Timing of creatine or protein supplementation and resistance training in the elderly

2008 ◽  
Vol 33 (1) ◽  
pp. 184-190 ◽  
Author(s):  
Darren G. Candow ◽  
Philip D. Chilibeck
Keyword(s):  
Resistance Training ◽  
Muscle Mass ◽  
Daily Intake ◽  
Creatine Supplementation ◽  
The Elderly ◽  
Functional Independence ◽  
Protein Supplementation ◽  
Older Individuals ◽  
Age Related ◽  
Fiber Number

Muscle loss with age has a negative effect on strength and functional independence. Age-related loss of muscle is the result of decreased muscle fiber number and size, which are functions of altered hormonal status, physical inactivity, and variations in nutritional intake. Resistance training has a positive effect on muscle mass and strength in the elderly. Studies of protein or creatine supplementation for increasing muscle mass and strength in older individuals are equivocal. The timing of nutritional supplementation may be more important than the absolute daily intake of supplements. Protein or creatine ingestion proximate to resistance-training sessions may be more beneficial for increasing muscle mass and strength than ingestion of protein or creatine at other times of the day, possibly because of increased blood flow and therefore increased transport of amino acids and creatine to skeletal muscle.

scholarly journals Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

2018 ◽  
Vol 31 (2) ◽  
pp. 204-224 ◽  
Author(s):  
N. Aytekin ◽  
K. N. Mileva ◽  
A. D. Cunliffe
Keyword(s):  
Muscle Mass ◽  
Healthcare Providers ◽  
The Elderly ◽  
Mass Function ◽  
Evidence Base ◽  
B Vitamins ◽  
Micronutrient Deficiencies ◽  
Older Individuals ◽  
Dietary Recommendations ◽  
Age Related

AbstractThe possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function. In this connection, several B vitamins can be viewed as not only cofactors in muscle synthetic processes, but also as neurotrophic agents with involvements in both bioenergetic and trophic pathways. The B vitamins thus selected are examined with respect to their relevance to multiple aspects of neuromuscular function and evidence is considered that requirements, intakes or absorption may be altered in the elderly. In addition, the evidence base for recommended intakes (UK recommended daily allowance) is examined with particular reference to original datasets and their relevance to older individuals. It is possible that inconsistencies in the literature with respect to the nutritional management of sarcopenia may, in part at least, be the result of compromised micronutrient status in some study participants. It is suggested that in order, for example, for intervention with amino acids to be successful, underlying micronutrient deficiencies must first be addressed/eliminated.

scholarly journals Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2057 ◽  
Author(s):  
James McKendry ◽  
Brad S. Currier ◽  
Changhyun Lim ◽  
Jonathan C. Mcleod ◽  
Aaron C.Q. Thomas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Muscle Mass ◽  
Nutritional Supplements ◽  
Feeding Strategies ◽  
Older Individuals ◽  
Omega 3 ◽  
Age Related ◽  
The Impact ◽  
Nutritional Strategies

Skeletal muscle plays an indispensable role in metabolic health and physical function. A decrease in muscle mass and function with advancing age exacerbates the likelihood of mobility impairments, disease development, and early mortality. Therefore, the development of non-pharmacological interventions to counteract sarcopenia warrant significant attention. Currently, resistance training provides the most effective, low cost means by which to prevent sarcopenia progression and improve multiple aspects of overall health. Importantly, the impact of resistance training on skeletal muscle mass may be augmented by specific dietary components (i.e., protein), feeding strategies (i.e., timing, per-meal doses of specific macronutrients) and nutritional supplements (e.g., creatine, vitamin-D, omega-3 polyunsaturated fatty acids etc.). The purpose of this review is to provide an up-to-date, evidence-based account of nutritional strategies to enhance resistance training-induced adaptations in an attempt to combat age-related muscle mass loss. In addition, we provide insight on how to incorporate the aforementioned nutritional strategies that may support the growth or maintenance of skeletal muscle and subsequently extend the healthspan of older individuals.

scholarly journals Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3757
Author(s):  
Ellem Eduarda Pinheiro dos Santos ◽  
Rodrigo Cappato de de Araújo ◽  
Darren G. Candow ◽  
Scott C. Forbes ◽  
Jaddy Antunes Guijo ◽  
...  
Keyword(s):  
Resistance Training ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Creatine Supplementation ◽  
Upper Body ◽  
Lower Body ◽  
Level Of Evidence ◽  
Age Related ◽  
Body Strength ◽  
Lower Body Strength

Sarcopenia refers to the age-related loss of muscle strength and muscle mass, which is associated with a reduced quality of life, particularly in older females. Resistance training (RT) is well established to be an effective intervention to counter indices of sarcopenia. Accumulating research indicates that the addition of creatine supplementation (Cr) to RT augments gains in muscle strength and muscle mass, compared to RT alone. However, some evidence indicates that sex differences may alter the effectiveness of Cr. Therefore, we systematically reviewed randomized controlled trials (RCTs) investigating the efficacy of Cr + RT on measures of upper- and lower-body strength and muscle mass in older females. A systematic literature search was performed in nine electronic databases. Ten RCTs (N = 211 participants) were included the review. Overall, Cr significantly increased measures of upper-body strength (7 studies, n = 142, p = 0.04), with no effect on lower-body strength or measures of muscle mass. Sub-analyses revealed that both upper-body (4 studies, n = 97, p = 0.05) and lower-body strength (4 studies, n = 100, p = 0.03) were increased by Cr, compared to placebo in studies ≥ 24 weeks in duration. In conclusion, older females supplementing with Cr experience significant gains in muscle strength, especially when RT lasts for at least 24 weeks in duration. However, given the level of evidence, future high-quality studies are needed to confirm these findings.

Resistance Training Frequency Confers Greater Muscle Quality in Aged Individuals: A Brief NHANES Report

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Marshall A Naimo ◽  
Ja K Gu ◽  
Christa Lilly ◽  
George A Kelley ◽  
Brent A. Baker
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Resistance Training ◽  
Muscle Mass ◽  
Secondary Analysis ◽  
Analysis Of Covariance ◽  
Muscle Quality ◽  
Older Individuals ◽  
Nutrition Survey ◽  
Age Related

Background: Sarcopenia, the age-related decline in skeletal muscle mass, results in a loss of strength and functional capacity, which subsequently increases the risk of disease, disability frailty, and all-cause mortality. Skeletal muscle quality (MQ), i.e., strength per unit muscle mass, is the ability of muscle to perform its functions, and evidence indicates it is a more influential variable underlying age-related declines in muscle function than losses in muscle mass. Resistance training (RT) is known for enhancing skeletal MQ, improving health span, and reducing mortality; however, to the best of our knowledge, no studies have examined the relationship between RT frequency and MQ in an aged population. Thus, this study was designed to test the hypothesis that greater MQ in older individuals is associated with RT frequency. Methods: Utilizing data from 2,391 older adults in the National Health and Nutrition Survey (NHANES; 1999-2002), a secondary analysis of data was performed to see if an association existed between RT frequency and MQ in persons aged 55 years and older. Data were analyzed using analysis of covariance (ANCOVA) with three different models. Individuals were stratified into two groups based on how many days per week they performed RT: Insufficient (i.e., < two days per week) or sufficient (≥ two days per week). Muscle quality was calculated by taking the average peak force (Newtons) obtained from an isokinetic dynamometer and dividing it by lean mass, excluding bone mineral content (grams), obtained from dual-energy X-ray absorptiometry. The alpha level was set at <0.05. Results: For persons aged 55 and over, a statistically significant association was found between sufficient RT and greater MQ in both unadjusted as well as adjusted models that accounted for various demographic, behavioral, and clinical characteristics (p<0.05 for all). However, when limited to those 65 and older, no statistically significant associations were observed between sufficient RT and greater MQ (p>0.05 for all). When partitioned according to those 55 to 64 years of age and those 55 to 79 years, a statistically significant association was again observed (p<0.05 for all). No statistically significant associations were observed for individuals 65-79 years of age or those 80 years of age and older (p>0.05 for all). Conclusions: Sufficient amounts of RT are associated with greater MQ in selected older individuals. A need exists for future randomized controlled trials that examine the dose-response relationship between resistance training and MQ in older adults.

scholarly journals PROTEIN SUPPLEMENTATION DOES NOT RESCUE MUSCLE MASS AND FUNCTION–HEAVY RESISTANCE TRAINING IS REQUIRED

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
Lars Holm ◽  
Rasmus Bechshoeft ◽  
Soren Reitelseder ◽  
Kenneth Mertz ◽  
Jacob Bulow ◽  
...  
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Muscle Mass ◽  
Protein Intake ◽  
Protein Supplementation ◽  
Light Load ◽  
Age Related ◽  
Heavy Resistance Training ◽  
And Function ◽  
The Impact

Abstract The requirement of an enhanced dietary protein intake to counteract the age-related loss of muscle mass is still debated. Further, the dinner meal generally contains the majority of protein and energy and since, the muscle of older adults responds less to protein intake than that of younger adults it is hypothesized that older adults would benefit from taking more protein in at other meals. The aim of this study was to investigate whether the provision of protein supplements for breakfast and lunch meals over the course of a year would make healthy, older, home-dwelling adults (N=136) take in more protein and whether that then would affect their muscle mass (primary outcome) and a number of metabolic health parameters, muscle strength parameters and functional capabilities. More than 77% ingested more than 75% of the provided supplements, irrespective of supplementation type (isocaloric carbohydrate; collagen hydrolysate low quality protein: whey hydrolysate high quality protein). Providing supplementation for a year among older adults makes them comply very well. However, provision of extra protein has no impact on the muscle mass or strength or on the functional parameters. Further, we studied the impact of adding resistance training on top of WHEY protein supplementation and found that heavy more than light-load resistance training affects fat-free mass and maximal-voluntary contraction. Daily protein intake can be enhanced by supplementation but do not impact muscle mass and function over the course of a year, where heavy resistance training on top benefits, but to a lesser than expected degree.

scholarly journals Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3536
Author(s):  
Manoel E. Lixandrão ◽  
Igor Longobardi ◽  
Alice E. Leitão ◽  
João V. M. Morais ◽  
Paul A. Swinton ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Protein Intake ◽  
The Elderly ◽  
Quadriceps Muscle ◽  
Future Research ◽  
Older Individuals ◽  
Cross Sectional ◽  
Anabolic Resistance ◽  
Age Related

Higher daily protein intake, with an emphasis on leucine content, is thought to mitigate age-related anabolic resistance, potentially counteracting age-related morphological and functional declines. The present study investigated potential associations between total daily leucine intake and dependent variables, including quadriceps muscle cross-sectional area (CSA) and maximum dynamic muscle strength (1-RM) in a cohort of healthy free-living older individuals of both sexes (n = 67; 34/33 men/women). Participants performed three 24 h dietary recalls and underwent a magnetic resonance imaging exam followed by 1-RM tests. Our results demonstrate moderate associations between total daily leucine and both quadriceps CSA (r = 0.42; p = 0.004) and 1-RM (r = 0.45; p = 0.001). Furthermore, our exploratory biphasic linear regression analyses, adjusted for sex, age, and protein intake relative to body weight, revealed a plateau for daily leucine intake and muscle mass and muscle strength (~7.6–8.0 g·day−1) in older adults. In conclusion, we demonstrated that total daily leucine intake is associated with muscle mass and strength in healthy older individuals and this association remains after controlling for multiple factors, including overall protein intake. Furthermore, our breakpoint analysis revealed non-linearities and a potential threshold for habitual leucine intake, which may help guide future research on the effects of chronic leucine intake in age-related muscle loss.

scholarly journals Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age

Blood ◽  
1988 ◽  
Vol 71 (6) ◽  
pp. 1726-1730
Author(s):  
KA Melez ◽  
LF Fries ◽  
BS Bender ◽  
T Quinn ◽  
MM Frank
Keyword(s):  
Aging Process ◽  
Elderly Population ◽  
The Elderly ◽  
Older Individuals ◽  
Immune Functions ◽  
Macrophage Function ◽  
Normal Volunteers ◽  
Age Related ◽  
Male Subjects

Decreased immune functions have been suggested as a cause for the increased incidence of autoimmunity, malignancy, and infection in the elderly population. To assess the possible role of changes in macrophage function in the aging process we studied the Fc receptor- mediated clearance of IgG-coated erythrocytes in 56 healthy normal volunteers by following the removal of radiolabeled autologous erythrocytes. An age-related decrease in Fc-mediated clearance rates in both female and male subjects was found, which suggests a physiological decline of this macrophage function in older individuals.

scholarly journals Age-related mortality in 61,993 confirmed COVID-19 cases over three epidemic waves in Aragon, Spain. Implications for vaccination programmes

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261061
Author(s):  
Diego Casas-Deza ◽  
Vanesa Bernal-Monterde ◽  
Angel Nicolás Aranda-Alonso ◽  
Enrique Montil-Miguel ◽  
Ana Belen Julián-Gomara ◽  
...  
Keyword(s):  
Age Groups ◽  
Case Fatality ◽  
The Elderly ◽  
Progressive Increase ◽  
University Hospital ◽  
Rapid Progression ◽  
Targeted Prevention ◽  
Older Individuals ◽  
Prevention Measures ◽  
Age Related

Background Risk for severe COVID-19 increases with age. Different vaccination strategies are currently being considered, including those aimed at slowing down transmission and those aimed at providing direct protection to those most at risk. Methods The objectives of the current study were i) to assess age-related incidence and survival between PCR-diagnosed COVID-19 cases (n = 61,993) in the Autonomous Community of Aragon from March to November 2020, and ii) to characterize age differences regarding the course of the disease in hospitalized patients in a tertiary university hospital. Results We found a similar incidence of COVID-19 in individuals between 10 and 79 years. Incidence increased in those over 80 years possibly because of the elevated transmission within the nursing homes. We observed a profound disparity among age groups; case fatality rates (CFRs) were near 0 in cases younger than 39 years throughout different waves. In contrast, there was an age-dependent and progressive increase in the CFRs, especially during the first pandemic wave. SARS-CoV-2 infection caused a more severe and rapid progression in older patients. The elderly required faster hospitalization, presented more serious symptoms on admission, and had a worse clinical course. Hospitalized older individuals, even without comorbidities, had an increased mortality risk directly associated with their age. Lastly, the existence of comorbidities dramatically increased the CFRs in the elderly, especially in males. Conclusion The elevated incidence of COVID-19 and the vulnerability of the elderly call for their prioritization in vaccination and targeted prevention measures specifically focused on this aged population.

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