Evaluation of U-Net Based Architectures for Automatic Aortic Dissection Segmentation

Segmentation and reconstruction of arteries is important for a variety of medical and engineering fields, such as surgical planning and physiological modeling. However, manual methods can be laborious and subject to a high degree of human variability. In this work, we developed various convolutional neural network ( CNN ) architectures to segment Stanford type B aortic dissections ( TBADs ), characterized by a tear in the descending aortic wall creating a normal channel of blood flow called a true lumen and a pathologic channel within the wall called a false lumen. We introduced several variations to the two-dimensional ( 2D ) and three-dimensional (3 D ) U-Net, where small stacks of slices were inputted into the networks instead of individual slices or whole geometries. We compared these variations with a variety of CNN segmentation architectures and found that stacking the input data slices in the upward direction with 2D U-Net improved segmentation accuracy, as measured by the Dice similarity coefficient ( DC ) and point-by-point average distance ( AVD ), by more than 15\% . Our optimal architecture produced DC scores of 0.94, 0.88, and 0.90 and AVD values of 0.074, 0.22, and 0.11 in the whole aorta, true lumen, and false lumen, respectively. Altogether, the predicted reconstructions closely matched manual reconstructions.