Comparison of Cell Response and Surface Characteristics on Titanium Implant with SLA and SLAffinity Functionalization

2014 ◽  
Vol 161 (3) ◽  
pp. G15-G20 ◽  
Author(s):  
Chiung-Fang Huang ◽  
Hsi-Jen Chiang ◽  
Hao-Jan Lin ◽  
Hossein Hosseinkhani ◽  
Keng-Liang Ou ◽  
...  
Keyword(s):  
Cell Response ◽  
Titanium Implant ◽  
Surface Characteristics

Alkali-Modified Titanium Surface Stimulating Formation of Bone-Implant Interface

2007 ◽  
Vol 361-363 ◽  
pp. 749-752
Author(s):  
J. Strnad ◽  
Jan Macháček ◽  
Z. Strnad ◽  
C. Povýšil ◽  
Marie Strnadová
Keyword(s):  
Titanium Implant ◽  
Surface Characteristics ◽  
Healing Time ◽  
Machined Surface ◽  
Implant Surface ◽  
Bone Implant ◽  
Bone Response ◽  
Modified Surface ◽  
The Difference ◽  
Titanium Implant Surface

This study was carried out to assess the bone response to alkali-modified titanium implant surface (Bio surface), using histomorphometric investigation on an animal model. The mean net contribution of the Bio surface to the increase in bone implant contact (BIC) with reference to the turned, machined surface was evaluated at 7.94 % (BIC/week), within the first five weeks of healing. The contribution was expressed as the difference in the osseointegration rates ( BIC/'healing time) between the implants with alkali modified surface (Bio surface) and those with turned, machined surface. The surface characteristics that differed between the implant surfaces, i.e. surface morphology, specific surface area, contact angle, hydroxylation/hydration, may represent factors that influence the rate of osseointegration.

scholarly journals Surface characteristics and osteoblastic cell response of alkali-and heat-treated titanium-8tantalum-3niobium alloy

2012 ◽  
Vol 42 (6) ◽  
pp. 248 ◽  
Author(s):  
Bo-Ah Lee ◽  
Choong-Hee Kang ◽  
Mong-Sook Vang ◽  
Young-Suk Jung ◽  
Xing Hui Piao ◽  
...  
Keyword(s):  
Cell Response ◽  
Surface Characteristics ◽  
Osteoblastic Cell ◽  
Heat Treated

scholarly journals Functionalized titanium implant in regulating bacteria and cell response

2019 ◽  
Vol Volume 14 ◽  
pp. 1433-1450 ◽  
Author(s):  
Jianfeng Jin ◽  
Dongdong Fei ◽  
Yumei Zhang ◽  
Qintao Wang
Keyword(s):  
Cell Response ◽  
Titanium Implant

Surface characteristics and osteoblast cell response on TiN- and TiAlN-coated Ti implant

2011 ◽  
Vol 1 (2) ◽  
pp. 99-107 ◽  
Author(s):  
Hak Won Jang ◽  
Hyo-Jin Lee ◽  
Jung-Yun Ha ◽  
Kyo-Han Kim ◽  
Tae-Yub Kwon
Keyword(s):  
Cell Response ◽  
Surface Characteristics ◽  
Osteoblast Cell

scholarly journals Cellular Responses Evoked by Different Surface Characteristics of Intraosseous Titanium Implants

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Liviu Feller ◽  
Yusuf Jadwat ◽  
Razia A. G. Khammissa ◽  
Robin Meyerov ◽  
Israel Schechter ◽  
...  
Keyword(s):  
Surface Energy ◽  
Surface Chemistry ◽  
High Surface ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Cellular Responses ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone To Implant Contact ◽  
And Migration

The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.

scholarly journals Development of a Surface-Functionalized Titanium Implant for Promoting Osseointegration: Surface Characteristics, Hemocompatibility, and In Vivo Evaluation

2020 ◽  
Vol 10 (23) ◽  
pp. 8582
Author(s):  
Ping-Jen Hou ◽  
Syamsiah Syam ◽  
Wen-Chien Lan ◽  
Keng-Liang Ou ◽  
Bai-Hung Huang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Dental Implant ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Cell Aggregation ◽  
Dip Coating ◽  
Pluronic F127 ◽  
In Vivo Evaluation ◽  
The Impact

This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.

scholarly journals The Affinity of Human Fetal Osteoblast to Laser-Modified Titanium Implant Fixtures

2020 ◽  
Vol 14 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Lee Kian Khoo ◽  
Sirichai Kiattavorncharoen ◽  
Verasak Pairuchvej ◽  
Nisanat Lakkhanachatpan ◽  
Natthamet Wongsirichat ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Adhesion ◽  
Surface Chemistry ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Titanium Implants ◽  
Cell Maturation ◽  
Implant Surface ◽  
Pure Grade

Introduction: Implant surface modification methods have recently involved laser treatment to achieve the desired implant surface characteristics. Meanwhile, surface modification could potentially introduce foreign elements to the implant surface during the manufacturing process. Objectives: The study aimed to investigate the surface chemistry and topography of commercially available laser-modified titanium implants, together with evaluating the cell morphology and cell adhesion of human fetal osteoblast (hFOB) seeded onto the same implants. Method: Six (6) samples of commercially available laser-modified titanium implants were investigated. These implants were manufactured by two different companies. Three (3) implants were made from commercially pure grade 4 Titanium (Brand X); and three were made from grade 5 Ti6Al4V (Brand Y). The surface topography of these implants was analyzed by scanning electron microscope (SEM) and the surface chemistry was evaluated with electron dispersive x-ray spectroscopy(EDS). Human fetal osteoblasts were seeded onto the implant fixtures to investigate the biocompatibility and adhesion. Results & Discussion: Brand X displayed dark areas under SEM while it was rarely found on brand Y. These dark areas were consistent with their organic matter. The hFOB cell experiments revealed cell adhesion with filopodia on Brand X samples which is consistent with cell maturation. The cells on Brand Y were morphologically round and lacked projections, one sample was devoid of any noticeable cells under SEM. Cell adhesion was observed early at 48 hrs in laser-irradiated titanium fixtures from both the brands. Conclusion: The presence of organic impurities in Brand X should not be overlooked because disruption of the osseointegration process may occur due to the rejection of the biomaterial in an in-vivo model. Nevertheless, there was insufficient evidence to link implant failure directly with carbon contaminated implant surfaces. Further studies to determine the toxicity of Vanadium from Ti6Al4V in an in-vivo environment should indicate the reason for different cell maturation.

Developing biomedical nano-grained β-type titanium alloys using high pressure torsion for improved cell adherence

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7426-7430 ◽  
Author(s):  
Hakan Yilmazer ◽  
Mustafa Şen ◽  
Mitsuo Niinomi ◽  
Masaaki Nakai ◽  
Liu Huihong ◽  
...  
Keyword(s):  
High Pressure ◽  
Titanium Alloys ◽  
High Pressure Torsion ◽  
Cell Attachment ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Cell Adherence

Proper surface characteristics for a titanium implant are crucial for the formation of different cellular protrusions known as filopodia and lamellipodia, both of which have a significant impact on cell attachment, spreading, and proliferation.

scholarly journals Optimized Size and Distribution of Silver Nanoparticles on the Surface of Titanium Implant Regarding Cell Viability

2020 ◽  
Vol 10 (20) ◽  
pp. 7063
Author(s):  
Péter Hajdu ◽  
István Lampé ◽  
Richárd Rácz ◽  
Sándor Biri ◽  
Attila Csík ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Cell Viability ◽  
Silver Nanoparticle ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Physical Characteristics ◽  
Control Surface ◽  
Alamar Blue ◽  
Drop Shape ◽  
Titanium Surfaces

Though the antibacterial effect is advantageous, silver and silver nanoparticles can negatively affect the viability of human tissues. This study aims to check the viability of cells on surfaces with different particle size and to find the biologically optimal configuration. We investigated the effect of modified thickness of vaporized silver and applied heat and time on the physical characteristics of silver nanoparticle covered titanium surfaces. Samples were examined by scanning electron microscopy, mass spectrometry, and drop shape analyzer. To investigate how different physical surface characteristics influence cell viability, Alamar Blue assay for dental pulp stem cells was carried out. We found that different surface characteristics can be achieved by modifying procedures when creating silver nanoparticle covered titanium. The size of the nanoparticles varied between 60 to 368 nm, and hydrophilicity varied between 63 and 105 degrees of contact angle. Investigations also demonstrated that different physical characteristics are related to a different level of viability. Surfaces covered with 60 nm particle sizes proved to be the most hydrophilic, and the viability of the cells was comparable to the viability measured on the untreated control surface. Physical and biological characteristics of silver nanoparticle covered titanium, including cell viability, have an acceptable level to be used for antibacterial effects to prevent periimplantitis around implants.

Sign in / Sign up

Export Citation Format

Share Document