scholarly journals WHEN TO CALL THE CUSTOMER? TIMING OF CUSTOMER INVOLVEMENT IN THE DEVELOPMENT OF NEW PRODUCTS AND SERVICES

2019 ◽  
Vol 23 (01) ◽  
pp. 1950055
Author(s):  
SABIT VESELAJ ◽  
MAGNUS THOR TORFASON
Keyword(s):  
New Products ◽  
Large Body ◽  
Project Performance ◽  
Customer Needs ◽  
Customer Involvement ◽  
Early Stages ◽  
Different Types

Involving customers in the development of new products and services helps firms understand customer needs, increasing the likelihood of meeting those needs and expectations. Although a large body of literature addresses the implications of customer involvement for project performance, the results of previous research are somewhat inconsistent. This paper explores this issue by examining the differing impact of customer involvement on the development of new products and new services. We propose that the role of customer involvement differs for these two types of innovations, with involvement in the early stages more important for products and involvement in the launch stage more important for services. Our results, based on a comprehensive dataset on customer involvement in innovation, are consistent with such a pattern, suggesting that more attention should be paid to the conditional benefits of customer involvement in different types of solution development.

scholarly journals The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining

2021 ◽  
Author(s):  
Olga Kutova ◽  
Anton Pospelov ◽  
Irina Balalaeva
Keyword(s):  
Tumor Microenvironment ◽  
Purinergic Signaling ◽  
Large Body ◽  
Molecular Transport ◽  
Tumor Tissues ◽  
Cancer Initiation ◽  
Different Types ◽  
Channel Assembly ◽  
Extracellular Environment

The modern paradigm of studying the processes of carcinogenesis and vital activity of tumor tissues implies increased attention to constituents of tumor microenvironment (TME) and their interactions. These interactions between the cells in TME can be mediated via protein junctions of different types. Connexins (Cnxs) are one of the major contributors to intercellular communication. They form gap junctions responsible for the transfer of ions, metabolites, peptides, miRNA, etc. between neighboring tumor cells as well as between tumor and stromal cells. Cnx hemichannels mediate purinergic signaling and bidirectional molecular transport with the extracellular environment. Additionally, Cnxs were reported to localize in tumor-derived exosomes and facilitate the release of their cargo. A large body of evidence implies that the role of connexins in cancer is multifaceted. Pro- or anti-tumorigenic properties of connexins are determined by their abundance, localization and functionality as well as channel assembly and non-channel functions. In this review we have summarized the data on the Cnxs contribution in TME and to the cancer initiation and progression.

FAST-GROWING SMEs AND THE ROLE OF INNOVATION

2012 ◽  
Vol 16 (03) ◽  
pp. 1240003 ◽  
Author(s):  
CHRISTINA GRUNDSTRÖM ◽  
ROLAND SJÖSTRÖM ◽  
ANDERS UDDENBERG ◽  
ANNA ÖHRWALL RÖNNBÄCK
Keyword(s):  
New Products ◽  
Customer Needs ◽  
Fast Growing ◽  
Performance Change ◽  
The Difference

In a study of 409 Swedish SMEs, the difference between the highest growing, which can be characterized as gazelles, and the lowest growing companies were examined regarding performance change over a four year period and what contributed to the growth from an innovation perspective. It was concluded that, besides growing, the highest growing companies also showed high profitability,increased number of employees, and significantly higher markets shares locally, nationally and internationally than the lowest growing companies. Several traits were found to contribute to this. The highest growing companies had a significantly higher portion of new products as part of the turnover during the four years studied and they perceived themselves as differentiating from their competitors concerning: (1) offering better products, (2) understanding customer needs better, (3) having a higher pace or being more agile, and (4) keeping costs down. They also found it more important to take risks, reinvest any profit, and to focus on growth than the lowest growing companies, and this regardless of industry.

scholarly journals Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review

Biomedicines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 39 ◽  
Author(s):  
Emanuel Vamanu ◽  
Florentina Gatea
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Phenolic Acids ◽  
New Products ◽  
Gastrointestinal Transit ◽  
Physiological Functions ◽  
Human Microbiota ◽  
Different Types ◽  
Probiotic Strains ◽  
Functional Components

Numerous studies have demonstrated the role of the microbiota in supporting the physiological functions, owing to its metabolomic component. The presence of biocomponents generally leads to the correction of the microbial pattern correlated with the reduction of oxidative pressure. This study aims to present the main processes that correlate the bioavailability and bioactivity of some functional components through the action of the human microbiota. The use of probiotics and prebiotics is an innovative manner involving alternatives that increase the bioavailability of certain natural or metabolic components has been proposed. Probiotic strains (Saccharomyces cerevisiae or Lactobacillus (L.) plantarum) may represent an intermediary for increasing the antioxidant bioactivity, and they may be administered in the form of a biomass enriched with functional compounds, such as phenolic acids. The limiting effect of gastrointestinal transit is, in several cases, the key to the biopharmaceutical value of new products (or supplements). The identification of newer ways of formulating supplements also involves the compatibility of different types of products, the testing of bioaccessibility, and the elimination of biotransformations.

How rumors and preannouncements foster curiosity toward products

2017 ◽  
Vol 20 (3) ◽  
pp. 350-371 ◽  
Author(s):  
Maria Sääksjärvi ◽  
Tripat Gill ◽  
Erik Jan Hultink
Keyword(s):  
New Products ◽  
Purchase Intentions ◽  
Adoption Process ◽  
Positive Role ◽  
Content Type ◽  
Consumer Responses ◽  
Different Types ◽  
Two Factors ◽  
Product Study

Purpose The purpose of this paper is to focus on the potentially positive role of rumors in generating curiosity about new products, and further shows how this prior knowledge through rumors affects consumer responses to subsequent official preannouncements about these products. Design/methodology/approach Building on the seminal work by Rogers (2003) on the innovation-adoption process, the authors examine how two factors – product newness (incremental vs radical) and rumor ambiguity (ambiguous vs unambiguous) shape consumer interest (curiosity) toward new products. Findings Study 1 experimentally tests the assumption that incremental and radical new products may benefit from different types of rumors, and shows that radical new products benefit more from ambiguous rumors as compared to incremental new products in terms of increased curiosity toward the product. Study 2 links rumors to preannouncements, and shows that rumors set expectations that become confirmed or disconfirmed by preannouncements. The results show that the curiosity evoked by the rumor has a significant impact on purchase intentions toward the new product, especially when they are confirmed by the preannouncements about the same product. Originality/value There is scant research investigating how rumors may shape consumer expectations about new products despite the prevalence of rumors in the marketplace, and this research provides a first outlook on the positive role that rumors play in the marketplace.

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

2016 ◽  
Vol 86 (3-4) ◽  
pp. 127-151 ◽  
Author(s):  
Zeshan Ali ◽  
Zhenbin Wang ◽  
Rai Muhammad Amir ◽  
Shoaib Younas ◽  
Asif Wali ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Review Paper ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Active Role ◽  
Current Review ◽  
Different Types ◽  
Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

The Diagnosis of Lupus Anticoagulants by the Activated Partial Thromboplastin Time - The Central Role of Phosphatidyl Serine

1984 ◽  
Vol 52 (02) ◽  
pp. 172-175 ◽  
Author(s):  
P R Kelsey ◽  
K J Stevenson ◽  
L Poller
Keyword(s):  
Screening Method ◽  
Coagulation Factors ◽  
Phosphatidyl Serine ◽  
Test System ◽  
Specific Factor ◽  
Marginal Effect ◽  
Constant Composition ◽  
Lupus Anticoagulants ◽  
Different Types

SummaryLiposomes of pure phospholipids were used in a modified APTT test system and the role of phosphatidyl serine (PS) in determining the sensitivity of the test system to the presence of lupus anticoagulants was assessed. Six consecutive patients with lupus anticoagulants and seven haemophiliacs with anticoagulants directed at specific coagulation factors, were studied. Increasing the concentration of phospholipid in the test system markedly reduced the sensitivity to lupus anticoagulants but had marginal effect on the specific factor inhibitors. The same effect was achieved when the content of PS alone was increased in a vehicle liposome of constant composition.The results suggest that the lupus anticoagulants can best be detected by a screening method using an APTT test with a reagent of low PS content. The use of a reagent rich in PS will largely abolish the lupus anticoagulant’s effect on the APTT. An approach using the two different types of reagent may facilitate differentiation of lupus inhibitors from other types of anticoagulant.

The Role of Evaluative Tools in the Creation of the Memorial Media Portrait of Jacques Chirac (1932—2019)

2020 ◽  
pp. 97-110
Author(s):  
E. N. Mikhailova ◽  
V. A. Telegina
Keyword(s):  
Print Media ◽  
Political Elite ◽  
Systematic Analysis ◽  
Research Material ◽  
Political Orientations ◽  
Different Types ◽  
The Media ◽  
The Creation ◽  
Entire Text

The article is devoted to the study of evaluative tools used in modern French media in order to form the media image of a representative of the political elite. The techniques used in the creation of a memorial media portrait of Jacques Chirac (1932—2019), President of France from 1995 to 2007 are considered. The research material was the most prestigious French print media of various political orientations, published in late September — early October 2019 in connection with the death of the ex-President of the French Republic. The relevance of the research topic is dictated by the close attention of modern linguistics to axiological phenomena, differently presented in different types of discursive practices. The novelty of the study is due to the appeal to the analysis of the complex of evaluation tools used in the French print media when characterizing the former leader of the state during the nation’s farewell period. The estimated potential of the title of the article and its influence on the formation of the estimated vector of the entire text of the publication are shown. A systematic analysis of the assessment expression means, reflected in the memorial media portrait of the politician, is given. The factors that influenced the peculiarities of their use in this type of media portrait are revealed.

The influence of information relevance on the continued influence effect of misinformation

2020 ◽  
Author(s):  
Hua Jin ◽  
Lina Jia ◽  
Xiaojuan Yin ◽  
Shilin Wei ◽  
Guiping Xu
Keyword(s):  
Experimental Study ◽  
Questionnaire Survey ◽  
Personal Involvement ◽  
Influence Effect ◽  
Information Relevance ◽  
Different Types ◽  
Role Of Information

Misinformation often continues to influence people’s cognition even after corrected (the ‘continued influence effect of misinformation’, the CIEM). This study investigated the role of information relevance in the CIEM by questionnaire survey and experimental study. The results showed that information with higher relevance to the individuals had a larger CIEM, indicating a role of information relevance in the CIEM. Personal involvement might explain the effects of information relevance on the CIEM. This study provides insightful clues for reducing the CIEM in different types of misinformation and misinformation with varying relevance.

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