Predicted and measured stresses and displacements around the Darlington Intake Tunnel

1984 ◽  
Vol 21 (1) ◽  
pp. 147-165 ◽  
Author(s):  
K. Y. Lo ◽  
B. Lukajic
Keyword(s):  
Field Measurements ◽  
Time Dependent ◽  
Long Term Conditions ◽  
Field Instrumentation ◽  
Deformation Properties ◽  
Strength And Deformation ◽  
Short And Long Term ◽  
Keywords Stress

The C.W. Intake Tunnel of the Darlington Nuclear Station is D-shaped in section with a span of 8 m and a length of 925 m beneath Lake Ontario. The tunnel is located in a horizontally bedded limestone with variable shaly interbeds.The geotechnical investigation including in-situ rock stress measurements, and laboratory determination of strength and deformation properties as well as time-dependent behaviour are reported. Design of the tunnel, in particular provisions for "rock squeeze," is described in detail.To verify the design approach adopted and the provisions made, field instrumentation was performed during excavation of the tunnel. The results of field measurements of stresses and displacements were compared with premonitoring analysis. Postmonitoring analyses were also performed using the as-constructed condition. It is shown that the performance of the tunnel is in general agreement with the predicted behaviour in both short and long term conditions. Keywords: stress, displacement, time-dependent deformation, stressmeter, tunnel, rock mechanics, rock squeeze.

Analysis of field performance—the Thunder Bay tunnel

1986 ◽  
Vol 23 (1) ◽  
pp. 30-50 ◽  
Author(s):  
Robert M. C. Ng ◽  
K. Y. Lo ◽  
R. K. Rowe
Keyword(s):  
Field Performance ◽  
Field Measurements ◽  
Pressure Change ◽  
Long Term Conditions ◽  
Perfectly Plastic ◽  
Thunder Bay ◽  
Short And Long Term ◽  
Elastic Perfectly Plastic ◽  
Spatial Displacements

A numerical method for the calculation of the distribution of displacements for tunnelling in clays has been developed. The method employs an orthotropic elastic – perfectly plastic soil model that takes into account various sources of ground loss and soil–lining interaction. Both undrained and drained analyses have been carried out and the results are compared with the measured soil displacements of two instrumented arrays at the Thunder Bay tunnel. It is shown that the range of maximum settlements, the shape of the settlement troughs, and the pore pressure change, as well as the magnitude and direction of spatial displacements obtained from the analyses, compare reasonably well with the results of field measurements for both short- and long-term conditions. Key words: tunnelling, clays, anisotropy, elastic–plastic displacements, settlement trough, Thunder Bay tunnel.

Time-Dependent Changes in Excitability After One-Trial Conditioning of Hermissenda

1997 ◽  
Vol 78 (6) ◽  
pp. 3460-3464 ◽  
Author(s):  
Terry Crow ◽  
Vilma Siddiqi
Keyword(s):  
Time Dependent ◽  
Control Group ◽  
Type B ◽  
Control Groups ◽  
Phototactic Behavior ◽  
Parallel Processes ◽  
Short And Long Term ◽  
A Site ◽  
Different Levels

Crow, Terry and Vilma Siddiqi. Time-dependent changes in excitability after one-trial conditioning of Hermissenda. J. Neurophysiol. 78: 3460–3464, 1997. The visual system of Hermissenda has been studied extensively as a site of cellular plasticity produced by classical conditioning. A one-trial conditioning procedure consisting of light paired with the application of serotonin (5-HT) to the exposed, but otherwise intact, nervous system produces suppression of phototactic behavior tested 24 h after conditioning. Short- and long-term enhancement (STE and LTE) of excitability in identified type B photoreceptors is a cellular correlate of one-trial conditioning. LTE can be expressed in the absence of STE suggesting that STE and LTE may be parallel processes. To examine the development of enhancement, we studied its time-dependent alterations after one-trial conditioning. Intracellular recordings from identified type B photoreceptors of independent groups collected at different times after conditioning revealed that enhanced excitability follows a biphasic pattern in its development. The analysis of spikes elicited by 2 and 30 s extrinsic current pulses at different levels of depolarization showed that enhancement reached a peak 3 h after conditioning. From its peak, excitability decreased toward baseline control levels 5–6 h after conditioning followed by an increase to a stable plateau at 16 to 24 h postconditioning. Excitability changes measured in cells from unpaired control groups showed maximal changes 1 h posttreatment that rapidly decremented within 2 h. The conditioned stimulus (CS) elicited significantly more spikes 24 h postconditioning for the conditioned group as compared with the unpaired control group. The analysis of the time-dependent development of enhancement may reveal the processes underlying different stages of memory for this associative experience.

Surface-groundwater interactions in karst: overview, concept and mapping

2021 ◽  
Author(s):  
Natasa Ravbar ◽  
Cyril Mayaud ◽  
Matej Blatnik ◽  
Metka Petrič
Keyword(s):  
Environmental Changes ◽  
Temporal Dynamics ◽  
Field Measurements ◽  
Spatial Dimension ◽  
Karst Aquifers ◽  
Wetland Ecosystems ◽  
Spatial And Temporal Dynamics ◽  
Ecohydrological Processes

<p>Under special meteorological and hydrological circumstances, shallow karst areas and karst poljes may experience surface water overflow. As a result, surface- groundwater interaction occurs usually creating intermittent lakes. Although human settlements and activities have traditionally adapted to these natural conditions, extensive temporary floods are classified among the most common natural disasters in karst. On the other hand, intermittent lakes are considered as natural reservoirs of excess recharge and good flood regulators in the lower parts of river basins. Due to specific ecohydrological processes and environmental conditions, these areas host unique wetland ecosystems with high levels of biodiversity and provide various ecosystem services, such as ecological productivity, photosynthesis and carbon storage. Given the dynamic nature of hydrological processes in karst aquifers, a distinctive feature of the phenomena described is its high variability of occurrence and duration. Therefore, the identification, characterization as well as the determination of the spatial dimension of flood levels is a challenging task. Focusing on the Slovenian karst, a literature review and analysis of topographical and hydrological data of the selected study areas was conducted. The hydrological analyses were based on long-term monitoring data from Slovenian Environmental Agency and partly on the authors' own database of field measurements and knowledge of the areas concerned. Consequently, the conceptual framework and the key criterion for the determination and recording of areas subject to temporary flooding were developed. A systematic survey reveals the significance of the extent, duration and frequency of flooding. Evaluation results are useful to designers of various water policies and management mechanisms for flood mitigation and protection of special habitats. Observing trends in the spatial and temporal dynamics of flood levels is also valuable for understanding how and to what extent karst aquifers are vulnerable to environmental changes. Finally, the analyses also enable prediction of the effects of these changes on other parts of the environment (e.g., hydrophilic habitats).</p>

Delayed arteriolar relaxation after prolonged agonist exposure: functional remodeling involving tyrosine phosphorylation

2003 ◽  
Vol 285 (2) ◽  
pp. H849-H856 ◽  
Author(s):  
Michael A. Hill ◽  
Simon J. Potocnik ◽  
Luis A. Martinez-Lemus ◽  
Gerald A. Meininger
Keyword(s):  
Tyrosine Phosphorylation ◽  
Prolonged Exposure ◽  
Time Dependent ◽  
Physiological Salt Solution ◽  
Microtubule Network ◽  
Biochemical Alterations ◽  
Dependent Behavior ◽  
Functional Remodeling ◽  
Short And Long Term

Although arteriolar contraction is dependent on Ca2+-induced myosin phosphorylation, other mechanisms including Ca2+ sensitization and time-dependent phenomena such as cytoskeletal and cellular reorganization may contribute to contractile events. We hypothesized that if arteriolar smooth muscle exhibits time-dependent behavior this may be manifested in differences in relaxation after short- and long-term exposure to contractile agonists. Studies were conducted in isolated arterioles pressurized to 70 mmHg. In initial experiments ( n = 10), rate of relaxation was measured after acute (5 min) or prolonged (4 h) exposure to 5 μM norepinephrine (NE). Prolonged exposure to NE resulted in significantly ( P < 0.05) increased time for relaxation in physiological salt solution. Rapid relaxation of vessels exposed to NE for 4 h was observed after superfusion with 0 mM Ca2+ buffer, indicating that the alteration in relaxation was reversible and Ca2+ dependent. A similarly impaired dilation was not observed with 4-h exposure to KCl (75 mM). To determine mechanisms contributing to the effects of prolonged NE exposure, studies were performed in the presence of the microtubule depolymerizing agent demecolcine (10 μM) or a series of tyrosine phosphorylation inhibitors. Although demecolcine caused significant vasoconstriction ( P < 0.05) and potentiated NE vasoconstriction, it did not prevent the effect of long-term NE exposure on relaxation. Genistein, although having no effect on acute NE-induced contraction, concentration-dependently inhibited prolonged NE constriction. Similarly, Src (PP1) and p42/44 MAP kinase (PD-98059) inhibitors prevented maintenance of long-term NE contraction. The data indicate that prolonged exposure to NE induces biochemical alterations that impair relaxation after removal of the agonist. The contractile effects are Ca2+ dependent and involve tyrosine phosphorylation but do not appear to involve the polymerization state of the microtubule network.

scholarly journals Quantitative Determination of Vinpocetine in Dietary Supplements

2016 ◽  
Vol 11 (5) ◽  
pp. 1934578X1601100
Author(s):  
John M. T. French ◽  
Matthew D. King ◽  
Owen M. McDougal
Keyword(s):  
United States ◽  
Quantitative Determination ◽  
Dietary Supplements ◽  
Nootropic Drugs ◽  
Regulatory Policies ◽  
Short And Long Term ◽  
Pharmacologically Active ◽  
Active Substances

Current United States regulatory policies allow for the addition of pharmacologically active substances in dietary supplements if derived from a botanical source. The inclusion of certain nootropic drugs, such as vinpocetine, in dietary supplements has recently come under scrutiny due to the lack of defined dosage parameters and yet unproven short- and long-term benefits and risks to human health. This study quantified the concentration of vinpocetine in several commercially available dietary supplements and found that a highly variable range of 0.6–5.1 mg/serving was present across the tested products, with most products providing no specification of vinpocetine concentrations.

Association of adrenal hormone metabolites and mortality over a 6-year follow-up in COPD patients with acute exacerbation

2018 ◽  
Vol 56 (4) ◽  
pp. 669-680 ◽  
Author(s):  
Seline Zurfluh ◽  
Manuela Nickler ◽  
Manuel Ottiger ◽  
Christian Steuer ◽  
Alexander Kutz ◽  
...  
Keyword(s):  
Cox Regression ◽  
Time Dependent ◽  
Chronic Obstructive ◽  
Short Term ◽  
Therapeutic Implications ◽  
Adrenal Hormone ◽  
Copd Patients ◽  
Short And Long Term ◽  
Long Term Mortality

Abstract Background: The release of hormones from the adrenal gland is vital in acute and chronic illnesses such as chronic obstructive pulmonary disease (COPD) involving recurrent exacerbations. Using a metabolomic approach, we aim to investigate associations of different adrenal hormone metabolites with short- and long-term mortality in COPD patients. Methods: We prospectively followed 172 COPD patients (median age 75 years, 62% male) from a previous Swiss multicenter trial. At baseline, we measured levels of a comprehensive spectrum of adrenal hormone metabolites, including glucocorticoid, mineralocorticoid and androgen hormones by liquid chromatography coupled with tandem mass spectrometry (MS). We calculated Cox regression models adjusted for gender, age, comorbidities and previous corticosteroid therapy. Results: Mortality was 6.4% after 30 days and increased to 61.6% after 6 years. Higher initial androgen hormones predicted lower long-term mortality with significant results for dehydroepiandrosterone (DHEA) [adjusted hazard ratio (HR), 0.82; 95% confidence interval (CI), 0.70–0.98; p=0.026] and dehydroepiandrosterone sulfate (DHEA-S) (adjusted HR, 0.68; 95% CI, 0.50–0.91; p=0.009). An activation of stress hormones (particularly cortisol and cortisone) showed a time-dependent effect with higher levels pointing towards higher mortality at short term, but lower mortality at long term. Activation of the mineralocorticoid axis tended to be associated with increased short-term mortality (adjusted HR of aldosterone, 2.76; 95% CI, 0.79–9.65; p=0.111). Conclusions: Independent of age, gender, corticosteroid exposure and exacerbation type, adrenal hormones are associated with mortality at short and long term in patients with COPD exacerbation with different time-dependent effects of glucocorticoids, androgens and mineralocorticoids. A better physiopathological understanding of the causality of these effects may have therapeutic implications.

scholarly journals Effect of percent air voids content on the deformation properties of the asphalt mixture

2021 ◽  
Vol 1209 (1) ◽  
pp. 012078
Author(s):  
J Bokomlasko ◽  
J Mandula
Keyword(s):  
Laboratory Tests ◽  
Asphalt Mixture ◽  
Road Construction ◽  
Air Voids ◽  
Aggregate Fraction ◽  
Deformation Properties ◽  
Load Effects ◽  
Air Void

Abstract Asphalt mixture is a building material with many advantages. Therefore, it is most used in road construction. If the asphalt mixture is laid with the prescribed technology, it can withstand load effects to long-term. It is necessary to take samples that will be subjected to laboratory measurements. There are several laboratory test, for example measurement thickness of the asphalt mixture layers, the aggregate fraction, quantity of binder in the mixture, determination of air void in asphalt mixture layers. Samples taken directly from the construction site are subjected to laboratory tests. This article focuses on one of the laboratory tests and it is determination of air void in asphalt mixture layers. The determination of air void in asphalt mixture layers is test in detail, because this effect has influence on the deformation properties of asphalt mixture layers. Therefore, it was necessary to model of air void in asphalt mixture layers with different degrees air void. On this purpose was use program Abaqus. The results were plotted. This graphs showed that increasing the air void in asphalt mixture layers has effect on the expansion of deformations. This can lead to faster pavement degradation.

scholarly journals Determination of polyadenylate-rich ribonucleic acid in the nucleus and in the cytoplasm of plasmacytoma cells

1975 ◽  
Vol 149 (3) ◽  
pp. 669-674 ◽  
Author(s):  
K A Abraham ◽  
T S Eikhom
Keyword(s):  
Ph Dependence ◽  
Specific Radioactivity ◽  
Nuclear Fraction ◽  
High Concentration ◽  
Millipore Filter ◽  
Filter Technique ◽  
Short And Long Term ◽  
Millipore Filters

A number of parameters affecting the adsorption of rRNA and poly(A)-containing RNA to Millipore filters were investigated separately. Binding of both types of RNA to the filter was dependent on the concentration of RNA, pH and Mg2+ concentration of the reaction mixture. Both types of RNA bound to the filter optimally at slightly acid pH values. The binding of poly(A)-containing RNA to the filter exhibited a broad pH-dependence compared with that of rRNA. The ratio of poly(A)-rich RNA/rRNA retained by the filter was maximal between pH7 and 8. The presence of 1 mM-EDTA or a high concentration of NaCl (over 0.5M) decreased the affinity of RNA for the filter. The amount of poly(A)-containing RNA in the nucleus and in the cytoplasm of a plasmacytoma cell line (MPC-11) labelled with [32P]Pi was determined by the Millipore-filter technique under conditions that minimized contamination by rRNA. These data were compared with the estimations made by oligo(dT)-cellulose chromatography. The results obtained by these two methods were in good agreement for RNA labelled for short periods (up to 2h). In long labelling and pulse-chase experiments, however, contamination of the filter by rRNA of increasing specific radioactivity in the cytoplasm gave an erroneous value for poly(A)-containing RNA by the Millipore-filter technique. Determinations made on the nuclear fraction by these two methods did not show significant variation in short- and long-term labelling experiments.

EFFECT OF LONG‐TERM LOADING AND FIRE TEMPERATURES ON MECHANICAL PROPERTIES OF CONCRETE

2005 ◽  
Vol 11 (4) ◽  
pp. 283-288 ◽  
Author(s):  
Bronius Jonaitis ◽  
Vytautas Papinigis
Keyword(s):  
High Temperature ◽  
Compression Strength ◽  
Normal Weight ◽  
Experimental Investigations ◽  
Reinforced Concrete Structures ◽  
Normal Weight Concrete ◽  
Deformation Properties ◽  
Strength And Deformation ◽  
Service Conditions

During a fire, reinforced concrete structures are exposed to high temperatures and subjected to long‐term action of variable and permanent loads. This paper deals with analysis of influence of fire temperatures and long‐term action of loads on compression strength and deformability of normal weight concrete. Results of experimental investigations of compression strength and deformability of normal‐weight concrete subjected to long‐term load and exposed to high temperature are presented. Specimens in the shape of prisms of normal‐weight concrete were subjected to long‐term compression of intensity η(t) = σc/fc (τ) = 0,3. The long‐term compression was sustained for 400 days. Some of the specimens were heated (at 250 °C and 450 °C) before application of long‐term load; other specimens were heated after application of long‐term load. The paper presents coefficient of service conditions for concrete subjected to long‐term load and exposed to high temperature that gives opportunity to evaluate compression strength and deformation properties of concrete.

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