Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia

2012 ◽  
Vol 302 (6) ◽  
pp. E687-E693 ◽  
Author(s):  
Hisashi Masuyama ◽  
Etsuko Nobumoto ◽  
Seiji Inoue ◽  
Yuji Hiramatsu
Keyword(s):  
Brain Natriuretic Peptide ◽  
Mrna Expression ◽  
Natriuretic Peptide ◽  
Primary Cultures ◽  
Cross Sectional Study ◽  
Potential Interaction ◽  
Normal Weight ◽  
Cross Sectional ◽  
Omental Adipose Tissue ◽  
Positive Correlations

Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational age and body mass index. The BNP, leptin, and adiponectin levels were measured by ELISA, and their mRNA expressions were evaluated in omental adipose tissue by real-time PCR. The effects of BNP on adiponectin and leptin mRNA expression and secretion were investigated in primary cultures of adipocytes from obese and normal-weight women. The BNP, adiponectin, and leptin levels were significantly higher in preeclampsia patients compared with controls. The adiponectin level was increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients. Adiponectin mRNA expression was increased significantly in adipose tissues of preeclampsia patients compared with controls and was also increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients, whereas leptin was not. BNP and adiponectin showed significant positive correlations in both normal-weight and overweight preeclampsia patients. BNP had a significantly weaker effect on adiponectin in overweight compared with normal-weight preeclampsia patients. Moreover, BNP had a weaker effect on adiponectin production in adipocytes from overweight women compared with adipocytes from normal-weight women using primary culture of human adipocytes. These data suggested that BNP may play a role in hyperadiponectinemia of preeclampsia patients. The weaker effect of BNP on adiponectin production may participate in the pathophysiology of overweight preeclampsia patients.

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

2017 ◽  
Vol 49 (09) ◽  
pp. 667-672 ◽  
Author(s):  
Lachezar Lozanov ◽  
Desislava Gorcheva ◽  
Bojan Lozanov ◽  
Radka Argirova ◽  
Veselina Koleva ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Serum Insulin ◽  
Visceral Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Metabolic Status ◽  
Cross Sectional ◽  
Secondary Resistance ◽  
Positive Correlations ◽  
Hypothyroid Patients

AbstractHypothyroidism results in disturbances of metabolism influencing many regulatory systems and active molecules as adipocytokines. Objective of the study was to investigate leptin and adiponectin in patients with visceral obesity and hypothyroidism in relation to metabolic status, insulin resistance and systemic inflammation. A total of 118 patients (59 hypothyroid and 59 euthyroid) were enrolled divided into four age-matched groups according to body wеight (BMI) and thyroid function. Laboratory panel includes TSH, FT4, FT3 (CMIA), adiponectin and leptin (ELISA), IL- 6 (ECLIA), CRP, insulin, glucose, apolipoprotein B and lipoprotein (a) - Lp(a). Hypothyroid patients revealed significant positive correlations of TSH, adiponectin and Lp(a). Their medians of 10.4 mU/l, 12.5 µg/ml and 116.3 mg/l respectively were significantly higher than in euthyroid patients- 1.5 mU/l, 6.26 µg/ml and 32.0 mU/l (p < 0.0001). Leptin in both obese groups was significantly higher than in patients with normal weight. Leptin in hypothyroid patients was lower but not significant to euthyroid ones (9.7 ng/ml vs 13.4 ng/ml respectively, p = 0.16), correlated negatively to TSH and positively to CRP, IL-6, ApoB, Lp(a) and BMI. HOMA-IR and serum insulin at 120 min in OGTT were significantly higher in hypothyroid than in euthyroid patients independent of BMI (p < 0.001). Adiponectin, insulin resistance and chronic inflammation indices in hypothyroid patients correlated positively to TSH, BMI and atherogenic lipoproteins subclasses ApoB/Lp(a). Increased adiponectin in thyroid deficiency could be due to secondary resistance of adiponectin receptors or appeared as a compensatory pathogenetic factor in hypothyroidism.

scholarly journals The correlation between serum level of brain natriuretic peptide and amount of left to right shunt

2019 ◽  
Vol 11 (1) ◽  
pp. 68-71
Author(s):  
Ahmad Jamei Khosroshahi ◽  
Akbar Molaei ◽  
Mahmoud Samadi ◽  
Elnaz Eskandartash
Keyword(s):  
Serum Level ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Significant Relationship ◽  
Septal Defect ◽  
Ductus Arteriosus ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Physical Examinations ◽  
The Relationship

Introduction: Natriuretic peptides such as brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and pro-BNP are secreted in response to atrial and/or ventricular stretch. Left to right shunts such as ventricular septal defect (VSD), atrial septal defect (ASD), and patent ductus arteriosus (PDA), are treated medically or surgically. We aimed to evaluate whether the serum level of pro-BNP would be useful to measure the amount of the shunt. Methods: In this cross sectional study, 60 infants and children, in whom physical examinations approved heart murmur, and had undergone echocardiography by which VSD, ASD, or PDA had been proven, were included in the study. The relationship between serum BNP levels and severity of shunt (Qp/Qs) based on echocardiographic and hemodynamic evaluations, was studied. Results: There was a significant relationship between serum level of pro-BNP and the amount of the shunt in the patients with VSD, ASD, and PDA (P=0.01). A positive correlation was seen between pro-BNP serum level and Qp/Qs ratio. The mean ± SE serum level of pro-BNP in patients with Qp/Qs ratio of less than 1.5, equal to 1.5-2, and more than 2 was 30.83±2.4, 217.88±44.6, and 217.13±51.8, respectively showing a significant relationship (P=0.0001). The cut-off point of pro-BNP demonstrating a Qp/Qs ratio more than 1.5 was measured at the level of 40.36 pg/mL, with a sensitivity and specificity of 92% and 79%, respectively. Conclusion: Based on our study, the cut-off point of 40.36 pg/mL or more for pro-BNP, showing a Qp/Qs ratio more than 1.5, can be considered as an indication for interventional procedures.

scholarly journals Effect of obesity on risk and severity of periodontitis: a cross-sectional study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 643
Author(s):  
Chaerita Maulani ◽  
Elza Ibrahim Auerkari ◽  
Sri Lelyati C. Masulili ◽  
Lindawati S. Kusdhany ◽  
Chiquita Prahasanti ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Chi Square ◽  
Crude Odds Ratio ◽  
Cross Sectional ◽  
Logistic Analysis ◽  
Severe Periodontitis ◽  
Prevalence Of Obesity ◽  
Positive Correlations

Background: The present study aimed to investigate the correlation between obesity and periodontitis, among other risk factors for periodontitis.   Methods:  In total, 262 Indonesian male and female subjects were analysed for body mass index (BMI), oral hygiene, plaque index, and clinically evaluated periodontitis. Statistical analysis was performed using Spearman tests and Pearson chi-square tests to estimate the correlation between BMI and periodontitis. Multivariate binary logistic analysis was conducted between covariate and periodontitis. P<0.05 was considered as statistically significant.   Results: The prevalence of obesity was 48.47%. There were positive correlations between BMI and periodontal status for healthy-mild periodontitis, moderate, and severe periodontitis respectively. BMI and periodontitis crude odds ratio (OR) = 2.31 (95% CI 1.41-3.78); p < 0.05, adjusted OR of BMI among other variables, was 1.88 (95%CI 1.05-3.37); p < 0.05. Exploration of the ROC curve found a BMI cut off point of 24.785 kg/m2.  Conclusion: Obesity by BMI measurement of ≥ 25kg/m2 correlated to a higher risk of acquiring periodontitis compared to normal-weight individuals.

scholarly journals Serum brain natriuretic peptide in healthy Nigerian newborn babies

2021 ◽  
Vol 48 (1) ◽  
pp. 8-11
Author(s):  
Amudalat Issa ◽  
Mohammed B. Abdulkadir ◽  
Omotayo O. Adesiyun ◽  
Bilkis Owolabi ◽  
Surajudeen O. Bello ◽  
...  
Keyword(s):  
Birth Weight ◽  
Brain Natriuretic Peptide ◽  
Racial Differences ◽  
Natriuretic Peptide ◽  
Gestational Age ◽  
Adult Population ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Chronological Age ◽  
Cross Sectional

Background: Brain natriuretic peptide (BNP) is a sensitive biomarker that is valuable in the management of childhood heart failure. Studies have reported racial differences in the level of BNP, especially in the adult population. The level of BNP in healthy Nigerian newborn babies is unknown. Hence, we determined the level of BNP in healthy term appropriate for gestational age (AGA) newborn babies. Methods: This was a cross sectional study,85 healthy term AGA newborn babies aged 24 to 72 hours. The babies had relevant demographic parameters documented in a proforma and BNP assay analysed using ELISA method. Results: The median IQR serum BNP level was 341.43 (313.39 to 425.45) pg/ml. The median level in females, was higher than males, {393.86 (296.97- 460.62) pg/ml vs328.05 (313.61-389.39) pg/ml, p >0.05}.There was no significant relationship between serum BNP and birth weight, chronological age, gestational age, or mode of delivery (p>0.05 in each case). Conclusion: The study demonstrated high BNP levels in healthy term Nigerian newborns. There was no relationship between BNP, the chronological age, birth weight, gender, gestational age or mode of delivery in babies between 24 to 72 hours of life.

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