scholarly journals Serum brain natriuretic peptide in healthy Nigerian newborn babies

2021 ◽  
Vol 48 (1) ◽  
pp. 8-11
Author(s):  
Amudalat Issa ◽  
Mohammed B. Abdulkadir ◽  
Omotayo O. Adesiyun ◽  
Bilkis Owolabi ◽  
Surajudeen O. Bello ◽  
...  
Keyword(s):  
Birth Weight ◽  
Brain Natriuretic Peptide ◽  
Racial Differences ◽  
Natriuretic Peptide ◽  
Gestational Age ◽  
Adult Population ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Chronological Age ◽  
Cross Sectional

Background: Brain natriuretic peptide (BNP) is a sensitive biomarker that is valuable in the management of childhood heart failure. Studies have reported racial differences in the level of BNP, especially in the adult population. The level of BNP in healthy Nigerian newborn babies is unknown. Hence, we determined the level of BNP in healthy term appropriate for gestational age (AGA) newborn babies. Methods: This was a cross sectional study,85 healthy term AGA newborn babies aged 24 to 72 hours. The babies had relevant demographic parameters documented in a proforma and BNP assay analysed using ELISA method. Results: The median IQR serum BNP level was 341.43 (313.39 to 425.45) pg/ml. The median level in females, was higher than males, {393.86 (296.97- 460.62) pg/ml vs328.05 (313.61-389.39) pg/ml, p >0.05}.There was no significant relationship between serum BNP and birth weight, chronological age, gestational age, or mode of delivery (p>0.05 in each case). Conclusion: The study demonstrated high BNP levels in healthy term Nigerian newborns. There was no relationship between BNP, the chronological age, birth weight, gender, gestational age or mode of delivery in babies between 24 to 72 hours of life.

scholarly journals Prevalence of small for gestational age newborns and associated factors in a Brazilian Northeast capital

2018 ◽  
Vol 18 (3) ◽  
pp. 539-547
Author(s):  
Micaely Cristina dos Santos Tenório ◽  
Marilene Brandão Tenório ◽  
Raphaela Costa Ferreira ◽  
Carolina Santos Mello ◽  
Alane Cabral Menezes de Oliveira
Keyword(s):  
Birth Weight ◽  
Hierarchical Model ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Associated Factors ◽  
Protective Factor ◽  
Mode Of Delivery ◽  
Low Frequency ◽  
Cross Sectional Study ◽  
Cross Sectional

Abstract Objectives: to analyze the factors associated with the birth of small for gestational age (SGA)infants, in a Northeastern Brazilian capital. Methods: a cross-sectional study was carried out with 331 pregnant women and their newborns attending the public health network in the city of Maceió, in 2014. Maternal antenatal data were collected (socioeconomic, lifestyle, clinical and nutritional) as well as data of the newborns (gestational age, mode of delivery, sex, birth weight and length), after delivery. Birth weight was classified according to the INTERGROWTH-21st curves, being considered SGA those below the 10th percentile according to gestational age and gender. The results were analyzed by Poisson regression using a hierarchical model and were expressed as prevalence ratios (PR) and their respective 95% confidence intervals (CI95%). Results: it was verified that 5.1% of the newborns were SGA. Regarding the associated factors, after adjustment of the hierarchical model, the variable working outside the home was associated with the endpoint studied [PR = 0.14; (CI95% = 0.02-0.75); p=0.022]. Conclusions: it was verified a low frequency of SGA infants in the evaluated population. The fact that the mother works outside the home proved to be a protective factor for this condition.

scholarly journals The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia: A Cross-sectional Study

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110196
Author(s):  
Sitotaw Molla Mekonnen ◽  
Daniel Mengistu Bekele ◽  
Fikrtemariam Abebe Fenta ◽  
Addisu Dabi Wake
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Gestational Age ◽  
Associated Factors ◽  
Addis Ababa ◽  
Cross Sectional Study ◽  
Public Hospitals ◽  
Sectional Study ◽  
Cross Sectional

Necrotizing enterocolitis (NEC) remains to be the most critical and frequent gastrointestinal disorder understood in neonatal intensive care units (NICU). The presented study was intended to assess the prevalence of NEC and associated factors among enteral Fed preterm and low birth weight neonates. Institution based retrospective cross-sectional study was conducted on 350 enteral Fed preterm and low birth weight neonates who were admitted at selected public hospitals of Addis Ababa from March 25/2020 to May 10/2020. The data were collected through neonates’ medical record chart review. A total of 350 participants were enrolled in to the study with the response rate of 99.43%. One hundred eighty-four (52.6%) of them were male. The majority 123 (35.1%) of them were (32 + 1 to 34) weeks gestational age. The prevalence of NEC was (25.4%) (n = 89, [95% CI; 21.1, 30.0]). Being ≤28 weeks gestational age (AOR = 3.94, 95% CI [2.67, 9.97]), being (28 + 1 to 32 weeks) gestational age (AOR = 3.65, 95% CI [2.21, 8.31]), birth weight of 1000 to 1499 g (AOR = 2.29, 95% CI [1.22, 4.33]), APGAR score ≤3 (AOR = 2.34, 95% CI [1.32, 4.16]), prolonged labor (AOR = 2.21, 95% CI [1.35, 6.38]), maternal chronic disease particularly hypertension (AOR = 3.2, 95% CI [1.70, 5.90]), chorioamnionitis (AOR = 4.8, 95% CI [3.9, 13]), failure to breath/resuscitated (AOR = 2.1, 95% CI [1.7, 4.4]), CPAP ventilation (AOR = 3.7, 95% CI [1.50, 12.70]), mixed milk (AOR = 3.58, 95% CI [2.16, 9.32]) were factors significantly associated with NEC. Finally, the prevalence of NEC in the study area was high. So that, initiating the programs that could minimize this problem is required to avoid the substantial morbidity and mortality associated with NEC.

scholarly journals Association of Maternal Hemoglobin and Birth Weight at Paropakar Maternity and Women’s Hospital, Kathmandu

2017 ◽  
Vol 11 (2) ◽  
pp. 20-23
Author(s):  
Safiur Rahman Ansari ◽  
Gehanath Baral
Keyword(s):  
Birth Weight ◽  
Negative Correlation ◽  
Strong Correlation ◽  
Neonatal Death ◽  
Maternal Age ◽  
Pearson Correlation ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Aims: To examine the association between maternal hemoglobin with birth weight.Methods: Cross sectional study of obstetrics database at Paropakar Maternity and Women’s Hospital. Hospital delivery of over 18 years of age women tested for Pearson correlation using SPSS-17.Results: Total of 2085 cases analyzed. There was mean hemoglobin value of 12.05 ± 1.30 (95% CI=11.992-12.103) g/dL and no any significant impact on mode of delivery (p=0.15) and neonatal death (p=0.736). There was a small but a significant correlation (p<0.01) of maternal age with hemoglobin (r = 0.106) and birth weight (r = 0.093); but a very small negative correlation between maternal hemoglobin and birth weight.Conclusions: Optimal maternal hemoglobin during labor rules out any strong correlation with birth weight.

scholarly journals Stillbirths - Determining the associated factors and causes according to relevant condition at death: an experience from Pokhara, Nepal

2018 ◽  
Vol 6 (2) ◽  
pp. 58-65
Author(s):  
Junu Shrestha ◽  
Rami Shrestha ◽  
Sonam Gurung
Keyword(s):  
Birth Weight ◽  
Antenatal Care ◽  
Amniotic Fluid ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Intrauterine Growth ◽  
Factors Associated ◽  
Relevant Condition ◽  
Cord Prolapse

Background: Stillbirth contributes significantly to perinatal mortality. This study was conducted with aim to determine various factors associated with it and to define the causes of stillbirth according to relevant condition at birth.Materials and Methods :This is prospective cross-sectional study conducted in the Department of Obstetrics and Gynaecology of Manipal Teaching Hospital from July 2015 to June 2017. All cases of stillbirth occurring during antenatal or intrapartum period after 28 weeks of gestation or fetus weighing 1000 grams or more were included. Detailed demographic parameters were noted. After delivery, fetus, placenta, umbilical cord and amniotic fluid were noted in detail. Data was entered in SPSS version 16 and analysis done.Results: The stillbirth rate was 22 per 1000 births. Low educational level of women, lack of antenatal care, multiparous status, gestational age less than 34 weeks, low birth weight and male gender of fetus were found to be significantly associated with stillbirths. The cause of fetal death could be identified according to relevant condition at death in 84% of cases. Only in 16%, the cause of stillbirth was not identified. Intrauterine growth restriction was the commonest cause of stillbirth (22%), followed by congenital anomalies (15%) and hypertensive disorders of pregnancy (14%). Other causes were abruptio (7%), intrapartum asphyxia (7%) and rupture uterus (5%). Other minor causes were anemia, diabetes, cord prolapse and amniotic fluid abnormalities.Conclusion :Low level of education, lack of quality antenatal care, multiparity, low gestational age and birth weight and male sex of fetus were factors associated with stillbirth. The cause of stillbirth was identified in most of the cases and largely was due to intrauterine growth restriction.Journal of Nobel Medical CollegeVolume 6, Number 2, Issue 11, July-December 2017, 58-65

scholarly journals LOW BIRTH WEIGHT BABIES;

2017 ◽  
Vol 24 (08) ◽  
pp. 1176-1180
Author(s):  
Brig® Khalid Mehmood ◽  
Ijaz Ali ◽  
Syed Hyder Raza
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Data Collection Tool ◽  
Cross Sectional ◽  
Normal Birth ◽  
Low Birth Weight Babies ◽  
Study Setting

Objectives: To determine the proportion of LBW Babies among those deliveredat DHQ Hospital Mirpur. Study design: Descriptive cross sectional study. Setting: DHQ hospitalMirpur AJK. Duration of study: January 2013-May 2013. Sample size: 459 deliveries. Studypopulation: women reporting in Peads OPD of DHQ hospital Mirpur AJ&K with their babiesduring study period. Sampling technique: Convenience method. Data collection tool: Datacollection Performa. Data analysis: SPSS version 14.0.Results: Out of 459 deliveriesconducted at Divisional Head Quarter hospital Mirpur, 149 cases of low birth weight babies(<2500gms) whereas the rest 310 had normal birth weight. Frequency of Low Birth Weight inmale new born babies was high, i.e ratio of male babies were 55% (82) out of 149 individualswhile females were 45% (67). Less than 37 weeks of gestational age, 37% (55) were pretermbabies and 37 – 42 weeks of gestational age, 63% (94) were full term babies.

scholarly journals Reference values for N-terminal Pro-brain natriuretic peptide in premature infants during their first weeks of life

2020 ◽  
Author(s):  
Agnes-Sophie Fritz ◽  
Titus Keller ◽  
Angela Kribs ◽  
Christoph Hünseler
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Preterm Infants ◽  
Premature Infants ◽  
Reference Values ◽  
Gestational Age ◽  
Temporal Distribution ◽  
Cross Sectional ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Abstract The aim of our study was to observe the temporal distribution of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in premature infants of ≤ 31 weeks of gestational age (GA) during the first weeks of life. NT-proBNP values of 118 preterm infants born ≤ 31 weeks GA were determined during the first week of life, after 4 ± 1 weeks of life, and at a corrected GA of 36 ± 2 weeks. Infants were divided into two groups: those without relevant complications and those with complications related to prematurity. NT-proBNP values of infants without complications define our exploratory reference values. The Median NT-proBNP level of these infants was 1896 ng/l (n = 27, interquartile range (IQR): 1277–5200) during the first week of life, 463 ng/l (n = 26, IQR: 364–704) at 4 ± 1 weeks of life, and 824 ng/l (n = 33, IQR: 714–1233) at a corrected GA of 36 ± 2 weeks. Infants born < 28 + 0 weeks GA had significantly higher NT-proBNP values (n = 9, median: 5200, IQR: 1750–8972) than infants born ≥ 28 + 0–31 weeks GA (n = 18, median: 1528, IQR: 838–3052; p = 0.017). Growth restriction or PDA status could not account for the difference in NT-proBNP values between GA groups. Conclusions: The results of our observational and cross-sectional study describe exploratory reference values for NT-proBNP levels in preterm infants of ≤ 31 weeks GA according to postnatal age. NT-proBNP levels during the first week of life are high and widely distributed in preterm infants and decrease subsequently to reach a distinctly lower and stable plateau at around 1 month of life. Our results suggest an influence of GA on NT-proBNP values in the first week of life. What is Known:• Several complications related to prematurity, e.g., hemodynamically significant PDA, pulmonary hypertension, bronchopulmonary dysplasia, and retinopathy of prematurity, have been associated with a temporary rise in NT-proBNP values in preterm infants during their first weeks of life.What is New:• This observational study provides reference values for NT-proBNP levels of very and extremely preterm infants during their first weeks of life.• In premature infants without complications, NT-proBNP values during their first week of life depend on gestational age at birth.

Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia

2012 ◽  
Vol 302 (6) ◽  
pp. E687-E693 ◽  
Author(s):  
Hisashi Masuyama ◽  
Etsuko Nobumoto ◽  
Seiji Inoue ◽  
Yuji Hiramatsu
Keyword(s):  
Brain Natriuretic Peptide ◽  
Mrna Expression ◽  
Natriuretic Peptide ◽  
Primary Cultures ◽  
Cross Sectional Study ◽  
Potential Interaction ◽  
Normal Weight ◽  
Cross Sectional ◽  
Omental Adipose Tissue ◽  
Positive Correlations

Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational age and body mass index. The BNP, leptin, and adiponectin levels were measured by ELISA, and their mRNA expressions were evaluated in omental adipose tissue by real-time PCR. The effects of BNP on adiponectin and leptin mRNA expression and secretion were investigated in primary cultures of adipocytes from obese and normal-weight women. The BNP, adiponectin, and leptin levels were significantly higher in preeclampsia patients compared with controls. The adiponectin level was increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients. Adiponectin mRNA expression was increased significantly in adipose tissues of preeclampsia patients compared with controls and was also increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients, whereas leptin was not. BNP and adiponectin showed significant positive correlations in both normal-weight and overweight preeclampsia patients. BNP had a significantly weaker effect on adiponectin in overweight compared with normal-weight preeclampsia patients. Moreover, BNP had a weaker effect on adiponectin production in adipocytes from overweight women compared with adipocytes from normal-weight women using primary culture of human adipocytes. These data suggested that BNP may play a role in hyperadiponectinemia of preeclampsia patients. The weaker effect of BNP on adiponectin production may participate in the pathophysiology of overweight preeclampsia patients.

Influence of Patient-Level Factors on Mode of Delivery among Operative Vaginal Delivery Candidates in Modern Practice

2017 ◽  
Vol 34 (10) ◽  
pp. 0974-0981 ◽  
Author(s):  
Christina Gonzalez ◽  
Amanda Allshouse ◽  
Erick Henry ◽  
Sean Esplin ◽  
Torri Metz
Keyword(s):  
Vaginal Delivery ◽  
Gestational Age ◽  
Maternal Age ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Second Stage ◽  
Patient Level ◽  
Operative Vaginal Delivery

Objective We aimed to evaluate which patient-level factors influence mode of delivery among candidates for operative vaginal delivery. Study Design Cross-sectional study of candidates for operative vaginal delivery from 18 hospitals over 8 years. Probabilities of mode of delivery were estimated using hierarchical logistic modeling adjusting for clustering within physician and hospital. Results Total 3,771 (64%) women delivered with forceps, 1,474 (25%) vacuums, and 665 (11%) cesareans. Odds of forceps versus vacuum were higher with induction (OR = 2.16, 95% CI: 1.76–2.65), nulliparity (OR = 2.06, 95% CI: 1.59–2.66), epidural (OR = 2.05, 95% CI: 1.19–3.56), maternal indication (OR = 1.53, 95% CI 1.16–2.02), older maternal age (OR 1.18, 95% CI 1.06–1.31 per 5 years), and longer second stage (OR = 1.10, 95% CI: 1.01–1.20 per hour).Odds of cesarean versus operative vaginal delivery were higher with maternal indication (OR = 9.0, 95% CI: 7.23–11.20), a perinatologist (OR = 2.51, 95% CI: 1.09–5.78), longer second stage (OR = 1.79, 95% CI: 1.65–1.93 per hour), older gestational age (OR = 1.10, 95% CI: 1.01–1.20 per week), and longer labor (OR = 1.02, 95% CI: 1.01–1.04 per hour). Conclusion Patient-level factors influence the decision to proceed with an operative vaginal delivery and the choice of instrument, thereby emphasizing the importance of maintaining availability of both forceps and vacuums.

scholarly journals Factors affecting the fetal & maternal outcome in a trial of labour after previous one caesarean section

2019 ◽  
Vol 10 (2) ◽  
pp. 1110-1117
Author(s):  
Aseel Ghazi Rifat
Keyword(s):  
Caesarean Section ◽  
Gestational Age ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Safe Alternative ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Fetal Complications ◽  
History Of ◽  
Maternal Bmi

This study was designed to evaluate maternal and obstetrical factors associated with a successful trial of labour after one caesarean section (TOLAC) as well as evaluating the associated fetal and maternal outcomes and to determine the rate of vaginal delivery and repeated C/S. A prospective cross-sectional study was done on 237 women with previous one C/S then patients were selected for the trial of labour based on the department protocol. Those who were chosen for TOL were strictly monitored & observed for the progress of labour and the outcomes were recorded in terms of mode of delivery, maternal & fetal complications and were analysed and compared with those who had repeated C/S. Seventy-three (30.8%) patient was delivered by elective C/S without trial, 109 (46%) of the patients who were admitted to labour room delivered vaginally while 55 (23.2%) delivered by emergency C/S. It has been found that maternal BMI of (<25), history of vaginal birth after C/S (VBAC) and smaller gestational age were significantly associated with the success of TOL and can predict the outcome. Higher maternal & fetal complications rates were reported in cases delivered by emergency C/S compared to those who delivered vaginally or through elective C/S. The trial of labour after one caesarean section is a safe alternative to repeated C/S and decreases the associated morbidities with repeated C/S. The success rate of TOLAC reported in this study was (66.5%). A successful TOLAC is associated with normal maternal BMI, smaller gestational age and history of the previous VBAC.

scholarly journals A cross-sectional study on the correlation between postnatal foot length and various other anthropometric parameters along with the gestational age

2020 ◽  
Vol 7 (8) ◽  
pp. 414-419
Author(s):  
Dr. Abhinaya Arun Raj ◽  
◽  
Dr. K. Maheswari ◽  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Head Circumference ◽  
Cross Sectional Study ◽  
Chest Circumference ◽  
Sectional Study ◽  
Cross Sectional ◽  
Foot Length ◽  
The Mean ◽  
R Value

Introduction: This study was done to assess the utility of foot length in determining theanthropometric parameters of a newborn in a tertiary care teaching hospital. Materials andMethods: This cross-sectional study among 270 newborns were done at Sri Venkateswaraa medicalcollege hospital and research centre, from Nov 2018 to May 2020. All the healthy live newbornswere taken into the study and newborns with congenital lower limb anomalies were excluded.Results: The mean birth weight of the neonate 2.948+0.344 kg which ranged from 2.050 kg to3.750kg. The mean foot length, head circumference and chest circumference of the foot length was8.113+0.468 cm, 48.989+1.093 cm, 34.437+0.659 cm and 32.372+0.734 cm respectively. The footlength had a maximum correlation with birth weight (r-value=0.905) followed by gestational age (r-value=0.809), length (r-value=0.786), head circumference (r-value=0.719) and chest circumference(r-value=0.603). Conclusion: Foot length had a significant correlation with birth weight andgestational age of the neonates. Foot length also correlated significantly with other anthropometricvariables like length, head circumference and chest circumference.

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