S significant. Therefore, poor sleep and hyperlipemia/hyperglycemia are associated with OA, and further studies on the additive interaction among females and males ≥ 65 are warranted.

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Diverging trends in US male-female condom use by STI risk factors: a nationally representative study

Sexually Transmitted Infections ◽

10.1136/sextrans-2020-054642 ◽

2020 ◽

pp. sextrans-2020-054642

Author(s):

Casey E Copen ◽

Patricia J Dittus ◽

Jami S Leichliter ◽

Sagar Kumar ◽

Sevgi O Aral

Keyword(s):

Risk Factors ◽

Condom Use ◽

Illicit Drugs ◽

Female Condom ◽

Cross Sectional ◽

The Past ◽

Representative Study ◽

The Usa ◽

Over Time ◽

Sex Partner

ObjectiveCondom use behaviours are proximal to recent STI increases in the USA, yet it remains unclear whether the use of condoms has changed over time among unmarried, non-cohabiting young men who have sex with women (MSW) and how this variability is influenced by STI risk factors.MethodsTo examine condom use over time among MSW aged 15–29, we used three cross-sectional surveys from the 2002, 2006–2010 and 2011–2017 National Survey of Family Growth. We estimated weighted percentages, adjusted prevalence ratios (APRs) and 95% confidence intervals (CI) to assess changes in condom use, stratified by whether MSW reported any STI risk factors in the past 12 months (ie, perceived partner non-monogamy, male-to-male sex, sex in exchange for money or drugs, sex partner who injects illicit drugs, or an HIV-positive sex partner).ResultsWe observed a divergence in trends in condom use at last sex between men aged 15 –29 with STI risk factors in the past 12 months and those without such history. We saw significant declines in condom use from 2002 to 2011–2017 among men with STI risk factors (APR=0.80, 95% CI 0.68 to 0.95), specifically among those aged 15–19 (APR=0.73, 95% CI 0.57 to 0.94) or non-Hispanic white (APR=0.71, 95% CI 0.54 to 0.93). In contrast, trends in condom use among men with no STI factors remained stable or increased. Across all time periods, the most prevalent STI risk factor reported was perception of a non-monogamous female partner (23.0%–26.9%). Post-hoc analyses examined whether condom use trends changed once this variable was removed from analyses, but no different patterns were observed.ConclusionsWhile STIs have been increasing, men aged 15–29 with STI risk factors reported a decline in condom use. Rising STI rates may be sensitive to behavioural shifts in condom use among young MSW with STI risk factors.

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Chronic disruptive pain in emerging adults with and without chronic health conditions and the moderating role of psychiatric disorders: Evidence from a population-based cross-sectional survey in Canada

Scandinavian Journal of Pain ◽

10.1016/j.sjpain.2017.07.009 ◽

2017 ◽

Vol 17 (1) ◽

pp. 30-36 ◽

Cited By ~ 5

Author(s):

Rana A. Qadeer ◽

Lilly Shanahan ◽

Mark A. Ferro

Keyword(s):

Mental Health ◽

Psychiatric Disorders ◽

Emerging Adults ◽

Regression Models ◽

Daily Functioning ◽

Moderating Effects ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Logistic Regression Models ◽

Drug Disorders

AbstractBackground and aimsThere has been a growth in the proportion of emerging adults vulnerable to pain-related sequelae of chronic health conditions (CHCs). Given the paucity of research during this important developmental period, this study investigated the association between CHCs and chronic disruptive pain among emerging adults and the extent to which psychiatric disorders moderate this association.MethodsData come from the 2012 Canadian Community Health Survey - Mental Health (CCHS-MH). This cross-sectional survey included 5987 participants that were 15-30 years of age and self-reported their CHCs (n = 2460,41%) and the extent to which pain impacted daily functioning using items from the Health Utilities Index Mark 3 (HUI 3). Group comparisons between respondents with CHCs and healthy controls were made using chi-square tests. Odds ratios (OR) and 95% confidence intervals (CI) were computed from ordinal logistic regression models adjusting for sociodemographic covariates. Product-term interactions between CHCs and psychiatric disorders were included in the models to explore moderating effects. All analyses were weighted to maintain representativeness of the study sample to the Canadian population.ResultsThe mean age of participants was 23.5 (SE 0.1) years and 48% were female. Compared to healthy controls, a greater proportion of participants with CHCs reported having chronic pain (20.3% vs. 4.5%, p < 0.001). Among those with chronic pain, respondents with CHCs reported a greater number of activities prevented because of chronic disruptive pain (χ2 = 222.28, p< 0.001). Similarly, in logistic regression models, participants with CHCs had greater odds of reporting chronic disruptive pain (OR = 4.94, 95% CI = 4.08-5.99). Alcohol (β = –0.66; p = 0.025) and drug abuse/dependence disorders (β = –1.24; p = 0.012) were found to moderate the association between CHCs and chronic disruptive pain. Specifically, the probability of chronic disruptive pain was higher for emerging adults without CHCs and with alcohol or drug disorders; however, among participants with CHCs, probability was higher for those without these disorders.ConclusionsThere is a robust association between CHCs and chronic disruptive pain. The moderating effects suggest that alcohol or drug disorders are especially harmful for emerging adults without CHCs and contribute to higher levels of chronic disruptive pain; however, among those with CHCs, alcohol and illicit drugs may be used as a numbing agent to blunt chronic disruptive pain.ImplicationsFindings from this study have implications for the integration and coordination of services to design strategies aimed at managing chronic disruptive pain and preventing pain-related disabilities later in life. Within the health system, healthcare providers should engage in dialogues about mental health and substance use regularly with emerging adults, be proactive in screening for psychiatric disorders, and continue to monitor the impact of pain on daily functioning. Given the age range of emerging adults, there is tremendous opportunity for clinicians to work cooperatively with colleagues in the education system to support emerging adults with and without CHCs. Overall, clinicians, researchers, educators, and those in social services should continue to be mindful of the complex interrelationships between physical and mental health and chronic disruptive pain and work cooperatively to optimize health outcomes and prevent pain-related disabilities among emerging adults.

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Physician Perceptions on Quality of Life and Resuscitation Preferences for Extremely Early Newborns

American Journal of Perinatology ◽

10.1055/s-0041-1733782 ◽

2021 ◽

Author(s):

Danielle LoRe ◽

Christopher Mattson ◽

Dalia M. Feltman ◽

Jessica T. Fry ◽

Kathleen G. Brennan ◽

...

Keyword(s):

Quality Of Life ◽

Logistic Regression ◽

Regression Models ◽

Mixed Effects ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Comfort Care ◽

Logistic Regression Models ◽

Extremely Preterm

Objective The study aimed to explore physician views on whether extremely early newborns will have an acceptable quality of life (QOL), and if these views are associated with physician resuscitation preferences. Study Design We performed a cross-sectional survey of neonatologists and maternal fetal medicine (MFM) attendings, fellows, and residents at four U.S. medical centers exploring physician views on future QOL of extremely early newborns and physician resuscitation preferences. Mixed-effects logistic regression models examined association of perceived QOL and resuscitation preferences when adjusting for specialty, level of training, gender, and experience with ex-premature infants. Results A total of 254 of 544 (47%) physicians were responded. A minority of physicians had interacted with surviving extremely early newborns when they were ≥3 years old (23% of physicians in pediatrics/neonatology and 6% in obstetrics/MFM). The majority of physicians did not believe an extremely early newborn would have an acceptable QOL at the earliest gestational ages (11% at 22 and 23% at 23 weeks). The majority of physicians (73%) believed that having an extremely preterm infant would have negative effects on the family's QOL. Mixed-effects logistic regression models (odds ratio [OR], 95% confidence interval [CI]) revealed that physicians who believed infants would have an acceptable QOL were less likely to offer comfort care only at 22 (OR: 0.19, 95% CI: 0.05–0.65, p < 0.01) and 23 weeks (OR: 0.24, 95% CI: 0.07–0.78, p < 0.02). They were also more likely to offer active treatment only at 24 weeks (OR: 9.66, 95% CI: 2.56–38.87, p < 0.01) and 25 weeks (OR: 19.51, 95% CI: 3.33–126.72, p < 0.01). Conclusion Physician views of extremely early newborns' future QOL correlated with self-reported resuscitation preferences. Residents and obstetric physicians reported more pessimistic views on QOL. Key Points

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Temporal Trends in the Severity and Mortality of Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Hypothermia

Neonatology ◽

10.1159/000518654 ◽

2021 ◽

pp. 1-8

Author(s):

Cristina Vega-Del-Val ◽

Juan Arnaez ◽

Sonia Caserío ◽

Elena Pilar Gutiérrez ◽

Marta Benito ◽

...

Keyword(s):

Temporal Trends ◽

Cross Sectional Study ◽

Annual Incidence ◽

Hypoxic Ischemic Encephalopathy ◽

Cross Sectional ◽

Incidence And Mortality ◽

Changes Over Time ◽

Ischemic Encephalopathy ◽

Annual Decline ◽

Over Time

Introduction: There is a paucity of studies examining temporal trends in the incidence and mortality of moderate-to-severe hypoxic-ischemic encephalopathy (HIE) during the last decade of therapeutic hypothermia (TH). Methods: Multicenter cross-sectional study of all infants ≥35 weeks gestational age diagnosed with moderate-to-severe HIE within 6 h of birth in an extensive region of Spain between 2011 and 2019, in order to detect trend changes over time in the (1) annual incidence, (2) severity of neurological and systemic organ involvement, and (3) neonatal death from HIE. Results: Annual incidence rate of moderate-to-severe HIE was 0.84 (95% confidence interval [CI] 0.7–0.97) per 1,000 births, without trend changes over time (p = 0.8), although the proportion of severe HIE infants showed an average annual decline of 0.86 points (95% CI 0.75–0.98). There were 102 (70%) infants diagnosed with moderate HIE and 44 (30%) with severe HIE. TH was offered to 139/146 (95%) infants. Infants with clinical and/or electrical seizures showed a decreasing trend from 56 to 28% (p = 0.006). Mortality showed a nonstatistically significant decline (p = 0.4), and the severity of systemic damage showed no changes (p = 0.3). Obstetric characteristics remained unchanged, while higher perinatal pH values (p = 0.03) and Apgar scores (p = 0.05), and less need for resuscitation (p = 0.07), were found over time. Conclusion: The annual incidence of moderate-to-severe HIE has stabilized at around 1 per 1,000 births, with a temporal trend toward a decrease in severe HIE infants and a slight decline of mortality. No association was found between temporal trends and changes in perinatal/obstetric characteristics over time.

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Abstract P707: Trends, Predictors and Outcomes of Cerebrovascular Disease Amongst Patients With Thrombotic Microangiopathy

Stroke ◽

10.1161/str.52.suppl_1.p707 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Priyadarshee Patel ◽

Urvish K Patel ◽

Graca Vanessa ◽

Abhinav Patel ◽

Davis Chacko ◽

...

Keyword(s):

Thrombotic Microangiopathy ◽

Thrombus Formation ◽

Cerebral Arteries ◽

Temporal Trends ◽

Cross Sectional Study ◽

Coagulation System ◽

Trend Test ◽

Cross Sectional ◽

Logistic Regression Models ◽

The Usa

Background: Thrombotic Microangiopathy (TMA) is a rare disorder affecting the coagulation system causing microangiopathic thrombus formation within various blood vessels including the cerebral arteries. It may be seen in association with thrombocytopenia, anemia, purpura and kidney failure as well as complications of various systemic viral illnesses. We sought to estimate the trends, predictors, and outcomes of CeVD in patients having ™ from a nationally representative database of the USA. Methods: In this cross-sectional study, we identified hospitalization with TM using ICD-9/10-CM from the National Inpatient Sample (NIS) for the years 2008-2017. Prevalence of CeVD was identified by validated ICD-9/10-CM codes. We utilized Cochran Armitage trend test and multivariable survey logistic regression models to analyze temporal trends, outcomes and predictors of any CeVD in TM patients. Results: Out of a total 58,850 hospitalizations among TMA patients, 4,668 (7.9%) developed CeVD. Prevalence of CeVD increased from 6.2% in 2008 to 8.2% in 2017 (pTrend<0.001). Patients who developed CeVD were older and more likely to be female. In multivariable regression analysis, increasing age (OR 1.2; 95%CI 1.1-1.2; p<0.0001); females (OR 1.3; 95%CI 1.1-1.6;p<0.0004); African American (OR 1.4; 95%CI 1.2-1.7;p<0.001) and hypertension (OR 1.3; 95%CI 1.1-1.6; p<0.0001). CeVD was also associated with higher length of stay (18 vs 12 days; p<0.001). Additionally, CeVD was associated with higher in-hospital mortality (aOR 2.1; 95%CI 1.7-2.5; p<0.001) and discharge to facility (aOR 3.0; 95%CI 2.4-3.5; p<0.001) after adjusting with confounders. Conclusion: We observed the mildly incremental prevalence of CeVD among TMA patients. We were able to identify the TMA patient population susceptible to CeVD, most commonly occurring in older, females and African Americans. CeVD was also associated with significantly poor outcomes in TM. These findings may pose similarities to other systemic viral illness-induced thrombotic microangiopathy such as COVID-19. Further studies are required to improve the outcomes of these susceptible patient populations.

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