Labdane diterpenes from the marine pulmonate gastropod Trimusculus peruvianus

1996 ◽  
Vol 74 (12) ◽  
pp. 2471-2475 ◽  
Author(s):  
Aurelio San-Martín ◽  
Elías Quezada ◽  
Pilar Soto ◽  
Juana Rovirosa ◽  
Yolanda Palacios

The marine gastropod mollusk Trimusculus peruvianus collected on the coast of Central Chile yielded four new labdane metabolites. The structural elucidation of all compounds was accomplished by spectral analysis. One diterpenoid showed modest antimicrobial activity. Key words: Trimusculus peruvianus, labdanes, marine mollusk.


1970 ◽  
Vol 46 (3) ◽  
pp. 329-332 ◽  
Author(s):  
N Sultana ◽  
MM Rahman ◽  
S Ahmed ◽  
S Akter ◽  
MM Haque ◽  
...  

Three known compounds were isolated from the n-hexane extract of the rihzomes of Sansevieria hyacinthoides, they were two steriods; β- sitosterol (1) and daucosterol (2), and a flavonoid; isokaemferide (3). The structures of the compounds were elucidated on the basis of NMR spectral analysis as well as comparison with available data in the literature. All extracts and the three pure compounds were evaluated for their antimicrobial activity. The compounds showed moderate activity against Bacillus subtilis, Stapylococcus aureus, Salmonella typhi and Candida albicans. Key words: Sansevieria hyacinthoides; Antimicrobial activity; Infectious diseases; Flavonoid; Steriods DOI: http://dx.doi.org/10.3329/bjsir.v46i3.9038 BJSIR 2011; 46(3): 329-332



Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.



2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.



2020 ◽  
Vol 12 (1) ◽  
pp. 128-132
Author(s):  
I.A. Raubilu ◽  
U. Isah ◽  
M.A. Ahmad

Moringa oleifera Lam. (Family Moringaceae) is well – known for its various medicinal properties. It grows wild in the tropical and subtropical areas of Asia, Africa and the Middle East. In Nigeria, Moringa oleifera trees are planted at a large scale especially in the northern part of the country. It has been widely used in the treatment of certain diseases as a traditional medicinal herb. Antimicrobial activity is the most studied property of Moringa oleifera. Many studies have shown that nearly all types of Moringa oleifera tissues exhibit antimicrobial activity including antibacterial, antifungal, antiviral and anti parasitic property. This review describes progress on research conducted to understand the antimicrobial activity of Moringa oleifera and discusses the potential use of Moringa oleifera in the control of pathogenic microbes. Key words: Antimicrobial activity; Moringa oleifera; pathogenic microbes, control.  



2007 ◽  
Vol 18 (6) ◽  
pp. 664-674 ◽  
Author(s):  
Saira Shahzadi ◽  
Saqib Ali ◽  
Klaus Wurst ◽  
Muhammad Najam-ul-Haq




1970 ◽  
Vol 8 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Kulsum Ara ◽  
Mohammad S Rahman ◽  
AHMM Rahman ◽  
Choudhury M Hasan ◽  
Mohammad A Rashid

Two terpenoids, β-amyrin (1) and β-sitostenone (2) and a coumarin, scopoletin (3) were isolated from petroleum ether and dichloromethane soluble extracts of the stem bark of Bursera serrata Wall. The structures of the isolated compounds 1-3 were established by extensive spectroscopic studies as well as by comparison with published data. Although compounds 1-3 have been isolated from various plant species previously, this is the first report of the occurrence of these compounds from B. serrata. The crude extractives exhibited weak antimicrobial activity and cytotoxicity. Key words: Bursera serrata; Burseraceae; β-amyrin; β-sitostenone; scopoletin; antimicrobial; cytotoxicity   DOI: 10.3329/dujps.v8i2.6023 Dhaka Univ. J. Pharm. Sci. 8(2): 107-110, 2009 (December)



2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Elena Ancheeva ◽  
Georgios Daletos ◽  
Rini Muharini ◽  
Wen Han Lin ◽  
Leonid Teslov ◽  
...  

Stellaria nemorum L. and S. holostea L. (Caryophyllaceae) were investigated for their flavonoids. The new flavonoid 6- C-[(α-arabinopyranosyl)-(1→2)- O-β-xylopyranosyl]apigenin (1) and the four known C-glycosides, 6- C-[(α-arabinopyranosyl)-(1→2)- O-β-glucopyranosyl]apigenin (2), apigenin 6- C-β-galactopyranoside-8- C-β-glucopyranoside (3), apigenin 6- C-β-glucopyranoside-8- C-α-arabinopyranoside (4), and apigenin 6- C-β-glucopyranoside-8- C-β-xylopyranoside (5) were isolated from the aerial parts of S. nemorum for the first time. Furthemore, five known flavonoids, 3,5,7-trihydroxy-3′,5′-dimethoxyflavone (9), diosmetin 6- C-β-glucopyranoside (8), schaftoside (4), isoorientin (6) and orientin (7) were obtained from the aerial parts of S. holostea. Compounds 4, 8 and 9 are reported for the first time from this species. The structures of all isolated compounds were unambiguously elucidated by one- and two- dimensional NMR and mass spectral analysis, by acid hydrolysis, as well as by comparison with literature data. The crude extracts of the investigated species exhibited antimicrobial activity against Staphylococcus aureus, while none of the isolated compounds was found to be active.



2020 ◽  
Vol 22 (17) ◽  
pp. 6927-6931 ◽  
Author(s):  
Xiaoqi Ji ◽  
Yuliang Dong ◽  
Chunyao Ling ◽  
Zhenbin Zhou ◽  
Qinglian Li ◽  
...  


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