COMPARISON OF SCAPULAR MORPHOLOGY IN DEGENERATIVE AND TRAUMATIC ROTATOR CUFF TEARS

2021 ◽  
Author(s):  
Samarth Thakkar ◽  
Seetharama Rao ◽  
Atmananda Hegde ◽  
Prajwal Mane ◽  
Vikranth Khanna ◽  
...  
Keyword(s):  
Intraclass Correlation ◽  
Repeated Measurements ◽  
Rotator Cuff Tears ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Traumatic Group ◽  
Blinded Manner ◽  
Chi Square Test ◽  
Reliability Methods ◽  
Shoulder Angle

Background: Degenerative cuff tears have impingement pathophysiology due to altered scapular morphology as measured by increased critical shoulder angle (CSA), decreased lateral acromial angle (LAA) and increased acromion index (AI). But scapular morphology in traumatic tears has neither been studied nor compared with degenerative tears. Aim: To compare scapular morphology with CSA, LAA, AI between traumatic and degenerative tears and determine their reliability. Methods: This observational study includes 100 patients (50 with traumatic and degenerative tears). We analyzed MRI and standardized AP shoulder radiograph of these patients. Parameters, such as CSA, LAA, AI, were measured on AP radiographs by two separate observers in a blinded manner. The 1st observer repeated measurements after four weeks. We compared age, gender, degree of cuff tear, and CSA values, LAA, and AI between the two groups. Results: On comparison using chi-square test, degenerative group had significantly higher age, higher CSA (mean 37.55, SD 0.88 versus traumatic group mean 36.6, SD 0.95, [Formula: see text]-[Formula: see text], highly significant), higher AI (mean 0.73, SD 0.02 versus traumatic mean 0.69, SD 0.04 [Formula: see text]-[Formula: see text], highly significant), and lower LAA (77.14, SD 2.03 versus traumatic mean 78.36, SD 2.73, [Formula: see text]-value 0.013, significant). Interobserver and intraobserver reliability of parameters using the intraclass correlation coefficient (ICC) revealed excellent (CSA, LAA) and good (AI) agreement. ROC curve analysis calculated sensitivity (0.7) and specificity (0.66) to diagnose degenerative tear for CSA above 37.05[Formula: see text]. Conclusion: Scapular morphology in traumatic tears differs from degenerative. CSA, LAA, AI can be reliably measured on standardized shoulder AP radiographs.

Hardy-Weinberg Testing for Continuous Data

Genetics ◽  
1997 ◽  
Vol 147 (4) ◽  
pp. 1965-1975
Author(s):  
Lauren M McIntyre ◽  
B S Weir
Keyword(s):  
Intraclass Correlation ◽  
Kernel Density ◽  
Variable Number ◽  
Continuous Data ◽  
Test Statistic ◽  
Test Procedures ◽  
Chi Square ◽  
Exact Test ◽  
Chi Square Test ◽  
The Many

Abstract Estimation of allelic and genotypic distributions for continuous data using kernel density estimation is discussed and illustrated for some variable number of tandem repeat data. These kernel density estimates provide a useful representation of data when only some of the many variants at a locus are present in a sample. Two Hardy-Weinberg test procedures are introduced for continuous data: a continuous chi-square test with test statistic TCCS and a test based on Hellinger's distance with test statistic TCCS. Simulations are used to compare the powers of these tests to each other and to the powers of a test of intraclass correlation TIC, as well as to the power of Fisher's exact test TFET applied to discretized data. Results indicate that the power of TCCS is better than that of THD but neither is as powerful as TFET. The intraclass correlation test does not perform as well as the other tests examined in this article.

A field test of the accuracy of the Barr and Stroud Type FP-12 optical dendrometer

1971 ◽  
Vol 47 (2) ◽  
pp. 69-74 ◽  
Author(s):  
John F. Bell ◽  
William A. Groman
Keyword(s):  
Field Test ◽  
Volume Growth ◽  
Douglas Fir ◽  
Repeated Measurements ◽  
Field Conditions ◽  
Extended Time ◽  
Chi Square ◽  
Standing Trees ◽  
Chi Square Test ◽  
First Time

Trees in a 55-year-old stand of Douglas-fir were measured with a Barr and Stroud Type FP-12 dendrometer while standing, then measured with tape and caliper after they were felled. The chi-square test of accuracy for diameters, whether determined according to size, elevation, or distance, fell within a range from ±0.222 to ±0.298 inch, and percentage accuracies varied from ±2.12 to ±3.25. The chi-square test of accuracy for stem lengths decreased from ±0.272 foot (±0.991 percent) at an average elevation of 23.30 feet for an 11.40-foot segment to ±0.782 foot (3.96 percent) for a 14.22-foot average segment at an average elevation of 62.91 feet.This study indicates that upper-stem diameters and segment lengths determined by the Barr and Stroud optical dendrometer are highly accurate under field conditions. Thus, the optical dendrometer provides the forester with a means of eliminating tree-volume tables. Results suggest that, for the first time, volume growth of the upper stem can be accurately determined on standing trees by making repeated measurements over an extended time.

scholarly journals Individual analysis of creatine kinase concentration in Brazilian elite soccer players

2015 ◽  
Vol 21 (2) ◽  
pp. 112-116 ◽  
Author(s):  
Adriano Lima Alves ◽  
Emerson Silami Garcia ◽  
Rodrigo Figueiredo Morandi ◽  
João Gustavo Claudino ◽  
Eduardo Mendonça Pimenta ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Initial Period ◽  
Repeated Measurements ◽  
Soccer Players ◽  
Muscle Adaptation ◽  
Chi Square ◽  
Significance Level ◽  
Chi Square Test ◽  
The One ◽  
The Individual

OBJECTIVE: to determine the individual profile of blood concentration of creatine kinase CK in elite soccer players as well as to analyze the CK concentrations in different periods during the Professional Brazilian Championship.METHODS: resting CK of 17 soccer players was evaluated before the competition pre-season and after the matches 36 and 46 hours after the games CKGame for the individual blood CK. The Chi-square test was used to analyze the individual CK during the season. The competitive season was divided into three periods: initial, intermediate and final. The one-way ANOVA with repeated measurements followed by post hoc Student-Newman-Keuls test was used to compare the individual CK of each soccer player in each competitive period. The significance level was set at p<0.05.RESULTS: the highest frequency of individual CK was found in the second quartile 71 observations and the lowest frequency in the first 26 observations and the fourth quartile 40 observations compared to the expected number of 45.8 x2=22.21. CK concentrations were lower in the intermediate mean=66.99% and final mean=60.21% periods than in the initial period mean=89.33%.CONCLUSION: soccer players did not show elevated muscle damage and probably a muscle adaptation occurred in the competition, due to the reduction of CK concentrations observed.

scholarly journals LIM and SH3 Protein 1 Stands for a Bio-Marker for Cholangiocarcinoma Detection

2020 ◽  
Author(s):  
Ning Wang ◽  
Yanni Li ◽  
Yanfang Zheng ◽  
Huoming Chen ◽  
Xiaolong Wen ◽  
...  
Keyword(s):  
Serum Level ◽  
Roc Curve ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Tissue Level ◽  
Healthy Controls ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Chi Square Test ◽  
Auc Value

Abstract Background: LIM and SH3 protein 1 (LASP-1) has been demonstrated to be overexpression in several types of cancers. The aim of this study was to verify the serum level of LASP-1 and investigate its diagnostic value in cholangiocarcinoma (CCA) patients.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expression level of LASP-1 in CCA patients and healthy controls. The correlation of LASP-1 expression with clinicopathological characteristic of CCA patients was analyzed via Chi-square test. Receiver operating characteristic (ROC) curve was built to evaluate the diagnostic value of serum LASP-1 in CCA.Results: Serum levels of LASP-1 were upregulated in CCA compared with healthy controls (P<0.01). And the serum level and tissue level of LASP-1 mRNA exhibited significant correlation (R=0.454, P=0.000). Serum expression of LASP-1 was closely associated with lymph node metastasis (P=0.018) and TNM stage (P=0.021). ROC curve analysis revealed that serum LASP-1 was of great value in differentiating CCA patients from healthy individuals. The area under the ROC curve (AUC) value was 0.879 corresponding with a sensitivity of 81.9% and a specificity of 79.6%.Conclusions: Serum LASP-1 might be an useful diagnostic biomarker for CCA.

Association between the Critical Shoulder Angle and Non-traumatic Rotator Cuff Tears

2019 ◽  
Vol 1 ◽  
pp. 88-91
Author(s):  
Aniket Jadhav ◽  
Sanjay Desai ◽  
Vikas Reddy ◽  
Robin Kuruvilla ◽  
Pranav Mahadeokar
Keyword(s):  
Rotator Cuff ◽  
Glenohumeral Joint ◽  
Study Groups ◽  
Joint Disease ◽  
Rotator Cuff Tears ◽  
Control Group ◽  
Study Group ◽  
Chi Square ◽  
Critical Shoulder Angle ◽  
Shoulder Angle

Background: Moor et al. developed a critical shoulder angle (CSA) as a radiological parameter for the development of rotator cuff injury and degenerative changes of the glenohumeral joint. The objective of this study is to evaluate the association between CSA and the development of non-traumatic rotator cuff tears (RCTs) to further validate this study. Materials and Methods: The study was performed as an observational study dividing subjects into control and study groups, differing in the presence of non-traumatic RCT. The study group comprised 50 subjects with 40 subjects in the control group. All acceptable radiographs were evaluated, to measure the CSA in accordance with Moor et al. Results: The mean CSA of control subjects was 31.79° (± 1.89°), while that of study subjects were 37.85° (± 2.25°). The relative variability in the control group was about 6% and that in the study group was also 6%, indicating internal homogeneity of the study groups. Chi-square test applied to the distribution gave a P = 0.00001, representing an excellent association between the study groups and the CSA. Conclusion: There is a significant association between larger CSA and RCTs (P = 0.00001). Individual (quantitative) anatomical parameters may imply altered biomechanics, which are likely to induce RCTs, independent of trauma and degenerative glenohumeral joint disease.

Reproducibility and diagnostic value of a new wedge-guided bitewing image receptor-holding device

2021 ◽  
pp. 20210186
Author(s):  
Deivi Cascante-Sequeira ◽  
Hugo Gaêta-Araujo ◽  
Danieli Moura Brasil ◽  
Deborah Queiroz Freitas ◽  
Francisco Haiter-Neto
Keyword(s):  
Correlation Coefficient ◽  
Intraclass Correlation ◽  
Diagnostic Value ◽  
Objective Analysis ◽  
Chi Square ◽  
Subjective Analysis ◽  
Holding Device ◽  
Chi Square Test ◽  
Dry Bone ◽  
Better Than

Objective To assess the reproducibility of a wedge-guided bitewing image receptor-holding device (IRHD-WG) compared to a commercially available bitewing image receptor-holding device (IRHD-XCP). Methods and materials Ten operators randomly acquired bitewing radiographs of four posterior regions (Premolar, Molar 1, Molar 2, Molar 3) distributed in two dry bone skulls and mandibles using 2 IRHDs (IRHD-WG and IRHD-XCP). The radiographs corresponding to the same region and IRHD but acquired by different operators were paired for reproducibility comparison. A total of 360 pairs of radiographs were randomized for analysis. Objective analysis consisted of extracting the pixel values from each radiograph and comparing the values between each pair by intraclass correlation coefficient. For subjective analysis, the IRHDs images were digitally removed. Five oral radiologists blinded for the study conditions classified the radiograph pairs according to their similarity and diagnostic value. The answers’ relative frequencies were compared by the chi-square test (α = 0.05). Results The IRHD-WG presented a higher reproducibility (Mean = 0.850; SD = 0.144) than the IRHD-XCP (Mean = 0.615; SD = 0.287) in the objective analysis. Radiographs acquired with the IRHD-WG were more similar than those acquired with the IRHD-XCP (p < 0.001). The diagnostic value of bitewing radiographs acquired with the IRHD-WG was considered superior to those acquired with the IRHD-XCP (p < 0.001). Conclusion For the objective and subjective analyses of reproducibility, the IRHD-WG performed better than the commercial IRHD-XCP.

scholarly journals Predicting mortality in critically ill COVID-19 patients in a low-resources setting

2021 ◽  
Author(s):  
Jorge Luis Vélez-Paez ◽  
Mario Patricio Montalvo ◽  
Fernando Esteban Jara ◽  
Santiago Aguayo-Moscoso ◽  
Wendy Tercero-Martínez ◽  
...  
Keyword(s):  
Intensive Care ◽  
Wald Test ◽  
Outcome Data ◽  
Positive Real ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Middle Income ◽  
Increased Risk ◽  
Chi Square Test ◽  
Novel Coronavirus

Abstract Background Since its molecular isolation on January 7, 2020, the novel coronavirus SARS-CoV-2 has spread rapidly, taking governments worldwide off-guard. The virus arrived in low and middle-income countries violently, especially in Latin America. Ecuador received the worst outbreak in the world if we count excess mortality per capita. Although one study has reported the epidemiological impact of COVID-19 in Ecuador, there is no clinical course or outcome data among intensive care patients with COVID-19 in Ecuador. This study describes the clinical, epidemiological, and therapeutical features of 89 patients hospitalized in a secondary-level hospital in Quito, Ecuador. Methods We did a retrospective cohort study. We collected health records data from adult patients with severe COVID-19 admitted to the intensive care unit (ICU) in Quito, Ecuador, during the first five months of the SARS-CoV-2 outbreak in Ecuador. All patients had a confirmed SARS-CoV-2 RNA infection diagnostic, a positive real-time RT-PCR, and pulmonary imaging suggesting COVID-19. We used the Chi-square test or a Fisher's exact statistic to analyze risk and associations between survivors and non-survivors due to COVID-19. We used the ROC curve analysis to predict mortality, determining cut-off points for the parameters related to mechanical, analytical, and cytometry ventilation. At the multivariate level, we used the Wald test to evaluate model categorical predictors during the regression analysis. Results 89 patients with COVID-19 were recruited during the study. The average age of the patients was 54.72 years. Man represented 68.54% (n = 61) and women 31,46% (n = 28). Significant differences were observed in terms of mortality (men 40.98% vs. women 17.76%). Serological parameters demonstrated that LDH and IL-6 at 24 hours were higher among non-survivors when compared with survivors. Persistent hypercapnia ( > > 45 mmHg), a PaFiO2 ratio of less than 140 mmHg, and a positive end-expiratory pressure (PEEP) titration greater than nine mmHg were also associated with higher mortality. Conclusions Increased levels of LDH at 24 hours, IL-6, the lymphocyte and platelet count at 48 hours, the neutrophil count at 48 hours, and the INL are factors associated with higher motility, increased risk of failed extubation and reintubation

scholarly journals Predicting Mortality in Critically Ill COVID-19 Patients in A Low-Resources Setting

2021 ◽  
Author(s):  
Jorge Vélez-Paez ◽  
Mario Montalvo ◽  
Fernando Jara ◽  
Santiago Aguayo-Moscoso ◽  
Wendy Tercero-Martínez ◽  
...  
Keyword(s):  
Intensive Care ◽  
Wald Test ◽  
Outcome Data ◽  
Positive Real ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Middle Income ◽  
Increased Risk ◽  
Chi Square Test ◽  
Novel Coronavirus

Abstract Background Since its molecular isolation on January 7, 2020, the novel coronavirus SARS-CoV-2 has spread rapidly, taking governments worldwide off-guard. The virus arrived in low and middle-income countries violently, especially in Latin America. Ecuador received the worst outbreak in the world if we count excess mortality per capita. Although one study has reported the epidemiological impact of COVID-19 in Ecuador, there is no clinical course or outcome data among intensive care patients with COVID-19 in Ecuador. This study describes the clinical, epidemiological, and therapeutical features of 89 patients hospitalized in a secondary-level hospital in Quito, Ecuador. Methods We did a retrospective cohort study. We collected health records data from adult patients with severe COVID-19 admitted to the intensive care unit (ICU) in Quito, Ecuador, during the first five months of the SARS-CoV-2 outbreak in Ecuador. All patients had a confirmed SARS-CoV-2 RNA infection diagnostic, a positive real-time RT-PCR, and pulmonary imaging suggesting COVID-19. We used the Chi-square test or a Fisher's exact statistic to analyze risk and associations between survivors and non-survivors due to COVID-19. We used the ROC curve analysis to predict mortality, determining cut-off points for the parameters related to mechanical, analytical, and cytometry ventilation. At the multivariate level, we used the Wald test to evaluate model categorical predictors during the regression analysis. Results 89 patients with COVID-19 were recruited during the study. The average age of the patients was 54.72 years. Man represented 68.54% (n = 61) and women 31,46% (n = 28). Significant differences were observed in terms of mortality (men 40.98% vs. women 17.76%). Serological parameters demonstrated that LDH and IL-6 at 24 hours were higher among non-survivors when compared with survivors. Persistent hypercapnia ( > > 45 mmHg), a PaFiO2 ratio of less than 140 mmHg, and a positive end-expiratory pressure (PEEP) titration greater than nine mmHg were also associated with higher mortality. Conclusions Increased levels of LDH at 24 hours, IL-6, the lymphocyte and platelet count at 48 hours, the neutrophil count at 48 hours, and the INL are factors associated with higher motility, increased risk of failed extubation and reintubation

scholarly journals Prognostic Factors for Conservative Treatments of Atraumatic Rotator Cuff Tears

2019 ◽  
Vol 13 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Takuya Sekiguchi ◽  
Junichiro Hamada ◽  
Yoshihiro Hagiwara ◽  
Akira Ando ◽  
Takashi Watanabe ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Rotator Cuff ◽  
Repeated Measures ◽  
Treatment Effectiveness ◽  
Rotator Cuff Tears ◽  
Final Visit ◽  
Chi Square ◽  
Size Groups ◽  
Chi Square Test ◽  
Student’S T

Background:Little consensus has been achieved on conservative treatments in patients with Rotator Cuff Tears (RCTs).Objective:To determine whether anatomical severities of RCTs were poor prognostic factors in conservative treatments.Method:This study included 102 shoulders with atraumatic RCTs diagnosed by magnetic resonance imaging. Partial-thickness tears were identified in 15 shoulders and full-thickness tears in 87 shoulders. Three patients had a concomitant subscapularis (SSC) tendon tear. All patients were treated conservatively with the administration of non-steroidal anti-inflammatory drugs and physical therapy. The visual analog scale (VAS), Constant scores, and active range of motion were evaluated as clinical outcomes. Pearson’s chi-square test and Student’s t test, Mann-Whitney U test, one-way analysis of variance (ANOVA), or Kruskal-Wallis test was performed to compare the participant’s characteristics and clinical data. Treatment effectiveness among the tear size groups and with/without SSC tear groups was assessed using a two-factor repeated measures ANOVA.Results:Larger tears were associated with less improvement in VAS (p = 0.032). At the initial and final visits, larger tears showed lower constant scores (p = 0.014 and p < 0.001, respectively) and restricted forward elevation (FE) (p = 0.042 and p = 0.013, respectively). Shoulders with SSC tear showed higher VAS, lower constant scores, and lower FE at the final visit (p = 0.002, p = 0.001, and p=0.019, respectively). Patients with SSC tear underwent surgery more frequently than those without tear (p < 0.001).Conclusion:Larger RCTs and concomitant SSC tear are poor prognostic factors for the conservative treatment of atraumatic RCTs.

scholarly journals LDHA and CPT2 association with therapy resistance in prostate cancer

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
F Q Vieira ◽  
A R Cardoso ◽  
D Gigliano ◽  
I Carneiro ◽  
R Henrique ◽  
...  
Keyword(s):  
Aerobic Glycolysis ◽  
Predictive Marker ◽  
Selective Advantage ◽  
Therapy Resistance ◽  
Cancer Drug ◽  
Chi Square ◽  
Significant Difference ◽  
Blinded Manner ◽  
Chi Square Test

Abstract Background The aerobic glycolysis as energy source in cancer confers a selective advantage for its proliferation and survival. Previous in vitro studies demonstrated that treatment with [C16Pyr][Amp], a potential anti-cancer drug in prostate, decreased the transcript levels of LDHA and CPT2, both involved in metabolic plasticity. In fact, LDHA and CPT2 were reported to be overexpressed in cancer, with association with poor prognosis and resistance to chemo- and radiotherapy. Since LDHA and CPT2 can be potential therapy resistance biomarkers, the aim of this work was to assess LDHA and CPT2 expression using PCa tissues. Methods LDHA and CPT2 expression was evaluated by immunohistochemistry in 57 PCa tissues, 24 from patients that developed resistance to hormonal therapy and 33 without therapy resistance. For both proteins, percentage of positive tumor cells, intensity of immunostaining, and immunoexpression pattern was determined by a blinded manner. Comparisons between therapy variables and protein expression were assessed using the Chi square test. P &lt; 0.05 indicated a statistically significant difference. Results LDHA expression is significantly associated with therapy resistance (P &lt; 0.001). Moreover, CPT2 pattern’s immunoexpression is also associated with therapy resistant (P &lt; 0.001), being cytoplasmatic expression most frequent in patients that respond to therapy (41%), whereas both nuclear and cytoplasmatic expression is more prevalent in therapy-resistant cases (48%). Conclusions LDHA overexpression is significantly associated with therapy resistance in PCa cases, while CPT2 cell expression distribution might be a predictive marker.

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