scholarly journals Cardiovascular consequences of the inspiratory muscle metaboreflex: effects of age and sex

2017 ◽  
Vol 312 (5) ◽  
pp. H1013-H1020 ◽  
Author(s):  
Joshua R. Smith ◽  
Andrew M. Alexander ◽  
Shane M. Hammer ◽  
Kaylin D. Didier ◽  
Stephanie P. Kurti ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Older Women ◽  
Young Men ◽  
Premenopausal Women ◽  
Older Men ◽  
Inspiratory Muscle ◽  
Muscle Metaboreflex ◽  
Resistive Breathing ◽  
Younger Men

With inspiratory muscle metaboreflex activation, we hypothesized that, compared with their younger counterparts, older men and women would exhibit greater 1) increases in mean arterial pressure (MAP) and limb vascular resistance (LVR) and 2) decreases in limb blood flow (Q̇L) but 3) no sex differences would be present in older adults. Sixteen young adults [8 young men (YM) and 8 young women (YW), 18–24 yr] and 16 older adults [8 older men (OM) and 8 older women (OW), 60–73 yr] performed inspiratory resistive breathing tasks (IRBTs) at 2% and 65% of their maximal inspiratory pressure. During the IRBTs, breathing frequency was 20 breaths/min with a 50% duty cycle. At baseline and during the IRBTs, MAP was measured via automated oscillometry, Q̇L was determined via Doppler ultrasound, and LVR was calculated. The 65% IRBT led to significantly greater increases in MAP in OW (15.9 ± 8.1 mmHg) compared with YW (6.9 ± 1.4 mmHg) but not ( P > 0.05) between OM (12.3 ± 5.7 mmHg) and YM (10.8 ± 5.7 mmHg). OW (−20.2 ± 7.2%) had greater ( P < 0.05) decreases in Q̇L compared with YW (−9.4 ± 10.2%), but no significant differences were present between OM (−22.8 ± 9.7%) and YM (−22.7 ± 11.3%) during the 65% IRBT. The 65% IRBT led to greater ( P < 0.05) increases in LVR in OW (48.2 ± 25.5%) compared with YW (19.7 ± 15.0%), but no differences ( P > 0.05) existed among OM (54.4 ± 17.8%) and YM (47.1 ± 23.3%). No significant differences were present in MAP, Q̇L, or LVR between OM and OW. These data suggest that OW exhibit a greater inspiratory muscle metaboreflex compared with YW, whereas no differences between OM and YM existed. Finally, sex differences in the inspiratory muscle metaboreflex are not present in older adults. NEW & NOTEWORTHY Premenopausal women exhibit an attenuated inspiratory muscle metaboreflex compared with young men; however, it is unknown whether these sex differences are present in older adults. Older women exhibited a greater inspiratory muscle metaboreflex compared with premenopausal women, whereas no differences were present between older and younger men.

scholarly journals Sex differences in the cardiovascular consequences of the inspiratory muscle metaboreflex

2016 ◽  
Vol 311 (3) ◽  
pp. R574-R581 ◽  
Author(s):  
Joshua R. Smith ◽  
Ryan M. Broxterman ◽  
Shane M. Hammer ◽  
Andrew M. Alexander ◽  
Kaylin D. Didier ◽  
...  
Keyword(s):  
Sex Differences ◽  
Premenopausal Women ◽  
Inspiratory Muscle ◽  
Breathing Frequency ◽  
Limb Blood Flow ◽  
Men And Women ◽  
Muscle Metaboreflex ◽  
Healthy Men ◽  
Mouth Pressure ◽  
Resistive Breathing

It is currently unknown whether sex differences exist in the cardiovascular consequences of the inspiratory muscle metaboreflex. We hypothesized that the activation of the inspiratory muscle metaboreflex will lead to less of an increase in mean arterial pressure (MAP) and limb vascular resistance (LVR) and less of a decrease in limb blood flow (Q̇L) in women compared with men. Twenty healthy men ( n = 10, 23 ± 2 yr) and women ( n = 10, 22 ± 3 yr) were recruited for this study. Subjects performed inspiratory resistive breathing tasks (IRBTs) at 2% or 65% of their maximal inspiratory mouth pressure (PIMAX). During the IRBTs, the breathing frequency was 20 breaths/min with a 50% duty cycle. At rest and during the IRBTs, MAP was measured via automated oscillometry, Q̇L was measured via Doppler ultrasound, and LVR was calculated. EMG was recorded on the leg to ensure no muscle contraction occurred. The 65% IRBT led to attenuated increases ( P < 0.01) from baseline in women compared with men for MAP (W: 7.3 ± 2.0 mmHg; M: 11.1 ± 5.0 mmHg) and LVR (W: 17.7% ± 14.0%; M: 47.9 ± 21.0%), as well as less of a decrease ( P < 0.01) in Q̇L (W: −7.5 ± 9.9%; M: −23.3 ± 10.2%). These sex differences in MAP, Q̇L, and LVR were still present in a subset of subjects matched for PIMAX. The 2% IRBT resulted in no significant changes in MAP, Q̇L, or LVR across time or between men and women. These data indicate premenopausal women exhibit an attenuated inspiratory muscle metaboreflex compared with age-matched men.

Abstract 17438: Sex Differences and Temporal Trends in Revascularization and Outcomes of ST-Elevation Myocardial Infarction in Older Adults in the United States

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Varun Pattisapu ◽  
Hua Hao
Keyword(s):  
Myocardial Infarction ◽  
Older Adults ◽  
Sex Differences ◽  
Hospital Mortality ◽  
Older Women ◽  
Temporal Trends ◽  
Older Men ◽  
St Elevation Myocardial Infarction ◽  
St Elevation ◽  
To Receive

Background: Prior studies have suggested that women with ST-elevation myocardial infarction (STEMI) have higher in-hospital mortality risk than younger men with STEMI. However, there is a significant STEMI risk in older patients. We analyzed temporal trends and sex differences in revascularization and other in-hospital outcomes in older STEMI patients. Methods: National Inpatient Sample databases from 2005 to 2014 were utilized to identify all STEMI patients with age greater than 60 years old. We studied the temporal trends and sex differences in revascularization therapies and in-hospital mortality. Results: There were N=192,204 older adults diagnosed with STEMI. Older women with STEMI were less likely to undergo coronary angiography (adjusted OR: 0.90; 95% CI: 0.88 to 0.93) and receive reperfusion (percutaneous coronary intervention (PCI) adjusted OR: 0.90; 95% CI: 0.87 to 0.92) compared to older men. Also, the adjusted odds ratio comparing the likelihood of receiving PCI between women and men decreased by an annual average of 0.9% (P=0.028). Older men were more likely to receive PCI on Hospital Day 0 compared to older women. There was a decreasing trend in both sexes for use of coronary artery bypass graft (CABG), though older men consistently underwent CABG more often than older women (Figure). Older women had higher in-hospital mortality than men (adjusted OR: 1.12; 95% CI: 1.08 to 1.17). However, the differences decreased with increasing patient age. There was no significant change in adjusted in-hospital mortality in both genders (all P>0.05). Conclusions: Older women were less likely to receive revascularization for STEMI than men, and this gap increased over the study period. Older women had higher in-hospital mortality compared with older men, but there was no significant temporal change for both genders. Further research is needed to identify the reasons why older women receive less revascularization.

Sex Differences in the Dynamic Component of Postural Balance in Older Adults

2020 ◽  
pp. 442-446
Author(s):  
Taisiya P. Shiryaeva ◽  
◽  
Anatoliy V. Gribanov ◽  
Denis M. Fedotov ◽  
◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Older Women ◽  
Postural Balance ◽  
Older Men ◽  
Dynamic Component ◽  
Sit To Stand ◽  
Pathological Conditions ◽  
Computer Aided ◽  
Rate Of Ageing

Gait and balance disorders are common in older adults and represent a multifaceted problem resulting from a combination of natural involutional processes and various pathological conditions. However, to date, the dynamic component of postural balance in older adults remains poorly studied. In order to determine sex differences in the dynamic component of postural balance, 40 older men and 40 older women were tested (Sit-to-Stand, Walk Across, Tandem Walk, Step/Quick Turn, Step-Up-and- Over tests) using the computer-aided stabilometric complex Balance Master. The research found that in older women, the parameters of the dynamic component of postural balance are more intact than in men, probably due to a slower rate of ageing.

scholarly journals Body mass index and mild cognitive impairment among rural older adults in China: the moderating roles of gender and age

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yemin Yuan ◽  
Jie Li ◽  
Nan Zhang ◽  
Peipei Fu ◽  
Zhengyue Jing ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older People ◽  
Older Women ◽  
Older Men ◽  
Gender And Age ◽  
Low Bmi ◽  
Rural Older Adults

Abstract Background Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. Methods Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. Results There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26–3.44], women (aOR = 2.06, 95% CI: 1.35–3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34–7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69–6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17–4.61) than normal BMI group. Conclusions Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.

scholarly journals Gender Differences in Resilience Among Older Taiwanese Adults

2021 ◽  
Author(s):  
Deleon Fergus ◽  
Yi-Hua Chen ◽  
Ying-Chih Chuang ◽  
Ai-Hsuan Ma ◽  
Kun-Yang Chuang
Keyword(s):  
Older Adults ◽  
Older Women ◽  
Social Relationships ◽  
Older Men ◽  
Living Environment ◽  
Multivariate Logistic Regression ◽  
Traditional Gender Roles ◽  
Resilience Scale ◽  
Behavioural Factors ◽  
Gender Impacts

Abstract Objectives The aim of this study was to determine whether gender impacts potential associations between social relationships, sociodemographic, health and behavioural factors with resilience among older Taiwanese adults. Methods High and low resilience of older adults was determined based on the median value of the Friborg’s Resilience Scale. An independent sample t-test, χ2, and multivariate logistic regression were used to examine predictors for resilience which were then stratified by gender. Results Older women were less likely to be resilient than older men. Marital status, age, financial stress, and satisfaction with one's living environment were only significant in women. Traditional gender roles in the wider Taiwanese context can be attributed to these differences. Conclusions The relationships between gender, sociodemographics, health, and social and behavioural factors with resilience provide unique insights into how culture shapes trends in data.

scholarly journals Objectively assessed physical activity patterns and physical function in community-dwelling older adults: a cross-sectional study in Taiwan

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e034645
Author(s):  
Ming-Chun Hsueh ◽  
Ru Rutherford ◽  
Chien-Chih Chou ◽  
Jong-Hwan Park ◽  
Hyun-Tae Park ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Function ◽  
Older Women ◽  
Handgrip Strength ◽  
Older Men ◽  
Daily Step ◽  
Cross Sectional ◽  
Step Counts ◽  
Single Leg Stance

ObjectivesTo objectively assess light physical activity (PA), moderate-to-vigorous PA (MVPA), step counts and number of 10 min MVPA bouts and their association with physical function among older adults.DesignCross-sectional design.SettingUrban community setting in Taiwan.Participants127 Taiwanese older adults aged over 65 years (mean age=70.8±5.3 years; 72% women).Primary and secondary outcome measuresTriaxial accelerometers were used to measure PA variables for 10 hours/day for seven consecutive days. Then, five physical function components (handgrip strength, single-leg stance, 5-metre walk speed, timed up and go and sit-to-stand test) were measured. Multiple linear regressions were used to perform separate analyses for older men and women.ResultsFor older women, daily MVPA time (β: 0.39, 95% CI: 0.12, 0.64; p=0.004), daily step counts (β: 0.46, 95% CI: 0.12, 0.78; p=0.009) and number of 10 min MVPA bouts (β: 0.27, 95% CI: 0.001, 0.53; p=0.049) were positively associated with handgrip strength after adjusting for accelerometer wear time, sedentary time and other confounders. Furthermore, daily MVPA time was positively associated with a single-leg stance (β: 0.25, 95% CI: 0.02, 0.49; p=0.036) and higher daily step counts were associated with shorter walking speed performance (β: −0.31, 95% CI: −0.57, −0.001; p=0.049). None of the variables of the objectively assessed PA patterns was associated with physical function outcomes among older men due to their small sample size.ConclusionsDaily MVPA, MVPA bouts of at least 10 min and accumulated daily steps are important for improving physical function among older women. Future prospective research should establish causal associations between PA patterns and functional ability among older adults.

Reference intervals for plasma lipoperoxides: age-, sex-, and specimen-related variations.

1987 ◽  
Vol 33 (12) ◽  
pp. 2289-2291 ◽  
Author(s):  
J A Knight ◽  
S E Smith ◽  
V E Kinder ◽  
H B Anstall
Keyword(s):  
Older Women ◽  
Young Women ◽  
Blood Donors ◽  
Sodium Citrate ◽  
Older Men ◽  
Reference Intervals ◽  
Female Adult ◽  
Experimental Animals ◽  
Age Related ◽  
Younger Men

Abstract We measured lipoperoxides, as malondialdehyde (MDA), by liquid chromatography in plasma from 230 male and 148 female adult blood donors, to establish reliable reference values and to compare possible sex-, age-, and specimen-related differences. Our studies show that mean have higher MDA concentrations in plasma than do women (P less than 0.05), older men have higher values than younger men (P less than 0.05), and older women have higher values than young women (P less than 0.001). These age-related results support earlier studies in experimental animals that lipid peroxidation increases with increasing age. In addition, plasma from liquid EDTA-anti-coagulated blood has significantly lower MDA concentrations than does serum or plasma from blood treated with lithium heparin, sodium citrate, or CPDA-1 (P less than 0.001).

Effect of Age on Sex Differences in the Inspiratory Muscle Metaboreflex

2017 ◽  
Vol 49 (5S) ◽  
pp. 796
Author(s):  
Joshua R. Smith ◽  
Andrew M. Alexander ◽  
Shane M. Hammer ◽  
Kaylin D. Didier ◽  
Stephanie P. Kurti ◽  
...  
Keyword(s):  
Sex Differences ◽  
Inspiratory Muscle ◽  
Muscle Metaboreflex ◽  
Effect Of Age

Sex Differences in the Inspiratory Muscle Metaboreflex

2016 ◽  
Vol 48 ◽  
pp. 670
Author(s):  
Joshua R. Smith ◽  
Ryan M. Broxterman ◽  
Shane M. Hammer ◽  
Andrew M. Alexander ◽  
Kaylin D. Didier ◽  
...  
Keyword(s):  
Sex Differences ◽  
Inspiratory Muscle ◽  
Muscle Metaboreflex

Sex differences in the perceived intensity of breathlessness during exercise with advancing age

2008 ◽  
Vol 104 (6) ◽  
pp. 1583-1593 ◽  
Author(s):  
Dror Ofir ◽  
Pierantonio Laveneziana ◽  
Katherine A. Webb ◽  
Yuk-Miu Lam ◽  
Denis E. O'Donnell
Keyword(s):  
Sex Differences ◽  
Older Women ◽  
Cross Sectional Study ◽  
Inspiratory Muscle ◽  
Cross Sectional ◽  
Respiratory Impairment ◽  
Mechanical Constraints ◽  
Age Related ◽  
Underlying Mechanisms ◽  
Age Related Changes

The prevalence of activity-related breathlessness increases with age, particularly in women, but the specific underlying mechanisms have not been studied. This novel cross-sectional study was undertaken to examine the effects of age and sex, and their interaction, on the perceptual and ventilatory responses to incremental treadmill exercise in 73 healthy participants (age range 40–80 yr old) with normal pulmonary function. Age-related changes at a standardized oxygen uptake (V̇o2) during exercise included significant increases in breathlessness ratings (Borg scale), ventilation (V̇e), ventilatory equivalent for carbon dioxide, and the ratio of tidal volume (Vt) to dynamic inspiratory capacity (IC) (all P < 0.05). These changes were quantitatively similar in women ( n = 39) and in men ( n = 34). For the group as a whole, exertional breathlessness ratings increased as resting static inspiratory muscle strength diminished ( P = 0.05), as exercise ventilation increased relative to capacity ( P = 0.013) and as the Vt/IC ratio increased ( P = 0.003) during exercise. Older women (60–80 yr old, n = 23) reported greater ( P < 0.05) intensity of exertional breathlessness at a standardized V̇o2 and V̇e than age-matched men ( n = 16), despite similar age-related changes in ventilatory demand and dynamic ventilatory mechanics. These increases in breathlessness ratings in older women disappeared when sex differences in baseline maximal ventilatory capacity were accounted for. In conclusion, although increased exertional breathlessness with advancing age is multifactorial, contributory factors included higher ventilatory requirements during exercise, progressive inspiratory muscle weakness, and restrictive mechanical constraints on Vt expansion related to reduced IC. The sensory consequences of this age-related respiratory impairment were more pronounced in women, who, by nature, have relatively reduced maximal ventilatory reserve.

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