scholarly journals The use of auxetic materials in tissue engineering

2020 ◽  
Vol 8 (8) ◽  
pp. 2074-2083 ◽  
Author(s):  
Paul Mardling ◽  
Andrew Alderson ◽  
Nicola Jordan-Mahy ◽  
Christine Lyn Le Maitre
Keyword(s):  
Tissue Engineering ◽  
Biological Tissues ◽  
Auxetic Materials ◽  
Potential Applications ◽  
Poissons Ratio

A number of biological tissues have been shown to behave in an auxetic manner, defined by having a negative poissons ratio. Thus mimicking this environment has a number of potential applications especially in tissue engineering.

scholarly journals Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1656
Author(s):  
Carla Huerta-López ◽  
Jorge Alegre-Cebollada
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Polymer Networks ◽  
Biological Tissues ◽  
Modern Medicine ◽  
Body Parts ◽  
Biomedical Sciences ◽  
Protein Hydrogels ◽  
Large Water ◽  
Design Options

Biomaterials are dynamic tools with many applications: from the primitive use of bone and wood in the replacement of lost limbs and body parts, to the refined involvement of smart and responsive biomaterials in modern medicine and biomedical sciences. Hydrogels constitute a subtype of biomaterials built from water-swollen polymer networks. Their large water content and soft mechanical properties are highly similar to most biological tissues, making them ideal for tissue engineering and biomedical applications. The mechanical properties of hydrogels and their modulation have attracted a lot of attention from the field of mechanobiology. Protein-based hydrogels are becoming increasingly attractive due to their endless design options and array of functionalities, as well as their responsiveness to stimuli. Furthermore, just like the extracellular matrix, they are inherently viscoelastic in part due to mechanical unfolding/refolding transitions of folded protein domains. This review summarizes different natural and engineered protein hydrogels focusing on different strategies followed to modulate their mechanical properties. Applications of mechanically tunable protein-based hydrogels in drug delivery, tissue engineering and mechanobiology are discussed.

scholarly journals Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamed Nosrati ◽  
Reza Aramideh Khouy ◽  
Ali Nosrati ◽  
Mohammad Khodaei ◽  
Mehdi Banitalebi-Dehkordi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
The Body ◽  
Key Factors ◽  
Potential Applications ◽  
Nanocomposite Scaffolds

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

Stress Concentration Factors in Auxetic Rods and Plates

2013 ◽  
Vol 394 ◽  
pp. 134-139 ◽  
Author(s):  
Teik Cheng Lim
Keyword(s):  
Stress Concentration ◽  
Circumferential Stress ◽  
Axial Direction ◽  
Thin Plates ◽  
Auxetic Materials ◽  
Circular Holes ◽  
Concentration Factors ◽  
Stress Concentration Factors ◽  
Future Work ◽  
Poissons Ratio

Auxetic materials are solids that possess negative Poissons ratio. Although rare, such materials do occur naturally and also have been artificially produced. Due to their unique properties, auxetic materials have been extensively investigated for load bearing applications including in biomedical engineering and aircraft structures. This paper considers the effect of Poissons ratio on the stress concentration factors on rods with hyperbolic groove and large thin plates with circular holes and rigid inclusions. Results reveal that the use of auxetic materials is useful for reducing stress concentration in the maximum circumferential stress of the rods with grooves, and in plates with circular holes and rigid inclusions. However, the use of auxetic materials increases the stress concentration in the axial direction of the rod. Therefore a procedure to accurately select and/or design materials with precise negative Poissons ratio for optimal design is suggested for future work.

scholarly journals Biological Effect of Gas Plasma Treatment on CO2Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Yeong Bak ◽  
Min-Suk Kook ◽  
Sang-Chul Jung ◽  
Byung-Hoon Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nitrogen Plasma ◽  
Salt Leaching ◽  
Foaming Process ◽  
Gas Plasma ◽  
Plasma Surface Treatment ◽  
Potential Applications ◽  
Gas Foaming

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2gas foaming process was carried out by solubilizing CO2within samples at 50°C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 μm. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

scholarly journals Current perspectives regarding the application and incorporation of silver nanoparticles into dental biomaterials

2018 ◽  
Vol 91 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Mihai Flaviu Şuhani ◽  
Grigore Băciuţ ◽  
Mihaela Băciuţ ◽  
Raluca Şuhani ◽  
Simion Bran
Keyword(s):  
Silver Nanoparticles ◽  
Oral Health ◽  
Nanostructured Materials ◽  
Case Reports ◽  
Protein Detection ◽  
Biological Tissues ◽  
Scientific Database ◽  
Nanostructured Particles ◽  
Database Research ◽  
Potential Applications

Introduction: The key idea of nanotechnology is to construct and preserve functional structures by means of exploiting atoms and molecules. Nanotechnology has proven to be crucial in pharmacological medicine, tissue engineering, clinical diagnosis, long term conservation of biological tissues in a cryogenic state, protein detection, tumor destruction and magnetic resonance imaging.The aim of this paper is to review the literature on the specific characteristics of nanostructured materials, their applications and advantages that they bring to dentistry.Method. We conducted an electronic scientific database research that included PubMed, Cochrane and Medline. The following keywords were used: nanotechnology, nanodentistry and silver nanoparticles. Initially 1650 original articles were retrieved from the  these mentioned international databases, which were screened in detail. We included literature reviews that dealt with the comprehensive applications of nanostructured particles and silver nanoparticles in particular, in all fields of contemporary dentistry. Case reports, clinical trials, editorials and opinion letters were excluded in the first phase of our research. Fifty two articles met all the selection criteria and were ultimately selected and reviewed.Results. Nanotechnology deals with the production of various types of nanomaterials with potential applications in the field of biomedicine. Silver nanoparticles have the capacity to eliminate dental caries producing bacteria or repair teeth enamel with signs of dental decay. Nanodentistry will allow better oral health by use of nanostructured materials. Treatment opportunities that nanotechnology has to offer in contemporary dentistry include local anesthesia, permanent treatment of dental hypersensitivity, orthodontic and oral health care with nanorobotic dentifrice.Conclusion. The studies that we reviewed are largely in favor of nanotechnology and nanostructured materials, highlighting their qualities and enhancements they bring to the field of dentistry. Although many of these products that benefit from silver nanoparticles properties are still expensive and exclusive, we can foresee major improvements and demand regarding dental biomaterials with nanoparticles incorporated in the near future.

New calcium-free Na2 O-Al2 O3 -P2 O5 bioactive glasses with potential applications in bone tissue engineering

2017 ◽  
Vol 101 (2) ◽  
pp. 602-611 ◽  
Author(s):  
Oliwia Jeznach ◽  
Marcin Gajc ◽  
Karolina Korzeb ◽  
Andrzej Kłos ◽  
Krzysztof Orliński ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bioactive Glasses ◽  
Potential Applications

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

scholarly journals Computer modelling and simulation of a novel printing head for complex tissue engineering constructs

2020 ◽  
Vol 318 ◽  
pp. 01045
Author(s):  
Gokhan Ates
Keyword(s):  
Tissue Engineering ◽  
Computer Modelling ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Biological Properties ◽  
Functionally Graded ◽  
Mixing Efficiency ◽  
Tissue Constructs ◽  
Multiple Materials ◽  
Graded Structures

In tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sophisticated tissue constructs. These multi-material biomanufacturing systems comprise multiple printing heads through which individual materials are sequentially printed. Nevertheless, as more printing heads are added the fabrication process significantly decreases, since it requires mechanical switching among the physically separated printheads to enable printing multiple materials. In addition, this approach is not able to create biomimetic tissue constructs with property gradients. To address these limitations, this paper presents a novel static mixing extrusion printing head to enable the fabrication of multi-material, functionally graded structures using a single nozzle. Computational fluid dynamics (CFD) was used to numerically analyze the influence of Reynolds number on the flow pattern of biomaterials and mixing efficiency considering different miscible materials.

Spatially Controllable Deposition of Electrospray Microparticles

2011 ◽  
Author(s):  
Xu Zhang ◽  
Yi Zhao
Keyword(s):  
Tissue Engineering ◽  
Contrast Enhancement ◽  
Electrode Arrays ◽  
Electrical Field ◽  
Nanoscale Particles ◽  
Size Dependent ◽  
Planar Surfaces ◽  
Cell Tissue ◽  
Potential Applications

Electrospray has been widely used in micro/nanotechnology which deposit micro/nanoscale particles on planar surfaces. However, in conventional electrospray approach the distribution of these particles patterned on the collecting surface is poorly controlled. This work introduces a programmable patterning method of electrospray, which microparticles are sprayed on micropatterned collecting chips. By manipulating the local electrical field using a combination of activated and floating electrodes, a good spatial contrast of microparticle patterning is obtained. In addition, the size-dependent contrast enhancement is demonstrated using a series of electrode arrays with different electrode patterns. Combined with encapsulation technique, this unique electrospray method promises potential applications in the field of functional cell/tissue engineering.

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