Tissue Engineering and its Significance in Healthcare during COVID-19 Pandemic: Potential Applications and Perspectives

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

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Biological Effect of Gas Plasma Treatment on CO2Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

Journal of Nanomaterials ◽

10.1155/2014/657542 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Tae-Yeong Bak ◽

Min-Suk Kook ◽

Sang-Chul Jung ◽

Byung-Hoon Kim

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Nitrogen Plasma ◽

Salt Leaching ◽

Foaming Process ◽

Gas Plasma ◽

Plasma Surface Treatment ◽

Potential Applications ◽

Gas Foaming

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2gas foaming process was carried out by solubilizing CO2within samples at 50°C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 μm. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

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New calcium-free Na2 O-Al2 O3 -P2 O5 bioactive glasses with potential applications in bone tissue engineering

Journal of the American Ceramic Society ◽

10.1111/jace.15216 ◽

2017 ◽

Vol 101 (2) ◽

pp. 602-611 ◽

Cited By ~ 7

Author(s):

Oliwia Jeznach ◽

Marcin Gajc ◽

Karolina Korzeb ◽

Andrzej Kłos ◽

Krzysztof Orliński ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Bioactive Glasses ◽

Potential Applications

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Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

International Journal of Polymer Science ◽

10.1155/2021/4907027 ◽

2021 ◽

Vol 2021 ◽

pp. 1-20 ◽

Cited By ~ 2

Author(s):

Dhinakaran Veeman ◽

M. Swapna Sai ◽

P. Sureshkumar ◽

T. Jagadeesha ◽

L. Natrayan ◽

...

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

3D Printing ◽

Regenerative Medicine ◽

Tissue Regeneration ◽

Three Dimensional ◽

Porous Scaffolds ◽

Wide Range ◽

Potential Applications ◽

Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

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Spatially Controllable Deposition of Electrospray Microparticles

Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology ◽

10.1115/imece2011-65383 ◽

2011 ◽

Cited By ~ 1

Author(s):

Xu Zhang ◽

Yi Zhao

Keyword(s):

Tissue Engineering ◽

Contrast Enhancement ◽

Electrode Arrays ◽

Electrical Field ◽

Nanoscale Particles ◽

Size Dependent ◽

Planar Surfaces ◽

Cell Tissue ◽

Potential Applications

Electrospray has been widely used in micro/nanotechnology which deposit micro/nanoscale particles on planar surfaces. However, in conventional electrospray approach the distribution of these particles patterned on the collecting surface is poorly controlled. This work introduces a programmable patterning method of electrospray, which microparticles are sprayed on micropatterned collecting chips. By manipulating the local electrical field using a combination of activated and floating electrodes, a good spatial contrast of microparticle patterning is obtained. In addition, the size-dependent contrast enhancement is demonstrated using a series of electrode arrays with different electrode patterns. Combined with encapsulation technique, this unique electrospray method promises potential applications in the field of functional cell/tissue engineering.

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The use of auxetic materials in tissue engineering

Biomaterials Science ◽

10.1039/c9bm01928f ◽

2020 ◽

Vol 8 (8) ◽

pp. 2074-2083 ◽

Cited By ~ 6

Author(s):

Paul Mardling ◽

Andrew Alderson ◽

Nicola Jordan-Mahy ◽

Christine Lyn Le Maitre

Keyword(s):

Tissue Engineering ◽

Biological Tissues ◽

Auxetic Materials ◽

Potential Applications ◽

Poissons Ratio

A number of biological tissues have been shown to behave in an auxetic manner, defined by having a negative poissons ratio. Thus mimicking this environment has a number of potential applications especially in tissue engineering.

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Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

Applied Sciences ◽

10.3390/app9173540 ◽

2019 ◽

Vol 9 (17) ◽

pp. 3540 ◽

Cited By ~ 9

Author(s):

Ferdows Afghah ◽

Caner Dikyol ◽

Mine Altunbek ◽

Bahattin Koc

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Cell Attachment ◽

Three Dimensional ◽

Future Perspective ◽

Melt Electrospinning ◽

Wide Range ◽

Challenges And Opportunities ◽

Potential Applications ◽

Homogeneous Cell

Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

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Soft network materials with isotropic negative Poisson's ratios over large strains

Soft Matter ◽

10.1039/c7sm02052j ◽

2018 ◽

Vol 14 (5) ◽

pp. 693-703 ◽

Cited By ~ 34

Author(s):

Jianxing Liu ◽

Yihui Zhang

Keyword(s):

Tissue Engineering ◽

Large Strains ◽

Potential Applications ◽

Poisson's Ratios ◽

Poisson’S Ratios ◽

Relative Constant

Soft network materials with isotropic and relative constant Poisson's ratios in the range from −1 to 1 over large strains are presented, with potential applications in tissue engineering and bioelectronics.

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