Interactions between gemini and nonionic pharmaceutical surfactants

2010 ◽  
Vol 88 (12) ◽  
pp. 1262-1270 ◽  
Author(s):  
Javed R. Akbar ◽  
Rubena Deubry ◽  
D. Gerrard Marangoni ◽  
Shawn D. Wettig
Keyword(s):  
Surface Tension ◽  
Critical Micelle Concentration ◽  
Gemini Surfactant ◽  
Tween 80 ◽  
Tween 20 ◽  
Micellar Systems ◽  
Strength Of Interaction ◽  
Tween 60 ◽  
Alkyl Tail ◽  
Mixing Behaviour

The nature and strength of the interactions between the 1,3-bis(dimethylhexadecyl)propanediammonium dibromide (16-3-16) gemini surfactant and a homologous series of nonionic polyoxyethylene (20) sorbitan ester surfactants having laurate (Tween 20), stearate (Tween 60), or oleate (Tween 80) alkyl tails has been investigated. The critical micelle concentration (cmc) values of the mixed gemini–tween systems were determined using the du Noüy ring surface tension method, and the results have been analyzed using Clint’s, Rubingh’s, Motomura’s, and Maeda’s theories for mixed micellar systems. The results demonstrate a synergistic mixing behaviour between the Tween surfactants and the 16-3-16 gemini surfactant, where the strength of interaction is dependent upon the chain length and saturation of the Tween alkyl tail.

Surface Activity Research of Cationic Gemini Surfactants

2013 ◽  
Vol 690-693 ◽  
pp. 2076-2080
Author(s):  
Zhen Zhong Fan ◽  
Lan Lan Li ◽  
Li Feng Zhang ◽  
Qing Wang Liu
Keyword(s):  
Surface Tension ◽  
Critical Micelle Concentration ◽  
Surface Activity ◽  
Surfactant Concentration ◽  
Gemini Surfactant ◽  
Gemini Surfactants ◽  
Ph Value ◽  
Inorganic Salts ◽  
Cationic Gemini Surfactant ◽  
Cationic Gemini Surfactants

Cationic Gemini surfactant concentration, the inorganic salts added and the pH value of surface tension obtained cationic gemini surfactant critical micelle concentration is 0.4mmol / L;by adding three kinds of inorganic salts NaCl, MgCl2, and Na2SO4 ,which Na2SO4 has the greatest impact on surface tension, followed by MgCl2.The surface minimum tension of the pH ranged from 9 to 11 , indicating that the surface activity of cationic gemini surfactants achieved the highest.

Surfactants for the Effective Recovery of Salmonella in Fatty Foods

1982 ◽  
Vol 45 (3) ◽  
pp. 249-252 ◽  
Author(s):  
J.-Y. D'AOUST ◽  
C. MAISHMENT ◽  
P. STOTLAND ◽  
A. BOVILLE
Keyword(s):  
Salmonella Enteritidis ◽  
Brilliant Green ◽  
False Negative ◽  
Tween 80 ◽  
Food Samples ◽  
Nutrient Broth ◽  
Tween 20 ◽  
Negative Results ◽  
False Negative Results ◽  
Tween 60

Inhibitory concentrations of 8 surfactants were determined for Salmonella typhimurium and Salmonella enteritidis. Pure culture work resulted in the exclusion of Tween 20, Teepol 610 and Brij 35 and retention of Tergitol-7 (T-7), Tween 80 (TW 80), Triton X-100 (TX), Myrj 52S (M), and Arlacel 80 + Tween 60 (AT) for a study on the quantitative recovery of Salmonella in 45 naturally contaminated fatty foods. Replicate food samples (100 g) were preenriched overnight at 35 C in nutrient broth supplemented with 3%(w/v) surfactant except AT (10%). Serial dilutions of preenrichment cultures were selectively enriched overnight in tetrathionate brilliant green (43 C) and selenite cystine (35 C) broths and streaked on bismuth sulfite and brilliant green sulfa agar media. Recovery with all test surfactants was comparable to that obtained with nutrient broth controls; of 270 preenrichment cultures tested, only 7 false-negative results attributable to TX (3), AT (2), M (1), and nutrient broth control (1) were obtained. None of the surfactants consistently yielded greater populations of Salmonella for given foods or food categories; median counts for preenrichment cultures were 104–105 salmonellae/ml for low and high moisture foods and 106–107 salmonellae/ml for animal feeds. These results suggest that use of surfactants to facilitate detection of Salmonella in fatty foods is not warranted.

Effect Of Surfactant Chain Length On Emulsification Dynamics Of Self Emulsifying Formulation Of Poorly Soluble Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Shailendra Chouhan ◽  
Lalit Singh Chauhan
Keyword(s):  
Chain Length ◽  
Tween 80 ◽  
Tween 20 ◽  
Almond Oil ◽  
Peg 400 ◽  
Globule Size ◽  
Poorly Soluble ◽  
Tween 40 ◽  
Poorly Soluble Drug ◽  
Tween 60

Aim: In this work the aim was to study the chain length of surfactant on the self emulsifying system of a poorly soluble drug, aceclofenac. The selection of almond oil as a lipid vehicle was done on basis of solubility and compatibility of the vehicle with the drug. Methods: The effect of varying chain length of different surfactants of Tween series namely Tween 20, Tween 40, Tween 60 and Tween 80 was evaluated on self emulsifying efficiency by constructing pseudoternary diagrams. PEG-400 was used as co-surfactant in a definite ratio with all the surfactants to minimize their concentration. The best self emulsifying ability was exhibited by Tween 80: PEG-400 combination followed by Tween 60: PEG-400, Tween 40: PEG-400, Tween 20: PEG-400. This observation indicates that as the chain length of Tweens increases their ability to form a good microemulsion increases if same co-surfactant is used. Results: However it has also been found that the presence of unsaturated bond in Tween 80 provides it an elasticity which supports good intermixing of oil and water and leading to formation of a fine microemulsion. Six different formulations were prepared using combination of almond oil, Tween 80, PEG-400 and the drug aceclofenac. Conclusion : The formulations were subjected to various evaluation parameters such as dispersibility, transmittance, pH, globule size, polydispersibility, zeta potential, viscosity, refractive index and in vitro dissolution. The best formulation was found to have globule size of less than 100 nm, zeta potential of -3.35 ± 0.60 mV which indicates formation of a microemulsion of aceclofenac with good stability.

Effect of some surfactants on the chemiluminescent reactions of bis(2,4,6-trichlorophenyl)oxalate and bis(2-nitrophenyl)oxalate with hydrogen peroxide

2012 ◽  
Vol 90 (6) ◽  
pp. 534-541 ◽  
Author(s):  
Patrícia Dantoni ◽  
Ana Clara B. Rodrigues ◽  
Margareth Mie N. Matsuda ◽  
Nina Coichev
Keyword(s):  
Hydrogen Peroxide ◽  
Tween 80 ◽  
Peak Height ◽  
Tris Buffer ◽  
Tween 20 ◽  
Ionic Surfactants ◽  
Maximum Peak ◽  
Buffer Solutions ◽  
Micellar Systems ◽  
Brij 35

The chemiluminescent reactions of bis(2,4,6-trichlorophenyl)oxalate (TCPO) and bis(2-nitrophenyl)oxalate (2-NPO) with hydrogen peroxide in acetonitrile/water micellar systems (anionic, cationic, and non-ionic) and γ-cyclodextrin were studied in the presence of fluoranthene or 9,10-diphenylanthracene, imidazole, and two buffer solutions, HTRIS+/TRIS and H2PO4–/HPO42–. The relative chemiluminenscence (CL) intensity is higher in the presence of the cationic (DDAB, CTAC, DODAC, and OTAC), anionic (SDS), and non-ionic (Tween 80) surfactants. In the presence of some non-ionic surfactants (Brij 35, Brij 76, and Tween 20), the CL intensity was partially quenched compared with the reaction with no surfactant. The sensitivity for hydrogen peroxide determination in the range 0.01 × 10−4 to 1.0 × 10−4 mol L–1, considering the slope of the calibration curves (maximum peak height of CL vs. concentration), improved with the introduction of DDAH, CTAB, and SDS in HTRIS+/TRIS buffer.

Comparative Analysis of the Properties of Tween‐20, Tween‐60, Tween‐80, Arlacel‐60, and Arlacel‐80

2007 ◽  
Vol 28 (3) ◽  
pp. 477-484 ◽  
Author(s):  
Shrinivas C. Kothekar ◽  
Adinath M. Ware ◽  
Jyotsna T. Waghmare ◽  
S. A. Momin
Keyword(s):  
Comparative Analysis ◽  
Tween 80 ◽  
Tween 20 ◽  
Tween 60

scholarly journals Skrining Berbagai Jenis Surfaktan Dan Kosurfaktan Sebagai Dasar Pemilihan Formulasi Nanoemulsi

2021 ◽  
Vol 1 (3) ◽  
pp. 158-166
Author(s):  
Ni Luh Putu Karunia Vidya Nirmalayanti
Keyword(s):  
Phase Diagram ◽  
Propylene Glycol ◽  
Research Method ◽  
Tween 80 ◽  
Tween 20 ◽  
Peg 400 ◽  
Tween 60 ◽  
Main Components ◽  
Optimum Formula ◽  
Pseudoternary Phase Diagram

The main components for making nanoemulsions are oil, surfactants, and cosurfactants. Before formulating nanoemulsions, screening the surfactants and cosurfactants is necessary to produce an optimum formula. Thus, it carries out surfactants screening, namely (tween 20, tween 60, tween 80) and cosurfactants (propyleneglycol, PEG 400, glycerin). This study aimed to screen suitable selection and cosurfactants as the basis for making nanoemulsions. Then, the research method was carried out in two ways: surfactant screening and cosurfactant screening. The final results were analyzed using a pseudoternary phase diagram. The surfactant screening results were tween 20 (40mL), tween 60 (40mL), tween 80 (60mL); thereby, the best surfactant candidate was tween 80. The results of the surfactant screening on the pseudoternary phase diagram are the most optimal, namely tween 80 with propylene glycol because it has a large nanoemulsion formation area. The study proposed the ratio of oil: smix (tween 80 and propyleneglycol) (1:9) as the optimum formula used to make a nanoemulsion base.

Thermodynamic Micellization of Cationic-Nonionic Surfactants in Aqueous Solution Using Conductivity and Surface Tension Measurements

2021 ◽  
Vol 19 (4) ◽  
pp. 20-26
Author(s):  
Inaam H. Ali ◽  
Sameer H. Kareem ◽  
Fouad A.A. AL-Saady
Keyword(s):  
Aqueous Solution ◽  
Surface Tension ◽  
Free Energy ◽  
Critical Micelle Concentration ◽  
Mixed Micelle ◽  
Nonionic Surfactants ◽  
Mixed Micelles ◽  
Tween 20 ◽  
Standard Thermodynamic Functions ◽  
Increasing Temperature

In the current work, we discuss the mixed micelles and thermodynamic micellization of aqueous binary mixture of polyoxyethylene - 20 sorbitan-monododecanoate (Tween 20) as nonionic surfactant and Benzyldimethylhexadecyl ammonium chloride (HDBAC) as cationic surfactant using conductivity and surface tension (γ) estimations in the temperatures range (288 -318K). Critical micelle concentration (CMC) and variables of micellization, like the standard thermodynamic functions: Gibbs free energy (Δ𝐺𝑚 ⁰ ), enthalpyΔ𝐻𝑚 ⁰ ) and entropy (Δ𝑆𝑚 ⁰ ) were calculated using the variation of conductivity and γ with molar concentration and the variation of ln XCMC with temperature. The experimental CMC values were applied to calculate the mole fractions of surfactant in the mixed micelle (𝑋1 𝑚 ), the β parameter and the coefficient of activity f1and f2, using the equations proposed by Clint and Rubingh, which indicate the β parameter, is always negative. In addition, the results of thermodynamic parameters show that ΔG⁰m are negative for both individual and mixture of HDBAC-Tween20 surfactants and the values negatively increased with increasing temperature while its negative values decreasing with decreasing initial mole fraction of HDBAC.

Surface Activity Research of Cationic Gemini Surfactants

2013 ◽  
Vol 652-654 ◽  
pp. 1450-1454
Author(s):  
Zhen Zhong Fan ◽  
Lan Lan Li ◽  
Li Feng Zhang ◽  
Qing Wang Liu
Keyword(s):  
Surface Tension ◽  
Critical Micelle Concentration ◽  
Surface Activity ◽  
Surfactant Concentration ◽  
Gemini Surfactant ◽  
Gemini Surfactants ◽  
Ph Value ◽  
Inorganic Salts ◽  
Cationic Gemini Surfactant ◽  
Cationic Gemini Surfactants

Cationic Gemini surfactant concentration, the inorganic salts added and the pH value of surface tension obtained cationic gemini surfactant critical micelle concentration is 0.4mmol / L;by adding three kinds of inorganic salts NaCl, MgCl2, and Na2SO4 ,which Na2SO4 has the greatest impact on surface tension, followed by MgCl2.The surface minimum tension of the pH ranged from 9 to 11 , indicating that the surface activity of cationic gemini surfactants achieved the highest.

Synthesis and Properties of Novel Cashew-Based Sulfonate Gemini Surfactant

2014 ◽  
Vol 915-916 ◽  
pp. 927-932
Author(s):  
Wei Guang Shi ◽  
Peng Xiang Wang ◽  
Xiao Gang Ma ◽  
Cui Qin Li ◽  
Jun Wang
Keyword(s):  
Surface Tension ◽  
Critical Micelle Concentration ◽  
Interfacial Tension ◽  
Sodium Hydroxide ◽  
Gemini Surfactant ◽  
Chlorosulfonic Acid ◽  
Inorganic Salts ◽  
Foam Properties ◽  
Sulfonate Gemini Surfactant ◽  
Oil Water

A novel cashew-based gemini surfactant was synthesized from cashew phenol, 1, 3-dibromopropane and chlorosulfonic acid through etherification, sulfonation and neutralization. The critical micelle concentration (cmc) for cashew-based gemini surfactant was 6.2×10-2 mmol·L-1, the surface tension (γcmc) was 36.92 mN.m-1. Foam properties and emulsification properties were investigated including the affection of inorganic salts and sodium hydroxide. The oil / water interfacial tension can be decreased efficiently to 10-3mN / m.

Orthogonal Test Design for Optimization of Emulsifying Effectiveness of Phytosterol Adding to Milk Using Tween as Emulsifiers

2013 ◽  
Vol 700 ◽  
pp. 280-283
Author(s):  
Guo Wei Shu ◽  
Ji Li Cao ◽  
He Chen ◽  
Yuan Tan ◽  
Ling Ma
Keyword(s):  
Orthogonal Experiment ◽  
Tween 80 ◽  
Orthogonal Test ◽  
Tween 20 ◽  
Test Design ◽  
Single Factor ◽  
Orthogonal Test Design ◽  
Tween 40 ◽  
Tween 60

Effect of four emulsifiers including Tween 20, Tween 40, Tween 60 and Tween 80 on emulsifying effectiveness of phytosterol adding to milk was studied by single factor and orthogonal experiment. The concentrations of four emulsifiers were all 0.2%, 0.3%, 0.4%, 0.5%, 0.6% and 0.7%. The optimal emulsified conditions showed as follows: the optimal concentrations of Tween 20, Tween 40, Tween 60 and Tween 80 were 0.40%, 0.40%, 0.20% and 0.30%, respectively, the emulsification R reached 1.043 under the conditions mentioned above.

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