VITAMIN SUPPLEMENTS AND RADIOGRAPHIC KNEE OSTEOARTHRITIS: THE CLEARWATER OSTEOARTHRITIS STUDY

2009 ◽  
Vol 12 (02) ◽  
pp. 85-93 ◽  
Author(s):  
Frances Vaughn Wilder ◽  
Paul E. Leaverton ◽  
Matthew W. Rogers ◽  
Nancy B. Lemrow
Keyword(s):  
Knee Osteoarthritis ◽  
Cost Effective ◽  
Protective Role ◽  
Ordinal Scale ◽  
Vitamin Supplement ◽  
Vitamin Supplements ◽  
Knee Oa ◽  
Supplement Usage ◽  
History Of ◽  
Radiographic Knee Osteoarthritis

Objective: To evaluate the association between vitamin supplements and the incidence and progression of radiographic knee osteoarthritis (OA). Study Design: Prospective cohort. Methods: Men and women aged 40 years and older (N = 2239) participating in the community-based Clearwater Osteoarthritis Study (1988–current) with biennial, sequential radiographs. The Lawrence & Kellgren ordinal scale was used to determine evidence of the study outcome, radiographic knee OA, and progression of radiographic knee OA. The study exposure was baseline history of self-reported vitamin supplement usage. Results: Individuals without baseline knee OA who self-reported vitamin supplement usage were 12% less likely to develop knee OA than were those individuals who self-reported no vitamin supplement usage (RR = 0.88; 95% C.I. 0.86–0.89). Those with baseline knee OA who self-reported vitamin supplement usage were 7% less likely to experience knee OA progression than were those individuals who self-reported no vitamin supplement usage (RR = 0.93; 95% C.I. 0.87–0.99). Conclusion: After consideration of BMI, gender, age, history of knee trauma, exercise and vitamin supplement usage prior to study baseline, these findings suggest that vitamin supplement usage may play a protective role in knee OA. Vitamin supplements may be a cost-effective strategy to reduce the incidence and/or slow the progression of knee OA. As many approved OA drugs are accompanied by adverse side effects, the role of vitamin supplements in the development and progression of knee OA warrants further investigation.

scholarly journals The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

2010 ◽  
Vol 14 (4) ◽  
pp. 709-715 ◽  
Author(s):  
Jennifer Peregoy ◽  
Frances Vaughn Wilder
Keyword(s):  
Cohort Study ◽  
Longitudinal Study ◽  
Vitamin C ◽  
Knee Osteoarthritis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ordinal Scale ◽  
Knee Oa ◽  
Supplement Usage ◽  
Vitamin C Supplementation

AbstractObjectiveTo evaluate the association between vitamin C supplementation and the incidence and progression of radiographic knee osteoarthritis (OA).DesignProspective cohort study.SettingClearwater Osteoarthritis Study (COS): (1988 to the present) a longitudinal study.SubjectsMale and female COS participants aged 40 years and above (n 1023). The study exposure was the participants’ self-reported history of vitamin C supplementation. The participants underwent biennial, sequential knee radiographs, which were assessed using the Kellgren–Lawrence ordinal scale to determine evidence of the study 2 outcomes: incident radiographic knee OA (RKOA) and progression of RKOA.ResultsIndividuals without baseline knee OA who self-reported vitamin C supplement usage were 11 % less likely to develop knee OA than were those individuals who self-reported no vitamin C supplement usage (risk ratio (RR) = 0·89, 95 % CI 0·85, 0·93). Among those participants with RKOA at baseline, vitamin C supplement usage did not demonstrate an association with RKOA progression (RR = 0·94, 95 % CI 0·79, 1·22).ConclusionsIn the present prospective cohort study, we found no evidence to support a protective role of vitamin C in the progression of knee OA. However, after controlling for confounding variables, these data suggest that vitamin C supplementation may indeed be beneficial in preventing incident knee OA. Given the massive public health burden of OA, the use of a simple, widely available and inexpensive supplement to potentially reduce the impact of this disease merits further consideration.

scholarly journals The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study

2012 ◽  
Vol 64 (7) ◽  
pp. 2243-2251 ◽  
Author(s):  
K. M. Leyland ◽  
D. J. Hart ◽  
M. K. Javaid ◽  
A. Judge ◽  
A. Kiran ◽  
...  
Keyword(s):  
Cohort Study ◽  
Natural History ◽  
Knee Osteoarthritis ◽  
Population Based ◽  
History Of ◽  
Radiographic Knee Osteoarthritis

scholarly journals Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study

2020 ◽  
Vol 48 (1) ◽  
pp. 123-128
Author(s):  
Guangju Zhai ◽  
Xianbang Sun ◽  
Edward W. Randell ◽  
Ming Liu ◽  
Na Wang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Radiographic Progression ◽  
Phenylalanine Level ◽  
Combined Analysis ◽  
Knee Oa ◽  
Increased Risk ◽  
Group 2 ◽  
Site Significance ◽  
Radiographic Knee Osteoarthritis ◽  
Group 1

Objective.To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis(OA) progression using a metabolomics approach.Methods.Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized into 2 groups based on the presence of baseline radiographic OA. Subjects in group 1 had unilateral knee OA and subjects in group 2 had bilateral knee OA. Progression was defined as a half-grade or greater worsening in joint space width at 30-month follow-up. For group 1, a participant progressed when their OA knee showed radiographic progression and the contralateral knee developed OA; for group 2, a participant progressed when both knees with OA showed radiographic progression. Metabolomic profiling was performed on plasma samples collected at baseline and logistic regression was performed to test the association between each metabolite and knee OA progression after adjustment for age, sex, BMI, and clinic site. Significance was defined as P ≤ 0.0003 in the combined analysis.Results.There were 234 progressors (57 in group 1 and 177 in group 2) and 322 nonprogressors (206 in group 1 and 116 in group 2) included in the analyses. Among 157 metabolites studied, we found that odds of progression were 1.46 times higher per SD increase of phenylalanine level (95% CI 1.20–1.77, P = 0.0001) in the combined analysis. Sex-specific analysis showed that an association was seen in women (P = 0.0002) but not in men.Conclusion.Our data suggest that phenylalanine might be a novel plasma marker for higher risk of bilateral radiographic knee OA progression in women.

scholarly journals Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jana Podlipská ◽  
Ali Guermazi ◽  
Petri Lehenkari ◽  
Jaakko Niinimäki ◽  
Frank W. Roemer ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
Diagnostic Performance ◽  
Structural Changes ◽  
Morphological Changes ◽  
Cost Effective ◽  
Conventional Radiography ◽  
Joint Space ◽  
Meniscal Extrusion ◽  
Knee Oa

Abstract Osteoarthritis (OA) is a common degenerative musculoskeletal disease highly prevalent in aging societies worldwide. Traditionally, knee OA is diagnosed using conventional radiography. However, structural changes of articular cartilage or menisci cannot be directly evaluated using this method. On the other hand, ultrasound is a promising tool able to provide direct information on soft tissue degeneration. The aim of our study was to systematically determine the site-specific diagnostic performance of semi-quantitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion, and of radiographic assessment of joint space narrowing and osteophytes, using MRI as a reference standard. Eighty asymptomatic and 79 symptomatic subjects with mean age of 57.7 years were included in the study. Ultrasound performed best in the assessment of femoral medial and lateral osteophytes, and medial meniscal extrusion. In comparison to radiography, ultrasound performed better or at least equally well in identification of tibio-femoral osteophytes, medial meniscal extrusion and medial femoral cartilage morphological degeneration. Ultrasound provides relevant additional diagnostic information on tissue-specific morphological changes not depicted by conventional radiography. Consequently, the use of ultrasound as a complementary imaging tool along with radiography may enable more accurate and cost-effective diagnostics of knee osteoarthritis at the primary healthcare level.

scholarly journals Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

2014 ◽  
Vol 74 (7) ◽  
pp. 1353-1359 ◽  
Author(s):  
Hans Liebl ◽  
Gabby Joseph ◽  
Michael C Nevitt ◽  
Nathan Singh ◽  
Ursula Heilmeier ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Knee Osteoarthritis ◽  
Case Control ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Knee Oa ◽  
Osteoarthritis Initiative ◽  
Nested Case Control ◽  
Radiographic Knee Osteoarthritis

ObjectiveTo evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).Materials and methodsWe performed a nested case–control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren–Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case–control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates.ResultsBaseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared with controls and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values, particularly in the patella, adjusted OR per 1 SD increase in T2 (3.37 (95% CI 1.72 to 6.62)), but also in the medial femur (1.90 (1.07 to 3.39)), lateral femur (2.17 (1.11 to 4.25)) and lateral tibia (2.23 (1.16 to 4.31)).ConclusionsThese findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

scholarly journals EFFICACY OF PANCHAKARMA IN SANDHIVATA W.S.R. TO KNEE ARTHRITIS

2021 ◽  
Vol 09 (1) ◽  
pp. 212-218
Author(s):  
Tanuja Mehta ◽  
Vipin Kumar ◽  
Sheetal Verma ◽  
Uttam Kumar Sharma
Keyword(s):  
Knee Osteoarthritis ◽  
Cost Effective ◽  
Knee Arthritis ◽  
Motor Disability ◽  
Traditional System ◽  
Pharmaceutical Management ◽  
Knee Oa ◽  
Therapeutic Benefits ◽  
Therapeutic Measures ◽  
Inflammatory Drugs

Inflammation of knee joint is called knee arthritis. Among various forms of knee arthritis common is degenerative type of knee osteoarthritis It is the major cause of loco motor disability in old age people particularly among women. Analgesics and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the current available pharmaceutical management of knee osteoarthritis which are associated with adverse side effects. Thus, there is need of research in traditional system of medicines for cost effective and long-term management of knee OA. Degenerative Knee osteo arthritis is almost similar to the Sandhivata describes in Ayuveda with respect to aetiology, pathology and clinical features. With the use of medicines Ayurveda also employs the prospective of Panchakarma in the various therapeutic measures, which is a kind of Shodhan Chikitsa. Panchakarma provides various therapeutic benefits as detoxification, improved circulation, spasm and pain relief. Hence objective of this review article is to describe the efficacy of Panchakarma in knee-arthritis with taking consideration of disease mentioned in Ayurvedic classics as Sandhivata

scholarly journals Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

2001 ◽  
Vol 4 (5) ◽  
pp. 935-942 ◽  
Author(s):  
Anneclaire J De Roos ◽  
Lenore Arab ◽  
Jordan B Renner ◽  
Neal Craft ◽  
Gheorghe Luta ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
High Performance ◽  
Conditional Logistic Regression ◽  
Serum Levels ◽  
Knee Oa ◽  
Antioxidant Intake ◽  
Matched Case ◽  
Serum Carotenoids ◽  
Β Carotene ◽  
Radiographic Knee Osteoarthritis

AbstractObjective:Antioxidant intake has been associated with less progression of radiographic knee osteoarthritis (OA), but studies of carotenoid biomarkers and OA have not been done. We examined associations between serum concentrations of nine naturally occurring carotenoids and radiographic knee OA.Design:The study design was matched case–control. Sera were analysed by high-performance liquid chromatography for nine carotenoids: lutein, zeaxanthin, α- and β-cryptoxanthin, trans- and cis-lycopene, α-carotene, and trans- and cis-β-carotene. Conditional logistic regression was used to estimate the association between tertiles of each carotenoid and radiographic knee OA, independent of body mass index, education, serum cholesterol, and the other carotenoids.Setting:Johnston County, North Carolina, United States of America.Subjects:Two-hundred cases with radiographic knee OA (Kellgren–Lawrence grades ≥2) and 200 controls (Kellgren–Lawrence grade = 0) were randomly selected from the Johnston County Osteoarthritis Project, and were matched on age, gender and race.Results:Participants with serum levels of lutein or β-cryptoxanthin in the highest tertile were approximately 70% less likely to have knee OA than controls {odds ratio (OR) [95% confidence interval (CI)] = 0.28 [0.11, 0.73] and 0.36 [0.14, 0.95], respectively}. Those in the highest tertile of trans-β-carotene (OR = 6.40 [1.86, 22.1]) and zeaxanthin (OR = 3.06 [1.19, 7.85]) were more likely to have knee OA.Conclusions:While certain carotenoids may protect against knee OA, others may increase the odds of knee OA. Further study of carotenoids and knee OA are warranted before clinical recommendations about these substances and knee OA can be made.

Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

2015 ◽  
Vol 42 (7) ◽  
pp. 1231-1236 ◽  
Author(s):  
Chao Zeng ◽  
Jie Wei ◽  
Hui Li ◽  
Tuo Yang ◽  
Fang-Jie Zhang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Concentration ◽  
Multivariable Model ◽  
Clear Trend ◽  
Cross Sectional ◽  
Knee Oa ◽  
Logistic Analysis ◽  
Radiographic Knee Osteoarthritis

Objective.To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA).Methods.There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88–0.91, 0.92–0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category.Results.Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71–1.13), 0.92 (95% CI 0.73–1.16), and 0.72 (95% CI 0.57–0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile.Conclusion.Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.

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