INSIDE INDUSTRY

2017 ◽  
Vol 21 (01) ◽  
pp. 39-47
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Cervical Cancer ◽  
High Risk ◽  
Lung Cancer Risk ◽  
Asia Pacific ◽  
Cigarette Smokers ◽  
Tunnel Vision ◽  
Lower Lung ◽  
Investment Agreement

Streamlining the Laboratories of Today for Success. Bayer and NUS Enterprise Launch “Grants4Apps Singapore” to Drive Health Tech Innovations across Asia Pacific. New Approaches for Cervical Cancer Treatment Being Studied in Singapore. Arterial Tunnel Vision: Computer Tomography Provides a Clearer View of Blood Vessel Interiors. Regular Use of Ibuprofen May Lower Lung Cancer Risk Among High-Risk Subgroups of Cigarette Smokers. Free Trade & Investment Agreement Threatens Public Health.

Association between meat and saturated fatty acid intake and lung cancer risk: The Japan Public Health Center‐based prospective study

2020 ◽  
Vol 147 (11) ◽  
pp. 3019-3028
Author(s):  
Honglin Cai ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Junko Ishihara ◽  
Norie Sawada ◽  
...  
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Prospective Study ◽  
Health Center ◽  
Saturated Fatty Acid ◽  
Lung Cancer Risk ◽  
Fatty Acid Intake ◽  
Public Health Center

scholarly journals A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer

2019 ◽  
Vol 112 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Jiaqi Huang ◽  
Stephanie J Weinstein ◽  
Kai Yu ◽  
Satu Männistö ◽  
Demetrius Albanes
Keyword(s):  
Lung Cancer ◽  
Vitamin E ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Statistical Tests ◽  
Serum Vitamin ◽  
Alpha Tocopherol ◽  
Lower Lung ◽  
Trial Intervention ◽  
Vitamin E Status

Abstract Background Epidemiologic data are inconsistent regarding the vitamin E-lung cancer association, and no study to our knowledge has examined serologic changes in vitamin E status in relation to subsequent risk. Methods In a cohort of 22 781 male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, we ascertained 3184 lung cancer cases during up to 28 years of observation. Cox proportional hazards models examined whether higher serum alpha-tocopherol concentrations at baseline, 3 years, or the interval change were associated with lower lung cancer risk. All statistical tests were two-sided. Results After adjustment for age, body mass index, smoking intensity and duration, serum total cholesterol, and trial intervention group, we found lower lung cancer risk in men with high baseline alpha-tocopherol (fifth quintile [Q5] vs Q1, hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.66 to 0.87, Ptrend < .001). A similar reduction in risk was seen for serum alpha-tocopherol at 3 years (Q5 vs Q1, HR = 0.78, 95% CI = 0.67 to 0.91, Ptrend = .004). The inverse risk association appeared stronger for younger men and those who had smoked fewer years but was similar across trial intervention groups. We also found reduced risk among men not supplemented with vitamin E who had a lower serum alpha-tocopherol at baseline and greater increases in concentrations at 3 years (third tertile vs first tertile of serum alpha-tocopherol change, HR = 0.74, 95% CI = 0.59 to 0.91, P = .005). Conclusions Higher vitamin E status, as measured by serum alpha-tocopherol concentration, as well as repletion of a low vitamin E state, was related to decreased lung cancer risk during a 28-year period. Our findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.

Screen-and-treat colposcopy as public health strategy for cervical cancer early detection in high-risk population: The experience of the Centro de Estudios y Prevencion del Cancer (CEPREC) in indigenous population of Southern Mexico

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 5012-5012
Author(s):  
S. Marcial-Toledo ◽  
J. Cortes-Guzman ◽  
L. Chavez ◽  
C. Guzman-Patraca ◽  
S. Terrazas-Espitia ◽  
...  
Keyword(s):  
Public Health ◽  
Cervical Cancer ◽  
High Risk ◽  
High Risk Population ◽  
Low Grade ◽  
Public Health Strategy ◽  
Southern Mexico ◽  
Risk Population ◽  
Screening Programs ◽  
Health Strategy

5012 Background: The incidence of cervical cancer in Mexico remains high, due to ineffective Papanicolau smear screening, social, educational, cultural and financial issues. Southern Mexico is a region with a high incidence of cervical cancer. CEPREC has designed educational, preventive and early cancer detection programs in that population (Onkologie 27:211). We propose screen-and-treat colposcopy for cervical cancer prevention as public health strategy in selected high-risk population. This study evaluates the feasibility and acceptability of this approach through an educational program. Methods: From 12/2002 to 12/2005, women living in Southern Mexico were educated about cervical cancer and its prevention and were offered colposcopy either in CEPREC facilities or in ambulatory clinics. Colposcopy diagnosis and cervical cytology were established according to the 1990 IFCPC criteria and the 2001 Bethesda System, respectively. A cone biopsy was indicated in patients diagnosed as having human papilloma virus (HPV), cervical intraepithelial neoplasia (CIN 1, CIN 2, CIN 3), or carcinoma. Patients diagnosed as having HPV, CIN 2 and CIN 3 were treated by large loop excision of the transformation zone under local anesthesia. Results: 8281 women (median age 39 years, range: 14–87) were evaluated. 5645 (68%) of them underwent colposcopy in ambulatory clinics. 1171 (14%) women were illiterates and the highest education level was 9 years in 4881 (59%). Median age at first intercourse and first Papanicolau smear were 19 and 29 years, respectively. 4251 (51%) women had vaginal symptoms before colposcopy. Abnormal colposcopy (HPV, CIN 1, CIN 2 or CIN 3), was diagnosed in 1073 (13%) patients and 9 (<1%) had carcinoma. 238 (22%) of them were treated on site. Low-Grade (n = 190) (80%), and high-grade squamous intraepithelial lesions (n = 48) (20%), were diagnosed in those patients. Conclusions: Screen-and-treat colposcopy is a feasible public health strategy with high acceptability in selected high-risk population and could be an alternative to cytology-based screening programs. No significant financial relationships to disclose.

scholarly journals Demographic, Social, and Behavioral Determinants of Lung Cancer Perceived Risk and Worries in a National Sample of American Adults; Does Lung Cancer Risk Matter?

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 97 ◽  
Author(s):  
Hamid Chalian ◽  
Pegah Khoshpouri ◽  
Shervin Assari
Keyword(s):  
Lung Cancer ◽  
Risk Perception ◽  
High Risk ◽  
Cancer Risk ◽  
Perceived Risk ◽  
Representative Sample ◽  
Lung Cancer Risk ◽  
Insurance Status ◽  
Behavioral Determinants ◽  
Screening Programs

Background: Perceived risk and worries of developing cancer are important constructs for cancer prevention. Many studies have investigated the relationship between health behaviors and subjective risk perception. However, factors correlated with lung cancer risk perception and worries in individuals more susceptible to lung cancer have rarely been investigated. Objective: To determine demographic, social, and behavioral determinants of cancer perceived risk and worries and to explore heterogeneities in these associations by the level of lung cancer risk in a nationally representative sample of American adults. Methods: For this cross-sectional study, data came from the Health Information National Trends Survey (HINTS) 2017, which included a 2277 representative sample of American adults. Smoking status, cancer perceived risk, cancer worries, age, gender, race, education, income, and insurance status were measured. We ran structural equation models (SEMs) for data analysis. Results: “Ever smoker” status was associated with higher cancer perceived risk (b = 0.25; 95% CI = 0.05–0.44, p = 0.013) and worries (b = 0.34, 95% CI = 0.18–0.50, p < 0.001), suggesting that “ever smokers” experience higher levels of cancer perceived risk and worries regarding cancer, compared to “never smokers”. Other factors that correlate with cancer perceived risk and worries were race, age, income, and insurance status. Blacks demonstrated less cancer perceived risk and worry (b = −0.98, 95% CI = −1.37–0.60, p < 0.001) in both low and high risk lung cancer groups. However, the effects of social determinants (income and insurance status) and age were observed in low but not high risk group. Conclusions: Determinants of cancer perceived risk and worries vary in individuals depending on the level of lung cancer risk. These differences should be considered in clinical practice and policy makings with the goal of improving participation rates in lung cancer screening programs.

scholarly journals LDCT lung cancer screening in populations at different risk for lung cancer

2020 ◽  
Vol 7 (1) ◽  
pp. e000455
Author(s):  
Gustavo Borges da Silva Teles ◽  
Ana Carolina Sandoval Macedo ◽  
Rodrigo Caruso Chate ◽  
Viviane Arevalo Tabone Valente ◽  
Marcelo Buarque de Gusmao Funari ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Lung Cancer Risk ◽  
Risk Group ◽  
False Positive Rate ◽  
Lung Cancer Screening ◽  
Low Risk ◽  
Positive Rate ◽  
Risk Patients

IntroductionThe improvement of low-dose CT (LDCT) lung cancer screening selection criteria could help to include more individuals who have lung cancer, or in whom lung cancer will develop, while avoiding significant cost increase. We evaluated baseline results of LDCT lung cancer screening in a population with a heterogeneous risk profile for lung cancer.MethodsLDCT lung cancer screening was implemented alongside a preventive health programme in a private hospital in Brazil. Individuals older than 45 years, smokers and former smokers, regardless of tobacco exposure, were included. Patients were classified according to the National Lung Screening Trial (NLST) eligibility criteria and to PLCOm2012 6-year lung cancer risk. Patient characteristics, CT positivity rate, detection rate of lung cancer and false-positive rate were assessed.ResultsLDCT scans of 472 patients were evaluated and three lung adenocarcinomas were diagnosed. CT positivity rate (Lung-RADS 3/4) was significantly higher (p=0.019) in the NLST group (10.1% (95% CI, 5.9% to 16.9%)) than in the non-NLST group (3.6% (95% CI, 2.62% to 4.83%)) and in the PLCOm2012 high-risk group (14.3% (95% CI, 6.8% to 27.7%)) than in the PLCOm2012 low-risk group (3.7% (95% CI, 2.9% to 4.8%)) (p=0.016). Detection rate of lung cancer was also significantly higher (p=0.018) among PLCOm2012 high-risk patients (5.7% (95% CI, 2.5% to 12.6%)) than in the PLCOm2012 low-risk individuals (0.2% (95% CI, 0.1% to 1.1%)). The false-positive rate for NLST criteria (16.4% (95% CI, 13.2% to 20.1%)) was higher (p<0.001) than for PLCOm2012 criteria (7.6 (95% CI, 5.3% to 10.5%)).DiscussionOur study indicates a lower performance when screening low-risk individuals in comparison to screening patients meeting NLST criteria and PLCOm2012 high-risk patients. Also, incorporating PLCOm2012 6-year lung cancer risk ≥0.0151 as an eligibility criterion seems to increase lung cancer screening effectiveness.

Perspectives on Pulmonary Inflammation and Lung Cancer Risk in Cigarette Smokers

2006 ◽  
Vol 18 (9) ◽  
pp. 667-677 ◽  
Author(s):  
Carr J. Smith ◽  
Thomas A. Perfetti ◽  
Judy A. King
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Pulmonary Inflammation ◽  
Cigarette Smokers
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