EFFECTS OF ACUTE HYPERGLYCEMIA AND INSULIN INTERVENTION ON THE SPONTANEOUS FIELD POTENTIAL OF SINOATRIAL NODE TISSUE BY USING MICROELECTRODE ARRAYS

2015 ◽  
Vol 15 (04) ◽  
pp. 1550046
Author(s):  
YU FENG ◽  
HUI CAO ◽  
YANBIN ZHANG

Traditional studies on the relationship between hyperglycemia and heart diseases generally focused on the impact of chronic and long-term effect of diabetes on cardiac functions. Most of the methods were culturing myocardial cells and giving outside stimulations. However, recent studies show that acute hyperglycemia might play a significant role in spontaneous cardiac electrophysiology. In this research we applied microelectrode arrays (MEA) to record the spontaneous sinoatrial node field potentials of C57/BL6J mice and analyzed the effects of different glucose concentrations in time domain and frequency domain by using statistical method, vector maps and fast Fourier transform (FFT). Meanwhile, we studied the effects of insulin interference in the experimental process. When the concentration of the glucose solution was greater than 40 mmol/L, the spontaneous sinoatrial node field potential changed markedly. In the time domain, the amplitude decreased rapidly and the conductive characteristics were disordered. In the frequency domain, the two spectrum peaks decreased rapidly. These changes were irreversible. However, insulin preconditioning could inhibit the impact of high glucose.

2021 ◽  
pp. 135481662110584
Author(s):  
Ying Wang ◽  
Hongwei Zhang ◽  
Wang Gao ◽  
Cai Yang

The impact of the COVID-19 pandemic on tourism has received general attention in the literature, while the role of news during the pandemic has been ignored. Using a time-frequency connectedness approach, this paper focuses on the spillover effects of COVID-19-related news on the return and volatility of four regional travel and leisure (T&L) stocks. The results in the time domain reveal significant spillovers from news to T&L stocks. Specifically, in the return system, T&L stocks are mainly affected by media hype, while in the volatility system, they are mainly affected by panic sentiment. This paper also finds two risk contagion paths. The contagion index and Global T&L stock are the sources of these paths. The results in the frequency domain indicate that the shocks in the T&L industry are mainly driven by short-term fluctuations. The spillovers from news to T&L stocks and among these T&L stocks are stronger within 1 month.


Stats ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 134-154 ◽  
Author(s):  
Xu Huang ◽  
Emmanuel Silva ◽  
Hossein Hassani

This paper investigates the causal relationship between oil price and tourist arrivals to further explain the impact of oil price volatility on tourism-related economic activities. The analysis itself considers the time domain, frequency domain, and information theory domain perspectives. Data relating to the US and nine European countries are exploited in this paper with causality tests which include the time domain, frequency domain, and Convergent Cross Mapping (CCM). The CCM approach is nonparametric and therefore not restricted by assumptions. We contribute to existing research through the successful and introductory application of an advanced method and via the uncovering of significant causal links from oil prices to tourist arrivals.


2018 ◽  
Vol 12 (7-8) ◽  
pp. 76-83
Author(s):  
E. V. KARSHAKOV ◽  
J. MOILANEN

Тhe advantage of combine processing of frequency domain and time domain data provided by the EQUATOR system is discussed. The heliborne complex has a towed transmitter, and, raised above it on the same cable a towed receiver. The excitation signal contains both pulsed and harmonic components. In fact, there are two independent transmitters operate in the system: one of them is a normal pulsed domain transmitter, with a half-sinusoidal pulse and a small "cut" on the falling edge, and the other one is a classical frequency domain transmitter at several specially selected frequencies. The received signal is first processed to a direct Fourier transform with high Q-factor detection at all significant frequencies. After that, in the spectral region, operations of converting the spectra of two sounding signals to a single spectrum of an ideal transmitter are performed. Than we do an inverse Fourier transform and return to the time domain. The detection of spectral components is done at a frequency band of several Hz, the receiver has the ability to perfectly suppress all sorts of extra-band noise. The detection bandwidth is several dozen times less the frequency interval between the harmonics, it turns out thatto achieve the same measurement quality of ground response without using out-of-band suppression you need several dozen times higher moment of airborne transmitting system. The data obtained from the model of a homogeneous half-space, a two-layered model, and a model of a horizontally layered medium is considered. A time-domain data makes it easier to detect a conductor in a relative insulator at greater depths. The data in the frequency domain gives more detailed information about subsurface. These conclusions are illustrated by the example of processing the survey data of the Republic of Rwanda in 2017. The simultaneous inversion of data in frequency domain and time domain can significantly improve the quality of interpretation.


2021 ◽  
Vol 9 (7) ◽  
pp. 781
Author(s):  
Shi He ◽  
Aijun Wang

The numerical procedures for dynamic analysis of mooring lines in the time domain and frequency domain were developed in this work. The lumped mass method was used to model the mooring lines. In the time domain dynamic analysis, the modified Euler method was used to solve the motion equation of mooring lines. The dynamic analyses of mooring lines under horizontal, vertical, and combined harmonic excitations were carried out. The cases of single-component and multicomponent mooring lines under these excitations were studied, respectively. The case considering the seabed contact was also included. The program was validated by comparing with the results from commercial software, Orcaflex. For the frequency domain dynamic analysis, an improved frame invariant stochastic linearization method was applied to the nonlinear hydrodynamic drag term. The cases of single-component and multicomponent mooring lines were studied. The comparison of results shows that frequency domain results agree well with nonlinear time domain results.


2002 ◽  
Vol 124 (4) ◽  
pp. 827-834 ◽  
Author(s):  
D. O. Baun ◽  
E. H. Maslen ◽  
C. R. Knospe ◽  
R. D. Flack

Inherent in the construction of many experimental apparatus designed to measure the hydro/aerodynamic forces of rotating machinery are features that contribute undesirable parasitic forces to the measured or test forces. Typically, these parasitic forces are due to seals, drive couplings, and hydraulic and/or inertial unbalance. To obtain accurate and sensitive measurement of the hydro/aerodynamic forces in these situations, it is necessary to subtract the parasitic forces from the test forces. In general, both the test forces and the parasitic forces will be dependent on the system operating conditions including the specific motion of the rotor. Therefore, to properly remove the parasitic forces the vibration orbits and operating conditions must be the same in tests for determining the hydro/aerodynamic forces and tests for determining the parasitic forces. This, in turn, necessitates a means by which the test rotor’s motion can be accurately controlled to an arbitrarily defined trajectory. Here in, an interrupt-driven multiple harmonic open-loop controller was developed and implemented on a laboratory centrifugal pump rotor supported in magnetic bearings (active load cells) for this purpose. This allowed the simultaneous control of subharmonic, synchronous, and superharmonic rotor vibration frequencies with each frequency independently forced to some user defined orbital path. The open-loop controller was implemented on a standard PC using commercially available analog input and output cards. All analog input and output functions, transformation of the position signals from the time domain to the frequency domain, and transformation of the open-loop control signals from the frequency domain to the time domain were performed in an interrupt service routine. Rotor vibration was attenuated to the noise floor, vibration amplitude ≈0.2 μm, or forced to a user specified orbital trajectory. Between the whirl frequencies of 14 and 2 times running speed, the orbit semi-major and semi-minor axis magnitudes were controlled to within 0.5% of the requested axis magnitudes. The ellipse angles and amplitude phase angles of the imposed orbits were within 0.3 deg and 1.0 deg, respectively, of their requested counterparts.


2021 ◽  
Vol 37 (1_suppl) ◽  
pp. 1420-1439
Author(s):  
Albert R Kottke ◽  
Norman A Abrahamson ◽  
David M Boore ◽  
Yousef Bozorgnia ◽  
Christine A Goulet ◽  
...  

Traditional ground-motion models (GMMs) are used to compute pseudo-spectral acceleration (PSA) from future earthquakes and are generally developed by regression of PSA using a physics-based functional form. PSA is a relatively simple metric that correlates well with the response of several engineering systems and is a metric commonly used in engineering evaluations; however, characteristics of the PSA calculation make application of scaling factors dependent on the frequency content of the input motion, complicating the development and adaptability of GMMs. By comparison, Fourier amplitude spectrum (FAS) represents ground-motion amplitudes that are completely independent from the amplitudes at other frequencies, making them an attractive alternative for GMM development. Random vibration theory (RVT) predicts the peak response of motion in the time domain based on the FAS and a duration, and thus can be used to relate FAS to PSA. Using RVT to compute the expected peak response in the time domain for given FAS therefore presents a significant advantage that is gaining traction in the GMM field. This article provides recommended RVT procedures relevant to GMM development, which were developed for the Next Generation Attenuation (NGA)-East project. In addition, an orientation-independent FAS metric—called the effective amplitude spectrum (EAS)—is developed for use in conjunction with RVT to preserve the mean power of the corresponding two horizontal components considered in traditional PSA-based modeling (i.e., RotD50). The EAS uses a standardized smoothing approach to provide a practical representation of the FAS for ground-motion modeling, while minimizing the impact on the four RVT properties ( zeroth moment, [Formula: see text]; bandwidth parameter, [Formula: see text]; frequency of zero crossings, [Formula: see text]; and frequency of extrema, [Formula: see text]). Although the recommendations were originally developed for NGA-East, they and the methodology they are based on can be adapted to become portable to other GMM and engineering problems requiring the computation of PSA from FAS.


Author(s):  
Mansour Tabatabaie ◽  
Thomas Ballard

Dynamic soil-structure interaction (SSI) analysis of nuclear power plants is often performed in frequency domain using programs such as SASSI [1]. This enables the analyst to properly a) address the effects of wave radiation in an unbounded soil media, b) incorporate strain-compatible soil shear modulus and damping properties and c) specify input motion in the free field using the de-convolution method and/or spatially variable ground motions. For structures that exhibit nonlinearities such as potential base sliding and/or uplift, the frequency-domain procedure is not applicable as it is limited to linear systems. For such problems, it is necessary to solve the problem in the time domain using the direct integration method in programs such as ADINA [2]. The authors recently introduced a sub-structuring technique called distributed parameter foundation impedance (DPFI) model that allows the structure to be partitioned from the total SSI system and analyzed in the time domain while the foundation soil is modeled using the frequency-domain procedure [3]. This procedure has been validated for linear systems. In this paper we have expanded the DPFI model to incorporate nonlinearities at the soil/structure interface by introducing nonlinear shear and normal springs arranged in series between the DPFI and structure model. This combination of the linear far-field impedance (DPFI) plus nonlinear near-field soil springs allows the foundation sliding and/or uplift behavior be analyzed in time domain while maintaining the frequency-dependent stiffness and radiation damping nature of the far-field foundation impedance. To check the accuracy of this procedure, a typical NPP foundation mat supported at the surface of a layered soil system and subjected to harmonic forced vibration was first analyzed in the frequency domain using SASSI to calculate the target linear response and derive a linear, far-field DPFI model. The target linear solution was then used to validate two linear time-domain ADINA models: Model 1 consisting of the mat foundation+DPFI derived from the linear SASSI model and Model 2 consisting of the total SSI system (mat foundation plus a soil block). After linear alignment, the nonlinear springs were added to both ADINA models and re-analyzed in time domain. Model 2 provided the target nonlinear solution while Model 1 provided the results using the DPFI+nonlinear springs. By increasing the amplitude of the vibration load, different levels of foundation sliding were simulated. Good agreement between the results of two models in terms of the displacement response of the mat and cyclic force-displacement behavior of the springs validates the accuracy of the procedure presented herein.


2021 ◽  
Vol 3 (1) ◽  
pp. 031-036
Author(s):  
S. A. GOROVOY ◽  
◽  
V. I. SKOROKHODOV ◽  
D. I. PLOTNIKOV ◽  
◽  
...  

This paper deals with the analysis of interharmonics, which are due to the presence of a nonlinear load. The tool for the analysis was a mathematical apparatus - wavelet packet transform. Which has a number of advantages over the traditional Fourier transform. A simulation model was developed in Simulink to simulate a non-stationary non-sinusoidal mode. The use of the wavelet packet transform will allow to determine the mode parameters with high accuracy from the obtained wavelet coefficients. It also makes it possible to obtain information, both in the frequency domain of the signal and in the time domain.


2018 ◽  
Vol 10 (12) ◽  
pp. 168781401881346 ◽  
Author(s):  
Tabi Fouda Bernard Marie ◽  
Dezhi Han ◽  
Bowen An ◽  
Jingyun Li

To detect and recognize any type of events over the perimeter security system, this article proposes a fiber-optic vibration pattern recognition method based on the combination of time-domain features and time-frequency domain features. The performance parameters (event recognition, event location, and event classification) are very important and describe the validity of this article. The pattern recognition method is precisely based on the empirical mode decomposition of time-frequency entropy and center-of-gravity frequency. It implements the function of identifying and classifying the event (intrusions or non-intrusion) over the perimeter to secure. To achieve this method, the first-level prejudgment is performed according to the time-domain features of the vibration signal, and the second-level prediction is carried out through time-frequency analysis. The time-frequency distribution of the signal is obtained by empirical mode decomposition and Hilbert transform and then the time-frequency entropy and center-of-gravity frequency are used to form the time-frequency domain features, that is, combined with the time-domain features to form feature vectors. Multiple types of probabilistic neural networks are identified to determine whether there are intrusions and the intrusion types. The experimental results demonstrate that the proposed method is effective and reliable in identifying and classifying the type of event.


2018 ◽  
Vol 211 ◽  
pp. 17009
Author(s):  
Natalia Espinoza Sepulveda ◽  
Jyoti Sinha

The development of technologies for the maintenance industry has taken an important role to meet the demanding challenges. One of the important challenges is to predict the defects, if any, in machines as early as possible to manage the machines downtime. The vibration-based condition monitoring (VCM) is well-known for this purpose but requires the human experience and expertise. The machine learning models using the intelligent systems and pattern recognition seem to be the future avenue for machine fault detection without the human expertise. Several such studies are published in the literature. This paper is also on the machine learning model for the different machine faults classification and detection. Here the time domain and frequency domain features derived from the measured machine vibration data are used separated in the development of the machine learning models using the artificial neutral network method. The effectiveness of both the time and frequency domain features based models are compared when they are applied to an experimental rig. The paper presents the proposed machine learning models and their performance in terms of the observations and results.


Sign in / Sign up

Export Citation Format

Share Document