The correlation between serum level of brain natriuretic peptide and amount of left to right shunt

Introduction: Natriuretic peptides such as brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and pro-BNP are secreted in response to atrial and/or ventricular stretch. Left to right shunts such as ventricular septal defect (VSD), atrial septal defect (ASD), and patent ductus arteriosus (PDA), are treated medically or surgically. We aimed to evaluate whether the serum level of pro-BNP would be useful to measure the amount of the shunt. Methods: In this cross sectional study, 60 infants and children, in whom physical examinations approved heart murmur, and had undergone echocardiography by which VSD, ASD, or PDA had been proven, were included in the study. The relationship between serum BNP levels and severity of shunt (Qp/Qs) based on echocardiographic and hemodynamic evaluations, was studied. Results: There was a significant relationship between serum level of pro-BNP and the amount of the shunt in the patients with VSD, ASD, and PDA (P=0.01). A positive correlation was seen between pro-BNP serum level and Qp/Qs ratio. The mean ± SE serum level of pro-BNP in patients with Qp/Qs ratio of less than 1.5, equal to 1.5-2, and more than 2 was 30.83±2.4, 217.88±44.6, and 217.13±51.8, respectively showing a significant relationship (P=0.0001). The cut-off point of pro-BNP demonstrating a Qp/Qs ratio more than 1.5 was measured at the level of 40.36 pg/mL, with a sensitivity and specificity of 92% and 79%, respectively. Conclusion: Based on our study, the cut-off point of 40.36 pg/mL or more for pro-BNP, showing a Qp/Qs ratio more than 1.5, can be considered as an indication for interventional procedures.

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Đánh giá nồng độ lactate và procalcitonin ở bệnh nhân Covid-19

Journal of Clinical Medicine- Hue Central Hospital ◽

10.38103/jcmhch.2022.75.8 ◽

2022 ◽

Author(s):

Thanh Xuan Nguyen

Keyword(s):

Serum Level ◽

Respiratory Infections ◽

Severe Pneumonia ◽

Cross Sectional Study ◽

Multiple Organ ◽

High Rate ◽

Rt Pcr ◽

Wuhan City ◽

Cross Sectional ◽

The Relationship

TÓM TẮT Đặt vấn đề: Bệnh COVID-19 đa dạng từ không có triệu chứng đến có các triệu chứng nhẹ cho đến viêm phổi nặng, hội chứng suy hô hấp cấp tiến triển (ARDS), nhiễm khuẩn huyết suy đa tạng và tử vong. Người cao tuổi, người có bệnh mạn tính sẽ có nguy cơ diễn biến nặng nhiều hơn. Nghiên cứu này nhằm xác định nồng độ lactate và PCT ở những bệnh nhân Covid-19 và xét mối liên quan giữa lactate và PCT trên bệnh nhân Covid-19. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 126 bệnh nhân được chẩn đoán nhiễm Sars-Cov-2 bằng xét nghiệm RT PCR. Kết quả: Tuổi trung bình 55,98 ± 17,1 tuổi (4 - 98 tuổi). Bệnh nhân > 60 tuổi chiếm tỉ lệ cao nhất (42,8%). Trung vị PCT: 3,6 (95%CI:3,21 - 3,75) ng/ml; trung vị lactate 1,5 (95%CI:1,21 - 1,91) mmol/L; lactate có tương quan thuận và yếu với procalcitonin với r = 0,241; p < 0,001. Nồng độ procalcitonin > 0,1 ng/ml; lactate > 2 mmol/l ở bệnh nhân Covid-19 chiếm tỷ lệ cao với 89,7% và 39,7%. Kết luận: Chỉ điểm procalcitonin, lactate tăng cao ở bệnh nhân Covid-19. ABSTRACT ASSESSMENT OF SERUM LEVEL OF LACTATE AND PROCALCITONIN IN COVID-19 PATIENTS Background: Sars-CoV-2 has been identified as the cause of acute respiratory infections in Wuhan city, Hubei province, China, and has since spread worldwide. Sars-CoV-2 is capable of aerosol transmission in enclosed, crowded, and poorly ventilated spaces. COVID-19 illness ranges from asymptomatic to mild symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), sepsis, multiple organ failure, and death. This study aims to determine lactate and PCT levels in Covid-19 patients and examine the relationship between lactate and PCT in Covid-19 patients. Methods: A cross-sectional study was performed on 126 patients diagnosed with Sars-Cov-2 infection by RT-PCR. Results: Mean age was 55.98 ± 17.1 years (range: 4-98 years). Patients more than 60 years old were accounted for the highest rate (42.8%). Median PCT: 3.6 (95%CI:3.21 - 3.75) ng/ml; median lactate 1.5 (95%CI:1.21 - 1,91) mmol/L; lactate has a positive and weak correlation with procalcitonin with r = 0.241; p < 0.001. Procalcitonin concentration > 0.1 ng/ml; lactate > 2 mmol/l in patients with Covid-19 accounted for a high rate with 89.7% and 39.7%. Conclusion: Serum level of procalcitonin and lactate raise highly in Covid-19 patients. Keywords: Covid-19, procalcitonin, lactate.

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Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00548.2011 ◽

2012 ◽

Vol 302 (6) ◽

pp. E687-E693 ◽

Cited By ~ 7

Author(s):

Hisashi Masuyama ◽

Etsuko Nobumoto ◽

Seiji Inoue ◽

Yuji Hiramatsu

Keyword(s):

Brain Natriuretic Peptide ◽

Mrna Expression ◽

Natriuretic Peptide ◽

Primary Cultures ◽

Cross Sectional Study ◽

Potential Interaction ◽

Normal Weight ◽

Cross Sectional ◽

Omental Adipose Tissue ◽

Positive Correlations

Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational age and body mass index. The BNP, leptin, and adiponectin levels were measured by ELISA, and their mRNA expressions were evaluated in omental adipose tissue by real-time PCR. The effects of BNP on adiponectin and leptin mRNA expression and secretion were investigated in primary cultures of adipocytes from obese and normal-weight women. The BNP, adiponectin, and leptin levels were significantly higher in preeclampsia patients compared with controls. The adiponectin level was increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients. Adiponectin mRNA expression was increased significantly in adipose tissues of preeclampsia patients compared with controls and was also increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients, whereas leptin was not. BNP and adiponectin showed significant positive correlations in both normal-weight and overweight preeclampsia patients. BNP had a significantly weaker effect on adiponectin in overweight compared with normal-weight preeclampsia patients. Moreover, BNP had a weaker effect on adiponectin production in adipocytes from overweight women compared with adipocytes from normal-weight women using primary culture of human adipocytes. These data suggested that BNP may play a role in hyperadiponectinemia of preeclampsia patients. The weaker effect of BNP on adiponectin production may participate in the pathophysiology of overweight preeclampsia patients.

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FAKTOR YANG BERHUBUNGAN DENGAN KELUHAN KELELAHAN MATA PADA PENGGUNA KOMPUTER DI STIKES HANG TUAH PEKANBARU TAHUN 2020

Media Kesmas (Public Health Media) ◽

10.25311/kesmas.vol1.iss2.339 ◽

2021 ◽

Vol 1 (2) ◽

pp. 241-250

Author(s):

Muhammad Hanafi Hanafi ◽

Asril Asril ◽

Ahmad Satria Efendi

Keyword(s):

Significant Relationship ◽

Sampling Technique ◽

Cross Sectional Study ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Probability Sampling ◽

Eye Fatigue ◽

Long Time ◽

The Relationship

Kelelahan mata adalah gangguan yang dialami mata karena otot-ototnya yang dipaksa bekerja keras terutama saat harus melihat objek dekat dalam jangka waktu lama. Tujuan penelitian ini adalah ntuk mengetahui hubungan antara karakteristik pekerja dan perangkat kerja dengan keluhan kelelahan mata pada pengguna komputer. Penelitian ini merupakan penelitian analitik kuantitatif dengan menggunakan desain studi cross sectional, dengan responden kasus adalah pekerja yang menggunakan komputer di STIKes Hang Tuah Pekanbaru. Jumlah sampel dalam penelitian ini adalah 46 orang. Teknik pengambilan sampel pada kasus adalah non probability sampling. Alat ukur yang di gunakan adalah kuesioner, dan pengukuran. Analisis yang di gunakan adalah univariat dan bivariat dengan uji statistik Chi-square. Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara usia (Pvalue=0,024, nilai OR=5,409), durasi penggunaan komputer (Pvalue=0,020, nilai OR=5,143), jarak pandang mata dengan monitor (Pvalue=0,009, nilai OR=6,500) dengan kelulahan kelelahan mata. Hasil penelitian menunjukkan tidak ada hubungan signifikan antara penggunaan anti glare (Pvalue=0,457, nilai OR=1,929) dengan keluhan kelelahan mata. Disarankan kepada pekerja menjaga jarak mata dengan layar monitor, melakukan istirahat mata sekitar 10 menit stiap jam, dan mengatur pencahayaan monitor dalam menggunakan komputer. Eye fatigue is a disorder experienced by the eye because the muscles are forced to work hard, especially when they have to look at close objects for a long time. The purpose of this study was to determine the relationship between the characteristics of workers and work equipment with complaints of eye fatigue in computer users. This research is a quantitative analytic study using a cross sectional study design, with case respondents being workers who use computers at STIKes Hang Tuah Pekanbaru. The number of samples in this study were 46 people. The sampling technique in this case is non-probability sampling. The measuring instrument used is a questionnaire, and measurement. The analysis used was univariate and bivariate with Chi-square statistical test. The results showed that there was a significant relationship between age (P value = 0.024, OR value = 5,409), duration of computer use (P value = 0.020, OR value = 5.143), distance between eyes and monitor (Pvalue = 0.009, OR value = 6,500) with complaints of eye fatigue. The results showed that there was no significant relationship between the use of anti-glare (P-value = 0.457, OR = 1.929) with complaints of eye fatigue. It is recommended for workers to keep their eyes away from the monitor screen, take an eye break of about 10 minutes every hour, and adjust the lighting of the monitor when using the computer.

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Hubungan antara Tingkat Pengetahuan dan Sikap dengan Tindakan Pencegahan Penyakit Rabies pada Warga di Wilayah Puskesmas Kuta II

Smart Medical Journal ◽

10.13057/smj.v1i1.24184 ◽

2018 ◽

Vol 1 (1) ◽

pp. 18

Author(s):

Ni Kadek Ayu Septiani Sarjana ◽

Arsita Eka Prasetyawati ◽

Dyah Ratna Budiani

Keyword(s):

Disease Prevention ◽

Significant Relationship ◽

Simple Random Sampling ◽

Cross Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Knowledge And Attitudes ◽

Level Of Knowledge ◽

Knowledge And Attitude ◽

The Relationship

Introduction: Rabies is a disease of animals (usually vertebrate) which is zoonotic (transmissible to humans). Rabies occurs in 24 out of the 34 provinces of Indonesia. Rabies is caused by a virus in the Family: Rhabdivoridae, Genus: Lyssavirus. Control the dog population and dog vaccination is effective and economical method to prevent the incidences of rabies in humans. This study aims to investigate the relationship between level of knowledge and attitude to the practice in prevention rabies infection in residents lived in area covered by Puskesmas Kuta II.Methods: This study was a cross-sectional study and carried out by simple random sampling of 96 residents in the area of Puskesmas Kuta II. In this study, the independent variables are knowledge of and attitudes towards rabies disease while the dependent variable is the practice to prevent rabies infection in human. Data were collected by a questionnaire-based interview. Analyses were then carried out using the chi-square (x2) followed by multivariate analysis using multiple logistic regressions.Results: This study showed that knowledge has a significant relationship with practice for rabies disease prevention (p = 0.013; OR 4.240; 95% CI 1.352 up to 13.296). Attitude has a significant positive relationship with the value of practice for rabies disease prevention (p = 0.015; OR 3.073; 95% CI 1.233 up to 7.627). The combined effect of knowledge and attitudes to practice for rabies prevention were approximately 20.90% (Negerkerke R square = 0.209).Conclusions: There was a significant relationship between knowledge and attitudes with the practice for rabies disease prevention in residents in the area of Puskesmas Kuta II, the higher level of knowledge and improved attitudes will improve practice for rabies disease prevention amongst residents in the area of Puskesmas Kuta II. Key words: Rabies; Rabies; Preventio; Knowledge; Attitude; Practice

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Komunikasi Interpersonal Pengawas Minum Obat Berperspektif Gender dengan Kepatuhan Berobat Penderita Tuberkulosis di Tiga Puskesmas di Kabupaten Bogor

Jurnal Komunikasi Pembangunan ◽

10.46937/15201722772 ◽

2017 ◽

Vol 15 (1) ◽

Author(s):

Widiawati Walangadi ◽

Dwi Sadono ◽

Djoko Susanto

Keyword(s):

Interpersonal Communication ◽

Communication Skills ◽

Significant Relationship ◽

Treatment Compliance ◽

Total Sample ◽

Cross Sectional Study ◽

Patient Treatment ◽

Cross Sectional ◽

Gender Perspective ◽

The Relationship

The problem of tuberculosis (TB) control is still very large in Indonesia. Pengawas minum obat (PMO) for each patient tuberculosis expected to ensure the regularity of the patients taking medicine. The objectives of the study are 1) to analyze interpersonal communication skills of PMO gender perspective with TB patient, and 2) to analyze relationship between interpersonal communication skills PMO gender perspective with TB patient treatment compliance. Explanatory research method with cross-sectional study design, with a total sample of 82 of the PMO at three Public Health Centers PMO Ciomas, Cileungsi, Cibinong. Data were collected using questionnaire and analyzed using chi-square. The results showed the relationship between the characteristics of the PMO with interpersonal communication skills PMO value of p > 0.01 so give no significant relationship, the relationship between gender perspectif with interpersonal communication skills PMO is p <0.01 means that there is significant correlation. The relationship between the PMO interpersonal communication skills with patient compliance level p <0.01 means that there is a significant relationship. Conclusion characteristics of the PMO are the largely nonexistent relationship with interpersonal communication skills of PMO, whereas the gender perspective is significally correlated to interpersonal communication skills of the PMO. The level of interpersonal communication skills are significantly correlated of TB treatment compliance.

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The Relationship Between Defense Mechanisms and Nurses’ Occupational Burnout: A Cross-Sectional Study

Iranian Journal of Psychiatry and Behavioral Sciences ◽

10.5812/ijpbs.106716 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Forouzan Elyasi ◽

Seyed Mohammad Hosseininejad ◽

Parisa Islami Parkoohi ◽

Mahsa Kamali ◽

Marzieh Azizi ◽

...

Keyword(s):

Significant Relationship ◽

Defense Mechanisms ◽

Maslach Burnout Inventory ◽

Cross Sectional Study ◽

Sectional Study ◽

Occupational Burnout ◽

Cross Sectional ◽

Low Level ◽

The Mean ◽

The Relationship

Background: Occupational burnout is a psychological syndrome that occurs in response to chronic stress in the workplace. Nowadays, it is known as one of the most important consequences of occupational stress. Defense mechanisms may also affect occupational burnout. Objectives: Since burnout is an important factor influencing the productivity of nurses, this study was conducted to investigate the relationship between the defense mechanisms and occupational burnout among nurses in the educational hospitals of an urban area in Iran. Methods: This descriptive cross-sectional study was conducted on 318 nurses who had at least one-year of work experience in four educational hospitals in Sari city, Iran, in 2018. Sampling was performed using the proportional stratified sampling method. The data were collected by the Maslach Burnout Inventory (MBI) scale, psychological Defense Styles questionnaire (DSQ-40), and a demographic questionnaire. Data were analyzed using descriptive and inferential statistics via the SPSS software V.20. Results: A total of 318 nurses were studied, 13 (4.1%) of the nurses had a burnout. The mean score of the dimension of emotional exhaustion (EE) was 17.49, in the dimension of depersonalization (DP) it was 5.42, and in the dimension of personal achievement (PA) it was 31.58. They indicated a low level of occupational burnout, and the mean scores of FE, DP, and PA subscales indicated a low level of occupational burnout. The use of more mature defense mechanisms had a significant negative correlation with the increase of the EE score (rho = -0.210, P < 0.001), but no significant relationship was reported with other aspects of burnout. Increased use of immature defense mechanisms had a direct correlation with the increase in the score of DP (rho = 0.255 and P < 0.001), but had a significant inverse relationship with the PA score (rho = -0.238 and P < 0.001) and no significant relationship with EE (P = 0.627). No significant relationship was found between the use of neurotic defense mechanisms and burnout dimensions (PEE = 0.119, PDP = 0.174, and PPA = 0.127). Conclusions: Since there is a significant relationship between defense mechanisms and occupational burnout, using the components of defense mechanisms in job interviews can lead to choosing appropriate nurses to perform different tasks in different settings, in accordance with individual and psychological characteristics. Also, teaching problem-solving skills, stress management, and useful information can improve defense mechanisms, nurses’ job performance, and patient satisfaction.

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HUBUNGAN PENGETAHUAN DAN MASA KERJA DENGAN GANGGUAN MUSKULOSKELETAL PADA PERAWAT DI RUMAH SAKIT

MEDICAL JURNAL OF AL QODIRI ◽

10.52264/jurnal_stikesalqodiri.v5i2.43 ◽

2020 ◽

Vol 5 (2) ◽

pp. 7

Author(s):

Ishana Balaputra

Keyword(s):

Musculoskeletal Disorders ◽

Significant Relationship ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Job Tenure ◽

Chi Square ◽

Cross Sectional ◽

Full Inclusion ◽

Work Posture ◽

The Relationship

A health problem that is often associated with a non-ergonomic workplace is musculoskeletal disorders. This study is aimed to evaluate the relationship between knowledge of ergonomics and job tenurewith musculoskeletal disorders (MSDs) among nurses in hospital. To perform this cross sectional study, 29 nursing personnel who had full inclusion to participate, were taken with total sampling. For collecting data, a verified questionnaire was used to assess knowledge of ergonomics and job tenure, OWAS was used to assess work posture, and NBM was used to assess musculoskeletal disorders. Data analysis used chi square for bivariate and logistic regression for multivariate test. Bivariate analysis showed there was no significant relationship between gender, age, and education level with musculoskeletal disorders (p>0,05). The relationship between knowledge of ergonomics, work posture, and job tenure with musculoskeletal disorders ware significant (p<0,05). Multivariate analysis showed the significant relationship between knowledge of ergonomics, work posture, and job tenure with musculoskeletal disorders together (p=0,000) with a contribution of 41.07% (R2 0,4107).Education and training on proper ergonomics and work posture should be introduced in the workplace to reduce the risk of musculoskeletal disorders (MSDs) among the nurses working in different settings. Keywords: knowledge of ergonomics,musculoskeletal disorders, job tenure, work posture, nurses

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Evaluating the Relationship Between Serum Level of Interleukin-6 and Rheumatoid Arthritis Severity and Disease Activity

Current Rheumatology Reviews ◽

10.2174/1573397115666190206144223 ◽

2020 ◽

Vol 16 (3) ◽

pp. 249-255 ◽

Cited By ~ 4

Author(s):

Elham Rajaei ◽

Karim Mowla ◽

Qodratollah Hayati ◽

Ali Ghorbani ◽

Mehrdad Dargahi-Malamir ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Serum Level ◽

Interleukin 6 ◽

Significant Relationship ◽

Serum Levels ◽

P Value ◽

Das28 Score ◽

Cross Sectional ◽

Das 28 ◽

The Relationship

Aim: The aim of this study was to evaluate the relationship between Interleukin-6 (IL-6) serum level and the severity and activity of Rheumatoid Arthritis (RA). Methods: In this cross-sectional study, 120 RA patients referred to the rheumatology clinic, the patients were diagnosed by rheumatologists according to ACR / EULAR 2010 criteria. Based on DAS28 score the patients were divided into 4 groups: Remission, Mild, Moderate and Severe. Each group contained 30 patients. Serum levels of Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF) and serum levels of IL-6, were measured. The relationship between these factors was measured and compared to the relationship between IL-6 and these factors, and the activity of the disease was evaluated based on DAS-28. Results: This study showed that the serum level of IL-6 has a significant relationship with RA activity according to DAS-28 (P value <0.001). There is also a significant relationship between the ESR level, the number of painful joints, and the number of swollen joints, and the severity of the disease based on VAS. Conclusion: Generally the findings of this study indicate that serum level of IL-6 plays an important role in the severity and activity of RA disease and can be considered as a determining factor in evaluating the severity of RA in RA patients and it is a good guide for a step up or down of treatment.

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An Investigation of the Relationship Between Attitudes Towards Caring for Dying Patients and Compassion

OMEGA - Journal of Death and Dying ◽

10.1177/00302228211004805 ◽

2021 ◽

pp. 003022282110048

Author(s):

Senay Karadag Arli

Keyword(s):

Significant Relationship ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Self Compassion ◽

Dying Patients ◽

Significant Difference ◽

Volunteer Participation ◽

The Relationship ◽

Compassion Scale

The study aims to investigate the relationship between nurses’ attitudes towards caring for dying patients and compassion levels. This cross-sectional study was conducted with the volunteer participation of 130 nurses working in various clinics in a hospital located in eastern Turkey between March and June 2019. Data were collected through the Socio-demographic Form, the Frommelt Attitude toward Care of Dying Scale (FATCOD), and the Self-Compassion Scale (SCS). A statistically significant difference was found between nurses’ education level and compassion level (p < 0.01). A significant difference was found between the units where they were working and attitude towards caring for dying patients (p < 0.01). A positive, statistically significant relationship was found between the FATCOD total score and SCS total score (p < 0.01). A significant relationship between the compassion level and attitude toward caring for dying patients is an important finding for nurses, who encounter death frequently.

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